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Entry version 96 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

4-hydroxyphenylacetate permease

Gene

hpaX

Organism
Salmonella dublin
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.14.9, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
4-hydroxyphenylacetate permeaseImported
Submitted name:
HpaXImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hpaXImported
ORF Names:AAG96_12270Imported, ASP09_08230Imported, B5Q64_11340Imported, CC728_12360Imported, DQQ75_15270Imported, DYM17_18145Imported, E5H40_05050Imported, EHB47_10625Imported, EJP12_04765Imported, EP077_12310Imported, FBH21_12385Imported, G0B14_21390Imported, G3A02_20155Imported, G4B41_004009Imported, GB127_21875Imported, GB128_19675Imported, GB155_20165Imported, GB329_22330Imported, GB377_21265Imported, GB457_06425Imported, GBX69_06405Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella dublinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri98360 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000419828 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 49HelicalSequence analysisAdd BLAST18
Transmembranei69 – 90HelicalSequence analysisAdd BLAST22
Transmembranei102 – 121HelicalSequence analysisAdd BLAST20
Transmembranei127 – 150HelicalSequence analysisAdd BLAST24
Transmembranei162 – 184HelicalSequence analysisAdd BLAST23
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei266 – 291HelicalSequence analysisAdd BLAST26
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei338 – 356HelicalSequence analysisAdd BLAST19
Transmembranei362 – 383HelicalSequence analysisAdd BLAST22
Transmembranei395 – 416HelicalSequence analysisAdd BLAST22
Transmembranei428 – 447HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell inner membraneARBA annotation, Cell membrane, Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 452MFSInterPro annotationAdd BLAST417

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012707, HPA_permease
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02332, HpaX, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9RPV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDTSSALPE SPESVGSHNA LSTGQQTVIN KLFRRLIVFL FVLFIFSFLD
60 70 80 90 100
RINIGFAGLT MGQDLGLSAT MFGLATTLFY ATYVIFGIPS NVMLSIVGAR
110 120 130 140 150
RWIATIMVLW GIASTATMFA VGPKSLYVLR MLVGITEAGF LPGILLYLTY
160 170 180 190 200
WFPAFFRARA NALFMIAMPA TTALGSIVSG YILSLDGIFN LHGWQWLFLL
210 220 230 240 250
EGFPSVLLGI MVWFYLDDTP AKAKWLTAED KKCLQEMMDN DRLTLVQPEG
260 270 280 290 300
AISHNAMQQR SLWREVFTPI VLMYTLAYFC LTNTLSAISI WTPQILKNFN
310 320 330 340 350
EGSSNITIGL LAAIPQICTI LGMIYWSRHS DKHQERKHHT ALPFLFAAAG
360 370 380 390 400
WLLASATDHN LIQLLGIVMA STGSFSAMAI FWTTPDQSIS LRARAIGIAV
410 420 430 440 450
INATGNIGSA LSPFMIGWLK DITGSFNSGL WFVASLLVVG AAIIWLIPMK

ASRPRATP
Length:458
Mass (Da):50,395
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38CDB7BB408449ED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF144422 Genomic DNA Translation: AAD53495.1
AAGDZO010000002 Genomic DNA Translation: EBM8730265.1
AAGEBA010000033 Genomic DNA Translation: EBM9048317.1
AAGJVX010000016 Genomic DNA Translation: EBO8601188.1
AAHSLO010000007 Genomic DNA Translation: EBZ8447046.1
AAHTZC010000004 Genomic DNA Translation: ECA3203286.1
AAKPOL010000023 Genomic DNA Translation: ECU3181096.1
AAKSEE010000014 Genomic DNA Translation: ECV3273081.1
AAKUVP010000007 Genomic DNA Translation: ECV9566075.1
AAKZOM010000005 Genomic DNA Translation: ECX6524460.1
AAMCSG010000007 Genomic DNA Translation: EDG0104498.1
AAMJPS010000007 Genomic DNA Translation: EDI0344274.1
DAAFZU010000168 Genomic DNA Translation: HAB2155638.1
DAAGCC010000003 Genomic DNA Translation: HAB2454312.1
DAAGQJ010000021 Genomic DNA Translation: HAB4126092.1
DAAGXZ010000166 Genomic DNA Translation: HAB5005208.1
DAAHAY010000107 Genomic DNA Translation: HAB5367180.1
DAAHGY010000119 Genomic DNA Translation: HAB6109168.1
DAAHIK010000177 Genomic DNA Translation: HAB6167570.1
DAAMFJ010000024 Genomic DNA Translation: HAC6498266.1
DAARBE010000043 Genomic DNA Translation: HAE1709656.1
DAARVE010000061 Genomic DNA Translation: HAE4077751.1

NCBI Reference Sequences

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RefSeqi
WP_001285788.1, NZ_VDCP01000004.1

Genome annotation databases

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|98360.39.peg.3123

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144422 Genomic DNA Translation: AAD53495.1
AAGDZO010000002 Genomic DNA Translation: EBM8730265.1
AAGEBA010000033 Genomic DNA Translation: EBM9048317.1
AAGJVX010000016 Genomic DNA Translation: EBO8601188.1
AAHSLO010000007 Genomic DNA Translation: EBZ8447046.1
AAHTZC010000004 Genomic DNA Translation: ECA3203286.1
AAKPOL010000023 Genomic DNA Translation: ECU3181096.1
AAKSEE010000014 Genomic DNA Translation: ECV3273081.1
AAKUVP010000007 Genomic DNA Translation: ECV9566075.1
AAKZOM010000005 Genomic DNA Translation: ECX6524460.1
AAMCSG010000007 Genomic DNA Translation: EDG0104498.1
AAMJPS010000007 Genomic DNA Translation: EDI0344274.1
DAAFZU010000168 Genomic DNA Translation: HAB2155638.1
DAAGCC010000003 Genomic DNA Translation: HAB2454312.1
DAAGQJ010000021 Genomic DNA Translation: HAB4126092.1
DAAGXZ010000166 Genomic DNA Translation: HAB5005208.1
DAAHAY010000107 Genomic DNA Translation: HAB5367180.1
DAAHGY010000119 Genomic DNA Translation: HAB6109168.1
DAAHIK010000177 Genomic DNA Translation: HAB6167570.1
DAAMFJ010000024 Genomic DNA Translation: HAC6498266.1
DAARBE010000043 Genomic DNA Translation: HAE1709656.1
DAARVE010000061 Genomic DNA Translation: HAE4077751.1
RefSeqiWP_001285788.1, NZ_VDCP01000004.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.1.14.9, the major facilitator superfamily (mfs)

Genome annotation databases

PATRICifig|98360.39.peg.3123

Family and domain databases

InterProiView protein in InterPro
IPR012707, HPA_permease
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR02332, HpaX, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9RPV1_SALDU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9RPV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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