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Entry version 117 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

Septin and tuftelin-interacting protein 1 homolog 1

Gene

STIPL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events (By similarity). Involved in snRNPs recycling (PubMed:25568310). Required for efficient splicing of genes that act within the plant circadian clock (PubMed:23110899). Part of a transcription elongation checkpoint at alternative exons (PubMed:25568310). Required for correct expression and splicing of DOG1, a regulator of seed dormancy (PubMed:25568310). May induce transient transcriptional pausing of polymerase II at slices sites (PubMed:25568310).By similarity2 Publications

Miscellaneous

Physically located at the target splice sites.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Septin and tuftelin-interacting protein 1 homolog 11 Publication
Alternative name(s):
Nineteen complex-related protein 1 homolog1 Publication
Short name:
AtNTR11 Publication
Protein SPLICEOSOMAL TIMEKEEPER LOCUS 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STIPL11 Publication
Synonyms:NTR11 Publication
Ordered Locus Names:At1g17070Imported
ORF Names:F20D23.23Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G17070

The Arabidopsis Information Resource

More...
TAIRi
locus:2020332 AT1G17070

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Long circadian-period phenotype under free-running conditions.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004294301 – 849Septin and tuftelin-interacting protein 1 homolog 1Add BLAST849

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SHG6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
228421

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SHG6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SHG6 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex (By similarity).

Interacts with ILP1 (PubMed:25568310).

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G17070.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SHG6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini200 – 245G-patchPROSITE-ProRule annotationAdd BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili354 – 401Sequence analysisAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi60 – 75Nuclear localization signalSequence analysisAdd BLAST16
Motifi156 – 186Nuclear localization signalSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFP11/STIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2184 Eukaryota
ENOG410XP4Y LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007977_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SHG6

KEGG Orthology (KO)

More...
KOi
K13103

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWEWHEL

Database of Orthologous Groups

More...
OrthoDBi
1238995at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SHG6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000467 G_patch_dom
IPR022783 GCFC_dom
IPR024933 STIP
IPR022159 STIP/TFIP11_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01585 G-patch, 1 hit
PF07842 GCFC, 1 hit
PF12457 TIP_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017706 TFIP11, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00443 G_patch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50174 G_PATCH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SHG6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEYQDMERF SMDNDYEGGR WEGDEFVYQK RKEKRKQTKN DATYGIFAES
60 70 80 90 100
DSDSDDSGGG GSRRKRRKDR DSGRKADLTK PVNFVSTGTV MPNQEIDKDS
110 120 130 140 150
REHNDEKDRD KIEDNDMIDE DVEVRGGLGI GSSGLGLGFN ANGFDDEDNL
160 170 180 190 200
LPGALGKKIA DRAKMRGKAK VEKRGQEGGG AKGGKKNTLG SDIGQFEKST
210 220 230 240 250
KGIGMKLLEK MGYKGGGLGK NQQGIVAPIE AQLRPKNMGM GYNDFKEAKL
260 270 280 290 300
PDLKKVEEKK IIGVSVSENE QSHGDRGGKN LWKKKKVRKA VYVTAEELLE
310 320 330 340 350
KKQEAGFGGG QTIIDMRGPQ VRVVTNLENL DAEEKAKEAD VPMPELQHNL
360 370 380 390 400
RLIVDLVEHE IQKIDRDLRN ERESALSLQQ EKEMLINEEE KQKRHLENME
410 420 430 440 450
YIADEISRIE LENTSGNLTL DSLAIRFEDL QTSYPDDYKL CSLSTIACSL
460 470 480 490 500
ALPLFIRMFQ GWDPLSDAVH GLKAISSWRK LLEVEEDHNI WVVSTPYSQL
510 520 530 540 550
VSEVVLPAVR IAGINTWEPR DPEPMLRFLE TWETLLPSSV LQTILDTVVL
560 570 580 590 600
PKLSTAVEYW DPRRELVAIH VWVHPWLPIL GQKLEFLYQI IQMKLSNVLD
610 620 630 640 650
AWHPSDSSAY TILSPWKTVF DTTSWEQLMR RYIVPKLQLA LQEFQVNPAN
660 670 680 690 700
QNLERFDWVM KWASAVPIHL MADMMERFFF PKWLDVLYHW LRAKPRFEEI
710 720 730 740 750
QGWYYGWKEL FPQELTANER IRIQLKRGLD MLMEAVEGVE VSQPRAKANE
760 770 780 790 800
RTQSVPAQAQ AQAKAQMDST EVLSLKEVLE VFAQEQELLF KPKPNRMHNG
810 820 830 840
LQIYGFGNVS VIIDSVNQKL LAQKDGGWFL VTPDDLLRMH NNTTVSAKR
Length:849
Mass (Da):96,884
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9900CCA70667E464
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM62572 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AK228772 differs from that shown. Reason: Frameshift.Curated
The sequence BAD95266 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007651 Genomic DNA Translation: AAD50023.1
CP002684 Genomic DNA Translation: AEE29537.1
AK222163 mRNA Translation: BAD95266.1 Different initiation.
AK228772 mRNA No translation available.
AY085341 mRNA Translation: AAM62572.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
E86306

NCBI Reference Sequences

More...
RefSeqi
NP_173150.1, NM_101567.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G17070.1; AT1G17070.1; AT1G17070

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
838277

Gramene; a comparative resource for plants

More...
Gramenei
AT1G17070.1; AT1G17070.1; AT1G17070

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G17070

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007651 Genomic DNA Translation: AAD50023.1
CP002684 Genomic DNA Translation: AEE29537.1
AK222163 mRNA Translation: BAD95266.1 Different initiation.
AK228772 mRNA No translation available.
AY085341 mRNA Translation: AAM62572.1 Different initiation.
PIRiE86306
RefSeqiNP_173150.1, NM_101567.3

3D structure databases

SMRiQ9SHG6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G17070.1

Proteomic databases

PaxDbiQ9SHG6
ProteomicsDBi228421

Genome annotation databases

EnsemblPlantsiAT1G17070.1; AT1G17070.1; AT1G17070
GeneIDi838277
GrameneiAT1G17070.1; AT1G17070.1; AT1G17070
KEGGiath:AT1G17070

Organism-specific databases

AraportiAT1G17070
TAIRilocus:2020332 AT1G17070

Phylogenomic databases

eggNOGiKOG2184 Eukaryota
ENOG410XP4Y LUCA
HOGENOMiCLU_007977_1_0_1
InParanoidiQ9SHG6
KOiK13103
OMAiVWEWHEL
OrthoDBi1238995at2759
PhylomeDBiQ9SHG6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SHG6

Gene expression databases

ExpressionAtlasiQ9SHG6 baseline and differential
GenevisibleiQ9SHG6 AT

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR022783 GCFC_dom
IPR024933 STIP
IPR022159 STIP/TFIP11_N
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF07842 GCFC, 1 hit
PF12457 TIP_N, 1 hit
PIRSFiPIRSF017706 TFIP11, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTIP1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SHG6
Secondary accession number(s): Q56W84, Q8LEM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 11, 2014
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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