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Protein

Heat shock 70 kDa protein 5

Gene

HSP70-5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-ATH-3371571 HSF1-dependent transactivation
R-ATH-6798695 Neutrophil degranulation
R-ATH-72163 mRNA Splicing - Major Pathway
R-ATH-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 5
Alternative name(s):
Heat shock protein 70-5
Short name:
AtHsp70-5
Heat shock protein 70b
Gene namesi
Name:HSP70-5
Synonyms:HSP70B
Ordered Locus Names:At1g16030
ORF Names:T24D18.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G16030
TAIRilocus:2200462 AT1G16030

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004154241 – 646Heat shock 70 kDa protein 5Add BLAST646

Proteomic databases

PaxDbiQ9S9N1
PRIDEiQ9S9N1

Expressioni

Inductioni

By heat shock. Up-regulated by virus infection.2 Publications

Gene expression databases

ExpressionAtlasiQ9S9N1 baseline and differential
GenevisibleiQ9S9N1 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi23414, 8 interactors
IntActiQ9S9N1, 3 interactors
MINTiQ9S9N1
STRINGi3702.AT1G16030.1

Structurei

3D structure databases

ProteinModelPortaliQ9S9N1
SMRiQ9S9N1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
HOGENOMiHOG000228135
InParanoidiQ9S9N1
KOiK03283
OMAiHFVSEFR
OrthoDBiEOG093604KP
PhylomeDBiQ9S9N1

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9S9N1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATKSEKAIG IDLGTTYSCV GVWMNDRVEI IPNDQGNRTT PSYVAFTDTE
60 70 80 90 100
RLIGDAAKNQ VALNPQNTVF DAKRLIGRKF SDPSVQSDIL HWPFKVVSGP
110 120 130 140 150
GEKPMIVVSY KNEEKQFSPE EISSMVLVKM KEVAEAFLGR TVKNAVVTVP
160 170 180 190 200
AYFNDSQRQA TKDAGAISGL NVLRIINEPT AAAIAYGLDK KGTKAGEKNV
210 220 230 240 250
LIFDLGGGTF DVSLLTIEEG VFEVKATAGD THLGGEDFDN RLVNHFVAEF
260 270 280 290 300
RRKHKKDIAG NARALRRLRT ACERAKRTLS STAQTTIEID SLHEGIDFYA
310 320 330 340 350
TISRARFEEM NMDLFRKCMD PVEKVLKDAK LDKSSVHDVV LVGGSTRIPK
360 370 380 390 400
IQQLLQDFFN GKELCKSINP DEAVAYGAAV QAAILTGEGS EKVQDLLLLD
410 420 430 440 450
VAPLSLGLET AGGVMTVLIP RNTTVPCKKE QVFSTYADNQ PGVLIQVYEG
460 470 480 490 500
ERARTRDNNL LGTFELKGIP PAPRGVPQIN VCFDIDANGI LNVSAEDKTA
510 520 530 540 550
GVKNQITITN DKGRLSKEEI EKMVQDAEKY KAEDEQVKKK VEAKNSLENY
560 570 580 590 600
AYNMRNTIKD EKLAQKLTQE DKQKIEKAID ETIEWIEGNQ LAEVDEFEYK
610 620 630 640
LKELEGICNP IISKMYQGGA AAGGMPTDGD FSSSGAAGGP KIEEVD
Length:646
Mass (Da):70,915
Last modified:May 1, 2000 - v1
Checksum:i46137E1DC9139895
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010924 Genomic DNA Translation: AAF18501.1
CP002684 Genomic DNA Translation: AEE29402.1
BT001988 mRNA Translation: AAN71999.1
BT008401 mRNA Translation: AAP37760.1
PIRiB86295
RefSeqiNP_173055.1, NM_101471.3
UniGeneiAt.41906

Genome annotation databases

EnsemblPlantsiAT1G16030.1; AT1G16030.1; AT1G16030
GeneIDi838174
GrameneiAT1G16030.1; AT1G16030.1; AT1G16030
KEGGiath:AT1G16030

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010924 Genomic DNA Translation: AAF18501.1
CP002684 Genomic DNA Translation: AEE29402.1
BT001988 mRNA Translation: AAN71999.1
BT008401 mRNA Translation: AAP37760.1
PIRiB86295
RefSeqiNP_173055.1, NM_101471.3
UniGeneiAt.41906

3D structure databases

ProteinModelPortaliQ9S9N1
SMRiQ9S9N1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23414, 8 interactors
IntActiQ9S9N1, 3 interactors
MINTiQ9S9N1
STRINGi3702.AT1G16030.1

Proteomic databases

PaxDbiQ9S9N1
PRIDEiQ9S9N1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G16030.1; AT1G16030.1; AT1G16030
GeneIDi838174
GrameneiAT1G16030.1; AT1G16030.1; AT1G16030
KEGGiath:AT1G16030

Organism-specific databases

AraportiAT1G16030
TAIRilocus:2200462 AT1G16030

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
HOGENOMiHOG000228135
InParanoidiQ9S9N1
KOiK03283
OMAiHFVSEFR
OrthoDBiEOG093604KP
PhylomeDBiQ9S9N1

Enzyme and pathway databases

ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-ATH-3371571 HSF1-dependent transactivation
R-ATH-6798695 Neutrophil degranulation
R-ATH-72163 mRNA Splicing - Major Pathway
R-ATH-8876725 Protein methylation

Miscellaneous databases

PROiPR:Q9S9N1

Gene expression databases

ExpressionAtlasiQ9S9N1 baseline and differential
GenevisibleiQ9S9N1 AT

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP7E_ARATH
AccessioniPrimary (citable) accession number: Q9S9N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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