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UniProtKB - Q9SGN6 (NSL1_ARATH)
Protein
MACPF domain-containing protein NSL1
Gene
NSL1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Negatively controls the salicylic acid (SA)-mediated pathway of programmed cell death in plant immunity.
1 PublicationGO - Biological processi
- cell death Source: UniProtKB
- defense response by callose deposition Source: TAIR
- immune response Source: UniProtKB
- plant-type hypersensitive response Source: TAIR
- regulation of salicylic acid mediated signaling pathway Source: InterPro
- regulation of salicylic acid metabolic process Source: TAIR
- response to salt stress Source: TAIR
Keywordsi
Biological process | Hypersensitive response, Immunity, Innate immunity, Plant defense |
Protein family/group databases
TCDBi | 1.C.39.11.4, the membrane attack complex/perforin (macpf) family |
Names & Taxonomyi
Protein namesi | Recommended name: MACPF domain-containing protein NSL1Alternative name(s): Protein NECROTIC SPOTTED LESIONS 1 Short name: Protein NSL1 |
Gene namesi | Name:NSL1 Ordered Locus Names:At1g28380 ORF Names:F3M18.18 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G28380 |
TAIRi | locus:2032532, AT1G28380 |
Pathology & Biotechi
Disruption phenotypei
Constitutively activated HR-like cell death phenotype with endogenous accumulation of high levels of salicylic acid (SA) and constitutively activated defense phenotype. Dwarf plant with spotted necrotic lesions on its rosette and cauline leaves. Accumulation of high levels of callose and autofluorescent phenolic compounds localized to the necrotic lesions.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000415540 | 1 – 612 | MACPF domain-containing protein NSL1Add BLAST | 612 |
Proteomic databases
PaxDbi | Q9SGN6 |
PRIDEi | Q9SGN6 |
ProteomicsDBi | 249399 |
PTM databases
iPTMneti | Q9SGN6 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SGN6, baseline and differential |
Genevisiblei | Q9SGN6, AT |
Structurei
3D structure databases
AlphaFoldDBi | Q9SGN6 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 338 | MACPFPROSITE-ProRule annotationAdd BLAST | 334 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QQTT, Eukaryota |
HOGENOMi | CLU_034245_1_0_1 |
InParanoidi | Q9SGN6 |
OMAi | WKEWIND |
OrthoDBi | 487462at2759 |
PhylomeDBi | Q9SGN6 |
Family and domain databases
InterProi | View protein in InterPro IPR044663, CAD1/NSL1-like IPR020864, MACPF |
PANTHERi | PTHR33199, PTHR33199, 1 hit |
Pfami | View protein in Pfam PF01823, MACPF, 1 hit |
SMARTi | View protein in SMART SM00457, MACPF, 1 hit |
PROSITEi | View protein in PROSITE PS51412, MACPF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9SGN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFNNFTRLD AHSAAEKAVS VIGLGYDLCS DVRFSACKTT PDGSRLVEID
60 70 80 90 100
PTRNRDLIFP GGIVVNNVSS SIKCDKGERT RLRSDILSFN QMSEKFNQDM
110 120 130 140 150
CLSGKIPSGM FNNMFAFSKC WPKDASSVKT LAYDGWFISL YSVEIVRKQL
160 170 180 190 200
TLRDEVKREV PSSWDSAALA GFIEKYGTHV VVGVTMGGKD VIHVKQMRKS
210 220 230 240 250
NHEPEEIQKM LKHWGDERFC VDPVESKSPA SVYSGKPKEE NLLQWGLQPF
260 270 280 290 300
GTSVSSAVVM HTKNEEIMRV CIRRGGVDLG QSHERWLSTV SQAPNVISMC
310 320 330 340 350
FVPITSLLSG LPGTGFLSHA VNLYLRYKPP IEELHQFLEF QLPRQWAPVY
360 370 380 390 400
GDLPLGLRRS KQSSPSLQFS LMGPKLYVNT SKVDSGERPV TGLRFFLEGK
410 420 430 440 450
KGNHLAIHLQ HLSACPPSLH LSHDDTYEPI EEPVEKGYYV PVKWGIFSHV
460 470 480 490 500
CTYPVQYNGA RSDDTASIVT KAWLEVKGMG MRKVLFLRLG FSLDASAVTR
510 520 530 540 550
KSCWDNLSTN SRKSGVFSMI STRLSTGLSP NPATTKPQSK IDINSAVYPR
560 570 580 590 600
GPSPPVKPKL LSLVDTKEVM RGPEEQPGYW VVTGAKLCVE AGKISIKAKY
610
SLLTVISEDS LV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010155 Genomic DNA Translation: AAF16762.1 CP002684 Genomic DNA Translation: AEE30965.1 AY059744 mRNA Translation: AAL24092.1 AY096632 mRNA Translation: AAM20282.1 |
PIRi | C86410 |
RefSeqi | NP_564307.1, NM_102605.3 |
Genome annotation databases
EnsemblPlantsi | AT1G28380.1; AT1G28380.1; AT1G28380 |
GeneIDi | 839735 |
Gramenei | AT1G28380.1; AT1G28380.1; AT1G28380 |
KEGGi | ath:AT1G28380 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010155 Genomic DNA Translation: AAF16762.1 CP002684 Genomic DNA Translation: AEE30965.1 AY059744 mRNA Translation: AAL24092.1 AY096632 mRNA Translation: AAM20282.1 |
PIRi | C86410 |
RefSeqi | NP_564307.1, NM_102605.3 |
3D structure databases
AlphaFoldDBi | Q9SGN6 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 3702.AT1G28380.1 |
Protein family/group databases
TCDBi | 1.C.39.11.4, the membrane attack complex/perforin (macpf) family |
PTM databases
iPTMneti | Q9SGN6 |
Proteomic databases
PaxDbi | Q9SGN6 |
PRIDEi | Q9SGN6 |
ProteomicsDBi | 249399 |
Genome annotation databases
EnsemblPlantsi | AT1G28380.1; AT1G28380.1; AT1G28380 |
GeneIDi | 839735 |
Gramenei | AT1G28380.1; AT1G28380.1; AT1G28380 |
KEGGi | ath:AT1G28380 |
Organism-specific databases
Araporti | AT1G28380 |
TAIRi | locus:2032532, AT1G28380 |
Phylogenomic databases
eggNOGi | ENOG502QQTT, Eukaryota |
HOGENOMi | CLU_034245_1_0_1 |
InParanoidi | Q9SGN6 |
OMAi | WKEWIND |
OrthoDBi | 487462at2759 |
PhylomeDBi | Q9SGN6 |
Miscellaneous databases
PROi | PR:Q9SGN6 |
Gene expression databases
ExpressionAtlasi | Q9SGN6, baseline and differential |
Genevisiblei | Q9SGN6, AT |
Family and domain databases
InterProi | View protein in InterPro IPR044663, CAD1/NSL1-like IPR020864, MACPF |
PANTHERi | PTHR33199, PTHR33199, 1 hit |
Pfami | View protein in Pfam PF01823, MACPF, 1 hit |
SMARTi | View protein in SMART SM00457, MACPF, 1 hit |
PROSITEi | View protein in PROSITE PS51412, MACPF_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NSL1_ARATH | |
Accessioni | Q9SGN6Primary (citable) accession number: Q9SGN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2012 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families