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UniProtKB - Q9RML4 (Q9RML4_NEIME)

Entry version 69 (02 Dec 2020)
Sequence version 1 (01 May 2000)
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Protein

Bifunctional chorismate mutase/prephenate dehydratase

Gene

pheA

Organism
Neisseria meningitidis
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.ARBA annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional chorismate mutase/prephenate dehydratase (JY21_06180), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (B1A92_08870), Bifunctional chorismate mutase/prephenate dehydratase (COI13_06215), Bifunctional chorismate mutase/prephenate dehydratase (COI09_11635), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (COH25_01025), Bifunctional chorismate mutase/prephenate dehydratase (pheA)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.ARBA annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional chorismate mutase/prephenate dehydratase (JY21_06180), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (B1A92_08870), Bifunctional chorismate mutase/prephenate dehydratase (COI13_06215), Bifunctional chorismate mutase/prephenate dehydratase (COI09_11635), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (COH25_01025), Bifunctional chorismate mutase/prephenate dehydratase (pheA)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei275Essential for prephenate dehydratase activityUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseARBA annotation, LyaseARBA annotation, Multifunctional enzymeARBA annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesisARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00120;UER00203
UPA00121;UER00345

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional chorismate mutase/prephenate dehydrataseARBA annotation (EC:4.2.1.51ARBA annotation, EC:5.4.99.5ARBA annotation)
Alternative name(s):
Chorismate mutaseARBA annotation
Chorismate mutase-prephenate dehydrataseARBA annotation
Prephenate dehydrataseARBA annotation
p-proteinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pheAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeisseria meningitidisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri487 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 104Chorismate mutaseInterPro annotationAdd BLAST89
Domaini104 – 282Prephenate dehydrataseInterPro annotationAdd BLAST179
Domaini294 – 369ACTInterPro annotationAdd BLAST76

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.59.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002912, ACT_dom
IPR008242, Chor_mutase/pphenate_deHydtase
IPR036263, Chorismate_II_sf
IPR036979, CM_dom_sf
IPR002701, CM_II_prokaryot
IPR010957, G/b/e-P-prot_chorismate_mutase
IPR001086, Preph_deHydtase
IPR018528, Preph_deHydtase_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01842, ACT, 1 hit
PF01817, CM_2, 1 hit
PF00800, PDT, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001500, Chor_mut_pdt_Ppr, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00830, CM_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48600, SSF48600, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01807, CM_P2, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51671, ACT, 1 hit
PS51168, CHORISMATE_MUT_2, 1 hit
PS00857, PREPHENATE_DEHYDR_1, 1 hit
PS00858, PREPHENATE_DEHYDR_2, 1 hit
PS51171, PREPHENATE_DEHYDR_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9RML4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLECTINYCS GEIMSQTIDE LLLPHRNAID TIDAEILRLL NERAQHAHAI 
        60         70         80         90        100
GELKGTGAVY RPEREVAVLR RIQDLNKGPL PDESVARLFR EVMSECLAVE 
       110        120        130        140        150
RPLTIAYLGP QGNVYQQAAI KHFGHAAHTM ACPTIDNCFK QVETRQADYL 
       160        170        180        190        200
VAPVENSTEG SVGRTLDLLA VTALQACGEV VLRIHHNLLR KNNGSTEGIA 
       210        220        230        240        250
KVFSHAQALA QCNDWLGRHL PNAERIAVSS NAEAARLVAE SDDGTVAAIA 
       260        270        280        290        300
GRTAAEIYGL DMVAECIEDE PNNTTRFLVM GHHETGASGS DKTSLAVSAP 
       310        320        330        340        350
NRAGAVASLL QPLTESGISM TKFESRPSKS VLWEYLFFID IEGHRRDAQI 
       360        370 
QTALERLGER ASFVKVIGSY PTAVL
Length:375
Mass (Da):40,846
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9DA6412344E333E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF194079 Genomic DNA Translation: AAF08824.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194079 Genomic DNA Translation: AAF08824.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Enzyme and pathway databases

UniPathwayiUPA00120;UER00203
UPA00121;UER00345

Family and domain databases

Gene3Di1.20.59.10, 1 hit
InterProiView protein in InterPro
IPR002912, ACT_dom
IPR008242, Chor_mutase/pphenate_deHydtase
IPR036263, Chorismate_II_sf
IPR036979, CM_dom_sf
IPR002701, CM_II_prokaryot
IPR010957, G/b/e-P-prot_chorismate_mutase
IPR001086, Preph_deHydtase
IPR018528, Preph_deHydtase_CS
PfamiView protein in Pfam
PF01842, ACT, 1 hit
PF01817, CM_2, 1 hit
PF00800, PDT, 1 hit
PIRSFiPIRSF001500, Chor_mut_pdt_Ppr, 1 hit
SMARTiView protein in SMART
SM00830, CM_2, 1 hit
SUPFAMiSSF48600, SSF48600, 1 hit
TIGRFAMsiTIGR01807, CM_P2, 1 hit
PROSITEiView protein in PROSITE
PS51671, ACT, 1 hit
PS51168, CHORISMATE_MUT_2, 1 hit
PS00857, PREPHENATE_DEHYDR_1, 1 hit
PS00858, PREPHENATE_DEHYDR_2, 1 hit
PS51171, PREPHENATE_DEHYDR_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9RML4_NEIME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9RML4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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