UniProtKB - Q9RXJ9 (RL2_DEIRA)
Protein
50S ribosomal protein L2
Gene
rplB
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Functioni
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).By similarity
GO - Molecular functioni
- RNA binding Source: GO_Central
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: GO_Central
- transferase activity Source: InterPro
GO - Biological processi
- cytoplasmic translation Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L2 |
Gene namesi | Name:rplB Ordered Locus Names:DR_0314 |
Organismi | Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) |
Taxonomic identifieri | 243230 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000129558 | 2 – 275 | 50S ribosomal protein L2Add BLAST | 274 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit.
Forms a bridge to the 30S subunit in the 70S ribosome (By similarity).
By similarityProtein-protein interaction databases
DIPi | DIP-58602N |
IntActi | Q9RXJ9, 1 interactor |
STRINGi | 243230.DR_0314 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9RXJ9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9RXJ9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL2 family.Curated
Phylogenomic databases
eggNOGi | COG0090, Bacteria |
HOGENOMi | CLU_036235_2_1_0 |
InParanoidi | Q9RXJ9 |
OMAi | SCIELRP |
OrthoDBi | 961486at2 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 4.10.950.10, 1 hit |
HAMAPi | MF_01320_B, Ribosomal_L2_B, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR022666, Rbsml_prot_L2_RNA-bd_dom IPR014722, Rib_L2_dom2 IPR002171, Ribosomal_L2 IPR005880, Ribosomal_L2_bac/org-type IPR022669, Ribosomal_L2_C IPR022671, Ribosomal_L2_CS IPR014726, Ribosomal_L2_dom3 IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR13691, PTHR13691, 1 hit |
Pfami | View protein in Pfam PF00181, Ribosomal_L2, 1 hit PF03947, Ribosomal_L2_C, 1 hit |
PIRSFi | PIRSF002158, Ribosomal_L2, 1 hit |
SMARTi | View protein in SMART SM01383, Ribosomal_L2, 1 hit SM01382, Ribosomal_L2_C, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR01171, rplB_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00467, RIBOSOMAL_L2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9RXJ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVKKYRPYT PSRRQMTTAD FSGLTKKRPE KALTEALPKT GGRNNRGRIT
60 70 80 90 100
SRFIGGGHKR LYRIIDFKRR DKSGVNAKVA AIEYDPNRSA RIALLHYADG
110 120 130 140 150
EKRYILAPEG LTVGATVNAG PEAEPKLGNA LPLRFVPVGA VVHALELVPG
160 170 180 190 200
KGAQLARSAG TSVQVQGKES DYVIVRLPSG ELRRVHSECY ATIGAVGNAE
210 220 230 240 250
HKNIVLGKAG RSRWLGRKPH QRGSAMNPVD HPHGGGEGRT GAGRVPVTPW
260 270
GKPTKGLKTR RKRKTSDRFI VTRRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000513 Genomic DNA Translation: AAF09895.1 |
PIRi | B75534 |
RefSeqi | NP_294037.1, NC_001263.1 WP_010886959.1, NZ_CP015081.1 |
Genome annotation databases
EnsemblBacteriai | AAF09895; AAF09895; DR_0314 |
KEGGi | dra:DR_0314 |
PATRICi | fig|243230.17.peg.480 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000513 Genomic DNA Translation: AAF09895.1 |
PIRi | B75534 |
RefSeqi | NP_294037.1, NC_001263.1 WP_010886959.1, NZ_CP015081.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NKW | X-ray | 3.10 | A | 1-275 | [»] | |
1NWX | X-ray | 3.50 | A | 2-275 | [»] | |
1NWY | X-ray | 3.30 | A | 2-275 | [»] | |
1SM1 | X-ray | 3.42 | A | 1-275 | [»] | |
1XBP | X-ray | 3.50 | A | 2-275 | [»] | |
2ZJP | X-ray | 3.70 | A | 2-275 | [»] | |
2ZJQ | X-ray | 3.30 | A | 2-275 | [»] | |
2ZJR | X-ray | 2.91 | A | 2-275 | [»] | |
3CF5 | X-ray | 3.30 | A | 2-275 | [»] | |
3DLL | X-ray | 3.50 | A | 2-275 | [»] | |
3PIO | X-ray | 3.25 | A | 2-275 | [»] | |
3PIP | X-ray | 3.45 | A | 2-274 | [»] | |
4IO9 | X-ray | 3.20 | A | 2-275 | [»] | |
4IOA | X-ray | 3.20 | A | 2-275 | [»] | |
4IOC | X-ray | 3.60 | A | 2-275 | [»] | |
4U67 | X-ray | 3.65 | A | 1-275 | [»] | |
4V49 | X-ray | 8.70 | A | 4-273 | [»] | |
4V4A | X-ray | 9.50 | A | 4-273 | [»] | |
4V4G | X-ray | 11.50 | D | 4-273 | [»] | |
4WFN | X-ray | 3.54 | A | 1-275 | [»] | |
5DM6 | X-ray | 2.90 | A | 2-275 | [»] | |
5DM7 | X-ray | 3.00 | A | 2-275 | [»] | |
5JVG | X-ray | 3.43 | A | 1-275 | [»] | |
5JVH | X-ray | 3.58 | A | 1-275 | [»] | |
SMRi | Q9RXJ9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-58602N |
IntActi | Q9RXJ9, 1 interactor |
STRINGi | 243230.DR_0314 |
Genome annotation databases
EnsemblBacteriai | AAF09895; AAF09895; DR_0314 |
KEGGi | dra:DR_0314 |
PATRICi | fig|243230.17.peg.480 |
Phylogenomic databases
eggNOGi | COG0090, Bacteria |
HOGENOMi | CLU_036235_2_1_0 |
InParanoidi | Q9RXJ9 |
OMAi | SCIELRP |
OrthoDBi | 961486at2 |
Miscellaneous databases
EvolutionaryTracei | Q9RXJ9 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 4.10.950.10, 1 hit |
HAMAPi | MF_01320_B, Ribosomal_L2_B, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR022666, Rbsml_prot_L2_RNA-bd_dom IPR014722, Rib_L2_dom2 IPR002171, Ribosomal_L2 IPR005880, Ribosomal_L2_bac/org-type IPR022669, Ribosomal_L2_C IPR022671, Ribosomal_L2_CS IPR014726, Ribosomal_L2_dom3 IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR13691, PTHR13691, 1 hit |
Pfami | View protein in Pfam PF00181, Ribosomal_L2, 1 hit PF03947, Ribosomal_L2_C, 1 hit |
PIRSFi | PIRSF002158, Ribosomal_L2, 1 hit |
SMARTi | View protein in SMART SM01383, Ribosomal_L2, 1 hit SM01382, Ribosomal_L2_C, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR01171, rplB_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00467, RIBOSOMAL_L2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL2_DEIRA | |
Accessioni | Q9RXJ9Primary (citable) accession number: Q9RXJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries