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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21GTPUniRule annotation1
Binding sitei64GTPUniRule annotation1
Metal bindingi93MagnesiumUniRule annotation1
Binding sitei93GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:DR_0645
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001348861 – 193Probable molybdenum cofactor guanylyltransferaseAdd BLAST193

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_0645

Structurei

3D structure databases

ProteinModelPortaliQ9RWM1
SMRiQ9RWM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41080QG Bacteria
COG0746 LUCA
HOGENOMiHOG000280425
InParanoidiQ9RWM1
KOiK03752
OMAiLFNCNTP
OrthoDBiPOG091H05CW

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RWM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPLTAAITA GGASSRFGSD KALALWQGRP LLDQVAAGLA ACERRLLIAP
60 70 80 90 100
PGKYALPGWE TWPDTRPGEG PLAGLEVALT HAAPGWVAFT GVDNPALTSD
110 120 130 140 150
YWLTLLAACR PGMSSVQALH PERGPQPLGA LYHTALLPRV TGLLAAGERR
160 170 180 190
LRLTAPAEQT VLVTGLGAHF FQNVNRPADL AELSGRGEES LEV
Length:193
Mass (Da):20,271
Last modified:May 1, 2000 - v1
Checksum:i87FCF9B96D9D6D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF10223.1
PIRiB75493
RefSeqiNP_294368.1, NC_001263.1
WP_010887290.1, NZ_CP015081.1

Genome annotation databases

EnsemblBacteriaiAAF10223; AAF10223; DR_0645
GeneIDi1798304
KEGGidra:DR_0645
PATRICifig|243230.17.peg.824

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF10223.1
PIRiB75493
RefSeqiNP_294368.1, NC_001263.1
WP_010887290.1, NZ_CP015081.1

3D structure databases

ProteinModelPortaliQ9RWM1
SMRiQ9RWM1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_0645

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF10223; AAF10223; DR_0645
GeneIDi1798304
KEGGidra:DR_0645
PATRICifig|243230.17.peg.824

Phylogenomic databases

eggNOGiENOG41080QG Bacteria
COG0746 LUCA
HOGENOMiHOG000280425
InParanoidiQ9RWM1
KOiK03752
OMAiLFNCNTP
OrthoDBiPOG091H05CW

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOBA_DEIRA
AccessioniPrimary (citable) accession number: Q9RWM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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