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Entry version 166 (26 Feb 2020)
Sequence version 2 (23 Mar 2010)
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Protein

Short transient receptor potential channel 2

Gene

Trpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. May also be activated by intracellular calcium store depletion. Plays a role in mediating responsivity to pheromones that elicit aggressive and mating behaviors. Required for response to the Esp1 pheromone which enhances female sexual receptive behavior and to the Esp22 pheromone which inhibits adult male mating behavior.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Short transient receptor potential channel 2
Short name:
TrpC2
Alternative name(s):
Transient receptor protein 2
Short name:
TRP-2
Short name:
mTrp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpc2
Synonyms:Trp2, Trrp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109527 Trpc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 659CytoplasmicSequence analysisAdd BLAST659
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei660 – 680HelicalSequence analysisAdd BLAST21
Topological domaini681 – 702ExtracellularSequence analysisAdd BLAST22
Transmembranei703 – 723HelicalSequence analysisAdd BLAST21
Topological domaini724 – 738CytoplasmicSequence analysisAdd BLAST15
Transmembranei739 – 759HelicalSequence analysisAdd BLAST21
Topological domaini760 – 789ExtracellularSequence analysisAdd BLAST30
Transmembranei790 – 810HelicalSequence analysisAdd BLAST21
Topological domaini811 – 833CytoplasmicSequence analysisAdd BLAST23
Transmembranei834 – 854HelicalSequence analysisAdd BLAST21
Topological domaini855 – 899ExtracellularSequence analysisAdd BLAST45
Transmembranei900 – 920HelicalSequence analysisAdd BLAST21
Topological domaini921 – 1172CytoplasmicSequence analysisAdd BLAST252

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduced electrophysiological response to pheromone mixtures in the vomeronasal organ. Mutant males and nursing females are docile and fail to initiate aggressive attacks on intruder males. Males display normal mating behavior towards females but display increased sexual behavior towards prepubescent females even when presented simultaneously with adult estrus females and also show increased sexual behavior towards juvenile and adult males. Lack of response to Esp1.4 Publications

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
487

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153071 – 1172Short transient receptor potential channel 2Add BLAST1172

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9R244

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R244

PRoteomics IDEntifications database

More...
PRIDEi
Q9R244

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R244

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9R244

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is ubiquitously expressed at low levels. Isoform 4 is expressed exclusively in vomeronasal organ.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000100254 Expressed in renal system and 19 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R244 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204328, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9R244

Database of interacting proteins

More...
DIPi
DIP-61090N

Protein interaction database and analysis system

More...
IntActi
Q9R244, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000081903

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9R244 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati301 – 330ANK 1Add BLAST30
Repeati377 – 406ANK 2Add BLAST30
Repeati430 – 459ANK 3Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1140 – 1143Poly-Ser4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3609 Eukaryota
ENOG410XQ0Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182670

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005716_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R244

KEGG Orthology (KO)

More...
KOi
K04965

Identification of Orthologs from Complete Genome Data

More...
OMAi
YFLDWWN

Database of Orthologous Groups

More...
OrthoDBi
60838at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9R244

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036770 Ankyrin_rpt-contain_sf
IPR008979 Galactose-bd-like_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005458 TRPC2_channel
IPR002153 TRPC_channel
IPR002706 Xrcc1_N

The PANTHER Classification System

More...
PANTHERi
PTHR10117 PTHR10117, 1 hit
PTHR10117:SF6 PTHR10117:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PF01834 XRCC1_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01097 TRNSRECEPTRP
PR01643 TRPCHANNEL2

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF49785 SSF49785, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9R244-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLMSRTDSKS GKNRSGVRMF KDGDFLTPAS GESWDRLRLT CSQPFTRHQS
60 70 80 90 100
FGLAFLRVRS SLGSLADPVV DPSAPGSSGL NQNSTDVLES DPRPWLTNPS
110 120 130 140 150
IRRTFFPDPQ TSTKEISELK GMLKQLQPGP LGRAARMVLS AARKAPPASV
160 170 180 190 200
VSPNNSHGEP GPSRAESAEP RAEEPNRKTA VGRRKRRKVQ EPRRSLSNSS
210 220 230 240 250
SQPNRRTGRT RQRQHRPQTK SDDGGVQAAG QCPICAGFFS IETLPQHAAT
260 270 280 290 300
CGESPPPQPA SPASLSSSES VLRRHHVALT PVPLVPKPQP NWTEIVNKKL
310 320 330 340 350
KFPPTLLRAI QEGQLGLVQQ LLESSSDASG AGPGGPLRNV EESEDRSWRE
360 370 380 390 400
ALNLAIRLGH EVITDVLLAN VKFDFRQIHE ALLVAVDTNQ PAVVRRLLAR
410 420 430 440 450
LEREKGRKVD TKSFSLAFFD SSIDGSRFAP GVTPLTLACQ KDLYEIAQLL
460 470 480 490 500
MDQGHTIARP HPVSCACLEC SNARRYDLLK FSLSRINTYR GIASRAHLSL
510 520 530 540 550
ASEDAMLAAF QLSRELRRLA RKEPEFKPQY IALESLCQDY GFELLGMCRN
560 570 580 590 600
QSEVTAVLND LGEDSETEPE AEGLGQAFEE GIPNLARLRL AVNYNQKQFV
610 620 630 640 650
AHPICQQVLS SIWCGNLAGW RGSTTIWKLF VAFLIFLTMP FLCIGYWLAP
660 670 680 690 700
KSQLGRLLKI PVLKFLLHSA SYLWFLIFLL GESLVMETQL STFKGRSQSV
710 720 730 740 750
WETSLHMIWV TGFLWFECKE VWIEGLRSYL LDWWNFLDVV ILSLYLASFA
760 770 780 790 800
LRLLLAGLAY MHCRDASDST TCRYFTTAER SEWRTEDPQF LAEVLFAVTS
810 820 830 840 850
MLSFTRLAYI LPAHESLGTL QISIGKMIDD MIRFMFILMI ILTAFLCGLN
860 870 880 890 900
NIYVPYQESE KLGNFNETFQ FLFWTMFGME EHTVVDMPQF LVPEFVGRAM
910 920 930 940 950
YGIFTIVMVI VLLNMLIAMI TNSFQKIEDD ADVEWKFARS KLYLSYFREG
960 970 980 990 1000
LTLPVPFNIL PSPKAAFYLV RRIFRFLCCG SSCCKAKKSD YPPIGTFTNP
1010 1020 1030 1040 1050
GARAGSAGEG ERVSYRLRVI KALVQRYIET ARREFEETRR KDLGNRLTEL
1060 1070 1080 1090 1100
TKTVSRLQSE VASVQKNLAA GGAPRPPDGA SILSRYITRV RNSFQNLGPP
1110 1120 1130 1140 1150
TSDTPAELTM PGIVETEVSL GDGLDGTGEA GAPAPGEPGS SSSAHVLVHR
1160 1170
EQEAEGSGDL LLEGDLETKG ES
Length:1,172
Mass (Da):130,531
Last modified:March 23, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9A9A9FEE01D1536
GO
Isoform 2 (identifier: Q9R244-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: MLMSRTDSKS...RRTFFPDPQT → MGTKTHPVVPW

Show »
Length:1,072
Mass (Da):119,508
Checksum:i0566C84794F190C6
GO
Isoform 3 (identifier: Q9R244-3) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     2-287: Missing.

Show »
Length:886
Mass (Da):99,545
Checksum:i19A4673B0B861E56
GO
Isoform 4 (identifier: Q9R244-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     2-283: Missing.
     284-287: LVPK → DPLS

Show »
Length:890
Mass (Da):99,957
Checksum:i50791C101A98C5B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti628K → R in AAD17195 (PubMed:10051594).Curated1
Sequence conflicti628K → R in AAD17196 (PubMed:10051594).Curated1
Sequence conflicti633F → S in AAD17195 (PubMed:10051594).Curated1
Sequence conflicti633F → S in AAD17196 (PubMed:10051594).Curated1
Sequence conflicti653Q → R in AAG29951 (PubMed:10998353).Curated1
Sequence conflicti653Q → R in AAG29950 (PubMed:10998353).Curated1
Sequence conflicti774Y → C in AAD17195 (PubMed:10051594).Curated1
Sequence conflicti774Y → C in AAD17196 (PubMed:10051594).Curated1
Sequence conflicti797A → T in AAD17195 (PubMed:10051594).Curated1
Sequence conflicti797A → T in AAD17196 (PubMed:10051594).Curated1
Sequence conflicti1161L → P in AAG29951 (PubMed:10998353).Curated1
Sequence conflicti1161L → P in AAG29950 (PubMed:10998353).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0065621 – 111MLMSR…PDPQT → MGTKTHPVVPW in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0065642 – 287Missing in isoform 3. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_0065632 – 283Missing in isoform 4. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_006565284 – 287LVPK → DPLS in isoform 4. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF111108 mRNA Translation: AAD17196.1
AF111107 mRNA Translation: AAD17195.1
AF230803 mRNA Translation: AAG29951.1
AF230802 mRNA Translation: AAG29950.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52333.1 [Q9R244-4]

NCBI Reference Sequences

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RefSeqi
NP_001103367.1, NM_001109897.2 [Q9R244-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000124189; ENSMUSP00000116934; ENSMUSG00000100254 [Q9R244-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:22064

UCSC genome browser

More...
UCSCi
uc009iqm.2 mouse [Q9R244-3]
uc009iqn.2 mouse [Q9R244-2]
uc012fqr.2 mouse [Q9R244-1]
uc012fqs.2 mouse [Q9R244-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111108 mRNA Translation: AAD17196.1
AF111107 mRNA Translation: AAD17195.1
AF230803 mRNA Translation: AAG29951.1
AF230802 mRNA Translation: AAG29950.1
CCDSiCCDS52333.1 [Q9R244-4]
RefSeqiNP_001103367.1, NM_001109897.2 [Q9R244-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi204328, 1 interactor
CORUMiQ9R244
DIPiDIP-61090N
IntActiQ9R244, 2 interactors
STRINGi10090.ENSMUSP00000081903

Chemistry databases

GuidetoPHARMACOLOGYi487

PTM databases

iPTMnetiQ9R244
PhosphoSitePlusiQ9R244

Proteomic databases

jPOSTiQ9R244
PaxDbiQ9R244
PRIDEiQ9R244

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22064

Genome annotation databases

EnsembliENSMUST00000124189; ENSMUSP00000116934; ENSMUSG00000100254 [Q9R244-4]
GeneIDi22064
KEGGimmu:22064
UCSCiuc009iqm.2 mouse [Q9R244-3]
uc009iqn.2 mouse [Q9R244-2]
uc012fqr.2 mouse [Q9R244-1]
uc012fqs.2 mouse [Q9R244-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7221
MGIiMGI:109527 Trpc2

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00950000182670
HOGENOMiCLU_005716_2_0_1
InParanoidiQ9R244
KOiK04965
OMAiYFLDWWN
OrthoDBi60838at2759
PhylomeDBiQ9R244

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dct mouse

Protein Ontology

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PROi
PR:Q9R244
RNActiQ9R244 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000100254 Expressed in renal system and 19 other tissues
GenevisibleiQ9R244 MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR036770 Ankyrin_rpt-contain_sf
IPR008979 Galactose-bd-like_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005458 TRPC2_channel
IPR002153 TRPC_channel
IPR002706 Xrcc1_N
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF6 PTHR10117:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PF01834 XRCC1_N, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01643 TRPCHANNEL2
SUPFAMiSSF48403 SSF48403, 1 hit
SSF49785 SSF49785, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPC2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R244
Secondary accession number(s): Q9ES59, Q9ES60, Q9R243
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 23, 2010
Last modified: February 26, 2020
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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