Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (17 Jun 2020)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Ethylene-insensitive protein 2

Gene

EIN2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Central factor in signaling pathways regulated by ethylene (ET), and involved in various processes including development, plant defense, senescence, nucleotide sugar flux, and tropisms. Necessary for ethylene-mediated gene regulation, and for the induction of some genes by ozone. Acts downstream of ET receptors, and upstream of ethylene regulated transcription factors. Required for cytokinin-mediated processes. Seems to be implicated in cross-talk between ET, jasmonate and other pathways. Probably not involved in iron uptake (PubMed:10381874, PubMed:12953109, PubMed:14973160, PubMed:15010611, PubMed:15272873, PubMed:7770519, PubMed:9351240). Has a short half-life and undergoes rapid proteasome-mediated turnover in the absence of ethylene (PubMed:19196655). Required for ethylene-induced EIN3 stabilization via proteasomal degradation of EBF1/EBF2 proteins (PubMed:20647342). Regulates the leaf senescence induced by methyl jasmonate, ethylene and abscisic acid (Ref. 17, PubMed:15010611). Required during salt stress to confer resistance (PubMed:21631530).11 Publications
Trafficking signal inducing ethylene response. The nuclear localization is both necessary and sufficient to activate EIN3-mediated transcription and ethylene responses (PubMed:23070300). Necessary and sufficient for 3'-UTR-mediated translational repression of EBF1 and EBF2 mRNAs. Ethylene induces EIN2-CEND to associate with 3' UTRs in cytoplasmic foci and target EBF1/2 mRNAs to cytoplasmic processing-body (P-body) (PubMed:26496607, PubMed:26496608). MPK6 regulates the cleavage and nuclear translocation of EIN2-CEND under methyl jasmonate treatment (PubMed:26507893). Required for EIN3 accumulation (PubMed:26507893).4 Publications

Miscellaneous

'Oresara' means 'long living' in Korean.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAuxin signaling pathway, Cytokinin signaling pathway, Ethylene signaling pathway, Plant defense, Stress response

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.55.2.8 the metal ion (mn(2+)-iron) transporter (nramp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ethylene-insensitive protein 21 Publication
Short name:
AtEIN21 Publication
Short name:
EIN-21 Publication
Alternative name(s):
Cytokinin-resistant protein AtCKR1
Protein ORESARA 31 Publication
Cleaved into the following chain:
EIN2-CEND1 Publication
Alternative name(s):
EIN2C1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIN21 Publication
Synonyms:CKR1, ORE31 Publication
Ordered Locus Names:At5g03280Imported
ORF Names:F12E4.10Imported, MOK16.19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G03280

The Arabidopsis Information Resource

More...
TAIRi
locus:2142594 AT5G03280

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 50ExtracellularSequence analysisAdd BLAST17
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 105CytoplasmicSequence analysisAdd BLAST34
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127ExtracellularSequence analysis1
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 155CytoplasmicSequence analysis7
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 194ExtracellularSequence analysisAdd BLAST18
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 237CytoplasmicSequence analysisAdd BLAST22
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 287ExtracellularSequence analysisAdd BLAST29
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 334CytoplasmicSequence analysisAdd BLAST26
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 397CytoplasmicSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 440ExtracellularSequence analysisAdd BLAST22
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 1294CytoplasmicSequence analysisAdd BLAST833

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Complete ethylene insensitivity (PubMed:10381874). Extreme salt sensitivity during seed germination and plant growth leading to epinastic backward growth of leaf blade and petiole, and small rosette size (PubMed:21631530).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi645S → A: Constitutive of ethylene response in absence of ethylene. 85% decreased phosphorylation and constitutive activation of ethylene response; when associated with A-924. 2 Publications1
Mutagenesisi645S → E: Loss of function. 1 Publication1
Mutagenesisi924S → A: 85% decreased phosphorylation and constitutive activation of ethylene response; when associated with A-645. 1 Publication1
Mutagenesisi1143H → P in ein2-9; lower sensitivity to ethylene. 1 Publication1
Mutagenesisi1262 – 1269LKRYKRRL → KPKKKRKV: No effect on nuclear translocation but loss of translational repression function. 1 Publication8
Mutagenesisi1262 – 1269Missing : Loss of nuclear localization, EIN2-CEND functions and interaction with ETR1. 2 Publications8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002126041 – 1294Ethylene-insensitive protein 2Add BLAST1294
ChainiPRO_0000435290646 – 1294EIN2-CEND1 PublicationAdd BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei645Phosphoserine1 Publication1
Modified residuei659Phosphoserine1 Publication1
Modified residuei757Phosphoserine1 Publication1
Modified residuei819Phosphothreonine1 Publication1
Modified residuei924Phosphoserine1 Publication1
Modified residuei1283Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CTR1 on at least 4 sites. Phosphorylation of Ser-645 and Ser-924 is involved in repressing EIN2 signaling. Loss of phosphorylation results in nuclear localization of the C-terminus of EIN2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9S814

PRoteomics IDEntifications database

More...
PRIDEi
Q9S814

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
220445

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9S814

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Localized to the guard cells after methyl jasmonate treatment.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9S814 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9S814 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via NLS) with ETR1 (PubMed:19769567, PubMed:25843012).

Interacts (via C-terminus) with EER5 and the COP9 signalosome subunits CSN3, CSN6A and CSN6B (PubMed:18429939).

Interacts with ETP1 and ETP2 (PubMed:19196655).

Interacts with CTR1 (PubMed:23132950).

Interacts with all members of the ethylene receptor family, including ETR1, ETR2, ERS1, ERS2 and EIN4 (PubMed:20591837). EIN2-CEND:

Interacts with several P-body components, such as XRN4/EIN5, PAB2, PAB4 and PAB8 (PubMed:26496607). Binds to MRF3/ECIP1 (PubMed:21631530).

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
17165, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9S814, 3 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G03280.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal (1-560) region seems to be regulated by upstream components of the ET signal transduction pathway, and may in turn regulate the C-terminal region. The C-terminal (454-1294) region regulates downstream events of ET and jasmonate signaling pathways, and can confer constitutive responses to ET. The C-terminal (1047-1294) region is necessary and sufficient for interactions with ETP1 and ETP2 (PubMed:19196655). The nuclear localization signal (1262-1269) is required for interaction with ETR1 (PubMed:25843012).3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1291 Eukaryota
COG1914 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006509_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9S814

KEGG Orthology (KO)

More...
KOi
K14513

Identification of Orthologs from Complete Genome Data

More...
OMAi
PMAPTIF

Database of Orthologous Groups

More...
OrthoDBi
666470at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9S814

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017187 EIN2
IPR001046 NRAMP_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11706 PTHR11706, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01566 Nramp, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037378 EIN2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00447 NATRESASSCMP

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9S814-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEIVNVRP QLGFIQRMVP ALLPVLLVSV GYIDPGKWVA NIEGGARFGY
60 70 80 90 100
DLVAITLLFN FAAILCQYVA ARISVVTGKH LAQICNEEYD KWTCMFLGIQ
110 120 130 140 150
AEFSAILLDL TMVVGVAHAL NLLFGVELST GVFLAAMDAF LFPVFASFLE
160 170 180 190 200
NGMANTVSIY SAGLVLLLYV SGVLLSQSEI PLSMNGVLTR LNGESAFALM
210 220 230 240 250
GLLGASIVPH NFYIHSYFAG ESTSSSDVDK SSLCQDHLFA IFGVFSGLSL
260 270 280 290 300
VNYVLMNAAA NVFHSTGLVV LTFHDALSLM EQVFMSPLIP VVFLMLLFFS
310 320 330 340 350
SQITALAWAF GGEVVLHDFL KIEIPAWLHR ATIRILAVAP ALYCVWTSGA
360 370 380 390 400
DGIYQLLIFT QVLVAMMLPC SVIPLFRIAS SRQIMGVHKI PQVGEFLALT
410 420 430 440 450
TFLGFLGLNV VFVVEMVFGS SDWAGGLRWN TVMGTSIQYT TLLVSSCASL
460 470 480 490 500
CLILWLAATP LKSASNRAEA QIWNMDAQNA LSYPSVQEEE IERTETRRNE
510 520 530 540 550
DESIVRLESR VKDQLDTTSV TSSVYDLPEN ILMTDQEIRS SPPEERELDV
560 570 580 590 600
KYSTSQVSSL KEDSDVKEQS VLQSTVVNEV SDKDLIVETK MAKIEPMSPV
610 620 630 640 650
EKIVSMENNS KFIEKDVEGV SWETEEATKA APTSNFTVGS DGPPSFRSLS
660 670 680 690 700
GEGGSGTGSL SRLQGLGRAA RRHLSAILDE FWGHLYDFHG QLVAEARAKK
710 720 730 740 750
LDQLFGTDQK SASSMKADSF GKDISSGYCM SPTAKGMDSQ MTSSLYDSLK
760 770 780 790 800
QQRTPGSIDS LYGLQRGSSP SPLVNRMQML GAYGNTTNNN NAYELSERRY
810 820 830 840 850
SSLRAPSSSE GWEHQQPATV HGYQMKSYVD NLAKERLEAL QSRGEIPTSR
860 870 880 890 900
SMALGTLSYT QQLALALKQK SQNGLTPGPA PGFENFAGSR SISRQSERSY
910 920 930 940 950
YGVPSSGNTD TVGAAVANEK KYSSMPDISG LSMSARNMHL PNNKSGYWDP
960 970 980 990 1000
SSGGGGYGAS YGRLSNESSL YSNLGSRVGV PSTYDDISQS RGGYRDAYSL
1010 1020 1030 1040 1050
PQSATTGTGS LWSRQPFEQF GVAERNGAVG EELRNRSNPI NIDNNASSNV
1060 1070 1080 1090 1100
DAEAKLLQSF RHCILKLIKL EGSEWLFGQS DGVDEELIDR VAAREKFIYE
1110 1120 1130 1140 1150
AEAREINQVG HMGEPLISSV PNCGDGCVWR ADLIVSFGVW CIHRVLDLSL
1160 1170 1180 1190 1200
MESRPELWGK YTYVLNRLQG VIDPAFSKLR TPMTPCFCLQ IPASHQRASP
1210 1220 1230 1240 1250
TSANGMLPPA AKPAKGKCTT AVTLLDLIKD VEMAISCRKG RTGTAAGDVA
1260 1270 1280 1290
FPKGKENLAS VLKRYKRRLS NKPVGMNQDG PGSRKNVTAY GSLG
Length:1,294
Mass (Da):140,956
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A806303B8B8E71B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF141202 Genomic DNA Translation: AAD41076.1
AF141203 mRNA Translation: AAD41077.1
AB005240 Genomic DNA Translation: BAB08388.1
AL162751 Genomic DNA Translation: CAB83284.1
CP002688 Genomic DNA Translation: AED90580.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T48349

NCBI Reference Sequences

More...
RefSeqi
NP_195948.1, NM_120406.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G03280.1; AT5G03280.1; AT5G03280

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
831889

Gramene; a comparative resource for plants

More...
Gramenei
AT5G03280.1; AT5G03280.1; AT5G03280

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G03280

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141202 Genomic DNA Translation: AAD41076.1
AF141203 mRNA Translation: AAD41077.1
AB005240 Genomic DNA Translation: BAB08388.1
AL162751 Genomic DNA Translation: CAB83284.1
CP002688 Genomic DNA Translation: AED90580.1
PIRiT48349
RefSeqiNP_195948.1, NM_120406.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi17165, 12 interactors
IntActiQ9S814, 3 interactors
STRINGi3702.AT5G03280.1

Protein family/group databases

TCDBi2.A.55.2.8 the metal ion (mn(2+)-iron) transporter (nramp) family

PTM databases

iPTMnetiQ9S814

Proteomic databases

PaxDbiQ9S814
PRIDEiQ9S814
ProteomicsDBi220445

Genome annotation databases

EnsemblPlantsiAT5G03280.1; AT5G03280.1; AT5G03280
GeneIDi831889
GrameneiAT5G03280.1; AT5G03280.1; AT5G03280
KEGGiath:AT5G03280

Organism-specific databases

AraportiAT5G03280
TAIRilocus:2142594 AT5G03280

Phylogenomic databases

eggNOGiKOG1291 Eukaryota
COG1914 LUCA
HOGENOMiCLU_006509_0_0_1
InParanoidiQ9S814
KOiK14513
OMAiPMAPTIF
OrthoDBi666470at2759
PhylomeDBiQ9S814

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9S814

Gene expression databases

ExpressionAtlasiQ9S814 baseline and differential
GenevisibleiQ9S814 AT

Family and domain databases

InterProiView protein in InterPro
IPR017187 EIN2
IPR001046 NRAMP_fam
PANTHERiPTHR11706 PTHR11706, 1 hit
PfamiView protein in Pfam
PF01566 Nramp, 1 hit
PIRSFiPIRSF037378 EIN2, 1 hit
PRINTSiPR00447 NATRESASSCMP

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEIN2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9S814
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again