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Entry version 144 (07 Oct 2020)
Sequence version 1 (01 May 2000)
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Protein

Periplakin

Gene

Ppl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processKeratinization

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6809371, Formation of the cornified envelope
R-MMU-8851680, Butyrophilin (BTN) family interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Periplakin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppl
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1194898, Ppl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781501 – 1755PeriplakinAdd BLAST1755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineBy similarity1
Modified residuei463PhosphoserineBy similarity1
Modified residuei885PhosphoserineBy similarity1
Modified residuei947PhosphoserineBy similarity1
Modified residuei1583PhosphoserineBy similarity1
Modified residuei1656PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9R269

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R269

PRoteomics IDEntifications database

More...
PRIDEi
Q9R269

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R269

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R269

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retinal lens (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the upper granular cell layer of dorsal lip and tongue, palate and dorsal epidermis of newborns (PubMed:15226441). Expressed in the corneal epithelium and conjunctiva, with expression prevalent in the cytoplasm of anterior lens epithelial cells, becoming predominantly membrane expressed in epithelial cells as they elongate into fiber cells at 3 weeks of age (PubMed:19029034).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or a heterodimer with EVPL (By similarity).

Found in a complex composed of PPL (via C-terminal linker domain), BFSP1 and BFSP2 in the retinal lens (PubMed:19029034). Within the complex interacts (via C-terminal linker domain) with BFSP2 (PubMed:19029034).

Interacts with VIM (PubMed:12244133, PubMed:19029034). Binds to the PH domain of AKT1 (PubMed:12244133).

Interacts with FCGR1A (By similarity). May interact with PPHLN1 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
202331, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q9R269, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9R269

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039360

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9R269, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R269

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati214 – 315Spectrin 1Add BLAST102
Repeati321 – 483Spectrin 2Add BLAST163
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini397 – 453SH3PROSITE-ProRule annotationAdd BLAST57
Repeati503 – 610Spectrin 3Add BLAST108
Repeati1650 – 1684Plectin 1Add BLAST35
Repeati1699 – 1734Plectin 2Add BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1556 – 1755Interacts with BFSP2 and VIM1 PublicationAdd BLAST200

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 125Sequence analysisAdd BLAST110
Coiled coili182 – 387Sequence analysisAdd BLAST206
Coiled coili611 – 819Sequence analysisAdd BLAST209
Coiled coili883 – 1644Sequence analysisAdd BLAST762

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R269

KEGG Orthology (KO)

More...
KOi
K10386

Database of Orthologous Groups

More...
OrthoDBi
35436at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9R269

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615, Desmoplakin_SH3
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17902, SH3_10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250, PLEC, 2 hits
SM00150, SPEC, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399, SSF75399, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9R269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSLFRKRNK GKYSPTVQTR SISNKELSDL IEQLQKNADQ VERNIVDTEA
60 70 80 90 100
KMQSDLARMQ EGQLPEHRDA ALQNVSDSEK LLYVLEADSA IAKHMKHPQG
110 120 130 140 150
DMIAEDIRQL KERVTNLRGK HKQMYSLAVK EADPRVNWDT LVDEKLDKLS
160 170 180 190 200
SQSFGTDLPL VDSQVEQHNI FHNEVKAIGP HLAKDKEQNS ELQAKYQKLL
210 220 230 240 250
TASQARQQHL SSLQDYMQRC TNELYWLDQQ AKGRMQYDWS DRNLDYPSRR
260 270 280 290 300
RQYENFINRN LEAKEERINK LHTEGDQLLT AEHPGRNSIE AHMEAVHAEW
310 320 330 340 350
KEYLNLLICE ESHLKYMEDY HQFHKDMKDA QELLRKVDSD LNQKYSPDFK
360 370 380 390 400
DRYQIELLLR ELDDQEKALD KYEDVVRGLQ RRGQQVVPLK YRRETPLKPI
410 420 430 440 450
PVEALCDFES DQGLISRGYS YTLQKNNGES WELTDSTGKK LAAPAVCFII
460 470 480 490 500
PPTDPEALAL ADSLGSQYRS VRQKATGSKH ALQQRHEVLR TENPGDASDL
510 520 530 540 550
QGRQLLAGLD KVASDLDRQE KAITGILRPP LEQGRAIEDS AERAKGLKNI
560 570 580 590 600
TNELLQIEPE KTQCTAECEA FVQALPASGT APLLKTRVED TNQKYERLVW
610 620 630 640 650
LLEAAQEKVD VANRLENSLQ RGRELLASYE NRLIQDDTMP ESGHVLDRKR
660 670 680 690 700
QELEAMASEL QAHKSLLGEV GKNLQVAKQC SSSLASRFQE HCPDLERQEA
710 720 730 740 750
EVHKLNQRFN NLSQQVERRA QSLQSARAAY DEYCSGYNRV LQFLAKTPSY
760 770 780 790 800
EPQETDSLGQ METKLKNQKN LLDELASREQ EVQKVYADSQ QYQQAVKDYE
810 820 830 840 850
LEAEKLRSLL DLENGRNSHV NKRARLQSPA AKVKEEEAAL AAKFTEVNAI
860 870 880 890 900
NRQRLQNLEF ALNLLRQQPE AGVTHETLQG GKLSSGMEET WKIKKELEEE
910 920 930 940 950
IERRQQLENE VKSAQEEIQT LKDQGPQESL VRKEVLKKVP DPALEESFQQ
960 970 980 990 1000
LQQTLAEEQH KNQLLQEELG ALQLRLQALE QETRDGGQEY VVKEVLRIEP
1010 1020 1030 1040 1050
DRAQEDEVLQ LREELEALRR QKGAREAEVL LLQQRVAALA AEKSRVQEKV
1060 1070 1080 1090 1100
TEREVVKLQN DPQLEAEYRR LQEEHQREGT LREKQEEELS FLQAKLRRLE
1110 1120 1130 1140 1150
KERAMAEGKI TVKEVLKVEK DAAVEREVND LTRQYEDEAA KARSGQREKT
1160 1170 1180 1190 1200
ELLRKIWALE EENAKVVVQE KVREIVRPDP KAESEVANLR LELVEQERKF
1210 1220 1230 1240 1250
RGAEEQLKSY QSELEALRNR GPQVEVKEVT KEVIKYTTDP ETEQELQRLR
1260 1270 1280 1290 1300
EEIMDKTRLI ERCDLEIYQL KQEIQALKDT KPQVQTREVV QEILQFQEDP
1310 1320 1330 1340 1350
QTKKEVESLR IQLSEEQKKQ VDLEGERASQ EEKIKRKEEE LAQQRKERVV
1360 1370 1380 1390 1400
RQEVVQYEDE PDLRAEVTAF TNSIDAELRQ IDKLHVELRR LQHRRAELER
1410 1420 1430 1440 1450
QLEELERERQ ARRAAELEVQ RLQQRLAALE QEEAKTGEKV THTQKVVLQQ
1460 1470 1480 1490 1500
DPQQTREHAL LRAQLEEERH RRQLLEGELE PLRRKLAALE KAEIKEKVVF
1510 1520 1530 1540 1550
SESVQVEKGD TEQEIQRLKK SLEEESQSKR ELDSEVTRLE AKLSELEFYN
1560 1570 1580 1590 1600
SKSSKELDFL REENHKLQLE RQNLQLETRR LQSEIEMAAT ETRDLKNITT
1610 1620 1630 1640 1650
IDSGTHLNSR LWSLEKELDD LKKMSKDKDL EIDELQRRLG SVAVKREQRE
1660 1670 1680 1690 1700
NHLRRSIVVI DPDTGRELSP EEAHRAGLID WKMFVKLRSQ ECDWEEISVK
1710 1720 1730 1740 1750
GPNGESSVIH DRKSGKKFSI EDALQSGRLT AAQYDRYVNK DMSIQELAVL

VSGQK
Length:1,755
Mass (Da):204,004
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FEA343086E4CB8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E898G5E898_MOUSE
Periplakin
Ppl
1,754Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti166E → Q in AAF29436 (PubMed:15226441).Curated1
Sequence conflicti592N → T in AAF29436 (PubMed:15226441).Curated1
Sequence conflicti648R → S in AAF29436 (PubMed:15226441).Curated1
Sequence conflicti671 – 672GK → EQ in AAF29436 (PubMed:15226441).Curated2
Sequence conflicti983T → A in AAF29436 (PubMed:15226441).Curated1
Sequence conflicti1325G → R in AAF29436 (PubMed:15226441).Curated1
Sequence conflicti1344 – 1345QR → G in AAF29436 (PubMed:15226441).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF126834 mRNA Translation: AAD20642.1
AF116523 AF116522 Genomic DNA Translation: AAF29436.2
AK014700 mRNA Translation: BAB29510.1
AF013715 Genomic DNA Translation: AAC40068.1

NCBI Reference Sequences

More...
RefSeqi
NP_032935.2, NM_008909.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19041

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19041

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126834 mRNA Translation: AAD20642.1
AF116523 AF116522 Genomic DNA Translation: AAF29436.2
AK014700 mRNA Translation: BAB29510.1
AF013715 Genomic DNA Translation: AAC40068.1
RefSeqiNP_032935.2, NM_008909.2

3D structure databases

SMRiQ9R269
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202331, 8 interactors
IntActiQ9R269, 5 interactors
MINTiQ9R269
STRINGi10090.ENSMUSP00000039360

PTM databases

iPTMnetiQ9R269
PhosphoSitePlusiQ9R269

Proteomic databases

MaxQBiQ9R269
PaxDbiQ9R269
PRIDEiQ9R269

Genome annotation databases

GeneIDi19041
KEGGimmu:19041

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5493
MGIiMGI:1194898, Ppl

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
InParanoidiQ9R269
KOiK10386
OrthoDBi35436at2759
PhylomeDBiQ9R269

Enzyme and pathway databases

ReactomeiR-MMU-6809371, Formation of the cornified envelope
R-MMU-8851680, Butyrophilin (BTN) family interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
19041, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ppl, mouse

Protein Ontology

More...
PROi
PR:Q9R269
RNActiQ9R269, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR041615, Desmoplakin_SH3
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 1 hit
PfamiView protein in Pfam
PF17902, SH3_10, 1 hit
SMARTiView protein in SMART
SM00250, PLEC, 2 hits
SM00150, SPEC, 4 hits
SUPFAMiSSF75399, SSF75399, 1 hit
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEPL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R269
Secondary accession number(s): O70231, Q9CUT1, Q9JLZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: October 7, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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