mobA

Functionⁱ

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityⁱ

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	21	GTPUniRule annotation	1
Binding siteⁱ	64	GTPUniRule annotation	1
Metal bindingⁱ	93	MagnesiumUniRule annotation	1
Binding siteⁱ	93	GTPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	9 – 11	GTPUniRule annotation		3

GO - Molecular functionⁱ

GTP binding Source: UniProtKB-UniRule
metal ion binding Source: UniProtKB-KW
molybdenum cofactor guanylyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Molybdenum cofactor biosynthesis
Ligand	GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation) Short name: MoCo guanylyltransferaseUniRule annotation Alternative name(s): GTP:molybdopterin guanylyltransferaseUniRule annotation Mo-MPT guanylyltransferaseUniRule annotation Molybdopterin guanylyltransferaseUniRule annotation Molybdopterin-guanine dinucleotide synthaseUniRule annotation Short name: MGD synthaseUniRule annotation
Gene namesⁱ	Name:mobAUniRule annotation Ordered Locus Names:DR_0645
Organismⁱ	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifierⁱ	243230 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus › Deinococcus radiodurans
Proteomesⁱ	UP000002524 Componentⁱ: Chromosome I

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00316

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000134886	1 – 193	Probable molybdenum cofactor guanylyltransferaseAdd BLAST		193

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	243230.DR_0645

STRINGⁱ

243230.DR_0645

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9RWM1
SMRⁱ	Q9RWM1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesⁱ

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG41080QG Bacteria COG0746 LUCA
HOGENOMⁱ	HOG000280425
InParanoidⁱ	Q9RWM1
KEGG Orthology (KO) More...KOⁱ	K03752
OMAⁱ	LFNCNTP
Database of Orthologous Groups More...OrthoDBⁱ	POG091H05CW

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02503 MobA, 1 hit
Gene3Dⁱ	3.90.550.10, 1 hit
HAMAPⁱ	MF_00316 MobA, 1 hit
InterProⁱ	View protein in InterPro IPR025877 MobA-like_NTP_Trfase IPR013482 Molybde_CF_guanTrfase IPR029044 Nucleotide-diphossugar_trans
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12804 NTP_transf_3, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9RWM1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPLTAAITA GGASSRFGSD KALALWQGRP LLDQVAAGLA ACERRLLIAP 
        60         70         80         90        100
PGKYALPGWE TWPDTRPGEG PLAGLEVALT HAAPGWVAFT GVDNPALTSD 
       110        120        130        140        150
YWLTLLAACR PGMSSVQALH PERGPQPLGA LYHTALLPRV TGLLAAGERR 
       160        170        180        190 
LRLTAPAEQT VLVTGLGAHF FQNVNRPADL AELSGRGEES LEV

Length:193

Mass (Da):20,271

Last modified:May 1, 2000 - v1

Checksum:ⁱ87FCF9B96D9D6D3C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE000513 Genomic DNA Translation: AAF10223.1
PIRⁱ	B75493
NCBI Reference Sequences More...RefSeqⁱ	NP_294368.1, NC_001263.1 WP_010887290.1, NZ_CP015081.1

Genome annotation databases

EnsemblBacteriaⁱ	AAF10223; AAF10223; DR_0645
GeneIDⁱ	1798304
KEGGⁱ	dra:DR_0645
PATRICⁱ	fig\|243230.17.peg.824

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9RWM1	Molybdenum cofactor guanylyltransferase		DEIPD		184	UniRef50_Q9RWM1
Molybdenum cofactor guanylyltransferase		Deinococcus swuensis		181
Probable molybdenum cofactor guanylyltransferase		Deinococcus grandis		189
Probable molybdenum cofactor guanylyltransferase		Deinococcus soli Cha et al. 2016		189
Probable molybdenum cofactor guanylyltransferase		Deinococcus actinosclerus		188
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE000513 Genomic DNA Translation: AAF10223.1
PIRⁱ	B75493
RefSeqⁱ	NP_294368.1, NC_001263.1 WP_010887290.1, NZ_CP015081.1

3D structure databases

ProteinModelPortalⁱ	Q9RWM1
SMRⁱ	Q9RWM1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	243230.DR_0645

STRINGⁱ

243230.DR_0645

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAF10223; AAF10223; DR_0645
GeneIDⁱ	1798304
KEGGⁱ	dra:DR_0645
PATRICⁱ	fig\|243230.17.peg.824

Phylogenomic databases

eggNOGⁱ	ENOG41080QG Bacteria COG0746 LUCA
HOGENOMⁱ	HOG000280425
InParanoidⁱ	Q9RWM1
KOⁱ	K03752
OMAⁱ	LFNCNTP
OrthoDBⁱ	POG091H05CW

Family and domain databases

CDDⁱ	cd02503 MobA, 1 hit
Gene3Dⁱ	3.90.550.10, 1 hit
HAMAPⁱ	MF_00316 MobA, 1 hit
InterProⁱ	View protein in InterPro IPR025877 MobA-like_NTP_Trfase IPR013482 Molybde_CF_guanTrfase IPR029044 Nucleotide-diphossugar_trans
Pfamⁱ	View protein in Pfam PF12804 NTP_transf_3, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MOBA_DEIRA
Accessionⁱ	Q9RWM1Primary (citable) accession number: Q9RWM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	May 1, 2000
	Last modified:	October 10, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniProtKB - Q9RWM1 (MOBA_DEIRA)

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Probable molybdenum cofactor guanylyltransferase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ