Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Short transient receptor potential channel 2

Gene

Trpc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to form a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Is not activated by intracellular calcium store depletion.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • damaged DNA binding Source: InterPro
  • inositol 1,4,5 trisphosphate binding Source: GO_Central
  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Short transient receptor potential channel 2
Short name:
TrpC2
Alternative name(s):
Transient receptor protein 2
Short name:
TRP-2
Short name:
rTrp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpc2
Synonyms:Trp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
628819 Trpc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 627CytoplasmicSequence analysisAdd BLAST627
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Topological domaini649 – 658ExtracellularSequence analysis10
Transmembranei659 – 679HelicalSequence analysisAdd BLAST21
Topological domaini680 – 701CytoplasmicSequence analysisAdd BLAST22
Transmembranei702 – 722HelicalSequence analysisAdd BLAST21
Topological domaini723 – 737ExtracellularSequence analysisAdd BLAST15
Transmembranei738 – 758HelicalSequence analysisAdd BLAST21
Topological domaini759 – 788CytoplasmicSequence analysisAdd BLAST30
Transmembranei789 – 809HelicalSequence analysisAdd BLAST21
Topological domaini810 – 832ExtracellularSequence analysisAdd BLAST23
Transmembranei833 – 853HelicalSequence analysisAdd BLAST21
Topological domaini854 – 898CytoplasmicSequence analysisAdd BLAST45
Transmembranei899 – 919HelicalSequence analysisAdd BLAST21
Topological domaini920 – 1170ExtracellularSequence analysisAdd BLAST251

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153081 – 1170Short transient receptor potential channel 2Add BLAST1170

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R283

PRoteomics IDEntifications database

More...
PRIDEi
Q9R283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed exclusively in vomeronasal organ neurons (sensory microvilli).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000020188 Expressed in 9 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9R283 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R283 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000047354

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R283

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati300 – 329ANK 1Add BLAST30
Repeati346 – 376ANK 2Add BLAST31
Repeati377 – 405ANK 3Add BLAST29
Repeati429 – 458ANK 4Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1030 – 1068Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi197 – 201Poly-Ser5
Compositional biasi1136 – 1141Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3609 Eukaryota
ENOG410XQ0Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153860

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000137678

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101351

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R283

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPPIPET

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0KP0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9R283

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR008979 Galactose-bd-like_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005458 TRPC2_channel
IPR002153 TRPC_channel
IPR002706 Xrcc1_N

The PANTHER Classification System

More...
PANTHERi
PTHR10117 PTHR10117, 1 hit
PTHR10117:SF6 PTHR10117:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PF01834 XRCC1_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01097 TRNSRECEPTRP
PR01643 TRPCHANNEL2

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF49785 SSF49785, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9R283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLMSLTDSKE GKNRSGVRMF KDDDFLIPAS GESWDRLRLT CSQPFTRHQS
60 70 80 90 100
FGLAFLRVRS SLDSLSDPVK DPSSPGSSGL NQNSSDKLES DPSPWLTNPS
110 120 130 140 150
IRRTFFPDPQ TSTKEISALK GMLKQLQPGP LGRAARMVLS AAHKAPPASV
160 170 180 190 200
VSPNNSHGEP DSSHPERAEP RAEEPNRKNN ASRGKRRKVQ EQRRPLSSSS
210 220 230 240 250
SQPNRRATGR TKQRQQRPQA KSDGSGVQAT GQCPICTGSF SIEALPRHAA
260 270 280 290 300
TCGESSPPQP ASPTSLSSSE SVLRCLHVAL TPVPLIPKPN WTEIVNKKLK
310 320 330 340 350
FPPTLLRAIQ EGQLGLVQQL LESGSDPSGA GPGGPLRNVE ESEDRSWREA
360 370 380 390 400
LNLAIRLGHE VITDVLLANV KFDFRQIHEA LLVAVDTNQP AVVRRLLARL
410 420 430 440 450
EREKGRKVDT KSFSLAFFDS SIDGSRFAPG VTPLTLACQK DLYEIAQLLM
460 470 480 490 500
DQGHTIARPH PVSCACLECS NARRYDLLKF SLSRINTYRG IASRAHLSLA
510 520 530 540 550
SEDAMLAAFQ LSRELRRLAR KEPEFKPQYI ALESLCQDYG FELLGMCRNQ
560 570 580 590 600
SEVTAVLNDL GEDSETEPEA EGLGQAFEEG IPNLARLRLA VNYNQKQFVA
610 620 630 640 650
HPICQQVLSS IWCGNLAGWR GSTTIWKLFV AFLIFLTMPF LCIGYWLAPK
660 670 680 690 700
SRLGRLLKIP VLKFLLHSAS YLWFLIFLLG ESLVMETQLS TFKGRSQSVW
710 720 730 740 750
ETSLHMIWVT GFLWFECKEV WIEGLRSYLL DWWNFLDVVI LSLYLASFAL
760 770 780 790 800
RLLLAGLAYM HCRDASDSST CRYFTTAERS EWRTEDPQFL AEVLFAVTSM
810 820 830 840 850
LSFTRLAYIL PAHESLGTLQ ISIGKMIDDM IRFMFILMII LTAFLCGLNN
860 870 880 890 900
IYVPYQETEK LGNFNETFQF LFWTMFGMEE HSVVDMPQFL VPEFVGRAMY
910 920 930 940 950
GIFTIVMVIV LLNMLIAMIT NSFQKIEDDA DVEWKFARSK LYLSYFREGL
960 970 980 990 1000
TLPVPFNILP SPKAAFYLLR RIFRFICCGS SCCKAKKSDY PPIPTFTNPG
1010 1020 1030 1040 1050
ARAGPGEGEH VSYRLRVIKA LVQRYIETAR REFEETRRKD LGNRLTELTK
1060 1070 1080 1090 1100
TVSRLQSEVA SVQKTVAAGG ALRPPDGASI LSRYITRVRN SFQNLGPPAP
1110 1120 1130 1140 1150
DTPAELTMPG IVETEVSLED SLDATGEAGT PASGESSSSS SAHVLVHREQ
1160 1170
EAEGAGDLPL GEDLETKGES
Note: No experimental confirmation available. Inferred from mouse sequence.
Length:1,170
Mass (Da):130,467
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDF876A83B28CA5C
GO
Isoform 2 (identifier: Q9R283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     284-288: PLIPK → MDPLS

Note: No experimental confirmation available.
Show »
Length:887
Mass (Da):99,809
Checksum:iF8A516AEB39F3A50
GO
Isoform 3 (identifier: Q9R283-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAPVKISHVV...PFVTLLPATM
     274-315: RCLHVALTPV...LRAIQEGQLG → WVSSPESSPP...ASVCGEVFPA
     316-1170: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):44,359
Checksum:i3C1FAF331F007681
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140TAF6A0A140TAF6_RAT
Short transient receptor potential ...
Trpc2
886Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1010H → R in AAD31453 (PubMed:10318963).Curated1
Sequence conflicti1069 – 1070Missing in AAD31453 (PubMed:10318963).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0372361 – 283Missing in isoform 2. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_0388071M → MAPVKISHVVSFSSQDPKYP VENLLNPDSHKGPWLSCPRD KTGQLKVEFQLERAVPISYI DVGNCGCAFLQIDVGRSSWP LDRPFVTLLPATM in isoform 3. 1 Publication1
Alternative sequenceiVSP_037238274 – 315RCLHV…EGQLG → WVSSPESSPPPSSWVQCPIC ELQFSAREIEEHASVCGEVF PA in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_037237284 – 288PLIPK → MDPLS in isoform 2. 1 Publication5
Alternative sequenceiVSP_037239316 – 1170Missing in isoform 3. 1 PublicationAdd BLAST855

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF136401 mRNA Translation: AAD31453.1
AABR03002379 Genomic DNA No translation available.
AABR03010502 Genomic DNA No translation available.
AABR03010734 Genomic DNA No translation available.
AABR03001253 Genomic DNA No translation available.
BC169022 mRNA Translation: AAI69022.1
AF061874 mRNA Translation: AAC16726.1

NCBI Reference Sequences

More...
RefSeqi
NP_001316819.1, NM_001329890.1 [Q9R283-3]
XP_006223495.1, XM_006223433.3 [Q9R283-3]
XP_006229966.1, XM_006229904.3 [Q9R283-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.48766

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000048172; ENSRNOP00000047354; ENSRNOG00000020188 [Q9R283-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102549471

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:102549471

UCSC genome browser

More...
UCSCi
RGD:628819 rat [Q9R283-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136401 mRNA Translation: AAD31453.1
AABR03002379 Genomic DNA No translation available.
AABR03010502 Genomic DNA No translation available.
AABR03010734 Genomic DNA No translation available.
AABR03001253 Genomic DNA No translation available.
BC169022 mRNA Translation: AAI69022.1
AF061874 mRNA Translation: AAC16726.1
RefSeqiNP_001316819.1, NM_001329890.1 [Q9R283-3]
XP_006223495.1, XM_006223433.3 [Q9R283-3]
XP_006229966.1, XM_006229904.3 [Q9R283-3]
UniGeneiRn.48766

3D structure databases

SMRiQ9R283
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047354

Proteomic databases

PaxDbiQ9R283
PRIDEiQ9R283

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048172; ENSRNOP00000047354; ENSRNOG00000020188 [Q9R283-1]
GeneIDi102549471
KEGGirno:102549471
UCSCiRGD:628819 rat [Q9R283-1]

Organism-specific databases

RGDi628819 Trpc2

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00940000153860
HOGENOMiHOG000137678
HOVERGENiHBG101351
InParanoidiQ9R283
OMAiGPPIPET
OrthoDBiEOG091G0KP0
PhylomeDBiQ9R283

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9R283

Gene expression databases

BgeeiENSRNOG00000020188 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiQ9R283 baseline and differential
GenevisibleiQ9R283 RN

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR008979 Galactose-bd-like_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005458 TRPC2_channel
IPR002153 TRPC_channel
IPR002706 Xrcc1_N
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF6 PTHR10117:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PF01834 XRCC1_N, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01643 TRPCHANNEL2
SUPFAMiSSF48403 SSF48403, 1 hit
SSF49785 SSF49785, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPC2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R283
Secondary accession number(s): B5DFD7, O70485
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 5, 2009
Last modified: December 5, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again