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Entry version 61 (05 Jun 2019)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

TcdA1

Gene

tcdA

Organism
Photorhabdus luminescens (Xenorhabdus luminescens)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TcdA1Imported
Submitted name:
Toxin AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tcdAImported
Synonyms:tcdA1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhotorhabdus luminescens (Xenorhabdus luminescens)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29488 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-16041374,EBI-16041374

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-60214N

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9RN43

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1091 – 1250NeuraminidaseInterPro annotationAdd BLAST160
Domaini1634 – 1761TcA_RBDInterPro annotationAdd BLAST128
Domaini2209 – 2340TcA_TcB_BDInterPro annotationAdd BLAST132
Domaini2445 – 2514TcA_TcB_BDInterPro annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2046 – 2066Sequence analysisAdd BLAST21
Coiled coili2075 – 2095Sequence analysisAdd BLAST21
Coiled coili2182 – 2216Sequence analysisAdd BLAST35
Coiled coili2224 – 2244Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018003 Insecticidal_toxin/plasmid_vir
IPR041079 Neuraminidase-like
IPR041568 TcA_RBD
IPR040840 TcA_TcB_BD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18413 Neuraminidase, 1 hit
PF18518 TcA_RBD, 1 hit
PF18276 TcA_TcB_BD, 2 hits
PF03538 VRP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9RN43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNESVKEIPD VLKSQCGFNC LTDISHSSFN EFRQQVSEHL SWSETHDLYH
60 70 80 90 100
DAQQAQKDNR LYEARILKRA NPQLQNAVHL AILAPNAELI GYNNQFSGRA
110 120 130 140 150
SQYVAPGTVS SMFSPAAYLT ELYREARNLH ASDSVYYLDT RRPDLKSMAL
160 170 180 190 200
SQQNMDIELS TLSLSNELLL ESIKTESKLE NYTKVMEMLS TFRPSGATPY
210 220 230 240 250
HDAYENVREV IQLQDPGLEQ LNASPAIAGL MHQASLLGIN ASISPELFNI
260 270 280 290 300
LTEEITEGNA EELYKKNFGN IEPASLAMPE YLKRYYNLSD EELSQFIGKA
310 320 330 340 350
SNFGQQEYSN NQLITPVVNS SDGTVKVYRI TREYTTNAYQ MDVELFPFGG
360 370 380 390 400
ENYRLDYKFK NFYNASYLSI KLNDKRELVR TEGAPQVNIE YSANITLNTA
410 420 430 440 450
DISQPFEIGL TRVLPSGSWA YAAAKFTVEE YNQYSFLLKL NKAIRLSRAT
460 470 480 490 500
ELSPTILEGI VRSVNLQLDI NTDVLGKVFL TKYYMQRYAI HAETALILCN
510 520 530 540 550
APISQRSYDN QPSQFDRLFN TPLLNGQYFS TGDEEIDLNS GSTGDWRKTI
560 570 580 590 600
LKRAFNIDDV SLFRLLKITD HDNKDGKIKN NLKNLSNLYI GKLLADIHQL
610 620 630 640 650
TIDELDLLLI AVGEGKTNLS AISDKQLATL IRKLNTITSW LHTQKWSVFQ
660 670 680 690 700
LFIMTSTSYN KTLTPEIKNL LDTVYHGLQG FDKDKADLLH VMAPYIAATL
710 720 730 740 750
QLSSENVAHS VLLWADKLQP GDGAMTAEKF WDWLNTKYTP GSSEAVETQE
760 770 780 790 800
HIVQYCQALA QLEMVYHSTG INENAFRLFV TKPEMFGAAT GAAPAHDALS
810 820 830 840 850
LIMLTRFADW VNALGEKASS VLAAFEANSL TAEQLADAMN LDANLLLQAS
860 870 880 890 900
IQAQNHQHLP PVTPENAFSC WTSINTILQW VNVAQQLNVA PQGVSALVGL
910 920 930 940 950
DYIQSMKETP TYAQWENAAG VLTAGLNSQQ ANTLHAFLDE SRSAALSTYY
960 970 980 990 1000
IRQVAKAAAA IKSRDDLYQY LLIDNQVSAA IKTTRIAEAI ASIQLYVNRA
1010 1020 1030 1040 1050
LENVEENANS GVISRQFFID WDKYNKRYST WAGVSQLVYY PENYIDPTMR
1060 1070 1080 1090 1100
IGQTKMMDAL LQSVSQSQLN ADTVEDAFMS YLTSFEQVAN LKVISAYHDN
1110 1120 1130 1140 1150
INNDQGLTYF IGLSETDAGE YYWRSVDHSK FNDGKFAANA WSEWHKIDCP
1160 1170 1180 1190 1200
INPYKSTIRP VIYKSRLYLL WLEQKEITKQ TGNSKDGYQT ETDYRYELKL
1210 1220 1230 1240 1250
AHIRYDGTWN TPITFDVNKK ISELKLEKNR APGLYCAGYQ GEDTLLVMFY
1260 1270 1280 1290 1300
NQQDTLDSYK NASMQGLYIF ADMASKDMTP EQSNVYRDNS YQQFDTNNVR
1310 1320 1330 1340 1350
RVNNRYAEDY EIPSSVSSRK DYGWGDYYLS MVYNGDIPTI NYKAASSDLK
1360 1370 1380 1390 1400
IYISPKLRII HNGYEGQKRN QCNLMNKYGK LGDKFIVYTS LGVNPNNSSN
1410 1420 1430 1440 1450
KLMFYPVYQY SGNTSGLNQG RLLFHRDTTY PSKVEAWIPG AKRSLTNQNA
1460 1470 1480 1490 1500
AIGDDYATDS LNKPDDLKQY IFMTDSKGTA TDVSGPVEIN TAISPAKVQI
1510 1520 1530 1540 1550
IVKAGGKEQT FTADKDVSIQ PSPSFDEMNY QFNALEIDGS GLNFINNSAS
1560 1570 1580 1590 1600
IDVTFTAFAE DGRKLGYESF SIPVTLKVST DNALTLHHNE NGAQYMQWQS
1610 1620 1630 1640 1650
YRTRLNTLFA RQLVARATTG IDTILSMETQ NIQEPQLGKG FYATFVIPPY
1660 1670 1680 1690 1700
NLSTHGDERW FKLYIKHVVD NNSHIIYSGQ LTDTNINITL FIPLDDVPLN
1710 1720 1730 1740 1750
QDYHAKVYMT FKKSPSDGTW WGPHFVRDDK GIVTINPKSI LTHFESVNVL
1760 1770 1780 1790 1800
NNISSEPMDF SGANSLYFWE LFYYTPMLVA QRLLHEQNFD EANRWLKYVW
1810 1820 1830 1840 1850
SPSGYIVHGQ IQNYQWNVRP LLEDTSWNSD PLDSVDPDAV AQHDPMHYKV
1860 1870 1880 1890 1900
STFMRTLDLL IARGDHAYRQ LERDTLNEAK MWYMQALHLL GDKPYLPLST
1910 1920 1930 1940 1950
TWSDPRLDRA ADITTQNAHD SAIVALRQNI PTPAPLSLRS ANTLTDLFLP
1960 1970 1980 1990 2000
QINEVMMNYW QTLAQRVYNL RHNLSIDGQP LYLPIYATPA DPKALLSAAV
2010 2020 2030 2040 2050
ATSQGGGKLP ESFMSLWRFP HMLENARGMV SQLTQFGSTL QNIIERQDAE
2060 2070 2080 2090 2100
ALNALLQNQA AELILTNLSI QDKTIEELDA EKTVLEKSKA GAQSRFDSYG
2110 2120 2130 2140 2150
KLYDENINAG ENQAMTLRAS AAGLTTAVQA SRLAGAAADL VPNIFGFAGG
2160 2170 2180 2190 2200
GSRWGAIAEA TGYVMEFSAN VMNTEADKIS QSETYRRRRQ EWEIQRNNAE
2210 2220 2230 2240 2250
AELKQIDAQL KSLAVRREAA VLQKTSLKTQ QEQTQSQLAF LQRKFSNQAL
2260 2270 2280 2290 2300
YNWLRGRLAA IYFQFYDLAV ARCLMAEQAY RWELNDDSAR FIKPGAWQGT
2310 2320 2330 2340 2350
YAGLLAGETL MLSLAQMEDA HLKRDKRALE VERTVSLAEV YAGLPKDNGP
2360 2370 2380 2390 2400
FSLAQEIDKL VSQGSGSAGS GNNNLAFGAG TDTKTSLQAS VSFADLKIRE
2410 2420 2430 2440 2450
DYPASLGKIR RIKQISVTLP ALLGPYQDVQ AILSYGDKAG LANGCEALAV
2460 2470 2480 2490 2500
SHGMNDSGQF QLDFNDGKFL PFEGIAIDQG TLTLSFPNAS MPEKGKQATM
2510
LKTLNDIILH IRYTIK
Length:2,516
Mass (Da):282,955
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8250A0650B614B99
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF188483 Genomic DNA Translation: AAF05542.1
AF346500 Genomic DNA Translation: AAL18486.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188483 Genomic DNA Translation: AAF05542.1
AF346500 Genomic DNA Translation: AAL18486.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O9YX-ray3.50A/B/C/D/E/F/G/H/I/J1-2516[»]
5LKHelectron microscopy3.46A/B/C/D/E1-2516[»]
5LKIelectron microscopy3.46A/B/C/D/E1-2516[»]
6H6Eelectron microscopy3.95A/B/C/D/E1-2516[»]
6H6Felectron microscopy3.72A/B/C/D/E1-2516[»]
SMRiQ9RN43
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-60214N

Family and domain databases

InterProiView protein in InterPro
IPR018003 Insecticidal_toxin/plasmid_vir
IPR041079 Neuraminidase-like
IPR041568 TcA_RBD
IPR040840 TcA_TcB_BD
PfamiView protein in Pfam
PF18413 Neuraminidase, 1 hit
PF18518 TcA_RBD, 1 hit
PF18276 TcA_TcB_BD, 2 hits
PF03538 VRP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9RN43_PHOLU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9RN43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 5, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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