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Protein

Heme-binding protein 1

Gene

Hebp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.2 Publications

GO - Molecular functioni

  • heme binding Source: UniProtKB

GO - Biological processi

  • heme metabolic process Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-binding protein 1
Alternative name(s):
p22HBP
Gene namesi
Name:Hebp1
Synonyms:Hbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1333880 Hebp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001168981 – 190Heme-binding protein 1Add BLAST190

Proteomic databases

MaxQBiQ9R257
PaxDbiQ9R257
PeptideAtlasiQ9R257
PRIDEiQ9R257

PTM databases

iPTMnetiQ9R257
PhosphoSitePlusiQ9R257
SwissPalmiQ9R257

Expressioni

Tissue specificityi

Ubiquitously expressed. Extremely abundant in liver.1 Publication

Gene expression databases

CleanExiMM_HEBP1

Interactioni

Subunit structurei

Monomer.3 Publications

Protein-protein interaction databases

BioGridi200269, 1 interactor
IntActiQ9R257, 5 interactors
MINTiQ9R257
STRINGi10090.ENSMUSP00000042232

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9R257
SMRiQ9R257
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9R257

Family & Domainsi

Domaini

Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure.2 Publications

Sequence similaritiesi

Belongs to the HEBP family.Curated

Phylogenomic databases

eggNOGiENOG410IKQ6 Eukaryota
ENOG4111HGX LUCA
HOGENOMiHOG000237638
HOVERGENiHBG053223
InParanoidiQ9R257
TreeFamiTF328887

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR011256 Reg_factor_effector_dom_sf
IPR006917 SOUL_haem-bd
PANTHERiPTHR11220 PTHR11220, 1 hit
PfamiView protein in Pfam
PF04832 SOUL, 1 hit
SUPFAMiSSF55136 SSF55136, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9R257-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGMIRNSLF GSVETWPWQV LSTGGKEDVS YEERACEGGK FATVEVTDKP
60 70 80 90 100
VDEALREAMP KIMKYVGGTN DKGVGMGMTV PVSFALFPNE DGSLQKKLKV
110 120 130 140 150
WFRIPNQFQG SPPAPSDESV KIEEREGITV YSTQFGGYAK EADYVAHATQ
160 170 180 190
LRTTLEGTPA TYQGDVYYCA GYDPPMKPYG RRNEVWLVKA
Length:190
Mass (Da):21,067
Last modified:October 3, 2012 - v2
Checksum:iC1EA42E1798931DB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8J4A0A140T8J4_MOUSE
Heme-binding protein 1
Hebp1 mCG_22258
190Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86L → V in BAA33770 (PubMed:9813049).Curated1
Sequence conflicti86L → V in AAD32096 (PubMed:10640688).Curated1
Sequence conflicti86L → V in CAJ18470 (Ref. 4) Curated1
Sequence conflicti86L → V in AAH12654 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013095 mRNA Translation: BAA33770.1
AF117613 mRNA Translation: AAD32096.1
CT010262 mRNA Translation: CAJ18470.1
AC131718 Genomic DNA No translation available.
BC012654 mRNA Translation: AAH12654.1
CCDSiCCDS20645.1
RefSeqiNP_038574.3, NM_013546.3
UniGeneiMm.378937

Genome annotation databases

GeneIDi15199
KEGGimmu:15199
UCSCiuc009elh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013095 mRNA Translation: BAA33770.1
AF117613 mRNA Translation: AAD32096.1
CT010262 mRNA Translation: CAJ18470.1
AC131718 Genomic DNA No translation available.
BC012654 mRNA Translation: AAH12654.1
CCDSiCCDS20645.1
RefSeqiNP_038574.3, NM_013546.3
UniGeneiMm.378937

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GOVNMR-A7-190[»]
2HVANMR-A1-190[»]
4A1MNMR-A7-190[»]
ProteinModelPortaliQ9R257
SMRiQ9R257
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200269, 1 interactor
IntActiQ9R257, 5 interactors
MINTiQ9R257
STRINGi10090.ENSMUSP00000042232

PTM databases

iPTMnetiQ9R257
PhosphoSitePlusiQ9R257
SwissPalmiQ9R257

Proteomic databases

MaxQBiQ9R257
PaxDbiQ9R257
PeptideAtlasiQ9R257
PRIDEiQ9R257

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15199
KEGGimmu:15199
UCSCiuc009elh.1 mouse

Organism-specific databases

CTDi50865
MGIiMGI:1333880 Hebp1

Phylogenomic databases

eggNOGiENOG410IKQ6 Eukaryota
ENOG4111HGX LUCA
HOGENOMiHOG000237638
HOVERGENiHBG053223
InParanoidiQ9R257
TreeFamiTF328887

Miscellaneous databases

EvolutionaryTraceiQ9R257
PROiPR:Q9R257
SOURCEiSearch...

Gene expression databases

CleanExiMM_HEBP1

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR011256 Reg_factor_effector_dom_sf
IPR006917 SOUL_haem-bd
PANTHERiPTHR11220 PTHR11220, 1 hit
PfamiView protein in Pfam
PF04832 SOUL, 1 hit
SUPFAMiSSF55136 SSF55136, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEBP1_MOUSE
AccessioniPrimary (citable) accession number: Q9R257
Secondary accession number(s): O88814
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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