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Entry version 138 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

Glutamate receptor 2.2

Gene

GLR2.2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glutamate-gated receptor that probably acts as non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate receptor 2.2
Alternative name(s):
Ligand-gated ion channel 2.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLR2.2
Ordered Locus Names:At2g24720
ORF Names:F27A10.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G24720

The Arabidopsis Information Resource

More...
TAIRi
locus:2047256, AT2G24720

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 580ExtracellularSequence analysisAdd BLAST556
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Topological domaini602 – 610CytoplasmicSequence analysis9
Transmembranei611 – 631HelicalSequence analysisAdd BLAST21
Topological domaini632 – 635CytoplasmicSequence analysis4
Transmembranei636 – 656HelicalSequence analysisAdd BLAST21
Topological domaini657 – 830ExtracellularSequence analysisAdd BLAST174
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 920CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001159725 – 920Glutamate receptor 2.2Add BLAST896

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi542N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi702N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SHV1

PRoteomics IDEntifications database

More...
PRIDEi
Q9SHV1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
247399

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in roots.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SHV1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SHV1, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form heteromers.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
2360, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9SHV1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT2G24720.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1052, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007358_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SHV1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEQCHEL

Database of Orthologous Groups

More...
OrthoDBi
188544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SHV1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd19990, PBP1_GABAb_receptor_plant, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR044440, GABAb_receptor_plant_PBP1
IPR001320, Iontro_rcpt
IPR017103, Iontropic_Glu_rcpt_pln
IPR028082, Peripla_BP_I
IPR001638, Solute-binding_3/MltF_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00060, Lig_chan, 1 hit
PF00497, SBP_bac_3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037090, Iontro_Glu-like_rcpt_pln, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00079, PBPe, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822, SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SHV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNSKLFFRF LFLFFFFCLE SSRGQDNGKT QVNIGVVSDV GTSYPDVAML
60 70 80 90 100
CINMSLADFY SSRPQFQTRL VVNVGDSKND VVGAATAAID LIKNKQVKAI
110 120 130 140 150
LGPWTSMQAH FLIEIGQKSR VPVVSYSATS PSLTSLRSPY FFRATYEDSS
160 170 180 190 200
QVHAIKAIIK LFGWREVVPV YIDNTFGEGI MPRLTDSLQD INVRIPYRSV
210 220 230 240 250
IPLNATDQDI SVELLKMMNM PTRVFIVHMS SSLASTVFIK AKELGLMKPG
260 270 280 290 300
YVWILTNGVM DGLRSINETG IEAMEGVLGI KTYIPKSKDL ETFRSRWKRR
310 320 330 340 350
FPQMELNVYG LWAYDATTAL AMAIEDAGIN NMTFSNVDTG KNVSELDGLG
360 370 380 390 400
LSQFGPKLLQ TVSTVQFKGL AGDFHFVSGQ LQPSVFEIVN MIGTGERSIG
410 420 430 440 450
FWTEGNGLVK KLDQEPRSIG TLSTWPDHLK HIIWPGEAVS VPKGWEIPTN
460 470 480 490 500
GKKLRIGVPK RIGFTDLVKV TRDPITNSTV VKGFCIDFFE AVIQAMPYDV
510 520 530 540 550
SYEFFPFEKP NGEPAGNHND LVHQVYLGQF DAVVGDTTIL ANRSSFVDFT
560 570 580 590 600
LPFMKSGVGL IVPLKDEVKR DKFSFLKPLS IELWLTTLVF FFLVGISVWT
610 620 630 640 650
LEHRVNSDFR GPANYQASTI FWFAFSTMVF APRERVLSFG ARSLVVTWYF
660 670 680 690 700
VLLVLTQSYT ASLASLLTSQ QLNPTITSMS SLLHRGETVG YQRTSFILGK
710 720 730 740 750
LNETGFPQSS LVPFDTAEEC DELLKKGPKN GGVAAAFLGT PYVRLFLGQY
760 770 780 790 800
CNTYKMVEEP FNVDGFGFVF PIGSPLVADV SRAILKVAES PKAVELEHAW
810 820 830 840 850
FKKKEQSCPD PVTNPDSNPT VTAIQLGVGS FWFLFLVVFV VCVLALGKFT
860 870 880 890 900
FCFLWKTKGK DLWKEFLKRD TDSYINDIEK CLCSQEMPEN SNKATNQTNY
910 920
GMELRVRNIV QVNQTDPDCL
Length:920
Mass (Da):102,847
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA08EBFE13EAC2EAB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY072068 mRNA Translation: AAL61997.1
AC007266 Genomic DNA Translation: AAD26895.1
CP002685 Genomic DNA Translation: AEC07622.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B84640

NCBI Reference Sequences

More...
RefSeqi
NP_180048.1, NM_128033.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G24720.1; AT2G24720.1; AT2G24720

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817008

Gramene; a comparative resource for plants

More...
Gramenei
AT2G24720.1; AT2G24720.1; AT2G24720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G24720

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072068 mRNA Translation: AAL61997.1
AC007266 Genomic DNA Translation: AAD26895.1
CP002685 Genomic DNA Translation: AEC07622.1
PIRiB84640
RefSeqiNP_180048.1, NM_128033.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi2360, 7 interactors
IntActiQ9SHV1, 1 interactor
STRINGi3702.AT2G24720.1

Proteomic databases

PaxDbiQ9SHV1
PRIDEiQ9SHV1
ProteomicsDBi247399

Genome annotation databases

EnsemblPlantsiAT2G24720.1; AT2G24720.1; AT2G24720
GeneIDi817008
GrameneiAT2G24720.1; AT2G24720.1; AT2G24720
KEGGiath:AT2G24720

Organism-specific databases

AraportiAT2G24720
TAIRilocus:2047256, AT2G24720

Phylogenomic databases

eggNOGiKOG1052, Eukaryota
HOGENOMiCLU_007358_0_2_1
InParanoidiQ9SHV1
OMAiPEQCHEL
OrthoDBi188544at2759
PhylomeDBiQ9SHV1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SHV1

Gene expression databases

ExpressionAtlasiQ9SHV1, baseline and differential
GenevisibleiQ9SHV1, AT

Family and domain databases

CDDicd19990, PBP1_GABAb_receptor_plant, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR044440, GABAb_receptor_plant_PBP1
IPR001320, Iontro_rcpt
IPR017103, Iontropic_Glu_rcpt_pln
IPR028082, Peripla_BP_I
IPR001638, Solute-binding_3/MltF_N
PfamiView protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00060, Lig_chan, 1 hit
PF00497, SBP_bac_3, 1 hit
PIRSFiPIRSF037090, Iontro_Glu-like_rcpt_pln, 1 hit
SMARTiView protein in SMART
SM00079, PBPe, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLR22_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SHV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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