UniProtKB - Q9SI52 (P4KG7_ARATH)
Phosphatidylinositol 4-kinase gamma 7
PI4KG7
Functioni
The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity).
Undergoes autophosphorylation and phosphorylates serine/threonine residues of protein substrates (PubMed:17880284).
By similarity1 PublicationCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H+1 PublicationEC:2.7.1.671 PublicationThis reaction proceeds in the forward1 Publication direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 194 | ATPBy similarity | 1 | |
Binding sitei | 345 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 173 – 179 | ATPBy similarity | 7 | |
Nucleotide bindingi | 283 – 286 | ATPBy similarity | 4 |
GO - Molecular functioni
- 1-phosphatidylinositol 4-kinase activity Source: TAIR
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- phosphatidylinositol phosphate biosynthetic process Source: TAIR
- protein autophosphorylation Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 4-kinase gamma 71 Publication (EC:2.7.1.671 Publication)Short name: AtPI4Kgamma71 Publication Short name: PI-4Kgamma71 Publication Short name: PI4K gamma 71 Publication Alternative name(s): Ubiquitin-like domain kinase gamma 71 Publication Short name: UbDK gamma 71 Publication |
Gene namesi | Name:PI4KG71 Publication Synonyms:PI4KGAMMA71 Publication, UBDKGAMMA71 Publication Ordered Locus Names:At2g03890Imported ORF Names:T18C20.9Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G03890 |
TAIRi | locus:2056799, AT2G03890 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423364 | 1 – 650 | Phosphatidylinositol 4-kinase gamma 7Add BLAST | 650 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 593 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9SI52 |
PRIDEi | Q9SI52 |
ProteomicsDBi | 251407 [Q9SI52-1] |
PTM databases
iPTMneti | Q9SI52 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SI52, baseline and differential |
Genevisiblei | Q9SI52, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 316, 1 interactor |
STRINGi | 3702.AT2G03890.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 103 | Ubiquitin-like; degenerateAdd BLAST | 58 | |
Domaini | 166 – 463 | PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST | 298 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 172 – 178 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 316 – 324 | Catalytic loopPROSITE-ProRule annotation | 9 | |
Regioni | 343 – 369 | Activation loopPROSITE-ProRule annotationAdd BLAST | 27 | |
Regioni | 508 – 534 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 560 – 595 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 516 – 530 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 581 – 595 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2381, Eukaryota |
HOGENOMi | CLU_027241_1_1_1 |
InParanoidi | Q9SI52 |
OMAi | CVSSANM |
PhylomeDBi | Q9SI52 |
Family and domain databases
InterProi | View protein in InterPro IPR044571, P4KG1-8 IPR000403, PI3/4_kinase_cat_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR45800, PTHR45800, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50290, PI3_4_KINASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketThis entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRNLDSPVQ TQMAVAVFKT PLTGASKMEG KQHHKHQHLQ RQSSGRRVFV
60 70 80 90 100
QTETGCVLGM ELDRSDNVHT VKRRLQIALN FPTEESSLTY GDMVLTNDLS
110 120 130 140 150
AVRNDSPLLL KRNFMHRSSS TPCLSPTGRD LQQKDRSGPI EILGHSDCFS
160 170 180 190 200
IVKHMVKDIV KAMKMGVEPL PVHSGLGGAY YFRNKRGESV AIVKPTDEEP
210 220 230 240 250
FAPNNPKGFV GKALGQPGLK SSVRVGETGF REVAAYLLDY GRFANVPPTA
260 270 280 290 300
LVKITHSVFN VNDGVKGNKP REKKLVSKIA SFQKFVAHDF DASDHGTSSF
310 320 330 340 350
PVTSVHRIGI LDIRIFNTDR HGGNLLVKKL DGVGMFGQVE LIPIDHGLCL
360 370 380 390 400
PETLEDPYFE WIHWPQASLP FSDEEVDYIQ SLDPVKDCDM LRRELPMIRE
410 420 430 440 450
ACLRVLVLCT IFLKEASAYG LCLAEIGEMM TREFRPGEEE PSELEVVCIE
460 470 480 490 500
AKRSVTERDV FSPRSDVVGE AEFQFDLDCD DLESVYSSKI QLTDDYFTKN
510 520 530 540 550
PFSNGRSSLG KLEESIKEEE EDEEEEEDKT ENTVPMIIMK DSFFSSAAFH
560 570 580 590 600
DKAPSLSKLS TSMKNTHLSD TTRKNPKPLT RGKSENTSSG HKSANEQLPV
610 620 630 640 650
SASFVKVADM KEDEWVLFLE RFQELLGPAF AKRKTATLSK RQRLGTSCQF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF4IU74 | F4IU74_ARATH | 1-phosphatidylinositol 4-kinase | PI4K GAMMA 7 ATPI4K GAMMA 7, UBDK GAMMA 7, At2g03890, T18C20.9, T18C20_9 | 530 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007196 Genomic DNA Translation: AAD24822.2 CP002685 Genomic DNA Translation: AEC05763.1 AY056101 mRNA Translation: AAL06989.1 BT002696 mRNA Translation: AAO11612.1 AK229831 mRNA Translation: BAF01661.1 |
PIRi | D84453 |
RefSeqi | NP_565307.1, NM_126434.4 [Q9SI52-1] |
Genome annotation databases
EnsemblPlantsi | AT2G03890.1; AT2G03890.1; AT2G03890 [Q9SI52-1] |
GeneIDi | 814915 |
Gramenei | AT2G03890.1; AT2G03890.1; AT2G03890 [Q9SI52-1] |
KEGGi | ath:AT2G03890 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007196 Genomic DNA Translation: AAD24822.2 CP002685 Genomic DNA Translation: AEC05763.1 AY056101 mRNA Translation: AAL06989.1 BT002696 mRNA Translation: AAO11612.1 AK229831 mRNA Translation: BAF01661.1 |
PIRi | D84453 |
RefSeqi | NP_565307.1, NM_126434.4 [Q9SI52-1] |
3D structure databases
SMRi | Q9SI52 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 316, 1 interactor |
STRINGi | 3702.AT2G03890.1 |
PTM databases
iPTMneti | Q9SI52 |
Proteomic databases
PaxDbi | Q9SI52 |
PRIDEi | Q9SI52 |
ProteomicsDBi | 251407 [Q9SI52-1] |
Genome annotation databases
EnsemblPlantsi | AT2G03890.1; AT2G03890.1; AT2G03890 [Q9SI52-1] |
GeneIDi | 814915 |
Gramenei | AT2G03890.1; AT2G03890.1; AT2G03890 [Q9SI52-1] |
KEGGi | ath:AT2G03890 |
Organism-specific databases
Araporti | AT2G03890 |
TAIRi | locus:2056799, AT2G03890 |
Phylogenomic databases
eggNOGi | KOG2381, Eukaryota |
HOGENOMi | CLU_027241_1_1_1 |
InParanoidi | Q9SI52 |
OMAi | CVSSANM |
PhylomeDBi | Q9SI52 |
Miscellaneous databases
PROi | PR:Q9SI52 |
Gene expression databases
ExpressionAtlasi | Q9SI52, baseline and differential |
Genevisiblei | Q9SI52, AT |
Family and domain databases
InterProi | View protein in InterPro IPR044571, P4KG1-8 IPR000403, PI3/4_kinase_cat_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR45800, PTHR45800, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50290, PI3_4_KINASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P4KG7_ARATH | |
Accessioni | Q9SI52Primary (citable) accession number: Q9SI52 Secondary accession number(s): Q0WMJ0, Q940C9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 18, 2013 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families