UniProtKB - Q9R216 (FZD9_MOUSE)
Frizzled-9
Fzd9
Functioni
Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).
Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (PubMed:24860427).
May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (By similarity).
During hippocampal development, regulates neuroblast proliferation and apoptotic cell death (PubMed:15930120).
Controls bone formation through non canonical Wnt signaling mediated via ISG15 (PubMed:21402791).
Positively regulates bone regeneration through non canonical Wnt signaling (PubMed:24391920).
By similarity4 PublicationsCaution
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
- Wnt-activated receptor activity Source: UniProtKB
- Wnt-protein binding Source: MGI
GO - Biological processi
- B cell differentiation Source: MGI
- bone regeneration Source: UniProtKB
- canonical Wnt signaling pathway Source: GO_Central
- learning or memory Source: MGI
- negative regulation of mitochondrial depolarization Source: UniProtKB
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
- negative regulation of necroptotic process Source: UniProtKB
- negative regulation of neuron apoptotic process Source: UniProtKB
- negative regulation of skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
- neuroblast proliferation Source: MGI
- ossification Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of bone mineralization Source: UniProtKB
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of neural precursor cell proliferation Source: UniProtKB
- postsynapse organization Source: MGI
- regulation of cell cycle Source: UniProtKB
- regulation of cytosolic calcium ion concentration Source: UniProtKB
- regulation of postsynaptic cytosolic calcium ion concentration Source: MGI
- regulation of skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
- release of cytochrome c from mitochondria Source: UniProtKB
- Wnt signaling pathway Source: MGI
Keywordsi
Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Biological process | Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Frizzled-9Short name: Fz-9 Short name: mFz3 Short name: mFz9 Alternative name(s): CD_antigen: CD349 |
Gene namesi | Name:Fzd9 Synonyms:Fzd3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1313278, Fzd9 |
VEuPathDBi | HostDB:ENSMUSG00000049551 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane.By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Mitochondrion
- mitochondrial membrane Source: UniProtKB
Plasma Membrane
- filopodium membrane Source: MGI
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
- glutamatergic synapse Source: MGI
- integral component of membrane Source: GO_Central
- perinuclear region of cytoplasm Source: MGI
- postsynapse Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 230 | ExtracellularAdd BLAST | 207 | |
Transmembranei | 231 – 251 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 252 – 267 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 268 – 288 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 289 – 316 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 317 – 337 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 338 – 356 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 357 – 377 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 378 – 401 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 402 – 422 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 423 – 448 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 449 – 469 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 470 – 509 | ExtracellularSequence analysisAdd BLAST | 40 | |
Transmembranei | 510 – 530 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 531 – 592 | CytoplasmicSequence analysisAdd BLAST | 62 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000013004 | 24 – 592 | Frizzled-9Add BLAST | 569 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 40 ↔ 101 | PROSITE-ProRule annotation | ||
Disulfide bondi | 48 ↔ 94 | PROSITE-ProRule annotation | ||
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 85 ↔ 123 | PROSITE-ProRule annotation | ||
Disulfide bondi | 112 ↔ 153 | PROSITE-ProRule annotation | ||
Disulfide bondi | 116 ↔ 140 | PROSITE-ProRule annotation | ||
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9R216 |
PRIDEi | Q9R216 |
ProteomicsDBi | 273401 |
PTM databases
GlyGeni | Q9R216, 2 sites |
iPTMneti | Q9R216 |
PhosphoSitePlusi | Q9R216 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000049551, Expressed in rib and 211 other tissues |
Genevisiblei | Q9R216, MM |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
- Wnt-protein binding Source: MGI
Protein-protein interaction databases
IntActi | Q9R216, 2 interactors |
STRINGi | 10090.ENSMUSP00000053551 |
Miscellaneous databases
RNActi | Q9R216, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 156 | FZPROSITE-ProRule annotationAdd BLAST | 122 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 59 – 173 | Required for Wnt-activated receptor activityBy similarityAdd BLAST | 115 | |
Regioni | 555 – 592 | Required for CTNNB1 accumulation and TCF transcription factor activityBy similarityAdd BLAST | 38 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 533 – 538 | Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000161226 |
HOGENOMi | CLU_007873_2_1_1 |
InParanoidi | Q9R216 |
OMAi | THCHYKS |
OrthoDBi | 509772at2759 |
PhylomeDBi | Q9R216 |
TreeFami | TF317907 |
Family and domain databases
CDDi | cd07463, CRD_FZ9, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR000539, Frizzled/Smoothened_TM IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR041777, FZ9_CRD IPR017981, GPCR_2-like |
PANTHERi | PTHR11309, PTHR11309, 1 hit |
Pfami | View protein in Pfam PF01534, Frizzled, 1 hit PF01392, Fz, 1 hit |
PRINTSi | PR00489, FRIZZLED |
SMARTi | View protein in SMART SM00063, FRI, 1 hit SM01330, Frizzled, 1 hit |
SUPFAMi | SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAVPPLLRGA LLLWQLLATG GAALEIGRFD PERGRGPAPC QAMEIPMCRG
60 70 80 90 100
IGYNLTRMPN LLGHTSQGEA AAQLAEFSPL VQYGCHSHLR FFLCSLYAPM
110 120 130 140 150
CTDQVSTPIP ACRPMCEQAR LRCAPIMEQF NFGWPDSLDC ARLPTRNDPH
160 170 180 190 200
ALCMEAPENA TAGPTEPHKG LGMLPVAPRP ARPPGDSAPG PGSGGTCDNP
210 220 230 240 250
EKFQYVEKSR SCAPRCGPGV EVFWSRRDKD FALVWMAVWS ALCFFSTAFT
260 270 280 290 300
VFTFLLEPHR FQYPERPIIF LSMCYNVYSL AFLIRAVAGA QSVACDQEAG
310 320 330 340 350
ALYVIQEGLE NTGCTLVFLL LYYFGMASSL WWVVLTLTWF LAAGKKWGHE
360 370 380 390 400
AIEAHGSYFH MAAWGLPALK TIVVLTLRKV AGDELTGLCY VASMDPAALT
410 420 430 440 450
GFVLVPLSCY LVLGTSFLLT GFVALFHIRK IMKTGGTNTE KLEKLMVKIG
460 470 480 490 500
VFSILYTVPA TCVIVCYVYE RLNMDFWRLR ATEQPCTAAT VPGGRRDCSL
510 520 530 540 550
PGGSVPTVAV FMLKIFMSLV VGITSGVWVW SSKTFQTWQS LCYRKMAAGR
560 570 580 590
ARAKACRTPG GYGRGTHCHY KAPTVVLHMT KTDPSLENPT HL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | S → P in AAB87503 (Ref. 3) Curated | 1 | |
Sequence conflicti | 73 – 74 | QL → HC in BAB32311 (PubMed:16141072).Curated | 2 | |
Sequence conflicti | 93 | L → F in BAB32311 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 144 | P → S in CAB44237 (Ref. 4) Curated | 1 | |
Sequence conflicti | 221 | E → K in CAB44237 (Ref. 4) Curated | 1 | |
Sequence conflicti | 237 | A → P in CAB44237 (Ref. 4) Curated | 1 | |
Sequence conflicti | 308 | G → D in AAB87503 (Ref. 3) Curated | 1 | |
Sequence conflicti | 374 | V → F in CAB44237 (Ref. 4) Curated | 1 | |
Sequence conflicti | 592 | L → P in BAB32311 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF088850 Genomic DNA Translation: AAD27789.1 AK021164 mRNA Translation: BAB32311.1 AF033585 mRNA Translation: AAB87503.2 Y17709 mRNA Translation: CAB44237.1 |
CCDSi | CCDS51661.1 |
RefSeqi | NP_034376.1, NM_010246.1 |
Genome annotation databases
Ensembli | ENSMUST00000062572; ENSMUSP00000053551; ENSMUSG00000049551 |
GeneIDi | 14371 |
KEGGi | mmu:14371 |
UCSCi | uc008zya.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF088850 Genomic DNA Translation: AAD27789.1 AK021164 mRNA Translation: BAB32311.1 AF033585 mRNA Translation: AAB87503.2 Y17709 mRNA Translation: CAB44237.1 |
CCDSi | CCDS51661.1 |
RefSeqi | NP_034376.1, NM_010246.1 |
3D structure databases
SMRi | Q9R216 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9R216, 2 interactors |
STRINGi | 10090.ENSMUSP00000053551 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9R216, 2 sites |
iPTMneti | Q9R216 |
PhosphoSitePlusi | Q9R216 |
Proteomic databases
PaxDbi | Q9R216 |
PRIDEi | Q9R216 |
ProteomicsDBi | 273401 |
Protocols and materials databases
Antibodypediai | 14305, 542 antibodies from 39 providers |
Genome annotation databases
Ensembli | ENSMUST00000062572; ENSMUSP00000053551; ENSMUSG00000049551 |
GeneIDi | 14371 |
KEGGi | mmu:14371 |
UCSCi | uc008zya.2, mouse |
Organism-specific databases
CTDi | 8326 |
MGIi | MGI:1313278, Fzd9 |
VEuPathDBi | HostDB:ENSMUSG00000049551 |
Phylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000161226 |
HOGENOMi | CLU_007873_2_1_1 |
InParanoidi | Q9R216 |
OMAi | THCHYKS |
OrthoDBi | 509772at2759 |
PhylomeDBi | Q9R216 |
TreeFami | TF317907 |
Miscellaneous databases
BioGRID-ORCSi | 14371, 0 hits in 65 CRISPR screens |
ChiTaRSi | Fzd3, mouse |
PROi | PR:Q9R216 |
RNActi | Q9R216, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049551, Expressed in rib and 211 other tissues |
Genevisiblei | Q9R216, MM |
Family and domain databases
CDDi | cd07463, CRD_FZ9, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR000539, Frizzled/Smoothened_TM IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR041777, FZ9_CRD IPR017981, GPCR_2-like |
PANTHERi | PTHR11309, PTHR11309, 1 hit |
Pfami | View protein in Pfam PF01534, Frizzled, 1 hit PF01392, Fz, 1 hit |
PRINTSi | PR00489, FRIZZLED |
SMARTi | View protein in SMART SM00063, FRI, 1 hit SM01330, Frizzled, 1 hit |
SUPFAMi | SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FZD9_MOUSE | |
Accessioni | Q9R216Primary (citable) accession number: Q9R216 Secondary accession number(s): O35494, Q9CX16, Q9R2B3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 5, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families