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UniProtKB - Q9SB81 (PER42_ARATH)
Protein
Peroxidase 42
Gene
PER42
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Might function as heat shock-like defense protein.
Miscellaneous
There are 73 peroxidase genes in A.thaliana.
Catalytic activityi
- EC:1.11.1.7
Cofactori
Protein has several cofactor binding sites:- heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
- Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 67 | Transition state stabilizerPROSITE-ProRule annotation | 1 | |
Active sitei | 71 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 72 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 75 | Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 79 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 81 | Calcium 1PROSITE-ProRule annotation | 1 | |
Binding sitei | 167 | Substrate; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 197 | Iron (heme b axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 198 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 247 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 250 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 255 | Calcium 2PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- peroxidase activity Source: GO_Central
GO - Biological processi
- hydrogen peroxide catabolic process Source: UniProtKB-KW
- response to oxidative stress Source: InterPro
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Biological process | Biological rhythms, Hydrogen peroxide |
Ligand | Calcium, Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | ARA:AT4G21960-MONOMER |
Protein family/group databases
PeroxiBasei | 208, AtPrx42 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxidase 42 (EC:1.11.1.7)Short name: Atperox P42 Alternative name(s): ATP1a/ATP1b PRXR1 |
Gene namesi | Name:PER42 Synonyms:P42 Ordered Locus Names:At4g21960 ORF Names:F1N20.3, T8O5.170 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G21960 |
TAIRi | locus:2141637, AT4G21960 |
Subcellular locationi
Extracellular region or secreted
- Secreted PROSITE-ProRule annotation
Cell Wall
- plant-type cell wall Source: TAIR
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000023708 | 24 – 330 | Peroxidase 42Add BLAST | 307 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 40 ↔ 119 | PROSITE-ProRule annotation | ||
Disulfide bondi | 73 ↔ 78 | PROSITE-ProRule annotation | ||
Disulfide bondi | 125 ↔ 323 | PROSITE-ProRule annotation | ||
Glycosylationi | 170 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 204 ↔ 231 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9SB81 |
PRIDEi | Q9SB81 |
ProteomicsDBi | 236303 |
Expressioni
Tissue specificityi
Constitutively expressed in the whole plant, with the highest expression in roots.1 Publication
Inductioni
Expressed under a diurnal rhythm (circadian clock control).1 Publication
Gene expression databases
ExpressionAtlasi | Q9SB81, baseline and differential |
Genevisiblei | Q9SB81, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 13574, 4 interactors |
IntActi | Q9SB81, 1 interactor |
STRINGi | 3702.AT4G21960.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QRC2, Eukaryota |
HOGENOMi | CLU_010543_0_0_1 |
InParanoidi | Q9SB81 |
OMAi | HNESMTV |
OrthoDBi | 902776at2759 |
PhylomeDBi | Q9SB81 |
Family and domain databases
CDDi | cd00693, secretory_peroxidase, 1 hit |
InterProi | View protein in InterPro IPR002016, Haem_peroxidase IPR010255, Haem_peroxidase_sf IPR000823, Peroxidase_pln IPR033905, Secretory_peroxidase |
PANTHERi | PTHR31235, PTHR31235, 1 hit |
Pfami | View protein in Pfam PF00141, peroxidase, 1 hit |
PRINTSi | PR00458, PEROXIDASE PR00461, PLPEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 1 hit |
PROSITEi | View protein in PROSITE PS50873, PEROXIDASE_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9SB81-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGKGVMMVA ILCLWALSAT SEAVTEAEPG LMMNFYKDTC PQAEDIVREQ
60 70 80 90 100
VKLLYKRHKN TAFSWLRNIF HDCAVESCDA SLLLDSTRRE LGEKEHDRSF
110 120 130 140 150
GLRNFRYIEE IKEALERECP GVVSCSDILV LSAREGIEAV GGPYIPLKTG
160 170 180 190 200
RRDGLKSRTD MLESYLPDHN ESISVVLEKF KSIGIDTPGL VALLGSHSVG
210 220 230 240 250
RTHCVKLVHR LYPEVDPSLN PDHVPHMLHK CPDSIPDPKA VQYVRNDRGT
260 270 280 290 300
PMVLDNNYYR NILDNKGLLL VDHQLAHDKR TRPIVKKMAK DQAYFFKEFT
310 320 330
RAIQILSENN PLTGSKGEIR KQCNLANKNH
Sequence cautioni
The sequence CAA17163 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB79151 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | C → F (PubMed:9132061).Curated | 1 | |
Sequence conflicti | 13 | C → F (Ref. 6) Curated | 1 | |
Sequence conflicti | 27 | A → T (PubMed:9132061).Curated | 1 | |
Sequence conflicti | 27 | A → T (Ref. 6) Curated | 1 | |
Sequence conflicti | 47 | V → I (PubMed:9132061).Curated | 1 | |
Sequence conflicti | 47 | V → I (Ref. 6) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98313 mRNA Translation: CAA66957.1 X98189 mRNA Translation: CAA66862.1 AL021890 Genomic DNA Translation: CAA17163.1 Different initiation. AL022140 Genomic DNA No translation available. AL161556 Genomic DNA Translation: CAB79151.1 Different initiation. CP002687 Genomic DNA Translation: AEE84535.1 AF325015 mRNA Translation: AAG40367.1 AF428379 mRNA Translation: AAL16147.1 AY056809 mRNA Translation: AAL10500.1 AY058071 mRNA Translation: AAL24179.1 AY059810 mRNA Translation: AAL24292.1 AY132009 mRNA Translation: AAM91042.1 AF083767 mRNA Translation: AAN60325.1 Z17792 mRNA Translation: CAA79071.1 |
PIRi | T05478 |
RefSeqi | NP_567641.1, NM_118317.4 |
Genome annotation databases
EnsemblPlantsi | AT4G21960.1; AT4G21960.1; AT4G21960 |
GeneIDi | 828285 |
Gramenei | AT4G21960.1; AT4G21960.1; AT4G21960 |
KEGGi | ath:AT4G21960 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98313 mRNA Translation: CAA66957.1 X98189 mRNA Translation: CAA66862.1 AL021890 Genomic DNA Translation: CAA17163.1 Different initiation. AL022140 Genomic DNA No translation available. AL161556 Genomic DNA Translation: CAB79151.1 Different initiation. CP002687 Genomic DNA Translation: AEE84535.1 AF325015 mRNA Translation: AAG40367.1 AF428379 mRNA Translation: AAL16147.1 AY056809 mRNA Translation: AAL10500.1 AY058071 mRNA Translation: AAL24179.1 AY059810 mRNA Translation: AAL24292.1 AY132009 mRNA Translation: AAM91042.1 AF083767 mRNA Translation: AAN60325.1 Z17792 mRNA Translation: CAA79071.1 |
PIRi | T05478 |
RefSeqi | NP_567641.1, NM_118317.4 |
3D structure databases
AlphaFoldDBi | Q9SB81 |
SMRi | Q9SB81 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 13574, 4 interactors |
IntActi | Q9SB81, 1 interactor |
STRINGi | 3702.AT4G21960.1 |
Protein family/group databases
PeroxiBasei | 208, AtPrx42 |
Proteomic databases
PaxDbi | Q9SB81 |
PRIDEi | Q9SB81 |
ProteomicsDBi | 236303 |
Genome annotation databases
EnsemblPlantsi | AT4G21960.1; AT4G21960.1; AT4G21960 |
GeneIDi | 828285 |
Gramenei | AT4G21960.1; AT4G21960.1; AT4G21960 |
KEGGi | ath:AT4G21960 |
Organism-specific databases
Araporti | AT4G21960 |
TAIRi | locus:2141637, AT4G21960 |
Phylogenomic databases
eggNOGi | ENOG502QRC2, Eukaryota |
HOGENOMi | CLU_010543_0_0_1 |
InParanoidi | Q9SB81 |
OMAi | HNESMTV |
OrthoDBi | 902776at2759 |
PhylomeDBi | Q9SB81 |
Enzyme and pathway databases
BioCyci | ARA:AT4G21960-MONOMER |
Miscellaneous databases
PROi | PR:Q9SB81 |
Gene expression databases
ExpressionAtlasi | Q9SB81, baseline and differential |
Genevisiblei | Q9SB81, AT |
Family and domain databases
CDDi | cd00693, secretory_peroxidase, 1 hit |
InterProi | View protein in InterPro IPR002016, Haem_peroxidase IPR010255, Haem_peroxidase_sf IPR000823, Peroxidase_pln IPR033905, Secretory_peroxidase |
PANTHERi | PTHR31235, PTHR31235, 1 hit |
Pfami | View protein in Pfam PF00141, peroxidase, 1 hit |
PRINTSi | PR00458, PEROXIDASE PR00461, PLPEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 1 hit |
PROSITEi | View protein in PROSITE PS50873, PEROXIDASE_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PER42_ARATH | |
Accessioni | Q9SB81Primary (citable) accession number: Q9SB81 Secondary accession number(s): Q41937, Q42579, Q43730 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | December 6, 2002 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families