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UniProtKB - Q9RKB5 (BVMO2_STRCO)
Protein
Baeyer-Villiger monooxygenase
Gene
SCO3172
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Functioni
Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters or lactones using NADPH and/or NADH as an electron donor. Thus, can convert bicyclo[3.2.0]hept-2-en-6-one into the oxidative lactone products 2-oxabicyclo[3.3.0]oct-6-en-3-one and 3-oxabicyclo[3.3.0]oct-6-en-2-one. Is also able to catalyze the sulfoxidation of methyl phenyl sulfide (thioanisole).
1 PublicationCofactori
FADBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 41 | FADBy similarity | 1 | |
Binding sitei | 61 | FADBy similarity | 1 | |
Binding sitei | 67 | FADBy similarity | 1 | |
Binding sitei | 110 | FAD; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Sitei | 293 | Transition state stabilizerBy similarity | 1 | |
Binding sitei | 399 | FAD; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 49 – 52 | FADBy similarity | 4 | |
Nucleotide bindingi | 59 – 61 | NADPBy similarity | 3 | |
Nucleotide bindingi | 183 – 189 | NADPBy similarity | 7 | |
Nucleotide bindingi | 206 – 207 | NADPBy similarity | 2 | |
Nucleotide bindingi | 292 – 293 | NADPBy similarity | 2 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- N,N-dimethylaniline monooxygenase activity Source: InterPro
- NADP binding Source: InterPro
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: UniProtKB
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | FAD, Flavoprotein, NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Baeyer-Villiger monooxygenase1 Publication (EC:1.14.13.-1 Publication)Short name: BVMO1 Publication |
Gene namesi | Ordered Locus Names:SCO3172Imported |
Organismi | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) |
Taxonomic identifieri | 100226 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › Streptomyces albidoflavus group › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000431627 | 1 – 519 | Baeyer-Villiger monooxygenaseAdd BLAST | 519 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 499 – 519 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the FAD-binding monooxygenase family.Curated
Phylogenomic databases
eggNOGi | COG2072, Bacteria |
HOGENOMi | CLU_006937_7_1_11 |
InParanoidi | Q9RKB5 |
OMAi | WNTGGCT |
PhylomeDBi | Q9RKB5 |
Family and domain databases
Gene3Di | 3.50.50.60, 3 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR020946, Flavin_mOase-like |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
SUPFAMi | SSF51905, SSF51905, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9RKB5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEHEQVHEH VRVAVIGSGF GGLGAAVRLR REGITDFVVL ERAGSVGGTW
60 70 80 90 100
RDNSYPGCAC DVPSHLYSFS FAPNPEWPRT FSGQEHIRAY LEHVADTFGL
110 120 130 140 150
RPHLRFDSEV KRMAWDTEQL RWEIETVRGT LTADVVVSAT GPLSDPKVPD
160 170 180 190 200
IPGLDTFPGK VFHSARWDHD YDLAGQRVAM IGTGASAIQI VPSIQPKVDR
210 220 230 240 250
LTLFQRTPAW VMPRVDRAIS GAERALHRAL PATTKLRRGL LWGIRELQVQ
260 270 280 290 300
AFTKHPNELG FVEQIAKRNM GAAIKDPALR AKLTPDYRIG CKRILLSSTY
310 320 330 340 350
YPALAKPNVD VVASGLSEVR GSTLVAADGT EAEADAIVFG TGFHVTDMPI
360 370 380 390 400
AERVVGADGR TLAETWKGGM EALRGGTAAG FPNFMTVIGP NTGLGNSSMI
410 420 430 440 450
LMIESQLNYL ADYLRQLNVL GGRTALDPRP AAVRNWNHRV QERMKRTVWN
460 470 480 490 500
TGGCTSWYLD ASGRNTTVWP GTTAEFRRET RRVDLAEYQV LRPAPAQVGA
510
KAAEADTGAD TGADAEVSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL939115 Genomic DNA Translation: CAB59668.1 |
RefSeqi | NP_627388.1, NC_003888.3 WP_011028809.1, NZ_VNID01000013.1 |
Genome annotation databases
GeneIDi | 1098606 |
KEGGi | sco:SCO3172 |
PATRICi | fig|100226.15.peg.3232 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL939115 Genomic DNA Translation: CAB59668.1 |
RefSeqi | NP_627388.1, NC_003888.3 WP_011028809.1, NZ_VNID01000013.1 |
3D structure databases
AlphaFoldDBi | Q9RKB5 |
SMRi | Q9RKB5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 100226.SCO3172 |
Genome annotation databases
GeneIDi | 1098606 |
KEGGi | sco:SCO3172 |
PATRICi | fig|100226.15.peg.3232 |
Phylogenomic databases
eggNOGi | COG2072, Bacteria |
HOGENOMi | CLU_006937_7_1_11 |
InParanoidi | Q9RKB5 |
OMAi | WNTGGCT |
PhylomeDBi | Q9RKB5 |
Family and domain databases
Gene3Di | 3.50.50.60, 3 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR020946, Flavin_mOase-like |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
SUPFAMi | SSF51905, SSF51905, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BVMO2_STRCO | |
Accessioni | Q9RKB5Primary (citable) accession number: Q9RKB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 7, 2015 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families