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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78NucleophileUniRule annotation1

GO - Molecular functioni

  • pseudouridine synthase activity Source: GO_Central
  • RNA binding Source: InterPro
  • tRNA pseudouridine synthase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:DR_1991
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001524941 – 353tRNA pseudouridine synthase DAdd BLAST353

Proteomic databases

PRIDEiQ9RSX8

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1991

Structurei

3D structure databases

ProteinModelPortaliQ9RSX8
SMRiQ9RSX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 296TRUDUniRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
InParanoidiQ9RSX8
KOiK06176
OMAiLWLWVEK
OrthoDBiPOG091H03KK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RSX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGRRCERTT SPGTGGRLRA EPADFQVQEV PAYLPGGSGE YLYLHVEKTR
60 70 80 90 100
HTTAHVVREL CAQLGVRDRD VGVAGLKDRH AVTTQWLSLP AKVEPRMGDF
110 120 130 140 150
SLPGVRILET SRHTNKLGMG HLHGNRFVVR VRGAAGMAEQ AGETLATLAQ
160 170 180 190 200
GGVPNYFGPQ RFGLGGLNAE EGLRVLRGES ELRDPRVRRF LTSSVQSAIF
210 220 230 240 250
NALVSLRLER EVFDRLLTGD MAKKHDTGGV FLVEDAGAET PRAQRGEVSA
260 270 280 290 300
TGTLFGRKVK PLTADAGALE AEALALFGLS PQVFASRKGD RRLIRVFPAE
310 320 330 340 350
AEVRPEDDGY VLAFTLPKGS FATSVLREVM KTEVDAPGAG PDTTDEGEAG

DGE
Length:353
Mass (Da):38,056
Last modified:May 1, 2000 - v1
Checksum:i3401C60EA877B926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF11542.1
PIRiD75328
RefSeqiNP_295714.1, NC_001263.1
WP_010888624.1, NC_001263.1

Genome annotation databases

EnsemblBacteriaiAAF11542; AAF11542; DR_1991
GeneIDi1797492
KEGGidra:DR_1991
PATRICifig|243230.17.peg.2214

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF11542.1
PIRiD75328
RefSeqiNP_295714.1, NC_001263.1
WP_010888624.1, NC_001263.1

3D structure databases

ProteinModelPortaliQ9RSX8
SMRiQ9RSX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1991

Proteomic databases

PRIDEiQ9RSX8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF11542; AAF11542; DR_1991
GeneIDi1797492
KEGGidra:DR_1991
PATRICifig|243230.17.peg.2214

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
InParanoidiQ9RSX8
KOiK06176
OMAiLWLWVEK
OrthoDBiPOG091H03KK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_DEIRA
AccessioniPrimary (citable) accession number: Q9RSX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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