Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 117 (02 Jun 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Glutamate synthase, large subunit

Gene

DR_0183

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
Biological processAmino-acid biosynthesis, Glutamate biosynthesisARBA annotation
Ligand3Fe-4SARBA annotation, Flavoprotein, FMNARBA annotation, Iron, Iron-sulfur, Metal-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C44.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Glutamate synthase, large subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:DR_0183Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243230 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002524 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243230.DR_0183

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 453Glutamine amidotransferase type-2InterPro annotationAdd BLAST401

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni1580 – 1615DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 35Polar residuesSequence analysisAdd BLAST15
Compositional biasi1588 – 1615Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutamate synthase family.ARBA annotation

Keywords - Domaini

Glutamine amidotransferaseARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0067, Bacteria
COG0069, Bacteria
COG0070, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000422_8_2_0

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9RXX2

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFYGATS

Database of Orthologous Groups

More...
OrthoDBi
5568at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00982, gltB_C, 1 hit
cd02808, GltS_FMN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.60, 1 hit
3.20.20.70, 2 hits
3.60.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785, Aldolase_TIM
IPR017932, GATase_2_dom
IPR002489, Glu_synth_asu_C
IPR036485, Glu_synth_asu_C_sf
IPR006982, Glu_synth_centr_N
IPR002932, Glu_synthdom
IPR029055, Ntn_hydrolases_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00310, GATase_2, 1 hit
PF04898, Glu_syn_central, 1 hit
PF01645, Glu_synthase, 1 hit
PF01493, GXGXG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56235, SSF56235, 1 hit
SSF69336, SSF69336, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51278, GATASE_TYPE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9RXX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSARGADM EKHDQRETPA AGPQTGPQQP ATAQEVRRAT ERGLYANAEH
60 70 80 90 100
DACGVGMVAH IGGQKSHHII AQGLKILENL DHRGAVGADP LMGDGAGILL
110 120 130 140 150
QIPDAFYRAE MSLQGVTLPP PGDYGVGMIF LPKEIASRRA CEQELERAVI
160 170 180 190 200
AEGQVVLGWR DVPINHAMPM SPAVKEKEPV IRQIFIGAGP DTLVPDALER
210 220 230 240 250
KLYVIRRRAS NAILGLNFTH GQEYYVPSMS CRTIIYKGLL LADQVGEYYR
260 270 280 290 300
DLQQPEVVSA LAVVHQRFST NTFPEWRLAH PYRMVAHNGE INTVKGNFNW
310 320 330 340 350
MRAREGILSS PVFGDDLGKL YPISYEGESD TATFDNAIEL LTLAGYPMAQ
360 370 380 390 400
AAMMMIPEAW EQNALLDDRR RAFYEYHASM MEPWDGPAAM VFTDGRQVGA
410 420 430 440 450
MLDRNGLRPA RYLQTRDGLV VLASESGVLP IPESQIVKKW RLQPGKMFMI
460 470 480 490 500
DLEQGRIVED DELKLQFAQA KPYRQWVENT RLRLDDSEET GTVDEFAEPL
510 520 530 540 550
LKRQQAFGYT QEDLKFLMGP MAKNGEEGIG SMGNDSPLAV LSHRSKPLYN
560 570 580 590 600
YFRQLFAQVT NPPIDPIRES VVMSLRSFVG PRPNLLDINA VNPAMRLEVE
610 620 630 640 650
QPILDFDDMA RVRNIEAHTR GKFKAFDLDI TYPAEWGARG IEAKLATINA
660 670 680 690 700
WAVDAIESGH NIIILTDKRV DRSRAAIPAL LALSSVHHHL VKKGLRMRTG
710 720 730 740 750
LVVETGDARE VHHFAALAGY GAEAIHPYLA LETITDLHTP IPGMPDLTEV
760 770 780 790 800
TPEKAIYNYV KAIGKGLSKI MSKMGVSTYL SYCGAQLFEA VGLQADFVQK
810 820 830 840 850
YFYGTASQVG GIGIFEVAEE AIRTHHAAFS GDPLMEKNLN AGGEYAWRAQ
860 870 880 890 900
GEEHMWTPDA VAKLQHSVRS GHAGTYAEYA RIINDQSRRH MTLRGLFDFK
910 920 930 940 950
TEGRNAVPLE EVEPASEIVK RFATGAMSLG SISTEAHATL AVAMNRIGGK
960 970 980 990 1000
SNTGEGGEDP ARYERELRGE QFNEGETLAS VLGGSRVEVD YPLQPGDSLR
1010 1020 1030 1040 1050
SKIKQVASGR FGVTAGYLSS ADQIQIKMAQ GAKPGEGGQL PGGKVSEYIG
1060 1070 1080 1090 1100
FLRHSVPGVG LISPPPHHDI YSIEDLKQLI HDLKNVNPRA DISVKLVSEV
1110 1120 1130 1140 1150
GVGTIAAGVA KAKADHIVIA GHDGGTGASP WSSIKHAGTP WELGLAETQQ
1160 1170 1180 1190 1200
TLVLNRLRDR VRVQTDGQLK TGRDVVIAAL LGADEFGFAT APLVAEGCIM
1210 1220 1230 1240 1250
MRKCHLNTCP VGVATQDPVL RARFQGKPEH VINYFFFVAE EVRQLMASLG
1260 1270 1280 1290 1300
VRSFDDLIGR SDLLDMRAGI DHWKAQGLDF SRVFYKPEMP AEVGTRHLTG
1310 1320 1330 1340 1350
QDHELDKALD LKLIEKCRPA IEHGERVHFL QDARNVNRSV GAMLSGELVR
1360 1370 1380 1390 1400
ARPGGLPDQT VFIQMEGTGG QSFGAFLAQG LTLYLIGDAN DYTGKGLSGG
1410 1420 1430 1440 1450
RVVVRPSIEF RGKAENNIII GNTALYGATS GEAYFRGVAG ERFAVRLSGA
1460 1470 1480 1490 1500
SAVVEGTGDH GCEYMTGGTV VVLGQTGRNF AAGMSGGVAY VYDVDGQFEK
1510 1520 1530 1540 1550
RCNLSMVGLE RVQPEDEQLQ SAVPHQLHNG KSDEAQLREL IENHHRWTGS
1560 1570 1580 1590 1600
SRASELLDDW DSALKKFVKV MPHEYARALR ERTQADEGTV QAADTTRMQT
1610
GQPDNKFGGK GTLTK
Length:1,615
Mass (Da):176,919
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE014DB1140BFE26
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF09770.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C75551

NCBI Reference Sequences

More...
RefSeqi
NP_293907.1, NC_001263.1
WP_010886829.1, NZ_CP015081.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAF09770; AAF09770; DR_0183

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dra:DR_0183

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|243230.17.peg.347

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF09770.1
PIRiC75551
RefSeqiNP_293907.1, NC_001263.1
WP_010886829.1, NZ_CP015081.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi243230.DR_0183

Protein family/group databases

MEROPSiC44.003

Genome annotation databases

EnsemblBacteriaiAAF09770; AAF09770; DR_0183
KEGGidra:DR_0183
PATRICifig|243230.17.peg.347

Phylogenomic databases

eggNOGiCOG0067, Bacteria
COG0069, Bacteria
COG0070, Bacteria
HOGENOMiCLU_000422_8_2_0
InParanoidiQ9RXX2
OMAiAFYGATS
OrthoDBi5568at2

Family and domain databases

CDDicd00982, gltB_C, 1 hit
cd02808, GltS_FMN, 1 hit
Gene3Di2.160.20.60, 1 hit
3.20.20.70, 2 hits
3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR017932, GATase_2_dom
IPR002489, Glu_synth_asu_C
IPR036485, Glu_synth_asu_C_sf
IPR006982, Glu_synth_centr_N
IPR002932, Glu_synthdom
IPR029055, Ntn_hydrolases_N
PfamiView protein in Pfam
PF00310, GATase_2, 1 hit
PF04898, Glu_syn_central, 1 hit
PF01645, Glu_synthase, 1 hit
PF01493, GXGXG, 1 hit
SUPFAMiSSF56235, SSF56235, 1 hit
SSF69336, SSF69336, 1 hit
PROSITEiView protein in PROSITE
PS51278, GATASE_TYPE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9RXX2_DEIRA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9RXX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again