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Protein

Peroxidase 14

Gene

PER14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei71Transition state stabilizerPROSITE-ProRule annotation1
Active sitei75Proton acceptorPROSITE-ProRule annotation1
Metal bindingi76Calcium 1PROSITE-ProRule annotation1
Metal bindingi79Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi81Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi83Calcium 1PROSITE-ProRule annotation1
Metal bindingi85Calcium 1PROSITE-ProRule annotation1
Binding sitei172Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi202Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi203Calcium 2PROSITE-ProRule annotation1
Metal bindingi254Calcium 2PROSITE-ProRule annotation1
Metal bindingi257Calcium 2PROSITE-ProRule annotation1
Metal bindingi262Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G18140-MONOMER

Protein family/group databases

PeroxiBasei95 AtPrx14

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 14 (EC:1.11.1.7)
Short name:
Atperox P14
Gene namesi
Name:PER14
Synonyms:P14
Ordered Locus Names:At2g18140
ORF Names:F8D23.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G18140
TAIRilocus:2053139 AT2G18140

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002368023 – 337Peroxidase 14Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 124PROSITE-ProRule annotation
Disulfide bondi77 ↔ 82PROSITE-ProRule annotation
Disulfide bondi130 ↔ 331PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi209 ↔ 241PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9SI17
PRIDEiQ9SI17

Expressioni

Gene expression databases

ExpressionAtlasiQ9SI17 baseline
GenevisibleiQ9SI17 AT

Interactioni

Protein-protein interaction databases

BioGridi1684, 1 interactor
STRINGi3702.AT2G18140.1

Structurei

3D structure databases

ProteinModelPortaliQ9SI17
SMRiQ9SI17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIQM Eukaryota
ENOG410YA1B LUCA
HOGENOMiHOG000237557
InParanoidiQ9SI17
KOiK00430
OMAiFERETRM
OrthoDBiEOG09360H0D
PhylomeDBiQ9SI17

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SI17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARIGSFLIL LSLTYALTLC ICDNASNFGG NKRNLFPDFY RSSCPRAEEI
60 70 80 90 100
VRSVVAKAFE RETRMAASLM RLHFHDCFVQ GCDGSLLLDT SGSIVTEKNS
110 120 130 140 150
NPNSRSARGF EVVDEIKAAL ENECPNTVSC ADALTLAARD SSVLTGGPSW
160 170 180 190 200
TVPLGRRDSA TASRAKPNKD LPEPDNLFDT IFLRFSNEGL NLTDLVALSG
210 220 230 240 250
SHTIGFSRCT SFRQRLYNQS GSGSPDTTLE KSYAAILRQR CPRSGGDQNL
260 270 280 290 300
SELDINSAGR FDNSYFKNLI ENMGLLNSDQ VLFSSNEQSR ELVKKYAEDQ
310 320 330
EEFFEQFAES MIKMGKISPL TGSSGEIRKK CRKINNS
Length:337
Mass (Da):37,204
Last modified:May 1, 2000 - v1
Checksum:iCB07C9D9DC256A1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007212 Genomic DNA Translation: AAD31352.1
CP002685 Genomic DNA Translation: AEC06730.1
PIRiG84560
RefSeqiNP_179406.1, NM_127371.1
UniGeneiAt.52798

Genome annotation databases

EnsemblPlantsiAT2G18140.1; AT2G18140.1; AT2G18140
GeneIDi816327
GrameneiAT2G18140.1; AT2G18140.1; AT2G18140
KEGGiath:AT2G18140

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007212 Genomic DNA Translation: AAD31352.1
CP002685 Genomic DNA Translation: AEC06730.1
PIRiG84560
RefSeqiNP_179406.1, NM_127371.1
UniGeneiAt.52798

3D structure databases

ProteinModelPortaliQ9SI17
SMRiQ9SI17
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1684, 1 interactor
STRINGi3702.AT2G18140.1

Protein family/group databases

PeroxiBasei95 AtPrx14

Proteomic databases

PaxDbiQ9SI17
PRIDEiQ9SI17

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18140.1; AT2G18140.1; AT2G18140
GeneIDi816327
GrameneiAT2G18140.1; AT2G18140.1; AT2G18140
KEGGiath:AT2G18140

Organism-specific databases

AraportiAT2G18140
TAIRilocus:2053139 AT2G18140

Phylogenomic databases

eggNOGiENOG410IIQM Eukaryota
ENOG410YA1B LUCA
HOGENOMiHOG000237557
InParanoidiQ9SI17
KOiK00430
OMAiFERETRM
OrthoDBiEOG09360H0D
PhylomeDBiQ9SI17

Enzyme and pathway databases

BioCyciARA:AT2G18140-MONOMER

Miscellaneous databases

PROiPR:Q9SI17

Gene expression databases

ExpressionAtlasiQ9SI17 baseline
GenevisibleiQ9SI17 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER14_ARATH
AccessioniPrimary (citable) accession number: Q9SI17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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