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Entry version 120 (02 Dec 2020)
Sequence version 2 (29 May 2007)
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Protein

Vacuolar protein sorting-associated protein 28 homolog 2

Gene

VPS28-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.31.1.2, the endosomal sorting complexes required for transport iii (escrt-iii) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 28 homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS28-2
Ordered Locus Names:At4g05000
ORF Names:T32N4.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G05000

The Arabidopsis Information Resource

More...
TAIRi
locus:2138426, AT4G05000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001209551 – 210Vacuolar protein sorting-associated protein 28 homolog 2Add BLAST210

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9S9T7

PRoteomics IDEntifications database

More...
PRIDEi
Q9S9T7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
242732

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9S9T7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9S9T7, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the endosomal sorting required for transport complex I (ESCRT-I), composed of ELC, VPS28 and VPS37.

Interacts with ELC.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
11153, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9S9T7, 3 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G05000.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9S9T7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 99VPS28 N-terminalPROSITE-ProRule annotationAdd BLAST99
Domaini109 – 205VPS28 C-terminalPROSITE-ProRule annotationAdd BLAST97

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS28 family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3284, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076417_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9S9T7

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPETGKW

Database of Orthologous Groups

More...
OrthoDBi
1281819at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9S9T7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1130, 1 hit
1.20.1440.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037202, ESCRT_assembly_dom
IPR007143, Vps28
IPR017899, VPS28_C
IPR037206, VPS28_C_sf
IPR017898, VPS28_N
IPR038358, VPS28_N_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12937, PTHR12937, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03997, VPS28, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017535, VPS28, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140111, SSF140111, 1 hit
SSF140427, SSF140427, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51310, VPS28_C, 1 hit
PS51313, VPS28_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9S9T7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEVKLWNDK REREMYENFA ELFAIIKATE KLEKAYIRDL INPSEYESEC
60 70 80 90 100
QKLIVHFKTL SATLKDTVPN IERFADTYKM DCPAALYRLV TSGLPATVEH
110 120 130 140 150
RATVAASTSN SASIVAECVQ NFITSMDSLK LNMVAVDQVY PLLSDLSASL
160 170 180 190 200
NKLSILPPDF EGKTKMKEWL SRLSKMGAAD ELTEQQSRQL HFDLESSYNS
210
FMAALPKAGN
Length:210
Mass (Da):23,689
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8011A0DAA55DE5FC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD48972 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB81042 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF162444 Genomic DNA Translation: AAD48972.1 Different initiation.
AL161502 Genomic DNA Translation: CAB81042.1 Different initiation.
CP002687 Genomic DNA Translation: AEE82456.1
CP002687 Genomic DNA Translation: AEE82457.1
CP002687 Genomic DNA Translation: ANM66421.1
BT015071 mRNA Translation: AAT71943.1
BT015727 mRNA Translation: AAU45225.1
AK229295 mRNA Translation: BAF01158.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H85062

NCBI Reference Sequences

More...
RefSeqi
NP_001328317.1, NM_001340525.1
NP_567281.2, NM_116739.4
NP_974513.1, NM_202784.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G05000.1; AT4G05000.1; AT4G05000
AT4G05000.2; AT4G05000.2; AT4G05000
AT4G05000.3; AT4G05000.3; AT4G05000

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
825842

Gramene; a comparative resource for plants

More...
Gramenei
AT4G05000.1; AT4G05000.1; AT4G05000
AT4G05000.2; AT4G05000.2; AT4G05000
AT4G05000.3; AT4G05000.3; AT4G05000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G05000

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162444 Genomic DNA Translation: AAD48972.1 Different initiation.
AL161502 Genomic DNA Translation: CAB81042.1 Different initiation.
CP002687 Genomic DNA Translation: AEE82456.1
CP002687 Genomic DNA Translation: AEE82457.1
CP002687 Genomic DNA Translation: ANM66421.1
BT015071 mRNA Translation: AAT71943.1
BT015727 mRNA Translation: AAU45225.1
AK229295 mRNA Translation: BAF01158.1
PIRiH85062
RefSeqiNP_001328317.1, NM_001340525.1
NP_567281.2, NM_116739.4
NP_974513.1, NM_202784.3

3D structure databases

SMRiQ9S9T7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi11153, 7 interactors
IntActiQ9S9T7, 3 interactors
STRINGi3702.AT4G05000.1

Protein family/group databases

TCDBi3.A.31.1.2, the endosomal sorting complexes required for transport iii (escrt-iii) family

Proteomic databases

PaxDbiQ9S9T7
PRIDEiQ9S9T7
ProteomicsDBi242732

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
825842

Genome annotation databases

EnsemblPlantsiAT4G05000.1; AT4G05000.1; AT4G05000
AT4G05000.2; AT4G05000.2; AT4G05000
AT4G05000.3; AT4G05000.3; AT4G05000
GeneIDi825842
GrameneiAT4G05000.1; AT4G05000.1; AT4G05000
AT4G05000.2; AT4G05000.2; AT4G05000
AT4G05000.3; AT4G05000.3; AT4G05000
KEGGiath:AT4G05000

Organism-specific databases

AraportiAT4G05000
TAIRilocus:2138426, AT4G05000

Phylogenomic databases

eggNOGiKOG3284, Eukaryota
HOGENOMiCLU_076417_1_0_1
InParanoidiQ9S9T7
OMAiGPETGKW
OrthoDBi1281819at2759
PhylomeDBiQ9S9T7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9S9T7

Gene expression databases

ExpressionAtlasiQ9S9T7, baseline and differential
GenevisibleiQ9S9T7, AT

Family and domain databases

Gene3Di1.20.120.1130, 1 hit
1.20.1440.200, 1 hit
InterProiView protein in InterPro
IPR037202, ESCRT_assembly_dom
IPR007143, Vps28
IPR017899, VPS28_C
IPR037206, VPS28_C_sf
IPR017898, VPS28_N
IPR038358, VPS28_N_sf
PANTHERiPTHR12937, PTHR12937, 1 hit
PfamiView protein in Pfam
PF03997, VPS28, 1 hit
PIRSFiPIRSF017535, VPS28, 1 hit
SUPFAMiSSF140111, SSF140111, 1 hit
SSF140427, SSF140427, 1 hit
PROSITEiView protein in PROSITE
PS51310, VPS28_C, 1 hit
PS51313, VPS28_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP282_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9S9T7
Secondary accession number(s): Q6DBF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 29, 2007
Last modified: December 2, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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