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Protein

Prostaglandin D2 receptor

Gene

Ptgdr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:Ptgdr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1565108 Ptgdr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 57CytoplasmicSequence analysisAdd BLAST16
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 106ExtracellularSequence analysisAdd BLAST28
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 149CytoplasmicSequence analysisAdd BLAST22
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 194ExtracellularSequence analysisAdd BLAST24
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 261CytoplasmicSequence analysisAdd BLAST46
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 306ExtracellularSequence analysisAdd BLAST24
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 357CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi338

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003707111 – 357Prostaglandin D2 receptorAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R261
PRIDEiQ9R261

PTM databases

PhosphoSitePlusiQ9R261

Expressioni

Tissue specificityi

Strongly expressed in eye and gastrointestinal tract (GIT), moderately in the brain and oviduct and weakly in the epididymis. In the eye, expressed in the epithelium of the iris and ciliary body and in photoreceptor cells of the retina. In the brain, expressed in leptomeninges, choroid plexus and spinal cord (sensory and motor neurons of the dorsal and ventral horns). In the stomach, expressed in the mucous-secreting goblet cells and the columnar epithelium. Expressed in platelets.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048101

Chemistry databases

BindingDBiQ9R261

Structurei

3D structure databases

ProteinModelPortaliQ9R261
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
InParanoidiQ9R261
KOiK04332

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000376 Pglndn_D_rcpt
IPR008365 Prostanoid_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF14 PTHR11866:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00854 PRSTNOIDDPR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESYRCQAA TWVERGSSAT MGGVAFSAGL LGNLLALVLL ARSGLGSCRP
60 70 80 90 100
GPLHPPPSVF YVLVCGLTVT DLLGKCLISP MVLAAYAQNR SLKELLPASG
110 120 130 140 150
NQLCEAFAFL MSFFGLASTL QLLAMALECW LSLGHPFFYQ RHITARRGVL
160 170 180 190 200
VAPVAGAFSL AFCALPFAGF GKFVQYCPGT WCFIQMIHKK RSFSVIGFSV
210 220 230 240 250
LYSSLMALLV LATVVCNLGA MSNLYAMHRR QRHHPRRCSR DRAQSGSDYR
260 270 280 290 300
HGSPNPLEEL DHFVLLALTT VLFTMCSLPL IYRAYYGAFK LVDRADGDSE
310 320 330 340 350
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKTFTRPLI YRNWCSHSWQ

TNMESTL
Length:357
Mass (Da):39,769
Last modified:May 1, 2000 - v1
Checksum:iA65E1355E52E8286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120101 mRNA Translation: AAD23564.1
RefSeqiNP_001128636.1, NM_001135164.1
UniGeneiRn.110861
Rn.57393

Genome annotation databases

GeneIDi498475
KEGGirno:498475

Similar proteinsi

Entry informationi

Entry nameiPD2R_RAT
AccessioniPrimary (citable) accession number: Q9R261
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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