UniProtKB - Q9SIA5 (DTX1_ARATH)
Protein
Protein DETOXIFICATION 1
Gene
DTX1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Efflux carrier for plant-derived alkaloids, antibiotics, heavy metal and other toxic compounds. Involved in cadmium detoxification. Requires probably a proton-motive force for the efflux.1 Publication
Caution
Mistakenly referred to as AT2G04070 in PubMed:11739388.Curated
GO - Molecular functioni
- antiporter activity Source: InterPro
- efflux transmembrane transporter activity Source: TAIR
- transmembrane transporter activity Source: GO_Central
- xenobiotic transmembrane transporter activity Source: InterPro
GO - Biological processi
- cadmium ion transport Source: TAIR
- sequestering of metal ion Source: TAIR
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.66.1.8, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Protein DETOXIFICATION 11 PublicationShort name: AtDTX11 Publication Alternative name(s): Multidrug and toxic compound extrusion protein 1Curated Short name: MATE protein 1Curated |
Gene namesi | Name:DTX11 Publication Synonyms:TX1 Ordered Locus Names:At2g04040Imported ORF Names:F3L12.13Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G04040 |
TAIRi | locus:2050190, AT2G04040 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: TAIR
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 184 – 204 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 260 – 280 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 289 – 309 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 331 – 351 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 370 – 390 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 433 – 453 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000405319 | 1 – 476 | Protein DETOXIFICATION 1Add BLAST | 476 |
Proteomic databases
PaxDbi | Q9SIA5 |
PRIDEi | Q9SIA5 |
ProteomicsDBi | 221824 |
Expressioni
Tissue specificityi
Ubiquitous. Highest expression in flowers and stems.1 Publication
Gene expression databases
ExpressionAtlasi | Q9SIA5, baseline and differential |
Genevisiblei | Q9SIA5, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 339, 37 interactors |
IntActi | Q9SIA5, 37 interactors |
STRINGi | 3702.AT2G04040.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1347, Eukaryota |
HOGENOMi | CLU_012893_1_0_1 |
InParanoidi | Q9SIA5 |
OMAi | TITTVHY |
OrthoDBi | 743037at2759 |
PhylomeDBi | Q9SIA5 |
Family and domain databases
InterProi | View protein in InterPro IPR002528, MATE_fam |
Pfami | View protein in Pfam PF01554, MatE, 2 hits |
TIGRFAMsi | TIGR00797, matE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9SIA5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEPFLLRDE LLVPSQVTWH TNPLTVELKR VSRLAAPMAT VTIAQYLLPV
60 70 80 90 100
ISVMVAGHNG ELQLSGVALA NSFTNVTGFS IMCGLVGALE TLCGQAYGAK
110 120 130 140 150
QYEKIGTYAY SAIASNIPIC FLISILWLYI EKILISLGQD PEISRIAGSY
160 170 180 190 200
AFWLIPALFG QAIVIPLSRF LLTQGLVIPL LFTAVTTLLF HVLVCWTLVF
210 220 230 240 250
LFGLGCNGPA MATSVSFWFY AVILSCYVRF SSSCEKTRGF VSRDFVSSIK
260 270 280 290 300
QFFQYGIPSA AMICLEWWLF EILILCSGLL PNPKLETSVL SICLTIETLH
310 320 330 340 350
YVISAGVAAA VSTRVSNNLG AGNPQVARVS VLAGLCLWIV ESAFFSILLF
360 370 380 390 400
TCRNIIGYAF SNSKEVLDYV ADLTPLLCLS FILDGFTAVL NGVARGSGWQ
410 420 430 440 450
HIGAWNNTVS YYLVGAPVGI YLAFSRELNG KGLWCGVVVG STVQATILAI
460 470
VTASINWKEQ AEKARKRIVS TENRLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007178 Genomic DNA Translation: AAD28687.1 CP002685 Genomic DNA Translation: AEC05791.1 BT022022 mRNA Translation: AAY25434.1 BT026371 mRNA Translation: ABH04478.1 AK227153 mRNA Translation: BAE99196.1 |
PIRi | A84454 |
RefSeqi | NP_178491.1, NM_126443.5 |
Genome annotation databases
EnsemblPlantsi | AT2G04040.1; AT2G04040.1; AT2G04040 |
GeneIDi | 814938 |
Gramenei | AT2G04040.1; AT2G04040.1; AT2G04040 |
KEGGi | ath:AT2G04040 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007178 Genomic DNA Translation: AAD28687.1 CP002685 Genomic DNA Translation: AEC05791.1 BT022022 mRNA Translation: AAY25434.1 BT026371 mRNA Translation: ABH04478.1 AK227153 mRNA Translation: BAE99196.1 |
PIRi | A84454 |
RefSeqi | NP_178491.1, NM_126443.5 |
3D structure databases
SMRi | Q9SIA5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 339, 37 interactors |
IntActi | Q9SIA5, 37 interactors |
STRINGi | 3702.AT2G04040.1 |
Protein family/group databases
TCDBi | 2.A.66.1.8, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily |
Proteomic databases
PaxDbi | Q9SIA5 |
PRIDEi | Q9SIA5 |
ProteomicsDBi | 221824 |
Genome annotation databases
EnsemblPlantsi | AT2G04040.1; AT2G04040.1; AT2G04040 |
GeneIDi | 814938 |
Gramenei | AT2G04040.1; AT2G04040.1; AT2G04040 |
KEGGi | ath:AT2G04040 |
Organism-specific databases
Araporti | AT2G04040 |
TAIRi | locus:2050190, AT2G04040 |
Phylogenomic databases
eggNOGi | KOG1347, Eukaryota |
HOGENOMi | CLU_012893_1_0_1 |
InParanoidi | Q9SIA5 |
OMAi | TITTVHY |
OrthoDBi | 743037at2759 |
PhylomeDBi | Q9SIA5 |
Miscellaneous databases
PROi | PR:Q9SIA5 |
Gene expression databases
ExpressionAtlasi | Q9SIA5, baseline and differential |
Genevisiblei | Q9SIA5, AT |
Family and domain databases
InterProi | View protein in InterPro IPR002528, MATE_fam |
Pfami | View protein in Pfam PF01554, MatE, 2 hits |
TIGRFAMsi | TIGR00797, matE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DTX1_ARATH | |
Accessioni | Q9SIA5Primary (citable) accession number: Q9SIA5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 8, 2011 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families