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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei593ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DR_2174
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520091 – 823Leucine--tRNA ligaseAdd BLAST823

Proteomic databases

PRIDEiQ9RSF0

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_2174

Structurei

3D structure databases

ProteinModelPortaliQ9RSF0
SMRiQ9RSF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 65"HIGH" regionAdd BLAST11
Motifi590 – 594"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
InParanoidiQ9RSF0
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RSF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQEATKPNI QEPRAERYNP HAIEQKWQGQ WQESGLYKFD ENAPGEKFYA
60 70 80 90 100
LTMFPYPSGN LHIGHWYANV APDARARWLR MRGYNVLFPM AFDAFGLPAE
110 120 130 140 150
NAAIKNNTNP ATWTYANIER MTGQFSRMGT MIDWSRKFAT CDPEYYRWNQ
160 170 180 190 200
WFFIEFWKRG LAYKKGGLVN WCPKDQTVLA NEQVVNGHCE RCGTAVERRN
210 220 230 240 250
LSQWYLKITD YAEELLDFSA TDMPEKVRAM QTNWIGKSVG AEVTFDTPAG
260 270 280 290 300
PETVFTTRPD TLMGATFMVL APEHAKVKEL TTDEQRAEVE AYVAAAGRKT
310 320 330 340 350
DVERQQEGEK TGVFTGSYAT HPISGHQLPI WVADYVLVTY GTGSIMAVPA
360 370 380 390 400
HDERDFAFAK KFDLPIREVI RAEGSEGMGD QPSEPYSGEG QIVNSGEFDG
410 420 430 440 450
MPGGKASIAA IIARLEERGV AKAKTTYRLR DWLFARQRYW GTPIPFVHCE
460 470 480 490 500
KCGMQPVPED QLPVKLPENV AFTPTGQSPL KLDEEWKTTT CPCCGGPAER
510 520 530 540 550
ETDTMDTFVD SSWYMYRYLS PNYDGGPFDP SKAGLLPVDL YTGGIEHAIL
560 570 580 590 600
HLLYSRFWTK VMRDMGLTTQ SEPFARLRNQ GMVLGEDGEK MSKSRGNVVD
610 620 630 640 650
PDDLVREYGA DTVRAFLMFI APWELGGPWD PQGINGPSKW LSRVWNVFFE
660 670 680 690 700
EKVSGPEEKM QGADVRFAVH SALKKVNDDF ERMSFNTIIS TLMELTNALV
710 720 730 740 750
KAKRSPVFGT PVWEEALDIF NRMLAPVVPH IAEEIWHERG QKGSVHTAQW
760 770 780 790 800
PQVDEAAAVR DTVTIGVQVS GKVRGEVSIS KTASQEEALS AARAIAEVQK
810 820
HLEGKTVVKE IYVPGRIINI VAK
Length:823
Mass (Da):92,613
Last modified:June 1, 2001 - v2
Checksum:i2E6445F39005A110
GO

Sequence cautioni

The sequence AAF11720 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF11720.1 Different initiation.
PIRiD75307
RefSeqiNP_295897.1, NC_001263.1

Genome annotation databases

EnsemblBacteriaiAAF11720; AAF11720; DR_2174
GeneIDi1799430
KEGGidra:DR_2174
PATRICifig|243230.17.peg.2398

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF11720.1 Different initiation.
PIRiD75307
RefSeqiNP_295897.1, NC_001263.1

3D structure databases

ProteinModelPortaliQ9RSF0
SMRiQ9RSF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_2174

Proteomic databases

PRIDEiQ9RSF0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF11720; AAF11720; DR_2174
GeneIDi1799430
KEGGidra:DR_2174
PATRICifig|243230.17.peg.2398

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
InParanoidiQ9RSF0
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_DEIRA
AccessioniPrimary (citable) accession number: Q9RSF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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Main funding by: National Institutes of Health

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