UniProtKB - Q9RUU0 (Q9RUU0_DEIRA)
Protein
D-3-phosphoglycerate dehydrogenase
Gene
DR_1291
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Functioni
Catalytic activityi
- EC:1.1.1.95UniRule annotation
: L-serine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- D-3-phosphoglycerate dehydrogenase (DR_1291)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- NAD binding Source: UniProtKB-UniRule
- phosphoglycerate dehydrogenase activity Source: GO_Central
GO - Biological processi
- cellular amino acid metabolic process Source: GO_Central
- L-serine biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | OxidoreductaseUniRule annotation |
Biological process | Amino-acid biosynthesis, Serine biosynthesisUniRule annotation |
Ligand | NADUniRule annotation |
Enzyme and pathway databases
BioCyci | DRAD243230:GH46-1319-MONOMER |
UniPathwayi | UPA00135;UER00196 |
Names & Taxonomyi
Protein namesi | Recommended name: D-3-phosphoglycerate dehydrogenaseUniRule annotation (EC:1.1.1.95UniRule annotation) |
Gene namesi | Ordered Locus Names:DR_1291Imported |
Organismi | Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported |
Taxonomic identifieri | 243230 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus › |
Proteomesi |
|
Family & Domainsi
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108JQ1 Bacteria COG0111 LUCA |
HOGENOMi | HOG000136693 |
InParanoidi | Q9RUU0 |
KOi | K00058 |
OMAi | NIAGMQV |
OrthoDBi | 1638924at2 |
Family and domain databases
Gene3Di | 3.30.1330.90, 1 hit |
InterProi | View protein in InterPro IPR002912 ACT_dom IPR029009 ASB_dom_sf IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf IPR006236 PGDH |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF143548 SSF143548, 1 hit SSF51735 SSF51735, 1 hit |
TIGRFAMsi | TIGR01327 PGDH, 1 hit |
PROSITEi | View protein in PROSITE PS51671 ACT, 1 hit PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9RUU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAPAPTPAQ TAAQTPTAPL RVLICDEMNP GNLDHEGFQI DYQGNLEREE
60 70 80 90 100
TLRRLPDYDA LITRSRTKVD RELLDAAGPR LKVIGRGGVG VDNIDLEYAS
110 120 130 140 150
RRGLLVLNAP ESNNVSAAEL AVMHLMAAAR GLTRSDRKTR AGEWDRKFLG
160 170 180 190 200
LELTDKTLGI VGLGRIGSIV ADRAQGLHMN VVAYDPYVPE NKFERLGVQR
210 220 230 240 250
AASLDELLGQ VDALTVHTPL TDETRGMIGE RELALLKRDA IVVNAARGGI
260 270 280 290 300
IEEQALVNAL HAGHLFAAGV DVFVDEPPTA EHIFLGAPNL GITAHLGANT
310 320 330 340 350
REAQERVGAE IVSRVLDALH GDVSKGAVNA PALDAKTMEQ LGGYLDLGEK
360 370 380 390 400
LGRILAQLLP GAHEVEVTFR GEFPTDPSPV VTAVLMGYLS GSTDEHPNMI
410 420 430 440 450
NARALARERG VTLSVREEED SPDYQTEVIV RVLNRSGEKE RTRKVGGTVF
460 470 480 490 500
GKSPRLTRLR DYRVELEPEG FILIASNLDK PGAVAKLSNL LGTWGINIAG
510 520 530 540
MALGRSEKGG QALFTLTLDD SLTPEQLQAI RDLDVIESAF LVRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000513 Genomic DNA Translation: AAF10861.1 |
PIRi | A75414 |
RefSeqi | NP_295015.1, NC_001263.1 WP_010887934.1, NZ_CP015081.1 |
Genome annotation databases
EnsemblBacteriai | AAF10861; AAF10861; DR_1291 |
GeneIDi | 1800289 |
KEGGi | dra:DR_1291 |
PATRICi | fig|243230.17.peg.1485 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000513 Genomic DNA Translation: AAF10861.1 |
PIRi | A75414 |
RefSeqi | NP_295015.1, NC_001263.1 WP_010887934.1, NZ_CP015081.1 |
3D structure databases
ProteinModelPortali | Q9RUU0 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 243230.DR_1291 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblBacteriai | AAF10861; AAF10861; DR_1291 |
GeneIDi | 1800289 |
KEGGi | dra:DR_1291 |
PATRICi | fig|243230.17.peg.1485 |
Phylogenomic databases
eggNOGi | ENOG4108JQ1 Bacteria COG0111 LUCA |
HOGENOMi | HOG000136693 |
InParanoidi | Q9RUU0 |
KOi | K00058 |
OMAi | NIAGMQV |
OrthoDBi | 1638924at2 |
Enzyme and pathway databases
UniPathwayi | UPA00135;UER00196 |
BioCyci | DRAD243230:GH46-1319-MONOMER |
Family and domain databases
Gene3Di | 3.30.1330.90, 1 hit |
InterProi | View protein in InterPro IPR002912 ACT_dom IPR029009 ASB_dom_sf IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf IPR006236 PGDH |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF143548 SSF143548, 1 hit SSF51735 SSF51735, 1 hit |
TIGRFAMsi | TIGR01327 PGDH, 1 hit |
PROSITEi | View protein in PROSITE PS51671 ACT, 1 hit PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | Q9RUU0_DEIRA | |
Accessioni | Q9RUU0Primary (citable) accession number: Q9RUU0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | January 16, 2019 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |