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Protein

Squalene synthase

Gene

BSS

Organism
Botryococcus braunii (Green alga)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts farnesyl diphosphate into squalene but has no botryococcene synthase activity.1 Publication

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.1 Publication

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandMagnesium, NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14640
BRENDAi2.5.1.21 915

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Gene namesi
Name:BSS
OrganismiBotryococcus braunii (Green alga)
Taxonomic identifieri38881 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaTrebouxiophyceaeTrebouxiophyceae incertae sedisBotryococcaceaeBotryococcus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei399 – 416HelicalSequence analysisAdd BLAST18
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004213641 – 461Squalene synthaseAdd BLAST461

Expressioni

Developmental stagei

Transient induction with an apparent maximum occurring 6 to 8 days after subculturing.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9SDW9
SMRiQ9SDW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR002060 Squ/phyt_synthse
IPR006449 Squal_synth-like
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR01559 squal_synth, 1 hit
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SDW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMLRWGVES LQNPDELIPV LRMIYADKFG KIKPKDEDRG FCYEILNLVS
60 70 80 90 100
RSFAIVIQQL PAQLRDPVCI FYLVLRALDT VEDDMKIAAT TKIPLLRDFY
110 120 130 140 150
EKISDRSFRM TAGDQKDYIR LLDQYPKVTS VFLKLTPREQ EIIADITKRM
160 170 180 190 200
GNGMADFVHK GVPDTVGDYD LYCHYVAGVV GLGLSQLFVA SGLQSPSLTR
210 220 230 240 250
SEDLSNHMGL FLQKTNIIRD YFEDINELPA PRMFWPREIW GKYANNLAEF
260 270 280 290 300
KDPANKAAAM CCLNEMVTDA LRHAVYCLQY MSMIEDPQIF NFCAIPQTMA
310 320 330 340 350
FGTLSLCYNN YTIFTGPKAA VKLRRGTTAK LMYTSNNMFA MYRHFLNFAE
360 370 380 390 400
KLEVRCNTET SEDPSVTTTL EHLHKIKAAC KAGLARTKDD TFDELRSRLL
410 420 430 440 450
ALTGGSFYLA WTYNFLDLRG PGDLPTFLSV TQHWWSILIF LISIAVFFIP
460
SRPSPRPTLS A
Length:461
Mass (Da):52,547
Last modified:May 1, 2000 - v1
Checksum:i9C23A7641B22213D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205791 mRNA Translation: AAF20201.1
AH009227 Genomic DNA Translation: AAF63255.1

Similar proteinsi

Entry informationi

Entry nameiBSS_BOTBR
AccessioniPrimary (citable) accession number: Q9SDW9
Secondary accession number(s): Q9M678
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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