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UniProtKB - Q9SDD6 (PRX2F_ORYSJ)
Protein
Peroxiredoxin-2F, mitochondrial
Gene
PRXIIF
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Reduces preferentially hydrogen peroxide rather than alkyl peroxides. May be involved in mitochondrial redox homeostasis.
By similarityMiscellaneous
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) can be reactivated by glutathione or the mitochondrial glutaredoxin (Grx) or thioredoxin (Trx) systems.By similarity
Catalytic activityi
- EC:1.11.1.25By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 86 | Cysteine sulfenic acid (-SOH) intermediateBy similarity | 1 |
GO - Molecular functioni
- thioredoxin peroxidase activity Source: GO_Central
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- cellular response to oxidative stress Source: GO_Central
- hydrogen peroxide catabolic process Source: GO_Central
Keywordsi
Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Protein family/group databases
PeroxiBasei | 4020, OsPrxII06 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxiredoxin-2F, mitochondrial (EC:1.11.1.25By similarity)Alternative name(s): Glutaredoxin-dependent peroxiredoxinCurated Peroxiredoxin IIF Thioredoxin peroxidase 2F |
Gene namesi | Name:PRXIIF Ordered Locus Names:Os01g0266600, LOC_Os01g16152 ORF Names:P0011D01.6, P0499C11.34 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrion Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 27 | MitochondrionSequence analysisAdd BLAST | 27 | |
ChainiPRO_0000282962 | 28 – 198 | Peroxiredoxin-2F, mitochondrialAdd BLAST | 171 |
Proteomic databases
PaxDbi | Q9SDD6 |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 4530.OS01T0266600-01 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 198 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 165 |
Sequence similaritiesi
Keywords - Domaini
Redox-active center, Transit peptidePhylogenomic databases
eggNOGi | KOG0541, Eukaryota |
HOGENOMi | CLU_072440_2_1_1 |
InParanoidi | Q9SDD6 |
OMAi | VNDPYTM |
OrthoDBi | 1281610at2759 |
Family and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9SDD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASALLRKAT VGGSAAAAAA RWASRGLASV GSGSDIVSAA PGVSLQKARS
60 70 80 90 100
WDEGVATNFS TTPLKDIFHG KKVVIFGLPG AYTGVCSQAH VPSYKNNIDK
110 120 130 140 150
LKAKGVDSVI CVSVNDPYAL NGWAEKLQAK DAIEFYGDFD GSFHKSLDLE
160 170 180 190
VDLSAALLGR RSHRWSAFVD DGKIKAFNVE VAPSDFKVSG AEVILDQI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000969 Genomic DNA Translation: BAA88530.1 AP001080 Genomic DNA Translation: BAA90363.1 AP008207 Genomic DNA Translation: BAF04594.1 AP014957 Genomic DNA Translation: BAS71469.1 AK058396 mRNA Translation: BAG86680.1 |
RefSeqi | XP_015621284.1, XM_015765798.1 |
Genome annotation databases
EnsemblPlantsi | Os01t0266600-01; Os01t0266600-01; Os01g0266600 Os01t0266600-02; Os01t0266600-02; Os01g0266600 |
GeneIDi | 4324376 |
Gramenei | Os01t0266600-01; Os01t0266600-01; Os01g0266600 Os01t0266600-02; Os01t0266600-02; Os01g0266600 |
KEGGi | osa:4324376 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000969 Genomic DNA Translation: BAA88530.1 AP001080 Genomic DNA Translation: BAA90363.1 AP008207 Genomic DNA Translation: BAF04594.1 AP014957 Genomic DNA Translation: BAS71469.1 AK058396 mRNA Translation: BAG86680.1 |
RefSeqi | XP_015621284.1, XM_015765798.1 |
3D structure databases
SMRi | Q9SDD6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS01T0266600-01 |
Protein family/group databases
PeroxiBasei | 4020, OsPrxII06 |
Proteomic databases
PaxDbi | Q9SDD6 |
Genome annotation databases
EnsemblPlantsi | Os01t0266600-01; Os01t0266600-01; Os01g0266600 Os01t0266600-02; Os01t0266600-02; Os01g0266600 |
GeneIDi | 4324376 |
Gramenei | Os01t0266600-01; Os01t0266600-01; Os01g0266600 Os01t0266600-02; Os01t0266600-02; Os01g0266600 |
KEGGi | osa:4324376 |
Phylogenomic databases
eggNOGi | KOG0541, Eukaryota |
HOGENOMi | CLU_072440_2_1_1 |
InParanoidi | Q9SDD6 |
OMAi | VNDPYTM |
OrthoDBi | 1281610at2759 |
Gene expression databases
Genevisiblei | Q9SDD6, OS |
Family and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRX2F_ORYSJ | |
Accessioni | Q9SDD6Primary (citable) accession number: Q9SDD6 Secondary accession number(s): B7E2T3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families