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Protein

Peroxidase 15

Gene

PER15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei72Transition state stabilizerPROSITE-ProRule annotation1
Active sitei76Proton acceptorPROSITE-ProRule annotation1
Metal bindingi77Calcium 1PROSITE-ProRule annotation1
Metal bindingi80Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi82Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi84Calcium 1PROSITE-ProRule annotation1
Metal bindingi86Calcium 1PROSITE-ProRule annotation1
Binding sitei173Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi203Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi204Calcium 2PROSITE-ProRule annotation1
Metal bindingi255Calcium 2PROSITE-ProRule annotation1
Metal bindingi258Calcium 2PROSITE-ProRule annotation1
Metal bindingi263Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G18150-MONOMER

Protein family/group databases

PeroxiBasei96 AtPrx15

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 15 (EC:1.11.1.7)
Short name:
Atperox P15
Alternative name(s):
ATP36
Gene namesi
Name:PER15
Synonyms:P15
Ordered Locus Names:At2g18150
ORF Names:F8D23.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G18150
TAIRilocus:2053129 AT2G18150

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002368123 – 338Peroxidase 15Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 125PROSITE-ProRule annotation
Disulfide bondi78 ↔ 83PROSITE-ProRule annotation
Disulfide bondi131 ↔ 332PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi210 ↔ 242PROSITE-ProRule annotation
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9SI16
PRIDEiQ9SI16

Expressioni

Gene expression databases

ExpressionAtlasiQ9SI16 baseline and differential
GenevisibleiQ9SI16 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G18150.1

Structurei

3D structure databases

ProteinModelPortaliQ9SI16
SMRiQ9SI16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIQM Eukaryota
ENOG410YA1B LUCA
HOGENOMiHOG000237557
InParanoidiQ9SI16
KOiK00430
OMAiLSLCICD
OrthoDBiEOG09360H0D
PhylomeDBiQ9SI16

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SI16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARIGSFLII LYLIYALTLC ICDDDESNYG GDKGNLFPGF YRSSCPRAEE
60 70 80 90 100
IVRSVVAKAV ARETRMAASL MRLHFHDCFV QGCDGSLLLD TSGSIVTEKN
110 120 130 140 150
SNPNSRSARG FEVVDEIKAA LENECPNTVS CADALTLAAR DSSVLTGGPS
160 170 180 190 200
WMVPLGRRDS TSASLSGSNN NIPAPNNTFN TIVTRFNNQG LDLTDVVALS
210 220 230 240 250
GSHTIGFSRC TSFRQRLYNQ SGNGSPDRTL EQSYAANLRQ RCPRSGGDQN
260 270 280 290 300
LSELDINSAG RFDNSYFKNL IENMGLLNSD EVLFSSNEQS RELVKKYAED
310 320 330
QEEFFEQFAE SMIKMGNISP LTGSSGEIRK NCRKINNS
Length:338
Mass (Da):37,079
Last modified:May 1, 2000 - v1
Checksum:i9496FE1962DEC27E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14I → T in AAM61616 (Ref. 4) Curated1
Sequence conflicti21I → V in AAM61616 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007212 Genomic DNA Translation: AAD31351.1
CP002685 Genomic DNA Translation: AEC06731.1
AY081298 mRNA Translation: AAL91187.1
BT002557 mRNA Translation: AAO00917.1
AY085060 mRNA Translation: AAM61616.1
PIRiH84560
RefSeqiNP_179407.1, NM_127372.4
UniGeneiAt.28467

Genome annotation databases

EnsemblPlantsiAT2G18150.1; AT2G18150.1; AT2G18150
GeneIDi816328
GrameneiAT2G18150.1; AT2G18150.1; AT2G18150
KEGGiath:AT2G18150

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007212 Genomic DNA Translation: AAD31351.1
CP002685 Genomic DNA Translation: AEC06731.1
AY081298 mRNA Translation: AAL91187.1
BT002557 mRNA Translation: AAO00917.1
AY085060 mRNA Translation: AAM61616.1
PIRiH84560
RefSeqiNP_179407.1, NM_127372.4
UniGeneiAt.28467

3D structure databases

ProteinModelPortaliQ9SI16
SMRiQ9SI16
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G18150.1

Protein family/group databases

PeroxiBasei96 AtPrx15

Proteomic databases

PaxDbiQ9SI16
PRIDEiQ9SI16

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18150.1; AT2G18150.1; AT2G18150
GeneIDi816328
GrameneiAT2G18150.1; AT2G18150.1; AT2G18150
KEGGiath:AT2G18150

Organism-specific databases

AraportiAT2G18150
TAIRilocus:2053129 AT2G18150

Phylogenomic databases

eggNOGiENOG410IIQM Eukaryota
ENOG410YA1B LUCA
HOGENOMiHOG000237557
InParanoidiQ9SI16
KOiK00430
OMAiLSLCICD
OrthoDBiEOG09360H0D
PhylomeDBiQ9SI16

Enzyme and pathway databases

BioCyciARA:AT2G18150-MONOMER

Miscellaneous databases

PROiPR:Q9SI16

Gene expression databases

ExpressionAtlasiQ9SI16 baseline and differential
GenevisibleiQ9SI16 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER15_ARATH
AccessioniPrimary (citable) accession number: Q9SI16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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