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Entry version 64 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Vicilin Jug r 2.0101

Gene
N/A
Organism
Juglans regia (English walnut)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seed storage protein.

4 Publications

Caution

It is uncertain whether cleavage occurs at Arg-172 or Glu-173.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi182CopperBy similarity1
Metal bindingi456CopperBy similarity1
Metal bindingi458Copper; via pros nitrogenBy similarity1
Metal bindingi500Copper; via tele nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSeed storage protein, Storage protein
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vicilin Jug r 2.0101Curated
Alternative name(s):
7S globulin3 Publications
7S seed storage protein2 Publications
Allergen Jug r 25 Publications
Vicilin Jug r 21 Publication
Vicilin-like Jug r 24 Publications
Allergen: Jug r 2.0101Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiJuglans regia (English walnut)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri51240 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesJuglandaceaeJuglans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000235220 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals. We usually specify in which species the protein is allergenic.<p><a href='/help/allergenic_properties' target='_top'>More...</a></p>Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE of patients allergic to walnuts (PubMed:10589017, PubMed:30054513, PubMed:21883278, PubMed:22042002, PubMed:25772597). Binds to IgE of patients allergic to peanuts (PubMed:21883278, PubMed:22042002). Recombinant protein binds to IgE in 60% of the 15 patients tested allergic to walnuts (PubMed:10589017). Natural protein binds to IgE in 67% of the 6 patients tested allergic to peanuts and/or walnuts (PubMed:21883278). Binds to IgE in 53% of the 17 patients tested allergic to walnuts. Provokes CD4+ T-cell responses. The central memory CD4+ T-cells are the most prevalent phenotype detected in the peripheral blood of the patients. T-helper 2 (Th2) cells are prominent among the terminal effector T-cells, but T-helper 17 (Th17) and Th2/Th17 cells are also detected (PubMed:25772597).5 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
3335, Jug r 2.0101
425, Jug r 2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000450861‹1 – 593Vicilin Jug r 2.0101Add BLAST›593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi229N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9SEW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in seed (at protein level).4 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SEW4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini187 – 341Cupin type-1 1Sequence analysisAdd BLAST155
Domaini386 – 556Cupin type-1 2Sequence analysisAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 123DisorderedSequence analysisAdd BLAST78
Regioni49 – 58IgE-binding1 Publication10
Regioni76 – 85IgE-binding1 Publication10
Regioni101 – 110IgE-binding1 Publication10
Regioni140 – 149IgE-binding. Involved in cross-reactivity with peanut allergen Ara h 2; able to inhibit binding of IgE from a peanut-allergic patient to Ara h 21 Publication10
Regioni150 – 184DisorderedSequence analysisAdd BLAST35
Regioni175 – 193T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST19
Regioni206 – 225T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni246 – 265T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni302 – 321T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni318 – 337T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni382 – 401T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni414 – 433T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni438 – 457T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni463 – 470IgE-binding1 Publication8
Regioni478 – 497T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni541 – 555IgE-binding1 PublicationAdd BLAST15
Regioni542 – 561T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20
Regioni558 – 577T-cell epitope; recognized by the HLA-DRB1-restricted CD4(+) T-cells1 PublicationAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili529 – 556Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi150 – 180Basic and acidic residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 7S seed storage protein family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006045, Cupin_1
IPR014710, RmlC-like_jellyroll
IPR011051, RmlC_Cupin_sf
IPR006792, Vicilin_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00190, Cupin_1, 2 hits
PF04702, Vicilin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00835, Cupin_1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51182, SSF51182, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q9SEW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RGRDDDDEEN PRDPREQYRQ CQEYCRRQGQ GQRQQQQCQI RCEERLEEDQ
60 70 80 90 100
RSQEERERRR GRDVDDQNPR DPEQRYEQCQ QQCERQRRGQ EQTLCRRRCE
110 120 130 140 150
QRRQQEERER QRGRDRQDPQ QQYHRCQRRC QIQEQSPERQ RQCQQRCERQ
160 170 180 190 200
YKEQQGRERG PEASPRRESR GREEEQQRHN PYYFHSQSIR SRHESEEGEV
210 220 230 240 250
KYLERFTERT ELLRGIENYR VVILDANPNT SMLPHHKDAE SVAVVTRGRA
260 270 280 290 300
TLTLVSQETR ESFNLECGDV IRVPAGATVY VINQDSNERL EMVKLLQPVN
310 320 330 340 350
NPGQFREYYA AGAKSPDQSY LRVFSNDILV AALNTPRDRL ERFFDQQEQR
360 370 380 390 400
EGVIIRASQE KLRALSQHAM SAGQRPWGRR SSGGPISLKS ESPSYSNQFG
410 420 430 440 450
QFFEACPEEH RQLQEMDVLV NYAEIKRGAM MVPHYNSKAT VVVYVVEGTG
460 470 480 490 500
RYEMACPHVS SQSYEGQGRR EQEEEESTGR FQKVTARLAR GDIFVIPAGH
510 520 530 540 550
PIAITASQNE NLRLLGFDIN GENNQRDFLA GQNNIINQLE REAKELSFNM
560 570 580 590
PREEIEEIFE SQMESYFVPT ERQSRRGQGR DHPLASILDF AFF
Length:593
Mass (Da):69,990
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BA127E19B18C0D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF066055 mRNA Translation: AAF18269.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF066055 mRNA Translation: AAF18269.1

3D structure databases

SMRiQ9SEW4
ModBaseiSearch...

Protein family/group databases

Allergomei3335, Jug r 2.0101
425, Jug r 2

Proteomic databases

PRIDEiQ9SEW4

Family and domain databases

Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR006045, Cupin_1
IPR014710, RmlC-like_jellyroll
IPR011051, RmlC_Cupin_sf
IPR006792, Vicilin_N
PfamiView protein in Pfam
PF00190, Cupin_1, 2 hits
PF04702, Vicilin_N, 1 hit
SMARTiView protein in SMART
SM00835, Cupin_1, 2 hits
SUPFAMiSSF51182, SSF51182, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVCL2_JUGRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SEW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 7, 2020
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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