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UniProtKB - Q9SGG3 (ALA5_ARATH)
Protein
Probable phospholipid-transporting ATPase 5
Gene
ALA5
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Involved in transport of phospholipids.
1 PublicationCatalytic activityi
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication EC:7.6.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 425 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 879 | MagnesiumBy similarity | 1 | |
Metal bindingi | 883 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase-coupled intramembrane lipid transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- flippase activity Source: TAIR
- magnesium ion binding Source: InterPro
GO - Biological processi
- phospholipid translocation Source: GO_Central
- protein localization involved in auxin polar transport Source: TAIR
Keywordsi
Molecular function | Translocase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ARA:AT1G72700-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable phospholipid-transporting ATPase 51 Publication (EC:7.6.2.11 Publication)Short name: AtALA51 Publication Alternative name(s): Aminophospholipid flippase 51 Publication |
Gene namesi | Name:ALA51 Publication Ordered Locus Names:At1g72700Imported ORF Names:F28P22.11Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G72700 |
TAIRi | locus:2030180, AT1G72700 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 74 | CytoplasmicSequence analysisAdd BLAST | 74 | |
Transmembranei | 75 – 96 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 97 – 100 | ExtracellularSequence analysis | 4 | |
Transmembranei | 101 – 123 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 124 – 305 | CytoplasmicSequence analysisAdd BLAST | 182 | |
Transmembranei | 306 – 327 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 328 – 359 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 360 – 377 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 378 – 934 | CytoplasmicSequence analysisAdd BLAST | 557 | |
Transmembranei | 935 – 954 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 955 – 968 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 969 – 988 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 989 – 1018 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 1019 – 1041 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 1042 – 1054 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 1055 – 1077 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 1078 – 1083 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 1084 – 1104 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1105 – 1117 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 1118 – 1146 | HelicalSequence analysisAdd BLAST | 29 | |
Topological domaini | 1147 – 1228 | CytoplasmicSequence analysisAdd BLAST | 82 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046389 | 1 – 1228 | Probable phospholipid-transporting ATPase 5Add BLAST | 1228 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 616 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | Q9SGG3 |
ProteomicsDBi | 244828 |
PTM databases
iPTMneti | Q9SGG3 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SGG3, baseline and differential |
Genevisiblei | Q9SGG3, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 28821, 1 interactor |
STRINGi | 3702.AT1G72700.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0206, Eukaryota |
HOGENOMi | CLU_000846_5_2_1 |
InParanoidi | Q9SGG3 |
OMAi | ETRYWTW |
OrthoDBi | 587717at2759 |
PhylomeDBi | Q9SGG3 |
Family and domain databases
Gene3Di | 3.40.1110.10, 2 hits 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR032631, P-type_ATPase_N IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit PF16209, PhoLip_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 1 hit TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9SGG3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARGRIRSKL RLSLLYTFGC LRPATLEGQD SQPIQGPGFS RTVFCNQPHM
60 70 80 90 100
HKKKPLRYRS NYVSTTRYNL ITFFPKSLYE QFHRAANLYF LVAAILSVFP
110 120 130 140 150
LSPFNKWSMI APLVFVVGLS MLKEALEDWR RFMQDVKINA RKTCVHKSDG
160 170 180 190 200
VFRQRKWKKV SVGDIVKVEK DEFFPADLLL LSSSYEDGIC YVETMNLDGE
210 220 230 240 250
TNLKVKRSLE VSLPLDDDES FKNFMATIRC EDPNPNLYTF VGNLEFERQT
260 270 280 290 300
FPLDPSQILL RDSKLRNTTY VYGVVVFTGF DTKVMQNSTK SPSKRSRIER
310 320 330 340 350
TMDYIIYTLL VLLILISCIS SSGFAWETEF HMPKMWYLRP GEPIDFTNPI
360 370 380 390 400
NPIYAGVVHL ITALLLYGYL IPISLYVSIE VVKVWQASFI NQDLHMYDDE
410 420 430 440 450
SGVPANARTS NLNEELGQVH TILSDKTGTL TCNQMDFLKC SIAGTSYGVR
460 470 480 490 500
SSEVEVAAAK QMAVDLEEHG EISSTPQSQT KVYGTWDSSR TQEIEVEGDN
510 520 530 540 550
NYNTPRAPIK GFGFEDNRLM NGNWLRESQP NDILQFFRIL AICHTAIPEL
560 570 580 590 600
NEETGKYTYE AESPDEASFL AAAREFGFEF FKRTQSSVFI RERFSGSGQI
610 620 630 640 650
IEREYKVLNL LEFTSKRKRM TVIVRDEEGQ ILLLCKGADS IIFERLAKNG
660 670 680 690 700
KTYLGPTTRH LTEYGEAGLR TLALAYRKLD EDEYAAWNSE FLKAKTSIGS
710 720 730 740 750
DRDELLETGA DMIEKELILI GATAVEDKLQ KGVPQCIDKL AQAGLKLWVL
760 770 780 790 800
TGDKMETAIN IGFACSLLRQ GMRQICITSM NSEGGSQDSK RVVKENILNQ
810 820 830 840 850
LTKAVQMVKL EKDPHAAFAL IIDGKTLTYA LEDDMKYQFL ALAVDCASVI
860 870 880 890 900
CCRVSPKQKA LVVRLVKEGT GKTTLAIGDG ANDVGMIQEA DIGVGISGVE
910 920 930 940 950
GMQAVMASDF SIAQFRFLER LLVVHGHWCY KRIAQMICYF FYKNIAFGLT
960 970 980 990 1000
LFYFEAFTGF SGQSVYNDYY LLLFNVVLTS LPVIALGVFE QDVSSEICLQ
1010 1020 1030 1040 1050
FPALYQQGTK NLFFDWSRIL GWMCNGVYAS LVIFFLNIGI IYSQAFRDNG
1060 1070 1080 1090 1100
QTADMDAVGT TMFTCIIWAA NVQIALTMSH FTWIQHVLIW GSIGMWYLFV
1110 1120 1130 1140 1150
AIYSMMPPSY SGNIYRILDE ILAPAPIYWM ATLLVTVAAV LPYVAHIAFQ
1160 1170 1180 1190 1200
RFLNPLDHHI IQEIKYYGRD IEDARLWTRE RTKAREKTKI GFTARVDAKI
1210 1220
RHLRSKLNKK QSNLSHFSAQ DAMSPRSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010926 Genomic DNA Translation: AAG51844.1 CP002684 Genomic DNA Translation: AEE35362.1 CP002684 Genomic DNA Translation: ANM60518.1 CP002684 Genomic DNA Translation: ANM60519.1 |
PIRi | G96751 |
RefSeqi | NP_001322799.1, NM_001334547.1 NP_001322800.1, NM_001334546.1 NP_177414.1, NM_105929.5 |
Genome annotation databases
EnsemblPlantsi | AT1G72700.1; AT1G72700.1; AT1G72700 AT1G72700.2; AT1G72700.2; AT1G72700 AT1G72700.3; AT1G72700.3; AT1G72700 |
GeneIDi | 843602 |
Gramenei | AT1G72700.1; AT1G72700.1; AT1G72700 AT1G72700.2; AT1G72700.2; AT1G72700 AT1G72700.3; AT1G72700.3; AT1G72700 |
KEGGi | ath:AT1G72700 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010926 Genomic DNA Translation: AAG51844.1 CP002684 Genomic DNA Translation: AEE35362.1 CP002684 Genomic DNA Translation: ANM60518.1 CP002684 Genomic DNA Translation: ANM60519.1 |
PIRi | G96751 |
RefSeqi | NP_001322799.1, NM_001334547.1 NP_001322800.1, NM_001334546.1 NP_177414.1, NM_105929.5 |
3D structure databases
AlphaFoldDBi | Q9SGG3 |
SMRi | Q9SGG3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 28821, 1 interactor |
STRINGi | 3702.AT1G72700.1 |
PTM databases
iPTMneti | Q9SGG3 |
Proteomic databases
PaxDbi | Q9SGG3 |
ProteomicsDBi | 244828 |
Genome annotation databases
EnsemblPlantsi | AT1G72700.1; AT1G72700.1; AT1G72700 AT1G72700.2; AT1G72700.2; AT1G72700 AT1G72700.3; AT1G72700.3; AT1G72700 |
GeneIDi | 843602 |
Gramenei | AT1G72700.1; AT1G72700.1; AT1G72700 AT1G72700.2; AT1G72700.2; AT1G72700 AT1G72700.3; AT1G72700.3; AT1G72700 |
KEGGi | ath:AT1G72700 |
Organism-specific databases
Araporti | AT1G72700 |
TAIRi | locus:2030180, AT1G72700 |
Phylogenomic databases
eggNOGi | KOG0206, Eukaryota |
HOGENOMi | CLU_000846_5_2_1 |
InParanoidi | Q9SGG3 |
OMAi | ETRYWTW |
OrthoDBi | 587717at2759 |
PhylomeDBi | Q9SGG3 |
Enzyme and pathway databases
BioCyci | ARA:AT1G72700-MONOMER |
Miscellaneous databases
PROi | PR:Q9SGG3 |
Gene expression databases
ExpressionAtlasi | Q9SGG3, baseline and differential |
Genevisiblei | Q9SGG3, AT |
Family and domain databases
Gene3Di | 3.40.1110.10, 2 hits 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR032631, P-type_ATPase_N IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit PF16209, PhoLip_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 1 hit TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALA5_ARATH | |
Accessioni | Q9SGG3Primary (citable) accession number: Q9SGG3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families