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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi56MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:DR_0247
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001756411 – 133Holo-[acyl-carrier-protein] synthaseAdd BLAST133

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_0247

Structurei

3D structure databases

ProteinModelPortaliQ9RXR0
SMRiQ9RXR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41084ZW Bacteria
COG0736 LUCA
HOGENOMiHOG000014315
InParanoidiQ9RXR0
KOiK00997
OMAiGWRDVWV
OrthoDBiPOG091H0071

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RXR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVAVGHDLI EIARIRRMLE REGVRAERLF TATELAYAGR YRDPAPSLAA
60 70 80 90 100
RFAAKEAFQK VWLRPHGWRD VWVERERTPD GPFPYAAPML GFAPAIAGEM
110 120 130
HERGWVAHLT LTHTREHASA VVILEHLEQR AAP
Length:133
Mass (Da):15,114
Last modified:May 1, 2000 - v1
Checksum:iC5E0009B9728D120
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF09829.1
PIRiF75544
RefSeqiNP_293971.1, NC_001263.1
WP_010886893.1, NZ_CP015081.1

Genome annotation databases

EnsemblBacteriaiAAF09829; AAF09829; DR_0247
GeneIDi1799694
KEGGidra:DR_0247
PATRICifig|243230.17.peg.411

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF09829.1
PIRiF75544
RefSeqiNP_293971.1, NC_001263.1
WP_010886893.1, NZ_CP015081.1

3D structure databases

ProteinModelPortaliQ9RXR0
SMRiQ9RXR0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_0247

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF09829; AAF09829; DR_0247
GeneIDi1799694
KEGGidra:DR_0247
PATRICifig|243230.17.peg.411

Phylogenomic databases

eggNOGiENOG41084ZW Bacteria
COG0736 LUCA
HOGENOMiHOG000014315
InParanoidiQ9RXR0
KOiK00997
OMAiGWRDVWV
OrthoDBiPOG091H0071

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00556 pantethn_trn, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACPS_DEIRA
AccessioniPrimary (citable) accession number: Q9RXR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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