ALA5

Functionⁱ

Involved in transport of phospholipids.1 Publication

Catalytic activityⁱ

ATP + H₂O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	425	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	879	MagnesiumBy similarity	1
Metal bindingⁱ	883	MagnesiumBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
magnesium ion binding Source: InterPro
phospholipid-translocating ATPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Golgi vesicle budding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phospholipid translocation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Translocase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	ARA:AT1G72700-MONOMER
Reactomeⁱ	R-ATH-6798695 Neutrophil degranulation R-ATH-936837 Ion transport by P-type ATPases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable phospholipid-transporting ATPase 51 Publication (EC:7.6.2.11 Publication) Short name: AtALA51 Publication Alternative name(s): Aminophospholipid flippase 51 Publication
Gene namesⁱ	Name:ALA51 Publication Ordered Locus Names:At1g72700Imported ORF Names:F28P22.11Imported
Organismⁱ	Arabidopsis thaliana (Mouse-ear cress)
Taxonomic identifierⁱ	3702 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesⁱ	UP000006548 Componentⁱ: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT1G72700
TAIRⁱ	locus:2030180 AT1G72700

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 74	CytoplasmicSequence analysisAdd BLAST	74
Transmembraneⁱ	75 – 96	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	97 – 100	ExtracellularSequence analysis	4
Transmembraneⁱ	101 – 123	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	124 – 305	CytoplasmicSequence analysisAdd BLAST	182
Transmembraneⁱ	306 – 327	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	328 – 359	ExtracellularSequence analysisAdd BLAST	32
Transmembraneⁱ	360 – 377	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	378 – 934	CytoplasmicSequence analysisAdd BLAST	557
Transmembraneⁱ	935 – 954	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	955 – 968	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	969 – 988	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	989 – 1018	CytoplasmicSequence analysisAdd BLAST	30
Transmembraneⁱ	1019 – 1041	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	1042 – 1054	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	1055 – 1077	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	1078 – 1083	CytoplasmicSequence analysis	6
Transmembraneⁱ	1084 – 1104	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1105 – 1117	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	1118 – 1146	HelicalSequence analysisAdd BLAST	29
Topological domainⁱ	1147 – 1228	CytoplasmicSequence analysisAdd BLAST	82

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046389	1 – 1228	Probable phospholipid-transporting ATPase 5Add BLAST		1228

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	616	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9SGG3
PRIDEⁱ	Q9SGG3

PTM databases

iPTMnetⁱ	Q9SGG3

iPTMnetⁱ

Q9SGG3

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q9SGG3 baseline and differential
Genevisibleⁱ	Q9SGG3 AT

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	28821, 1 interactor
STRINGⁱ	3702.AT1G72700.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9SGG3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410ITKD Eukaryota ENOG410XPYK LUCA
HOGENOMⁱ	HOG000202528
InParanoidⁱ	Q9SGG3
KEGG Orthology (KO) More...KOⁱ	K01530
OMAⁱ	ETDWKIR
Database of Orthologous Groups More...OrthoDBⁱ	EOG0936012H
PhylomeDBⁱ	Q9SGG3

Family and domain databases

Gene3Dⁱ	3.40.1110.10, 2 hits 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006539 P-type_ATPase_IV IPR032631 P-type_ATPase_N IPR001757 P_typ_ATPase IPR032630 P_typ_ATPase_c
PANTHERⁱ	PTHR24092 PTHR24092, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16212 PhoLip_ATPase_C, 1 hit PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01652 ATPase-Plipid, 1 hit TIGR01494 ATPase_P-type, 1 hit
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9SGG3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARGRIRSKL RLSLLYTFGC LRPATLEGQD SQPIQGPGFS RTVFCNQPHM 
        60         70         80         90        100
HKKKPLRYRS NYVSTTRYNL ITFFPKSLYE QFHRAANLYF LVAAILSVFP 
       110        120        130        140        150
LSPFNKWSMI APLVFVVGLS MLKEALEDWR RFMQDVKINA RKTCVHKSDG 
       160        170        180        190        200
VFRQRKWKKV SVGDIVKVEK DEFFPADLLL LSSSYEDGIC YVETMNLDGE 
       210        220        230        240        250
TNLKVKRSLE VSLPLDDDES FKNFMATIRC EDPNPNLYTF VGNLEFERQT 
       260        270        280        290        300
FPLDPSQILL RDSKLRNTTY VYGVVVFTGF DTKVMQNSTK SPSKRSRIER 
       310        320        330        340        350
TMDYIIYTLL VLLILISCIS SSGFAWETEF HMPKMWYLRP GEPIDFTNPI 
       360        370        380        390        400
NPIYAGVVHL ITALLLYGYL IPISLYVSIE VVKVWQASFI NQDLHMYDDE 
       410        420        430        440        450
SGVPANARTS NLNEELGQVH TILSDKTGTL TCNQMDFLKC SIAGTSYGVR 
       460        470        480        490        500
SSEVEVAAAK QMAVDLEEHG EISSTPQSQT KVYGTWDSSR TQEIEVEGDN 
       510        520        530        540        550
NYNTPRAPIK GFGFEDNRLM NGNWLRESQP NDILQFFRIL AICHTAIPEL 
       560        570        580        590        600
NEETGKYTYE AESPDEASFL AAAREFGFEF FKRTQSSVFI RERFSGSGQI 
       610        620        630        640        650
IEREYKVLNL LEFTSKRKRM TVIVRDEEGQ ILLLCKGADS IIFERLAKNG 
       660        670        680        690        700
KTYLGPTTRH LTEYGEAGLR TLALAYRKLD EDEYAAWNSE FLKAKTSIGS 
       710        720        730        740        750
DRDELLETGA DMIEKELILI GATAVEDKLQ KGVPQCIDKL AQAGLKLWVL 
       760        770        780        790        800
TGDKMETAIN IGFACSLLRQ GMRQICITSM NSEGGSQDSK RVVKENILNQ 
       810        820        830        840        850
LTKAVQMVKL EKDPHAAFAL IIDGKTLTYA LEDDMKYQFL ALAVDCASVI 
       860        870        880        890        900
CCRVSPKQKA LVVRLVKEGT GKTTLAIGDG ANDVGMIQEA DIGVGISGVE 
       910        920        930        940        950
GMQAVMASDF SIAQFRFLER LLVVHGHWCY KRIAQMICYF FYKNIAFGLT 
       960        970        980        990       1000
LFYFEAFTGF SGQSVYNDYY LLLFNVVLTS LPVIALGVFE QDVSSEICLQ 
      1010       1020       1030       1040       1050
FPALYQQGTK NLFFDWSRIL GWMCNGVYAS LVIFFLNIGI IYSQAFRDNG 
      1060       1070       1080       1090       1100
QTADMDAVGT TMFTCIIWAA NVQIALTMSH FTWIQHVLIW GSIGMWYLFV 
      1110       1120       1130       1140       1150
AIYSMMPPSY SGNIYRILDE ILAPAPIYWM ATLLVTVAAV LPYVAHIAFQ 
      1160       1170       1180       1190       1200
RFLNPLDHHI IQEIKYYGRD IEDARLWTRE RTKAREKTKI GFTARVDAKI 
      1210       1220 
RHLRSKLNKK QSNLSHFSAQ DAMSPRSL

Length:1,228

Mass (Da):139,342

Last modified:May 1, 2000 - v1

Checksum:ⁱ47E47A9297131CB8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC010926 Genomic DNA Translation: AAG51844.1 CP002684 Genomic DNA Translation: AEE35362.1 CP002684 Genomic DNA Translation: ANM60518.1 CP002684 Genomic DNA Translation: ANM60519.1
PIRⁱ	G96751
NCBI Reference Sequences More...RefSeqⁱ	NP_001322799.1, NM_001334547.1 NP_001322800.1, NM_001334546.1 NP_177414.1, NM_105929.5
UniGeneⁱ	At.35067

Genome annotation databases

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9SGG3	Phospholipid-transporting ATPase		ARATH		1228	UniRef100_Q9SGG3

Protein	Similar proteins		Species	Score	Length	Source
Q9SGG3	Phospholipid-transporting ATPase		ARATH		1228	UniRef90_Q9SGG3
Phospholipid-transporting ATPase		Capsella rubella		1234
Phospholipid-transporting ATPase		NOCCA		1231
Phospholipid-transporting ATPase		EUTSA		1231
Phospholipid-transporting ATPase		Brassica oleracea var. oleracea		1229
+18

Protein	Similar proteins		Species	Score	Length	Source
Q9SGG3	Probable phospholipid-transporting ATPase 7		ARATH		1243	UniRef50_Q9LVK9
Putative phospholipid-transporting ATPase 7 (Fragment)		NOCCA		77
Phospholipid-transporting ATPase		Brassica oleracea var. oleracea		1246
Phospholipid-transporting ATPase		EUTSA		1245
Phospholipid-transporting ATPase		ARALL		1243
+756

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC010926 Genomic DNA Translation: AAG51844.1 CP002684 Genomic DNA Translation: AEE35362.1 CP002684 Genomic DNA Translation: ANM60518.1 CP002684 Genomic DNA Translation: ANM60519.1
PIRⁱ	G96751
RefSeqⁱ	NP_001322799.1, NM_001334547.1 NP_001322800.1, NM_001334546.1 NP_177414.1, NM_105929.5
UniGeneⁱ	At.35067

3D structure databases

ProteinModelPortalⁱ	Q9SGG3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	28821, 1 interactor
STRINGⁱ	3702.AT1G72700.1

PTM databases

iPTMnetⁱ	Q9SGG3

iPTMnetⁱ

Q9SGG3

Proteomic databases

PaxDbⁱ	Q9SGG3
PRIDEⁱ	Q9SGG3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	AT1G72700.1; AT1G72700.1; AT1G72700 AT1G72700.2; AT1G72700.2; AT1G72700 AT1G72700.3; AT1G72700.3; AT1G72700
GeneIDⁱ	843602
Grameneⁱ	AT1G72700.1; AT1G72700.1; AT1G72700 AT1G72700.2; AT1G72700.2; AT1G72700 AT1G72700.3; AT1G72700.3; AT1G72700
KEGGⁱ	ath:AT1G72700

Organism-specific databases

Araportⁱ	AT1G72700
TAIRⁱ	locus:2030180 AT1G72700

Phylogenomic databases

eggNOGⁱ	ENOG410ITKD Eukaryota ENOG410XPYK LUCA
HOGENOMⁱ	HOG000202528
InParanoidⁱ	Q9SGG3
KOⁱ	K01530
OMAⁱ	ETDWKIR
OrthoDBⁱ	EOG0936012H
PhylomeDBⁱ	Q9SGG3

Enzyme and pathway databases

BioCycⁱ	ARA:AT1G72700-MONOMER
Reactomeⁱ	R-ATH-6798695 Neutrophil degranulation R-ATH-936837 Ion transport by P-type ATPases

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9SGG3

PROⁱ

PR:Q9SGG3

Gene expression databases

ExpressionAtlasⁱ	Q9SGG3 baseline and differential
Genevisibleⁱ	Q9SGG3 AT

Family and domain databases

Gene3Dⁱ	3.40.1110.10, 2 hits 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006539 P-type_ATPase_IV IPR032631 P-type_ATPase_N IPR001757 P_typ_ATPase IPR032630 P_typ_ATPase_c
PANTHERⁱ	PTHR24092 PTHR24092, 1 hit
Pfamⁱ	View protein in Pfam PF16212 PhoLip_ATPase_C, 1 hit PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01652 ATPase-Plipid, 1 hit TIGR01494 ATPase_P-type, 1 hit
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ALA5_ARATH
Accessionⁱ	Q9SGG3Primary (citable) accession number: Q9SGG3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9SGG3 (ALA5_ARATH)

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Probable phospholipid-transporting ATPase 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ