Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 92 (11 Dec 2019)
Sequence version 2 (23 Nov 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Non-hemolytic phospholipase C

Gene

plcN

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes phosphatidylserine as well as phosphatidylcholine.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BPSE272560:G1G3Q-2505-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.3 1031

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-hemolytic phospholipase C (EC:3.1.4.3)
Alternative name(s):
PLC-N
Phosphatidylcholine cholinephosphohydrolase
Phosphatidylcholine-hydrolyzing phospholipase C
Short name:
PC-PLC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:plcN
Ordered Locus Names:BPSL2403
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBurkholderia pseudomallei (strain K96243)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri272560 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000605 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Tat-type signalPROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002394035 – 700Non-hemolytic phospholipase CAdd BLAST666

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9RGS8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
272560.BPSL2403

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9RGS8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bacterial phospholipase C family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3511 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218669

KEGG Orthology (KO)

More...
KOi
K01114

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMHAAWN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.720.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017850 Alkaline_phosphatase_core_sf
IPR017767 Bact_PC-PLC
IPR007312 Phosphoesterase
IPR008475 PLipase_C_C
IPR006311 TAT_signal
IPR019546 TAT_signal_bac_arc

The PANTHER Classification System

More...
PANTHERi
PTHR31956 PTHR31956, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05506 DUF756, 2 hits
PF04185 Phosphoesterase, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03396 PC_PLC, 1 hit
TIGR01409 TAT_signal_seq, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51318 TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RGS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNQNRRDFL RLAAGTAGAA ALQLFPPVIR EALAIPANRR TGTIRDVEHI
60 70 80 90 100
VILMQENRSF DHYFGKLRGV RGFGDPRPLA LQNGKSVFHQ PVLLGPAELL
110 120 130 140 150
PFHPDASNLG MQFLQDLPHG WQDMHGAWNK GRYDRWIANK GTTTMAYLER
160 170 180 190 200
DDIPFHYQLA DAFTICDAYH CSIPSSTDPN RYYMWTGYVG NDGAGGGPVL
210 220 230 240 250
GNEEAGYGWS TYPETLEQAG VSWKIYQDIG TGLDAAGSWG WTQNPYIGNY
260 270 280 290 300
GDNSLLYFNQ YRNAQPGSPL YDKARTGTNV SAGGTLFDVL QQDVKNGTLP
310 320 330 340 350
QVSWICAPEA YSEHPNWPAN YGAWYVEQVL KALTSNPDVW SKTALFITYD
360 370 380 390 400
ENDGFFDHVA PPFAPQSREN GLSTVSTAGE IFAGDATHMA GPYGLGPRVP
410 420 430 440 450
MLVVSPWTKG GWVCSQTFDH TSLLQFIEAR FNDRYSVRAP NVTPWRRAVC
460 470 480 490 500
GDLTSAFNFS SPDGSWPQLP DTSGYAPPDR NRHPSYVPVP PAAQSMPKQE
510 520 530 540 550
AGLRAARALP YELFVLGRID QSTGKFKLTF ANTGRAGAAF QVTAGNRLDG
560 570 580 590 600
PWAYTVEARK RLSDEWSTAL TLSIYDLTVY GPNGFLCQFR GSTAAALGLS
610 620 630 640 650
ANPEVIYGYD VANGNITLRL SNRGRAAVRL TVTNAYGNAA PRVYELKPGQ
660 670 680 690 700
RINDYWDLRD SHSWYDLSVS DGAPNGFLRR FAGHVETGRP STSDPLIATA
Length:700
Mass (Da):77,077
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F7F4FB478ACFFD2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80A → T in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti86S → P in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti124M → T in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti151D → G in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti254S → A in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti369E → D in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti383A → P in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti387T → A in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti436S → P in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti492A → V in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti532N → K in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti548L → V in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti574I → L in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti600S → N in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti627A → T in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti633T → A in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti638 – 640NAA → KES in AAF17299 (PubMed:10523590).Curated3
Sequence conflicti668S → T in AAF17299 (PubMed:10523590).Curated1
Sequence conflicti700A → V in AAF17299 (PubMed:10523590).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF107252 Genomic DNA Translation: AAF17299.1
BX571965 Genomic DNA Translation: CAH36406.1

NCBI Reference Sequences

More...
RefSeqi
WP_004527449.1, NZ_CP009538.1
YP_108995.1, NC_006350.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAH36406; CAH36406; BPSL2403

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3093316

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bps:BPSL2403

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|272560.51.peg.2993

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107252 Genomic DNA Translation: AAF17299.1
BX571965 Genomic DNA Translation: CAH36406.1
RefSeqiWP_004527449.1, NZ_CP009538.1
YP_108995.1, NC_006350.1

3D structure databases

SMRiQ9RGS8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi272560.BPSL2403

Proteomic databases

PRIDEiQ9RGS8

Genome annotation databases

EnsemblBacteriaiCAH36406; CAH36406; BPSL2403
GeneIDi3093316
KEGGibps:BPSL2403
PATRICifig|272560.51.peg.2993

Phylogenomic databases

eggNOGiCOG3511 LUCA
HOGENOMiHOG000218669
KOiK01114
OMAiDMHAAWN

Enzyme and pathway databases

BioCyciBPSE272560:G1G3Q-2505-MONOMER
BRENDAi3.1.4.3 1031

Family and domain databases

Gene3Di3.40.720.10, 2 hits
InterProiView protein in InterPro
IPR017850 Alkaline_phosphatase_core_sf
IPR017767 Bact_PC-PLC
IPR007312 Phosphoesterase
IPR008475 PLipase_C_C
IPR006311 TAT_signal
IPR019546 TAT_signal_bac_arc
PANTHERiPTHR31956 PTHR31956, 1 hit
PfamiView protein in Pfam
PF05506 DUF756, 2 hits
PF04185 Phosphoesterase, 1 hit
TIGRFAMsiTIGR03396 PC_PLC, 1 hit
TIGR01409 TAT_signal_seq, 1 hit
PROSITEiView protein in PROSITE
PS51318 TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHLN_BURPS
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9RGS8
Secondary accession number(s): Q63SC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 23, 2004
Last modified: December 11, 2019
This is version 92 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again