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Entry version 123 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

Amino acid transporter ANT1

Gene

ANT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Translocates aromatic and neutral amino acids such as tyrosine, tryptophan, phenylalanine, histidine, proline, leucine, valine, glutamine, as well as arginine. Transports the auxins indole-3-acetic acid (IAA) and 2,4-dichlorophenoxyacetic acid (2,4-D).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=163 µM for leucine1 Publication
  2. KM=240 µM for tyrosine1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Transport

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9SF09

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Amino acid transporter ANT1Curated
    Alternative name(s):
    Aromatic and neutral amino acid transporter 11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ANT12 Publications
    Ordered Locus Names:At3g11900Imported
    ORF Names:F26K24.19Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT3G11900

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2081471 AT3G11900

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 35CytoplasmicCuratedAdd BLAST35
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini57 – 62LumenalCurated6
    Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini84 – 115CytoplasmicCuratedAdd BLAST32
    Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini137 – 147LumenalCuratedAdd BLAST11
    Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini169 – 172CytoplasmicCurated4
    Transmembranei173 – 193Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini194 – 219LumenalCuratedAdd BLAST26
    Transmembranei220 – 240Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini241 – 256CytoplasmicCuratedAdd BLAST16
    Transmembranei257 – 277Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini278 – 292LumenalCuratedAdd BLAST15
    Transmembranei293 – 313Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini314 – 353CytoplasmicCuratedAdd BLAST40
    Transmembranei354 – 374Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini375 – 379LumenalCurated5
    Transmembranei380 – 400Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini401 – 410CytoplasmicCurated10
    Transmembranei411 – 431Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini432LumenalCurated1

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004331051 – 432Amino acid transporter ANT1Add BLAST432

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9SF09

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    244481

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9SF09

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous (PubMed:27925655). Highly expressed in flowers and cauline leaves and at lower levels in stems, leaves and roots (PubMed:11299361).2 Publications

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9SF09 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9SF09 AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q9SF09, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT3G11900.1

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1304 Eukaryota
    COG0814 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_009646_6_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9SF09

    KEGG Orthology (KO)

    More...
    KOi
    K14209

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ALCYATF

    Database of Orthologous Groups

    More...
    OrthoDBi
    464614at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9SF09

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013057 AA_transpt_TM

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01490 Aa_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9SF09-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAIKDLTATT GDSSLPLIKS PPSETTGGDR TSALQTLGNI IVSIVGTGVL
    60 70 80 90 100
    GLPYAFRIAG WLAGSLGVII VGFATYYCML LLIQCRDKLE SEEGEEESKT
    110 120 130 140 150
    YGDLGFKCMG TKGRYLTEFL IFTAQCGGSV AYLVFIGRNL SSIFSSYGLS
    160 170 180 190 200
    MVSFILILVP IEVGLSWITS LSALSPFSIF ADICNIIAMC FVVKENVEMV
    210 220 230 240 250
    IEGDFSFSDR TAISSTIGGL PFAGGVAVFC FEGFAMTLAL ESSMREREAF
    260 270 280 290 300
    PKLLAKVLAG ITFVYVLFGF CGYMAYGDQT KDIITLNLPN NWSAIAVQIG
    310 320 330 340 350
    LCVGLTFTFP IMVHPLNEII EQKLKRIDWL QKHHNGYSNE TGSVSKFAIF
    360 370 380 390 400
    TTRTLLVVGL AAIASLVPGF GTFASLVGST LCALISFVLP ASYHLTLLGP
    410 420 430
    SLNVWNKSID VFIVICGLIF AVYGTYNTIV GV
    Length:432
    Mass (Da):46,470
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C2ACD41154B92D3
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAB82307 differs from that shown. Sequencing errors.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti219G → S in AAB82307 (Ref. 1) Curated1
    Sequence conflicti244M → I in AAB82307 (Ref. 1) Curated1
    Sequence conflicti282D → N in AAB82307 (Ref. 1) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U39783 mRNA Translation: AAB82307.1 Sequence problems.
    AC016795 Genomic DNA Translation: AAF23206.1
    CP002686 Genomic DNA Translation: AEE75115.1
    CP002686 Genomic DNA Translation: ANM65575.1
    BT008302 mRNA Translation: AAP37661.1
    AK227614 mRNA Translation: BAE99605.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001327533.1, NM_001337960.1
    NP_187796.1, NM_112023.2

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT3G11900.1; AT3G11900.1; AT3G11900
    AT3G11900.2; AT3G11900.2; AT3G11900

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    820363

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT3G11900.1; AT3G11900.1; AT3G11900
    AT3G11900.2; AT3G11900.2; AT3G11900

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT3G11900

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U39783 mRNA Translation: AAB82307.1 Sequence problems.
    AC016795 Genomic DNA Translation: AAF23206.1
    CP002686 Genomic DNA Translation: AEE75115.1
    CP002686 Genomic DNA Translation: ANM65575.1
    BT008302 mRNA Translation: AAP37661.1
    AK227614 mRNA Translation: BAE99605.1
    RefSeqiNP_001327533.1, NM_001337960.1
    NP_187796.1, NM_112023.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    IntActiQ9SF09, 1 interactor
    STRINGi3702.AT3G11900.1

    PTM databases

    iPTMnetiQ9SF09

    Proteomic databases

    PaxDbiQ9SF09
    ProteomicsDBi244481

    Genome annotation databases

    EnsemblPlantsiAT3G11900.1; AT3G11900.1; AT3G11900
    AT3G11900.2; AT3G11900.2; AT3G11900
    GeneIDi820363
    GrameneiAT3G11900.1; AT3G11900.1; AT3G11900
    AT3G11900.2; AT3G11900.2; AT3G11900
    KEGGiath:AT3G11900

    Organism-specific databases

    AraportiAT3G11900
    TAIRilocus:2081471 AT3G11900

    Phylogenomic databases

    eggNOGiKOG1304 Eukaryota
    COG0814 LUCA
    HOGENOMiCLU_009646_6_0_1
    InParanoidiQ9SF09
    KOiK14209
    OMAiALCYATF
    OrthoDBi464614at2759
    PhylomeDBiQ9SF09

    Enzyme and pathway databases

    SABIO-RKiQ9SF09

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q9SF09

    Gene expression databases

    ExpressionAtlasiQ9SF09 baseline and differential
    GenevisibleiQ9SF09 AT

    Family and domain databases

    InterProiView protein in InterPro
    IPR013057 AA_transpt_TM
    PfamiView protein in Pfam
    PF01490 Aa_trans, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANT1_ARATH
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SF09
    Secondary accession number(s): O24406
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2015
    Last sequence update: May 1, 2000
    Last modified: June 17, 2020
    This is version 123 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
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