UniProtKB - Q9R1Y5 (HIC1_MOUSE)
Hypermethylated in cancer 1 protein
Hic1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 437 – 464 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 507 – 534 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 535 – 562 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 563 – 590 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 591 – 618 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 28 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- histone deacetylase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
- multicellular organism development Source: UniProtKB-KW
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of Wnt signaling pathway Source: UniProtKB
- positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-3232118, SUMOylation of transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: Hypermethylated in cancer 1 proteinShort name: Hic-1 |
Gene namesi | Name:Hic1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338010, Hic1 |
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046943 | 1 – 733 | Hypermethylated in cancer 1 proteinAdd BLAST | 733 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 159 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 237 | PhosphoserineBy similarity | 1 | |
Modified residuei | 248 | PhosphoserineBy similarity | 1 | |
Modified residuei | 333 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 333 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity | ||
Modified residuei | 366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 704 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9R1Y5 |
MaxQBi | Q9R1Y5 |
PaxDbi | Q9R1Y5 |
PeptideAtlasi | Q9R1Y5 |
PRIDEi | Q9R1Y5 |
ProteomicsDBi | 269790 [Q9R1Y5-1] |
PTM databases
iPTMneti | Q9R1Y5 |
PhosphoSitePlusi | Q9R1Y5 |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
Subunit structurei
Self-associates (By similarity).
Interacts with HIC2 (By similarity).
Interacts with CTBP1 and CTBP2 (By similarity).
Interacts with TCF7L2 and ARID1A (By similarity).
Interacts with MTA1 and MBD3; indicative for an association with the NuRD complex (By similarity).
Interacts with SIRT1 (PubMed:16269335).
By similarity1 PublicationBinary interactionsi
Hide detailsGO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 200302, 1 interactor |
IntActi | Q9R1Y5, 4 interactors |
MINTi | Q9R1Y5 |
STRINGi | 10090.ENSMUSP00000053483 |
Miscellaneous databases
RNActi | Q9R1Y5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 110 | BTBPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 154 – 315 | Mediates HDAC-dependent transcriptional repressionBy similarityAdd BLAST | 162 | |
Regioni | 241 – 247 | Interaction with CTBP1By similarity | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 13 | Arg/Gly/Pro-richAdd BLAST | 13 | |
Compositional biasi | 112 – 119 | Poly-Ala | 8 | |
Compositional biasi | 160 – 167 | Poly-Gly | 8 | |
Compositional biasi | 195 – 199 | Poly-Pro | 5 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 437 – 464 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 507 – 534 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 535 – 562 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 563 – 590 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 591 – 618 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 28 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | Q9R1Y5 |
OMAi | VIQACYS |
TreeFami | TF333488 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR028424, HIC1 IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR24390:SF145, PTHR24390:SF145, 1 hit |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketThis entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTFPEADILL KSGECAGQTM LDTMEAPGHS RQLLLQLNNQ RTKGFLCDVI
60 70 80 90 100
IVVQNALFRA HKNVLAASSA YLKSLVVHDN LLNLDHDMVS PAVFRLVLDF
110 120 130 140 150
IYTGRLTDSV EAAAAAAVAP GAEPSLGAVL AAASYLQIPD LVALCKKRLK
160 170 180 190 200
RHGKYCHLRG GGSGGGGYAP YGRPGRGLRA ATPVIQACYS SPAGPPPPPA
210 220 230 240 250
AEPPSGPDAA VNTHCAELYA SGPGPAASLC APERRCSPLC GLDLSKKSPP
260 270 280 290 300
GSSVPERPLS ERELPPRPDS PPGAGPAVYK EPSLALPPLP PLPFQKLEEA
310 320 330 340 350
VPTPDPFRGS GGSPGPEPPG RPDGSSLLYR WMKHEPGLGS YGDELVRDRG
360 370 380 390 400
SPGERLEERG GDPAASPGGP PLGLVPPPRY PGSLDGPGTG ADGDDYKSSS
410 420 430 440 450
EETGSSEDPS PPGGHLEGYP CPHLAYGEPE SFGDNLYVCI PCGKGFPSSE
460 470 480 490 500
QLNAHVEAHV EEEEALYGRA EAAEVAAGAA GLGPPFGGGG DKVTGAPGGL
510 520 530 540 550
GELLRPYRCA SCDKSYKDPA TLRQHEKTHW LTRPYPCTIC GKKFTQRGTM
560 570 580 590 600
TRHMRSHLGL KPFACDACGM RFTRQYRLTE HMRIHSGEKP YECQVCGGKF
610 620 630 640 650
AQQRNLISHM KMHAVGGAAG AAGALAGLGG LPGVPGPDGK GKLDFPEGVF
660 670 680 690 700
AVARLTAEQL SLKQQDKAAA AELLAQTTHF LHDPKVALES LYPLAKFTAE
710 720 730
LGLSPDKAAE VLSQGAHLAA GPDSRTIDRF SPT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketZ4YJP0 | Z4YJP0_MOUSE | Hypermethylated in cancer 1 protein | Hic1 | 893 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | T → M in AAD30654 (PubMed:10072440).Curated | 1 | |
Sequence conflicti | 19 | T → M in AAD30655 (PubMed:10072440).Curated | 1 | |
Sequence conflicti | 19 | T → M no nucleotide entry (PubMed:11073960).Curated | 1 | |
Sequence conflicti | 83 | N → S in AAD30654 (PubMed:10072440).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036334 mRNA Translation: AAD30654.1 Different initiation. AF036582 Genomic DNA Translation: AAD30655.1 Sequence problems. AL603905 Genomic DNA No translation available. AJ132691 Genomic DNA Translation: CAB44493.1 |
RefSeqi | NP_001091673.1, NM_001098203.1 [Q9R1Y5-1] |
Genome annotation databases
GeneIDi | 15248 |
KEGGi | mmu:15248 |
UCSCi | uc007kdc.1, mouse [Q9R1Y5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036334 mRNA Translation: AAD30654.1 Different initiation. AF036582 Genomic DNA Translation: AAD30655.1 Sequence problems. AL603905 Genomic DNA No translation available. AJ132691 Genomic DNA Translation: CAB44493.1 |
RefSeqi | NP_001091673.1, NM_001098203.1 [Q9R1Y5-1] |
3D structure databases
SMRi | Q9R1Y5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200302, 1 interactor |
IntActi | Q9R1Y5, 4 interactors |
MINTi | Q9R1Y5 |
STRINGi | 10090.ENSMUSP00000053483 |
PTM databases
iPTMneti | Q9R1Y5 |
PhosphoSitePlusi | Q9R1Y5 |
Proteomic databases
jPOSTi | Q9R1Y5 |
MaxQBi | Q9R1Y5 |
PaxDbi | Q9R1Y5 |
PeptideAtlasi | Q9R1Y5 |
PRIDEi | Q9R1Y5 |
ProteomicsDBi | 269790 [Q9R1Y5-1] |
Genome annotation databases
GeneIDi | 15248 |
KEGGi | mmu:15248 |
UCSCi | uc007kdc.1, mouse [Q9R1Y5-1] |
Organism-specific databases
CTDi | 3090 |
MGIi | MGI:1338010, Hic1 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | Q9R1Y5 |
OMAi | VIQACYS |
TreeFami | TF333488 |
Enzyme and pathway databases
Reactomei | R-MMU-3232118, SUMOylation of transcription factors |
Miscellaneous databases
BioGRID-ORCSi | 15248, 3 hits in 53 CRISPR screens |
ChiTaRSi | Hic1, mouse |
PROi | PR:Q9R1Y5 |
RNActi | Q9R1Y5, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR028424, HIC1 IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR24390:SF145, PTHR24390:SF145, 1 hit |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HIC1_MOUSE | |
Accessioni | Q9R1Y5Primary (citable) accession number: Q9R1Y5 Secondary accession number(s): B1ARH0, Q9R1Y6, Q9R2B0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | December 14, 2011 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families