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Entry version 126 (02 Jun 2021)
Sequence version 2 (16 May 2003)
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Protein

Sister chromatid cohesion 1 protein 1

Gene

SYN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in chromosome condensation, pairing and segregation during meiosis. Responsible for cohesion between replicated sister chromatids.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Chromosome partition, Meiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion 1 protein 1
Alternative name(s):
Protein DETERMINATE INFERTILE 1
SCC1 homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYN1
Synonyms:DIF1
Ordered Locus Names:At5g05490
ORF Names:MOP10.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G05490

The Arabidopsis Information Resource

More...
TAIRi
locus:2169667, AT5G05490

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000978751 – 627Sister chromatid cohesion 1 protein 1Add BLAST627

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9S7T7

PRoteomics IDEntifications database

More...
PRIDEi
Q9S7T7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
232936 [Q9S7T7-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed at low levels in buds, leaves and roots, whereas expression of isoform 1 is confined to buds.

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9S7T7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9S7T7, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cohesin complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G05490.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9S7T7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni211 – 294DisorderedSequence analysisAdd BLAST84
Regioni395 – 416DisorderedSequence analysisAdd BLAST22
Regioni461 – 510DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi254 – 293Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi395 – 410Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi463 – 493Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rad21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1213, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9S7T7

Identification of Orthologs from Complete Genome Data

More...
OMAi
THDFIKV

Database of Orthologous Groups

More...
OrthoDBi
345127at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9S7T7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.580, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039781, Rad21/Rec8-like
IPR006909, Rad21/Rec8_C_eu
IPR006910, Rad21_Rec8_N
IPR023093, ScpA-like_C
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12585, PTHR12585, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04824, Rad21_Rec8, 1 hit
PF04825, Rad21_Rec8_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket
Isoform 2 (identifier: Q9S7T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRLESLIVT VWGPATLLAR KAPLGQIWMA ATLHAKINRK KLDKLDIIQI
60 70 80 90 100
CEEILNPSVP MALRLSGILM GGVVIVYERK VKLLFDDVNR FLVEINGAWR
110 120 130 140 150
TKSVPDPTLL PKGKTHARKE AVTLPENEEA DFGDFEQTRN VPKFGNYMDF
160 170 180 190 200
QQTFISMRLD ESHVNNNPEP EDLGQQFHQA DAENITLFEY HGSFQTNNET
210 220 230 240 250
YDRFERFDIE GDDETQMNSN PREGAEIPTT LIPSPPRHHD IPEGVNPTSP
260 270 280 290 300
QRQEQQENRR DGFAEQMEEQ NIPDKEEHDR PQPAKKRARK TATSAMDYEQ
310 320 330 340 350
TIIAGHVYQS WLQDTSDILC RGEKRKVRGT IRPDMESFKR ANMPPTQLFE
360 370 380 390 400
KDSSYPPQLY QLWSKNTQVL QTSSSESRHP DLRAEQSPGF VQERMHNHHQ
410 420 430 440 450
TDHHERSDTS SQNLDSPAEI LRTVRTGKGA SVESMMAGSR ASPETINRQA
460 470 480 490 500
ADINVTPFYS GDDVRSMPST PSARGAASIN NIEISSKSRM PNRKRPNSSP
510 520 530 540 550
RRGLEPVAEE RPWEHREYEF EFSMLPEKRF TADKEILFET ASTQTQKPVC
560 570 580 590 600
NQSDEMITDS IKSHLKTHFE TPGAPQVESL NKLAVGMDRN AAAKLFFQSC
610 620
VLATRGVIKV NQAEPYGDIL IARGPNM
Length:627
Mass (Da):71,228
Last modified:May 16, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05D815E914233650
GO
Isoform 1 (identifier: Q9S7T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MLRLESLIVTVWGPAT → MFYSHQ

Show »
Length:617
Mass (Da):70,254
Checksum:i4BE14F8524B538B6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0074921 – 16MLRLE…WGPAT → MFYSHQ in isoform 1. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF080620 mRNA Translation: AAF08982.1
AF080619 mRNA Translation: AAF08981.1
AJ238306 mRNA Translation: CAB64643.1
AB005241 Genomic DNA Translation: BAB11538.1
CP002688 Genomic DNA Translation: AED90879.1
CP002688 Genomic DNA Translation: AED90880.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T52571

NCBI Reference Sequences

More...
RefSeqi
NP_196168.1, NM_120631.2 [Q9S7T7-2]
NP_850773.1, NM_180442.2 [Q9S7T7-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G05490.1; AT5G05490.1; AT5G05490 [Q9S7T7-1]
AT5G05490.2; AT5G05490.2; AT5G05490 [Q9S7T7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
830432

Gramene; a comparative resource for plants

More...
Gramenei
AT5G05490.1; AT5G05490.1; AT5G05490 [Q9S7T7-1]
AT5G05490.2; AT5G05490.2; AT5G05490 [Q9S7T7-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G05490

Keywords - Coding sequence diversityi

Alternative promoter usage

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080620 mRNA Translation: AAF08982.1
AF080619 mRNA Translation: AAF08981.1
AJ238306 mRNA Translation: CAB64643.1
AB005241 Genomic DNA Translation: BAB11538.1
CP002688 Genomic DNA Translation: AED90879.1
CP002688 Genomic DNA Translation: AED90880.1
PIRiT52571
RefSeqiNP_196168.1, NM_120631.2 [Q9S7T7-2]
NP_850773.1, NM_180442.2 [Q9S7T7-1]

3D structure databases

SMRiQ9S7T7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G05490.1

Proteomic databases

PaxDbiQ9S7T7
PRIDEiQ9S7T7
ProteomicsDBi232936 [Q9S7T7-1]

Genome annotation databases

EnsemblPlantsiAT5G05490.1; AT5G05490.1; AT5G05490 [Q9S7T7-1]
AT5G05490.2; AT5G05490.2; AT5G05490 [Q9S7T7-2]
GeneIDi830432
GrameneiAT5G05490.1; AT5G05490.1; AT5G05490 [Q9S7T7-1]
AT5G05490.2; AT5G05490.2; AT5G05490 [Q9S7T7-2]
KEGGiath:AT5G05490

Organism-specific databases

AraportiAT5G05490
TAIRilocus:2169667, AT5G05490

Phylogenomic databases

eggNOGiKOG1213, Eukaryota
InParanoidiQ9S7T7
OMAiTHDFIKV
OrthoDBi345127at2759
PhylomeDBiQ9S7T7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9S7T7

Gene expression databases

ExpressionAtlasiQ9S7T7, baseline and differential
GenevisibleiQ9S7T7, AT

Family and domain databases

Gene3Di1.10.10.580, 1 hit
InterProiView protein in InterPro
IPR039781, Rad21/Rec8-like
IPR006909, Rad21/Rec8_C_eu
IPR006910, Rad21_Rec8_N
IPR023093, ScpA-like_C
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR12585, PTHR12585, 1 hit
PfamiView protein in Pfam
PF04824, Rad21_Rec8, 1 hit
PF04825, Rad21_Rec8_N, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCC11_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9S7T7
Secondary accession number(s): Q3E9L1, Q9SQI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 16, 2003
Last modified: June 2, 2021
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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