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Entry version 111 (25 May 2022)
Sequence version 1 (01 May 2000)
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Protein

MACPF domain-containing protein NSL1

Gene

NSL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively controls the salicylic acid (SA)-mediated pathway of programmed cell death in plant immunity.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHypersensitive response, Immunity, Innate immunity, Plant defense

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.39.11.4, the membrane attack complex/perforin (macpf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MACPF domain-containing protein NSL1
Alternative name(s):
Protein NECROTIC SPOTTED LESIONS 1
Short name:
Protein NSL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NSL1
Ordered Locus Names:At1g28380
ORF Names:F3M18.18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G28380

The Arabidopsis Information Resource

More...
TAIRi
locus:2032532, AT1G28380

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Constitutively activated HR-like cell death phenotype with endogenous accumulation of high levels of salicylic acid (SA) and constitutively activated defense phenotype. Dwarf plant with spotted necrotic lesions on its rosette and cauline leaves. Accumulation of high levels of callose and autofluorescent phenolic compounds localized to the necrotic lesions.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004155401 – 612MACPF domain-containing protein NSL1Add BLAST612

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SGN6

PRoteomics IDEntifications database

More...
PRIDEi
Q9SGN6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
249399

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9SGN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SGN6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SGN6, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G28380.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9SGN6

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 338MACPFPROSITE-ProRule annotationAdd BLAST334

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQTT, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034245_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SGN6

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKEWIND

Database of Orthologous Groups

More...
OrthoDBi
487462at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SGN6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR044663, CAD1/NSL1-like
IPR020864, MACPF

The PANTHER Classification System

More...
PANTHERi
PTHR33199, PTHR33199, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01823, MACPF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00457, MACPF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51412, MACPF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SGN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFNNFTRLD AHSAAEKAVS VIGLGYDLCS DVRFSACKTT PDGSRLVEID
60 70 80 90 100
PTRNRDLIFP GGIVVNNVSS SIKCDKGERT RLRSDILSFN QMSEKFNQDM
110 120 130 140 150
CLSGKIPSGM FNNMFAFSKC WPKDASSVKT LAYDGWFISL YSVEIVRKQL
160 170 180 190 200
TLRDEVKREV PSSWDSAALA GFIEKYGTHV VVGVTMGGKD VIHVKQMRKS
210 220 230 240 250
NHEPEEIQKM LKHWGDERFC VDPVESKSPA SVYSGKPKEE NLLQWGLQPF
260 270 280 290 300
GTSVSSAVVM HTKNEEIMRV CIRRGGVDLG QSHERWLSTV SQAPNVISMC
310 320 330 340 350
FVPITSLLSG LPGTGFLSHA VNLYLRYKPP IEELHQFLEF QLPRQWAPVY
360 370 380 390 400
GDLPLGLRRS KQSSPSLQFS LMGPKLYVNT SKVDSGERPV TGLRFFLEGK
410 420 430 440 450
KGNHLAIHLQ HLSACPPSLH LSHDDTYEPI EEPVEKGYYV PVKWGIFSHV
460 470 480 490 500
CTYPVQYNGA RSDDTASIVT KAWLEVKGMG MRKVLFLRLG FSLDASAVTR
510 520 530 540 550
KSCWDNLSTN SRKSGVFSMI STRLSTGLSP NPATTKPQSK IDINSAVYPR
560 570 580 590 600
GPSPPVKPKL LSLVDTKEVM RGPEEQPGYW VVTGAKLCVE AGKISIKAKY
610
SLLTVISEDS LV
Length:612
Mass (Da):67,980
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE461770C2209162
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010155 Genomic DNA Translation: AAF16762.1
CP002684 Genomic DNA Translation: AEE30965.1
AY059744 mRNA Translation: AAL24092.1
AY096632 mRNA Translation: AAM20282.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C86410

NCBI Reference Sequences

More...
RefSeqi
NP_564307.1, NM_102605.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G28380.1; AT1G28380.1; AT1G28380

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
839735

Gramene; a comparative resource for plants

More...
Gramenei
AT1G28380.1; AT1G28380.1; AT1G28380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G28380

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010155 Genomic DNA Translation: AAF16762.1
CP002684 Genomic DNA Translation: AEE30965.1
AY059744 mRNA Translation: AAL24092.1
AY096632 mRNA Translation: AAM20282.1
PIRiC86410
RefSeqiNP_564307.1, NM_102605.3

3D structure databases

AlphaFoldDBiQ9SGN6
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT1G28380.1

Protein family/group databases

TCDBi1.C.39.11.4, the membrane attack complex/perforin (macpf) family

PTM databases

iPTMnetiQ9SGN6

Proteomic databases

PaxDbiQ9SGN6
PRIDEiQ9SGN6
ProteomicsDBi249399

Genome annotation databases

EnsemblPlantsiAT1G28380.1; AT1G28380.1; AT1G28380
GeneIDi839735
GrameneiAT1G28380.1; AT1G28380.1; AT1G28380
KEGGiath:AT1G28380

Organism-specific databases

AraportiAT1G28380
TAIRilocus:2032532, AT1G28380

Phylogenomic databases

eggNOGiENOG502QQTT, Eukaryota
HOGENOMiCLU_034245_1_0_1
InParanoidiQ9SGN6
OMAiWKEWIND
OrthoDBi487462at2759
PhylomeDBiQ9SGN6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SGN6

Gene expression databases

ExpressionAtlasiQ9SGN6, baseline and differential
GenevisibleiQ9SGN6, AT

Family and domain databases

InterProiView protein in InterPro
IPR044663, CAD1/NSL1-like
IPR020864, MACPF
PANTHERiPTHR33199, PTHR33199, 1 hit
PfamiView protein in Pfam
PF01823, MACPF, 1 hit
SMARTiView protein in SMART
SM00457, MACPF, 1 hit
PROSITEiView protein in PROSITE
PS51412, MACPF_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSL1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SGN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 1, 2000
Last modified: May 25, 2022
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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