UniProtKB - Q9RXK1 (RL4_DEIRA)
50S ribosomal protein L4
rplD
Functioni
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly (By similarity).
By similarityMakes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit.
This protein is located close to the polypeptide exit tunnel, and interacts with the modified macrolide azithromycin, which blocks the tunnel.
GO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L4 |
Gene namesi | Name:rplD Ordered Locus Names:DR_0312 |
Organismi | Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) |
Taxonomic identifieri | 243230 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000129214 | 2 – 205 | 50S ribosomal protein L4Add BLAST | 204 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit. Contacts proteins L15 and L34.
6 PublicationsProtein-protein interaction databases
IntActi | Q9RXK1, 1 interactor |
STRINGi | 243230.DR_0312 |
Structurei
Secondary structure
3D structure databases
SMRi | Q9RXK1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9RXK1 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0088, Bacteria |
HOGENOMi | CLU_041575_5_1_0 |
InParanoidi | Q9RXK1 |
OMAi | PQVHILE |
OrthoDBi | 1572673at2 |
Family and domain databases
Gene3Di | 3.40.1370.10, 1 hit |
HAMAPi | MF_01328_B, Ribosomal_L4_B, 1 hit |
InterProi | View protein in InterPro IPR002136, Ribosomal_L4/L1e IPR023574, Ribosomal_L4_dom_sf IPR013005, Ribosomal_uL4/L1e |
PANTHERi | PTHR10746, PTHR10746, 1 hit |
Pfami | View protein in Pfam PF00573, Ribosomal_L4, 1 hit |
SUPFAMi | SSF52166, SSF52166, 1 hit |
TIGRFAMsi | TIGR03953, rplD_bact, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAQINVIGQN GGRTIELPLP EVNSGVLHEV VTWQLASRRR GTASTRTRAQ
60 70 80 90 100
VSKTGRKMYG QKGTGNARHG DRSVPTFVGG GVAFGPKPRS YDYTLPRQVR
110 120 130 140 150
QLGLAMAIAS RQEGGKLVAV DGFDIADAKT KNFISWAKQN GLDGTEKVLL
160 170 180 190 200
VTDDENTRRA ARNVSWVSVL PVAGVNVYDI LRHDRLVIDA AALEIVEEEA
GEEQQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000513 Genomic DNA Translation: AAF09893.1 |
PIRi | H75533 |
RefSeqi | NP_294035.1, NC_001263.1 WP_010886957.1, NZ_CP015081.1 |
Genome annotation databases
EnsemblBacteriai | AAF09893; AAF09893; DR_0312 |
KEGGi | dra:DR_0312 |
PATRICi | fig|243230.17.peg.478 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000513 Genomic DNA Translation: AAF09893.1 |
PIRi | H75533 |
RefSeqi | NP_294035.1, NC_001263.1 WP_010886957.1, NZ_CP015081.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1J5A | X-ray | 3.50 | K | 1-205 | [»] | |
1JZX | X-ray | 3.10 | K | 1-205 | [»] | |
1JZY | X-ray | 3.50 | K | 1-205 | [»] | |
1JZZ | X-ray | 3.80 | K | 1-205 | [»] | |
1K01 | X-ray | 3.50 | K | 1-205 | [»] | |
1NKW | X-ray | 3.10 | C | 1-205 | [»] | |
1NWX | X-ray | 3.50 | C | 2-205 | [»] | |
1NWY | X-ray | 3.30 | C | 2-205 | [»] | |
1SM1 | X-ray | 3.42 | C | 1-205 | [»] | |
1XBP | X-ray | 3.50 | C | 2-205 | [»] | |
2ZJP | X-ray | 3.70 | C | 1-205 | [»] | |
2ZJQ | X-ray | 3.30 | C | 1-205 | [»] | |
2ZJR | X-ray | 2.91 | C | 1-205 | [»] | |
3CF5 | X-ray | 3.30 | C | 1-205 | [»] | |
3DLL | X-ray | 3.50 | C | 1-205 | [»] | |
3PIO | X-ray | 3.25 | C | 1-205 | [»] | |
3PIP | X-ray | 3.45 | C | 1-205 | [»] | |
4IO9 | X-ray | 3.20 | C | 1-205 | [»] | |
4IOA | X-ray | 3.20 | C | 1-205 | [»] | |
4IOC | X-ray | 3.60 | C | 1-205 | [»] | |
4U67 | X-ray | 3.65 | C | 1-205 | [»] | |
4V49 | X-ray | 8.70 | C | 2-198 | [»] | |
4V4A | X-ray | 9.50 | C | 2-198 | [»] | |
4WFN | X-ray | 3.54 | C | 1-205 | [»] | |
5DM6 | X-ray | 2.90 | C | 2-198 | [»] | |
5DM7 | X-ray | 3.00 | C | 2-198 | [»] | |
5JVG | X-ray | 3.43 | C | 1-205 | [»] | |
5JVH | X-ray | 3.58 | C | 1-205 | [»] | |
7A0R | X-ray | 3.30 | C | 2-198 | [»] | |
7A0S | X-ray | 3.22 | C | 1-205 | [»] | |
7A18 | X-ray | 3.40 | C | 2-196 | [»] | |
SMRi | Q9RXK1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q9RXK1, 1 interactor |
STRINGi | 243230.DR_0312 |
Genome annotation databases
EnsemblBacteriai | AAF09893; AAF09893; DR_0312 |
KEGGi | dra:DR_0312 |
PATRICi | fig|243230.17.peg.478 |
Phylogenomic databases
eggNOGi | COG0088, Bacteria |
HOGENOMi | CLU_041575_5_1_0 |
InParanoidi | Q9RXK1 |
OMAi | PQVHILE |
OrthoDBi | 1572673at2 |
Miscellaneous databases
EvolutionaryTracei | Q9RXK1 |
Family and domain databases
Gene3Di | 3.40.1370.10, 1 hit |
HAMAPi | MF_01328_B, Ribosomal_L4_B, 1 hit |
InterProi | View protein in InterPro IPR002136, Ribosomal_L4/L1e IPR023574, Ribosomal_L4_dom_sf IPR013005, Ribosomal_uL4/L1e |
PANTHERi | PTHR10746, PTHR10746, 1 hit |
Pfami | View protein in Pfam PF00573, Ribosomal_L4, 1 hit |
SUPFAMi | SSF52166, SSF52166, 1 hit |
TIGRFAMsi | TIGR03953, rplD_bact, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL4_DEIRA | |
Accessioni | Q9RXK1Primary (citable) accession number: Q9RXK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families