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Protein

Probable phospholipid-transporting ATPase 5

Gene

ALA5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in transport of phospholipids.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4254-aspartylphosphate intermediateBy similarity1
Metal bindingi879MagnesiumBy similarity1
Metal bindingi883MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G72700-MONOMER
ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase 51 Publication (EC:7.6.2.11 Publication)
Short name:
AtALA51 Publication
Alternative name(s):
Aminophospholipid flippase 51 Publication
Gene namesi
Name:ALA51 Publication
Ordered Locus Names:At1g72700Imported
ORF Names:F28P22.11Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G72700
TAIRilocus:2030180 AT1G72700

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 96HelicalSequence analysisAdd BLAST22
Topological domaini97 – 100ExtracellularSequence analysis4
Transmembranei101 – 123HelicalSequence analysisAdd BLAST23
Topological domaini124 – 305CytoplasmicSequence analysisAdd BLAST182
Transmembranei306 – 327HelicalSequence analysisAdd BLAST22
Topological domaini328 – 359ExtracellularSequence analysisAdd BLAST32
Transmembranei360 – 377HelicalSequence analysisAdd BLAST18
Topological domaini378 – 934CytoplasmicSequence analysisAdd BLAST557
Transmembranei935 – 954HelicalSequence analysisAdd BLAST20
Topological domaini955 – 968ExtracellularSequence analysisAdd BLAST14
Transmembranei969 – 988HelicalSequence analysisAdd BLAST20
Topological domaini989 – 1018CytoplasmicSequence analysisAdd BLAST30
Transmembranei1019 – 1041HelicalSequence analysisAdd BLAST23
Topological domaini1042 – 1054ExtracellularSequence analysisAdd BLAST13
Transmembranei1055 – 1077HelicalSequence analysisAdd BLAST23
Topological domaini1078 – 1083CytoplasmicSequence analysis6
Transmembranei1084 – 1104HelicalSequence analysisAdd BLAST21
Topological domaini1105 – 1117ExtracellularSequence analysisAdd BLAST13
Transmembranei1118 – 1146HelicalSequence analysisAdd BLAST29
Topological domaini1147 – 1228CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463891 – 1228Probable phospholipid-transporting ATPase 5Add BLAST1228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki616Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9SGG3
PRIDEiQ9SGG3

PTM databases

iPTMnetiQ9SGG3

Expressioni

Gene expression databases

ExpressionAtlasiQ9SGG3 baseline and differential
GenevisibleiQ9SGG3 AT

Interactioni

Protein-protein interaction databases

BioGridi28821, 1 interactor
STRINGi3702.AT1G72700.1

Structurei

3D structure databases

ProteinModelPortaliQ9SGG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
HOGENOMiHOG000202528
InParanoidiQ9SGG3
KOiK01530
OMAiETDWKIR
OrthoDBiEOG0936012H
PhylomeDBiQ9SGG3

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SGG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGRIRSKL RLSLLYTFGC LRPATLEGQD SQPIQGPGFS RTVFCNQPHM
60 70 80 90 100
HKKKPLRYRS NYVSTTRYNL ITFFPKSLYE QFHRAANLYF LVAAILSVFP
110 120 130 140 150
LSPFNKWSMI APLVFVVGLS MLKEALEDWR RFMQDVKINA RKTCVHKSDG
160 170 180 190 200
VFRQRKWKKV SVGDIVKVEK DEFFPADLLL LSSSYEDGIC YVETMNLDGE
210 220 230 240 250
TNLKVKRSLE VSLPLDDDES FKNFMATIRC EDPNPNLYTF VGNLEFERQT
260 270 280 290 300
FPLDPSQILL RDSKLRNTTY VYGVVVFTGF DTKVMQNSTK SPSKRSRIER
310 320 330 340 350
TMDYIIYTLL VLLILISCIS SSGFAWETEF HMPKMWYLRP GEPIDFTNPI
360 370 380 390 400
NPIYAGVVHL ITALLLYGYL IPISLYVSIE VVKVWQASFI NQDLHMYDDE
410 420 430 440 450
SGVPANARTS NLNEELGQVH TILSDKTGTL TCNQMDFLKC SIAGTSYGVR
460 470 480 490 500
SSEVEVAAAK QMAVDLEEHG EISSTPQSQT KVYGTWDSSR TQEIEVEGDN
510 520 530 540 550
NYNTPRAPIK GFGFEDNRLM NGNWLRESQP NDILQFFRIL AICHTAIPEL
560 570 580 590 600
NEETGKYTYE AESPDEASFL AAAREFGFEF FKRTQSSVFI RERFSGSGQI
610 620 630 640 650
IEREYKVLNL LEFTSKRKRM TVIVRDEEGQ ILLLCKGADS IIFERLAKNG
660 670 680 690 700
KTYLGPTTRH LTEYGEAGLR TLALAYRKLD EDEYAAWNSE FLKAKTSIGS
710 720 730 740 750
DRDELLETGA DMIEKELILI GATAVEDKLQ KGVPQCIDKL AQAGLKLWVL
760 770 780 790 800
TGDKMETAIN IGFACSLLRQ GMRQICITSM NSEGGSQDSK RVVKENILNQ
810 820 830 840 850
LTKAVQMVKL EKDPHAAFAL IIDGKTLTYA LEDDMKYQFL ALAVDCASVI
860 870 880 890 900
CCRVSPKQKA LVVRLVKEGT GKTTLAIGDG ANDVGMIQEA DIGVGISGVE
910 920 930 940 950
GMQAVMASDF SIAQFRFLER LLVVHGHWCY KRIAQMICYF FYKNIAFGLT
960 970 980 990 1000
LFYFEAFTGF SGQSVYNDYY LLLFNVVLTS LPVIALGVFE QDVSSEICLQ
1010 1020 1030 1040 1050
FPALYQQGTK NLFFDWSRIL GWMCNGVYAS LVIFFLNIGI IYSQAFRDNG
1060 1070 1080 1090 1100
QTADMDAVGT TMFTCIIWAA NVQIALTMSH FTWIQHVLIW GSIGMWYLFV
1110 1120 1130 1140 1150
AIYSMMPPSY SGNIYRILDE ILAPAPIYWM ATLLVTVAAV LPYVAHIAFQ
1160 1170 1180 1190 1200
RFLNPLDHHI IQEIKYYGRD IEDARLWTRE RTKAREKTKI GFTARVDAKI
1210 1220
RHLRSKLNKK QSNLSHFSAQ DAMSPRSL
Length:1,228
Mass (Da):139,342
Last modified:May 1, 2000 - v1
Checksum:i47E47A9297131CB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010926 Genomic DNA Translation: AAG51844.1
CP002684 Genomic DNA Translation: AEE35362.1
CP002684 Genomic DNA Translation: ANM60518.1
CP002684 Genomic DNA Translation: ANM60519.1
PIRiG96751
RefSeqiNP_001322799.1, NM_001334547.1
NP_001322800.1, NM_001334546.1
NP_177414.1, NM_105929.5
UniGeneiAt.35067

Genome annotation databases

EnsemblPlantsiAT1G72700.1; AT1G72700.1; AT1G72700
AT1G72700.2; AT1G72700.2; AT1G72700
AT1G72700.3; AT1G72700.3; AT1G72700
GeneIDi843602
GrameneiAT1G72700.1; AT1G72700.1; AT1G72700
AT1G72700.2; AT1G72700.2; AT1G72700
AT1G72700.3; AT1G72700.3; AT1G72700
KEGGiath:AT1G72700

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010926 Genomic DNA Translation: AAG51844.1
CP002684 Genomic DNA Translation: AEE35362.1
CP002684 Genomic DNA Translation: ANM60518.1
CP002684 Genomic DNA Translation: ANM60519.1
PIRiG96751
RefSeqiNP_001322799.1, NM_001334547.1
NP_001322800.1, NM_001334546.1
NP_177414.1, NM_105929.5
UniGeneiAt.35067

3D structure databases

ProteinModelPortaliQ9SGG3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28821, 1 interactor
STRINGi3702.AT1G72700.1

PTM databases

iPTMnetiQ9SGG3

Proteomic databases

PaxDbiQ9SGG3
PRIDEiQ9SGG3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G72700.1; AT1G72700.1; AT1G72700
AT1G72700.2; AT1G72700.2; AT1G72700
AT1G72700.3; AT1G72700.3; AT1G72700
GeneIDi843602
GrameneiAT1G72700.1; AT1G72700.1; AT1G72700
AT1G72700.2; AT1G72700.2; AT1G72700
AT1G72700.3; AT1G72700.3; AT1G72700
KEGGiath:AT1G72700

Organism-specific databases

AraportiAT1G72700
TAIRilocus:2030180 AT1G72700

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
HOGENOMiHOG000202528
InParanoidiQ9SGG3
KOiK01530
OMAiETDWKIR
OrthoDBiEOG0936012H
PhylomeDBiQ9SGG3

Enzyme and pathway databases

BioCyciARA:AT1G72700-MONOMER
ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-936837 Ion transport by P-type ATPases

Miscellaneous databases

PROiPR:Q9SGG3

Gene expression databases

ExpressionAtlasiQ9SGG3 baseline and differential
GenevisibleiQ9SGG3 AT

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALA5_ARATH
AccessioniPrimary (citable) accession number: Q9SGG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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