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Entry version 146 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

V-type proton ATPase subunit C

Gene

VHA-C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • unidimensional cell growth Source: TAIR

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.2.2.5, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-type proton ATPase subunit C
Short name:
V-ATPase subunit C
Alternative name(s):
Vacuolar H(+)-ATPase subunit C
Vacuolar proton pump subunit C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VHA-C
Synonyms:DET3, VATC
Ordered Locus Names:At1g12840
ORF Names:F13K23.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G12840

The Arabidopsis Information Resource

More...
TAIRi
locus:2010386, AT1G12840

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002093551 – 375V-type proton ATPase subunit CAdd BLAST375

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser/Thr residues by WNK8.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SDS7

PRoteomics IDEntifications database

More...
PRIDEi
Q9SDS7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
228577

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9SDS7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9SDS7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9SDS7, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c'', d and e).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
23080, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9SDS7, 8 interactors

Molecular INTeraction database

More...
MINTi
Q9SDS7

STRING: functional protein association networks

More...
STRINGi
3702.AT1G12840.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SDS7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2909, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017554_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SDS7

Identification of Orthologs from Complete Genome Data

More...
OMAi
ETHLIVV

Database of Orthologous Groups

More...
OrthoDBi
1016088at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9SDS7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14785, V-ATPase_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004907, ATPase_V1-cplx_csu
IPR036132, Vac_ATP_synth_c_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10137, PTHR10137, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03223, V-ATPase_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118203, SSF118203, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SDS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSRYWVVSL PVKDSASSLW NRLQEQISKH SFDTPVYRFN IPNLRVGTLD
60 70 80 90 100
SLLALGDDLL KSNSFVEGVS QKIRRQIEEL ERISGVESNA LTVDGVPVDS
110 120 130 140 150
YLTRFVWDEA KYPTMSPLKE VVDNIQSQVA KIEDDLKVRV AEYNNIRGQL
160 170 180 190 200
NAINRKQSGS LAVRDLSNLV KPEDIVESEH LVTLLAVVPK YSQKDWLACY
210 220 230 240 250
ETLTDYVVPR SSKKLFEDNE YALYTVTLFT RVADNFRIAA REKGFQVRDF
260 270 280 290 300
EQSVEAQETR KQELAKLVQD QESLRSSLLQ WCYTSYGEVF SSWMHFCAVR
310 320 330 340 350
TFAESIMRYG LPPAFLACVL SPAVKSEKKV RSILERLCDS TNSLYWKSEE
360 370
DAGAMAGLAG DSETHPYVSF TINLA
Length:375
Mass (Da):42,619
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA50F11D168F31C97
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF208261 mRNA Translation: AAF20146.1
AC012187 Genomic DNA Translation: AAF78489.1
CP002684 Genomic DNA Translation: AEE28936.1
AF334725 mRNA Translation: AAG50103.1
AY059872 mRNA Translation: AAL24354.1
AY093334 mRNA Translation: AAM13333.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T52300

NCBI Reference Sequences

More...
RefSeqi
NP_563916.1, NM_101154.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G12840.1; AT1G12840.1; AT1G12840

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
837840

Gramene; a comparative resource for plants

More...
Gramenei
AT1G12840.1; AT1G12840.1; AT1G12840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G12840

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208261 mRNA Translation: AAF20146.1
AC012187 Genomic DNA Translation: AAF78489.1
CP002684 Genomic DNA Translation: AEE28936.1
AF334725 mRNA Translation: AAG50103.1
AY059872 mRNA Translation: AAL24354.1
AY093334 mRNA Translation: AAM13333.1
PIRiT52300
RefSeqiNP_563916.1, NM_101154.4

3D structure databases

SMRiQ9SDS7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi23080, 14 interactors
IntActiQ9SDS7, 8 interactors
MINTiQ9SDS7
STRINGi3702.AT1G12840.1

Protein family/group databases

TCDBi3.A.2.2.5, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiQ9SDS7

Proteomic databases

PaxDbiQ9SDS7
PRIDEiQ9SDS7
ProteomicsDBi228577

Genome annotation databases

EnsemblPlantsiAT1G12840.1; AT1G12840.1; AT1G12840
GeneIDi837840
GrameneiAT1G12840.1; AT1G12840.1; AT1G12840
KEGGiath:AT1G12840

Organism-specific databases

AraportiAT1G12840
TAIRilocus:2010386, AT1G12840

Phylogenomic databases

eggNOGiKOG2909, Eukaryota
HOGENOMiCLU_017554_3_0_1
InParanoidiQ9SDS7
OMAiETHLIVV
OrthoDBi1016088at2759
PhylomeDBiQ9SDS7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9SDS7

Gene expression databases

ExpressionAtlasiQ9SDS7, baseline and differential
GenevisibleiQ9SDS7, AT

Family and domain databases

CDDicd14785, V-ATPase_C, 1 hit
InterProiView protein in InterPro
IPR004907, ATPase_V1-cplx_csu
IPR036132, Vac_ATP_synth_c_sf
PANTHERiPTHR10137, PTHR10137, 1 hit
PfamiView protein in Pfam
PF03223, V-ATPase_C, 1 hit
SUPFAMiSSF118203, SSF118203, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVATC_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SDS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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