UniProtKB - Q9SI64 (SPE1_ARATH)
Arginine decarboxylase 1
ADC1
Functioni
Required for the biosynthesis of putrescine. Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine (PubMed:11576438, PubMed:15733873, PubMed:25409942).
Is a minor contributor to basal arginine decarboxylase (ADC) activity and putrescine biosynthesis (PubMed:25409942).
Accumulation of putrescine plays a positive role in freezing tolerance (PubMed:18701673).
Production of polyamines is essential for normal seed development (PubMed:15733873).
Controls PA homeostasis which is crucial for normal plant growth and development (PubMed:27014322).
5 PublicationsCatalytic activityi
- EC:4.1.1.191 Publication
Cofactori
Protein has several cofactor binding sites:: agmatine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.Curated This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.
GO - Molecular functioni
- arginine decarboxylase activity Source: GO_Central
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- arginine catabolic process Source: InterPro
- polyamine biosynthetic process Source: TAIR
- putrescine biosynthetic process from arginine Source: GO_Central
- response to cold Source: TAIR
- response to oxidative stress Source: TAIR
- response to salt stress Source: TAIR
- spermidine biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Putrescine biosynthesis, Spermidine biosynthesis, Stress response |
Ligand | Magnesium, Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | ARA:AT2G16500-MONOMER |
BRENDAi | 4.1.1.19, 399 |
UniPathwayi | UPA00186;UER00284 |
Names & Taxonomyi
Protein namesi | Recommended name: Arginine decarboxylase 1Curated (EC:4.1.1.191 Publication)Short name: ADC 1Curated Short name: ADC-OCurated Short name: ARGDC 1Curated Short name: AtADC11 Publication |
Gene namesi | Name:ADC11 Publication Synonyms:SPE11 Publication Ordered Locus Names:At2g16500Imported ORF Names:F1P15.12Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G16500 |
TAIRi | locus:2045111, AT2G16500 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 1 Publication
Chloroplast
- chloroplast 1 Publication
Note: Localizes mainly in the chloroplast.1 Publication
Chloroplast
- chloroplast Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Keywords - Cellular componenti
Chloroplast, Cytoplasm, PlastidPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 136 | K → A: Loss of decarboxylase activity. 1 Publication | 1 | |
Mutagenesisi | 524 | C → A: Loss of decarboxylase activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149946 | 1 – 702 | Arginine decarboxylase 1Add BLAST | 702 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 136 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Proteomic databases
PaxDbi | Q9SI64 |
PRIDEi | Q9SI64 |
ProteomicsDBi | 232568 |
Expressioni
Inductioni
Gene expression databases
ExpressionAtlasi | Q9SI64, baseline and differential |
Genevisiblei | Q9SI64, AT |
Interactioni
Subunit structurei
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 3702.AT2G16500.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 320 – 330 | Substrate-bindingBy similarityAdd BLAST | 11 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QTXD, Eukaryota |
HOGENOMi | CLU_027243_0_0_1 |
InParanoidi | Q9SI64 |
OMAi | TRAVMGQ |
OrthoDBi | 762520at2759 |
PhylomeDBi | Q9SI64 |
Family and domain databases
CDDi | cd06830, PLPDE_III_ADC, 1 hit |
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR009006, Ala_racemase/Decarboxylase_C IPR002985, Arg_decrbxlase IPR022657, De-COase2_CS IPR022644, De-COase2_N IPR022653, De-COase2_pyr-phos_BS IPR000183, Orn/DAP/Arg_de-COase IPR029066, PLP-binding_barrel |
PANTHERi | PTHR43295, PTHR43295, 1 hit |
Pfami | View protein in Pfam PF02784, Orn_Arg_deC_N, 1 hit |
PIRSFi | PIRSF001336, Arg_decrbxlase, 1 hit |
PRINTSi | PR01180, ARGDCRBXLASE PR01179, ODADCRBXLASE |
SUPFAMi | SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR01273, speA, 1 hit |
PROSITEi | View protein in PROSITE PS00878, ODR_DC_2_1, 1 hit PS00879, ODR_DC_2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPALAFVDTP IDTFSSIFTP SSVSTAVVDG SCHWSPSLSS SLYRIDGWGA
60 70 80 90 100
PYFAANSSGN ISVRPHGSNT LPHQDIDLMK VVKKVTDPSG LGLQLPLIVR
110 120 130 140 150
FPDVLKNRLE CLQSAFDYAI QSQGYDSHYQ GVYPVKCNQD RFIIEDIVEF
160 170 180 190 200
GSGFRFGLEA GSKPEILLAM SCLCKGNPEA FLVCNGFKDS EYISLALFGR
210 220 230 240 250
KLELNTVIVL EQEEELDLVI DLSQKMNVRP VIGLRAKLRT KHSGHFGSTS
260 270 280 290 300
GEKGKFGLTT VQILRVVRKL SQVGMLDCLQ LLHFHIGSQI PSTALLSDGV
310 320 330 340 350
AEAAQLYCEL VRLGAHMKVI DIGGGLGIDY DGSKSGESDL SVAYSLEEYA
360 370 380 390 400
AAVVASVRFV CDQKSVKHPV ICSESGRAIV SHHSVLIFEA VSAGQQHETP
410 420 430 440 450
TDHQFMLEGY SEEVRGDYEN LYGAAMRGDR ESCLLYVDQL KQRCVEGFKE
460 470 480 490 500
GSLGIEQLAG VDGLCEWVIK AIGASDPVLT YHVNLSVFTS IPDFWGIDQL
510 520 530 540 550
FPIVPIHKLD QRPAARGILS DLTCDSDGKI NKFIGGESSL PLHEMDNNGC
560 570 580 590 600
SGGRYYLGMF LGGAYEEALG GVHNLFGGPS VVRVLQSDGP HGFAVTRAVM
610 620 630 640 650
GQSSADVLRA MQHEPELMFQ TLKHRAEEPR NNNNKACGDK GNDKLVVASC
660 670 680 690 700
LAKSFNNMPY LSMETSTNAL TAAVNNLGVY YCDEAAAGGG GKGKDENWSY
FG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 452 | S → F in AAB09723 (PubMed:8756495).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U52851 mRNA Translation: AAB09723.1 AC007195 Genomic DNA Translation: AAD26494.1 CP002685 Genomic DNA Translation: AEC06503.1 BT008636 mRNA Translation: AAP40453.1 |
PIRi | A84541 S71239 |
RefSeqi | NP_179243.1, NM_127204.3 |
Genome annotation databases
EnsemblPlantsi | AT2G16500.1; AT2G16500.1; AT2G16500 |
GeneIDi | 816149 |
Gramenei | AT2G16500.1; AT2G16500.1; AT2G16500 |
KEGGi | ath:AT2G16500 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U52851 mRNA Translation: AAB09723.1 AC007195 Genomic DNA Translation: AAD26494.1 CP002685 Genomic DNA Translation: AEC06503.1 BT008636 mRNA Translation: AAP40453.1 |
PIRi | A84541 S71239 |
RefSeqi | NP_179243.1, NM_127204.3 |
3D structure databases
SMRi | Q9SI64 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT2G16500.1 |
Proteomic databases
PaxDbi | Q9SI64 |
PRIDEi | Q9SI64 |
ProteomicsDBi | 232568 |
Genome annotation databases
EnsemblPlantsi | AT2G16500.1; AT2G16500.1; AT2G16500 |
GeneIDi | 816149 |
Gramenei | AT2G16500.1; AT2G16500.1; AT2G16500 |
KEGGi | ath:AT2G16500 |
Organism-specific databases
Araporti | AT2G16500 |
TAIRi | locus:2045111, AT2G16500 |
Phylogenomic databases
eggNOGi | ENOG502QTXD, Eukaryota |
HOGENOMi | CLU_027243_0_0_1 |
InParanoidi | Q9SI64 |
OMAi | TRAVMGQ |
OrthoDBi | 762520at2759 |
PhylomeDBi | Q9SI64 |
Enzyme and pathway databases
UniPathwayi | UPA00186;UER00284 |
BioCyci | ARA:AT2G16500-MONOMER |
BRENDAi | 4.1.1.19, 399 |
Miscellaneous databases
PROi | PR:Q9SI64 |
Gene expression databases
ExpressionAtlasi | Q9SI64, baseline and differential |
Genevisiblei | Q9SI64, AT |
Family and domain databases
CDDi | cd06830, PLPDE_III_ADC, 1 hit |
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR009006, Ala_racemase/Decarboxylase_C IPR002985, Arg_decrbxlase IPR022657, De-COase2_CS IPR022644, De-COase2_N IPR022653, De-COase2_pyr-phos_BS IPR000183, Orn/DAP/Arg_de-COase IPR029066, PLP-binding_barrel |
PANTHERi | PTHR43295, PTHR43295, 1 hit |
Pfami | View protein in Pfam PF02784, Orn_Arg_deC_N, 1 hit |
PIRSFi | PIRSF001336, Arg_decrbxlase, 1 hit |
PRINTSi | PR01180, ARGDCRBXLASE PR01179, ODADCRBXLASE |
SUPFAMi | SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR01273, speA, 1 hit |
PROSITEi | View protein in PROSITE PS00878, ODR_DC_2_1, 1 hit PS00879, ODR_DC_2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPE1_ARATH | |
Accessioni | Q9SI64Primary (citable) accession number: Q9SI64 Secondary accession number(s): Q38938 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families