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Entry version 139 (13 Nov 2019)
Sequence version 3 (15 Mar 2005)
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Protein

Protein timeless homolog

Gene

Timeless

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:23418588, PubMed:10428031, PubMed:12875843). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:12875843). TIMELESS promotes TIPIN nuclear localization (PubMed:12875843). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:12875843). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (By similarity). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:23418588). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:10428031). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (PubMed:10963667).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processBiological rhythms, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5693607 Processing of DNA double-strand break ends

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein timeless homolog
Short name:
mTim
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TimelessImported
Synonyms:Tim1Imported, Timeless11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1321393 Timeless

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725391 – 1197Protein timeless homologAdd BLAST1197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei281PhosphoserineBy similarity1
Modified residuei1071PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1
Modified residuei1086PhosphothreonineBy similarity1
Modified residuei1165PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R1X4

PeptideAtlas

More...
PeptideAtlasi
Q9R1X4

PRoteomics IDEntifications database

More...
PRIDEi
Q9R1X4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R1X4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R1X4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly and robustly expressed in proliferative organs (spleen, thymus, intestine and testis) compared to those more differentiated such as kidney and liver (at protein level). Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Strongly expressed in the suprachiasmatic nucleus (SCN) and pars tuberalis, moderately in the cingulate cortex, pyrimidal cell layer of the piriform cortex, periventricular part of the caudate putamen, and granular layer of the cerebellum, and weakly in the cerebral cortex, gyrus dentatus, hippocampus and thalamic nuclei. In embryonic kidney, expression is highest in regions of active ureteric bud cell branching.7 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is highest in whole embryos at 11 dpc and gradually decreases as embryonic development progresses. At 7.5 dpc, expressed in germ cell layers. At 14.5 dpc, expressed at highest levels in thymus, liver, gastrointestinal tract, lung and the rapidly proliferating ventricular zone of the brain.4 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In retina, expression exhibits a circadian rhythm in the presence of light/dark cycles. In the suprachiasmatic nucleus (SCN), isoform 1 exhibited 24 hours oscillation, isoform 4 is constitutively expressed. Shows a circadian expression pattern in the intestine with peaks at ZT4 and ZT8.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039994 Expressed in 222 organ(s), highest expression level in primary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9R1X4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R1X4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or homomultimer (PubMed:12875843, PubMed:23418588).

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins (PubMed:9856465).

Interacts directly with PER2; the interaction with PER2 is via its second PAS domain (PubMed:14564007).

Interacts directly with PER1 and PER3 (PubMed:9856465, PubMed:10231394, PubMed:14564007).

Interacts with CRY1 (PubMed:10428031, PubMed:23418588, PubMed:24489120).

Interacts with CRY2 (PubMed:10428031).

Interacts with CHEK1, ATR and ATRIP (By similarity).

Interacts with CLSPN (By similarity).

Interacts with TIPIN (PubMed:12875843).

Interacts with DDX11; this interaction increases recruitment of both proteins onto chromatin in response to replication stress induction by hydroxyurea (By similarity).

Interacts with PARP1; interaction is direct and independent of poly-ADP-ribose (By similarity).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O359733EBI-1793117,EBI-1266764

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204198, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q9R1X4, 26 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058021

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R1X4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 309Required for homodimerization and for interaction with CRY1 and CHEK11 PublicationAdd BLAST309
Regioni997 – 1095Interaction with PARP1By similarityAdd BLAST99
Regioni1079 – 1197Required for nuclear localization1 PublicationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi655 – 687Glu-richAdd BLAST33
Compositional biasi964 – 1172Glu-richAdd BLAST209

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the timeless family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1974 Eukaryota
ENOG410XQM6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015124

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R1X4

KEGG Orthology (KO)

More...
KOi
K03155

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEEHCKE

Database of Orthologous Groups

More...
OrthoDBi
839367at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9R1X4

TreeFam database of animal gene trees

More...
TreeFami
TF312802

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006906 Timeless
IPR007725 TIMELESS_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04821 TIMELESS, 1 hit
PF05029 TIMELESS_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 14 Publications (identifier: Q9R1X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLYMMNCEL LATCSALGYL EGGTYHKEPD CLESVKDLIR YLRHEDETRD
60 70 80 90 100
VRQQLGAAQI LQSDLLPILT QHRQDKPLFD AVIRLMVNLT QPALLCFGSV
110 120 130 140 150
PKDSSVRHHF LQVLTYLQAY KEAFASEKAF GVLSETLYEL LQLGWEDRQE
160 170 180 190 200
EDNLLIERIL LLVRNILHVP ANLEQEKSID DDASIHDRLL WAIHLSGMDD
210 220 230 240 250
LLLFLSSSSA EQQWSLHVLE IISLMFRDQT PEQLAGVGQG RLAQERSTDV
260 270 280 290 300
AELEVLRQRE MAEKRARALQ RGNRHSRFGG SYIVQGLKSI GEKDVVFHKG
310 320 330 340 350
LHNLQNYSSD LGKQPRRVPK RRQAAQELSV HRRSVLNVRL FLRDFCSEFL
360 370 380 390 400
ENCYNPLMGA VKDHLLRERA QQHDETYYMW AMAFFMAFNR AATFRPGLVS
410 420 430 440 450
ETLSIRTFHF VEQNLTNYYE MMLTDRKEAA SWARRMHLAL KAYQELLATV
460 470 480 490 500
NEMDMCPDEA VRESSRIIKN NIFYMMEYRE LFLALFRKFD ERYHPRSFLR
510 520 530 540 550
DLVETTHLFL KMLERFCRSR GNLMVQNKRK KRKKKKKVQD QGVAFSQSPG
560 570 580 590 600
ELEAMWPALA EQLLQCAQDP ELSVDPVVPF DAASEVPVEE QRVEAMVRIQ
610 620 630 640 650
DCLTAGQAPQ ALALLRSARE VWPEGNAFGS PVISPGEEMQ LLKQILSTPL
660 670 680 690 700
PRQQEPEEGD AEEEEEEEEE EELQVVQVSE KEFNFLEYLK RFASSTIVRA
710 720 730 740 750
YVLLLRSYRQ NSAHTNHCIA KMLHRLAHGL GMEALLFQLS LFCLFNRLLS
760 770 780 790 800
DPAAAAYKEL VTFAKYIIGK FFALAAVNQK AFVELLFWKN TAVVREMTQG
810 820 830 840 850
YGSLDSGSSS HRAPLWSPEE EAQLQELYLA HKDVEGQDVV ETILAHLKVV
860 870 880 890 900
PRTRKQVIHH LVRMGLADSV KEFQKRKGTQ IVLWTEDQEL ELQRLFEEFR
910 920 930 940 950
DSDDVLGQIM KNITAKRSRA RVVDKLLALG LVSERRQLYK KRRKKLAPSC
960 970 980 990 1000
MQNGEKSPRD PWQEDPEEED EHLPEDESED EESEEGLPSG QGQGSSSLSA
1010 1020 1030 1040 1050
ENLGESLRQE GLSAPLLWLQ SSLIRAANDR EEDGCSQAIP LVPLTEENEE
1060 1070 1080 1090 1100
AMENEQFQHL LRKLGIRPPS SGQETFWRIP AKLSSTQLRR VAASLSQQEN
1110 1120 1130 1140 1150
EEEREEEPEP GVPGEQGPSE EHRTEALRAL LSARKRKAGL GPTEEEATGE
1160 1170 1180 1190
EEWNSAPKKR QLLDSDEEED DEGRRQAVSG TPRVHRKKRF QIEDEDD
Length:1,197
Mass (Da):137,503
Last modified:March 15, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB24B7F0F3D05787
GO
Isoform 2Curated (identifier: Q9R1X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     952-952: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,196
Mass (Da):137,375
Checksum:iF96561FD89D5941B
GO
Isoform 3Curated (identifier: Q9R1X4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     952-952: Missing.
     967-1104: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,058
Mass (Da):122,007
Checksum:i1132EA312EEF49AD
GO
Isoform 41 Publication (identifier: Q9R1X4-4) [UniParc]FASTAAdd to basket
Also known as: TIM-s

The sequence of this isoform differs from the canonical sequence as follows:
     1-721: Missing.
     952-952: Missing.

Show »
Length:475
Mass (Da):53,886
Checksum:i56706A9F906EF3B1
GO
Isoform 5Curated (identifier: Q9R1X4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-721: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:476
Mass (Da):54,014
Checksum:i3B6BA2FB91C9ECE0
GO
Isoform 61 Publication (identifier: Q9R1X4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1177: Missing.

Show »
Length:1,196
Mass (Da):137,432
Checksum:iED8B120D87B20E44
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BX89H7BX89_MOUSE
Protein timeless homolog
Timeless
534Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q302E9Q302_MOUSE
Protein timeless homolog
Timeless
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH52884 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64788 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179I → V in AAH64788 (PubMed:15489334).Curated1
Sequence conflicti298H → R in AAH64788 (PubMed:15489334).Curated1
Sequence conflicti317R → G in AAH64788 (PubMed:15489334).Curated1
Sequence conflicti583A → V in BAA76390 (PubMed:10231394).Curated1
Sequence conflicti744L → H in AAD24467 (PubMed:10963667).Curated1
Sequence conflicti846H → Y in AAD24467 (PubMed:10963667).Curated1
Sequence conflicti956K → R in AAD24467 (PubMed:10963667).Curated1
Sequence conflicti1068P → L in AAD24467 (PubMed:10963667).Curated1
Sequence conflicti1190F → L in BAA76390 (PubMed:10231394).Curated1
Sequence conflicti1196D → G in BAA76390 (PubMed:10231394).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0516941 – 721Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST721
Alternative sequenceiVSP_051695952Missing in isoform 2, isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_051696967 – 1104Missing in isoform 3. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_0516971177Missing in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB015598 mRNA Translation: BAA36500.1
AF098161 mRNA Translation: AAC80010.1
AF071506 mRNA Translation: AAC79687.1
AB019001 mRNA Translation: BAA76390.2
AF126480 mRNA Translation: AAD24467.1
BC026526 mRNA Translation: AAH26526.1
BC052884 mRNA Translation: AAH52884.1 Sequence problems.
BC058641 mRNA Translation: AAH58641.1
BC064788 mRNA Translation: AAH64788.1 Sequence problems.
BC082770 mRNA Translation: AAH82770.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24266.1 [Q9R1X4-1]
CCDS48724.1 [Q9R1X4-6]
CCDS48725.1 [Q9R1X4-2]

Protein sequence database of the Protein Information Resource

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PIRi
T13956

NCBI Reference Sequences

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RefSeqi
NP_001129554.1, NM_001136082.2 [Q9R1X4-2]
NP_001157552.1, NM_001164080.1 [Q9R1X4-6]
NP_001157553.1, NM_001164081.1 [Q9R1X4-1]
NP_035719.1, NM_011589.2 [Q9R1X4-1]
XP_006513646.1, XM_006513583.3 [Q9R1X4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000055539; ENSMUSP00000058021; ENSMUSG00000039994 [Q9R1X4-1]
ENSMUST00000105242; ENSMUSP00000100876; ENSMUSG00000039994 [Q9R1X4-2]
ENSMUST00000105244; ENSMUSP00000100878; ENSMUSG00000039994 [Q9R1X4-6]
ENSMUST00000105245; ENSMUSP00000100879; ENSMUSG00000039994 [Q9R1X4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
21853

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21853

UCSC genome browser

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UCSCi
uc007hlv.2 mouse [Q9R1X4-1]
uc007hlw.2 mouse [Q9R1X4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015598 mRNA Translation: BAA36500.1
AF098161 mRNA Translation: AAC80010.1
AF071506 mRNA Translation: AAC79687.1
AB019001 mRNA Translation: BAA76390.2
AF126480 mRNA Translation: AAD24467.1
BC026526 mRNA Translation: AAH26526.1
BC052884 mRNA Translation: AAH52884.1 Sequence problems.
BC058641 mRNA Translation: AAH58641.1
BC064788 mRNA Translation: AAH64788.1 Sequence problems.
BC082770 mRNA Translation: AAH82770.1
CCDSiCCDS24266.1 [Q9R1X4-1]
CCDS48724.1 [Q9R1X4-6]
CCDS48725.1 [Q9R1X4-2]
PIRiT13956
RefSeqiNP_001129554.1, NM_001136082.2 [Q9R1X4-2]
NP_001157552.1, NM_001164080.1 [Q9R1X4-6]
NP_001157553.1, NM_001164081.1 [Q9R1X4-1]
NP_035719.1, NM_011589.2 [Q9R1X4-1]
XP_006513646.1, XM_006513583.3 [Q9R1X4-1]

3D structure databases

SMRiQ9R1X4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi204198, 36 interactors
IntActiQ9R1X4, 26 interactors
STRINGi10090.ENSMUSP00000058021

PTM databases

iPTMnetiQ9R1X4
PhosphoSitePlusiQ9R1X4

Proteomic databases

PaxDbiQ9R1X4
PeptideAtlasiQ9R1X4
PRIDEiQ9R1X4

Genome annotation databases

EnsembliENSMUST00000055539; ENSMUSP00000058021; ENSMUSG00000039994 [Q9R1X4-1]
ENSMUST00000105242; ENSMUSP00000100876; ENSMUSG00000039994 [Q9R1X4-2]
ENSMUST00000105244; ENSMUSP00000100878; ENSMUSG00000039994 [Q9R1X4-6]
ENSMUST00000105245; ENSMUSP00000100879; ENSMUSG00000039994 [Q9R1X4-1]
GeneIDi21853
KEGGimmu:21853
UCSCiuc007hlv.2 mouse [Q9R1X4-1]
uc007hlw.2 mouse [Q9R1X4-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8914
MGIiMGI:1321393 Timeless

Phylogenomic databases

eggNOGiKOG1974 Eukaryota
ENOG410XQM6 LUCA
GeneTreeiENSGT00390000015124
InParanoidiQ9R1X4
KOiK03155
OMAiDEEHCKE
OrthoDBi839367at2759
PhylomeDBiQ9R1X4
TreeFamiTF312802

Enzyme and pathway databases

ReactomeiR-MMU-5693607 Processing of DNA double-strand break ends

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Timeless mouse

Protein Ontology

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PROi
PR:Q9R1X4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039994 Expressed in 222 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ9R1X4 baseline and differential
GenevisibleiQ9R1X4 MM

Family and domain databases

InterProiView protein in InterPro
IPR006906 Timeless
IPR007725 TIMELESS_C
PfamiView protein in Pfam
PF04821 TIMELESS, 1 hit
PF05029 TIMELESS_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIM_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R1X4
Secondary accession number(s): Q63ZX9
, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 13, 2019
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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