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Protein

ATPase 6, plasma membrane-type

Gene

AHA6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).By similarity

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3324-aspartylphosphate intermediateBy similarity1
Metal bindingi590MagnesiumBy similarity1
Metal bindingi594MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G07560-MONOMER

Protein family/group databases

TCDBi3.A.3.3.8 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase 6, plasma membrane-type (EC:3.6.3.6)
Alternative name(s):
Proton pump 6
Gene namesi
Name:AHA6
Ordered Locus Names:At2g07560
ORF Names:F9A16.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G07560
TAIRilocus:2053343 AT2G07560

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 64CytoplasmicSequence analysisAdd BLAST64
Transmembranei65 – 84Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini85 – 96ExtracellularSequence analysisAdd BLAST12
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 246CytoplasmicSequence analysisAdd BLAST129
Transmembranei247 – 267Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini268 – 276ExtracellularSequence analysis9
Transmembranei277 – 294Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini295 – 645CytoplasmicSequence analysisAdd BLAST351
Transmembranei646 – 667Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini668 – 672ExtracellularSequence analysis5
Transmembranei673 – 695Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini696 – 711CytoplasmicSequence analysisAdd BLAST16
Transmembranei712 – 732Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini733 – 753ExtracellularSequence analysisAdd BLAST21
Transmembranei754 – 774Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini775 – 786CytoplasmicSequence analysisAdd BLAST12
Transmembranei787 – 807Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini808 – 815ExtracellularSequence analysis8
Transmembranei816 – 836Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini837 – 949CytoplasmicSequence analysisAdd BLAST113

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462791 – 949ATPase 6, plasma membrane-typeAdd BLAST949

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei883PhosphothreonineBy similarity1
Modified residuei931PhosphoserineBy similarity1
Modified residuei948PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SH76
PRIDEiQ9SH76

PTM databases

iPTMnetiQ9SH76

Expressioni

Gene expression databases

ExpressionAtlasiQ9SH76 differential
GenevisibleiQ9SH76 AT

Interactioni

Subunit structurei

Binds to 14-3-3 proteins. The binding is induced by phosphorylation of Thr-948. Binding to 14-3-3 proteins activates the H+-ATPase (By similarity).By similarity

Protein-protein interaction databases

BioGridi719, 1 interactor
IntActiQ9SH76, 1 interactor
STRINGi3702.AT2G07560.1

Structurei

3D structure databases

ProteinModelPortaliQ9SH76
SMRiQ9SH76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni947 – 949Interaction with 14-3-3 proteinsBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0205 Eukaryota
COG0474 LUCA
HOGENOMiHOG000160005
InParanoidiQ9SH76
KOiK01535
OMAiRWEEQDA
OrthoDBiEOG093602AD
PhylomeDBiQ9SH76

Family and domain databases

CDDicd02076 P-type_ATPase_H, 1 hit
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006534 P-type_ATPase_IIIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01647 ATPase-IIIA_H, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SH76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADISWDEI KKENVDLEKI PVDEVFQQLK CSREGLSSEE GRNRLQIFGA
60 70 80 90 100
NKLEEKVENK FLKFLGFMWN PLSWVMEAAA IMAIVLANGG GRPPDWQDFV
110 120 130 140 150
GITCLLIINS TISFIEENNA GNAAAALMAN LAPKTKVLRD GRWGEQEAAI
160 170 180 190 200
LVPGDLISIK LGDIVPADAR LLEGDPLKID QSALTGESLP ATKHQGDEVF
210 220 230 240 250
SGSTCKQGEI EAVVIATGVH TFFGKAAHLV DSTNNVGHFQ KVLTAIGNFC
260 270 280 290 300
ICSIGIGMLI EIIIMYPIQH RKYRDGIDNL LVLLIGGIPI AMPTVLSVTM
310 320 330 340 350
AIGSHRLSQQ GAITKRMTAI EEMAGMDVLC SDKTGTLTLN KLTVDKNLIE
360 370 380 390 400
VFSKDVDKDY VILLSARASR VENQDAIDTS IVNMLGDPKE ARAGITEVHF
410 420 430 440 450
LPFNPVEKRT AITYIDTNGE WHRCSKGAPE QIIELCDLKG ETKRRAHEII
460 470 480 490 500
DKFAERGLRS LGVARQRVPE KDKESAGTPW EFVGLLPLFD PPRHDSAETI
510 520 530 540 550
RRALDLGVNV KMITGDQLAI GKETGRRLGM GTNMYPSSSL LENKDDTTGG
560 570 580 590 600
VPVDELIEKA DGFAGVFPEH KYEIVRKLQE RKHIVGMTGD GVNDAPALKK
610 620 630 640 650
ADIGIAVDDA TDAARSASDI VLTEPGLSVI VSAVLTSRAI FQRMKNYTIY
660 670 680 690 700
AVSITIRIVL GFMLVALIWE FDFSPFMVLI IAILNDGTIM TISKDRVKPS
710 720 730 740 750
PIPDSWKLKE IFATGVVLGT YMALVTVVFF WLAHDTTFFS DKFGVRSLQG
760 770 780 790 800
KDEELIAVLY LQVSIISQAL IFVTRSRSWS FVERPGLLLL IAFFVAQLIA
810 820 830 840 850
TLIATYAHWE FARIKGCGWG WCGVIWIYSI VTYIPLDILK FITRYTLSGK
860 870 880 890 900
AWNNMIENRT AFTTKKDYGR GEREAQWALA QRTLHGLKPP ESMFEDTATY
910 920 930 940
TELSEIAEQA KKRAEVARLR EVHTLKGHVE SVVKLKGLDI DNLNQHYTV
Length:949
Mass (Da):105,012
Last modified:May 1, 2000 - v1
Checksum:i25C076607DB214EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007662 Genomic DNA Translation: AAD32758.1
CP002685 Genomic DNA Translation: AEC06056.1
BT002855 mRNA Translation: AAO22672.1
PIRiG84486
RefSeqiNP_178762.1, NM_126721.3
UniGeneiAt.40955

Genome annotation databases

EnsemblPlantsiAT2G07560.1; AT2G07560.1; AT2G07560
GeneIDi815329
GrameneiAT2G07560.1; AT2G07560.1; AT2G07560
KEGGiath:AT2G07560

Similar proteinsi

Entry informationi

Entry nameiPMA6_ARATH
AccessioniPrimary (citable) accession number: Q9SH76
Secondary accession number(s): Q84WR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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