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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:Calcrl
Synonyms:Crlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1926944 Calcrl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 145ExtracellularSequence analysisAdd BLAST123
Transmembranei146 – 165Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini166 – 172CytoplasmicSequence analysis7
Transmembranei173 – 192Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini193 – 212ExtracellularSequence analysisAdd BLAST20
Transmembranei213 – 235Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini236 – 252CytoplasmicSequence analysisAdd BLAST17
Transmembranei253 – 272Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini273 – 288ExtracellularSequence analysisAdd BLAST16
Transmembranei289 – 312Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini313 – 335CytoplasmicSequence analysisAdd BLAST23
Transmembranei336 – 353Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini354 – 365ExtracellularSequence analysisAdd BLAST12
Transmembranei366 – 387Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini388 – 463CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2034811
GuidetoPHARMACOLOGYi47

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001281223 – 463Calcitonin gene-related peptide type 1 receptorAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 73By similarity
Disulfide bondi64 ↔ 104By similarity
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 126By similarity
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei419PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R1W5
PaxDbiQ9R1W5
PRIDEiQ9R1W5

PTM databases

iPTMnetiQ9R1W5
PhosphoSitePlusiQ9R1W5

Expressioni

Tissue specificityi

Expressed predominantly in the lung, thymus, heart and brain.2 Publications

Gene expression databases

BgeeiENSMUSG00000059588 Expressed in 247 organ(s), highest expression level in lung
CleanExiMM_CALCRL
ExpressionAtlasiQ9R1W5 baseline and differential
GenevisibleiQ9R1W5 MM

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.

Protein-protein interaction databases

ComplexPortaliCPX-3149 CGRP receptor complex
CPX-3150 Adrenomedullin receptor AM1 complex
CPX-3151 Adrenomedullin receptor AM2 complex
STRINGi10090.ENSMUSP00000073875

Chemistry databases

BindingDBiQ9R1W5

Structurei

3D structure databases

ProteinModelPortaliQ9R1W5
SMRiQ9R1W5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00900000140884
HOGENOMiHOG000230695
HOVERGENiHBG102129
InParanoidiQ9R1W5
KOiK04577
OMAiTESMQHC
OrthoDBiEOG091G027C
PhylomeDBiQ9R1W5
TreeFamiTF315710

Family and domain databases

CDDicd15274 7tmB1_calcitonin_R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR003289 GPCR_2_CGRP1_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01351 CGRPRECEPTOR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1W5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKKHILCFL VLLPLNMALI SAESEEGVNQ TDLGVTRNKI MTAQYECYQK
60 70 80 90 100
IMQDPIQQAE GLYCNRTWDG WLCWNDVAAG TESMQYCPDY FQDFDPSEKV
110 120 130 140 150
TKICDQDGHW FRHPDSNRTW TNYTLCNNST HEKVKTALNL FYLTIIGHGL
160 170 180 190 200
SIASLIISLI IFFYFKSLSC QRITLHKNLF FSFICNSIVT IIHLTAVANN
210 220 230 240 250
QALVATNPVS CKVSQFIHLY LMGCNYFWML CEGVYLHTLI VVAVFAEKQH
260 270 280 290 300
LMWYYFLGWG FPLLPACIHA IARSLYYNDN CWISSDTHLL YIIHGPICAA
310 320 330 340 350
LLVNLFFLLN IVRVLITKLK VTHQVESNLY MKAVRATLIL VPLLGIEFVL
360 370 380 390 400
FPWRPEGKVA EEVYDYVMHI LMHFQGLLVA TIFCFFNGEV QAILRRNWNQ
410 420 430 440 450
YKIQFGNGFS HSDALRSASY TVSTISDMQG YSHDCPTEHL NGKSIQDIEN
460
VALKSENMYD LVM
Length:463
Mass (Da):53,265
Last modified:September 26, 2003 - v2
Checksum:i630EC8956A4FB47E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235Y → C in BAA76492 (PubMed:12147211).Curated1
Sequence conflicti458M → T in AAD35021 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015595 mRNA Translation: BAA76492.1
AF146525 mRNA Translation: AAD35021.1
AF209905 mRNA Translation: AAF21037.1
CCDSiCCDS16184.1
RefSeqiNP_061252.2, NM_018782.2
XP_006499981.1, XM_006499918.3
UniGeneiMm.75467

Genome annotation databases

EnsembliENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588
ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588
GeneIDi54598
KEGGimmu:54598
UCSCiuc008kii.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015595 mRNA Translation: BAA76492.1
AF146525 mRNA Translation: AAD35021.1
AF209905 mRNA Translation: AAF21037.1
CCDSiCCDS16184.1
RefSeqiNP_061252.2, NM_018782.2
XP_006499981.1, XM_006499918.3
UniGeneiMm.75467

3D structure databases

ProteinModelPortaliQ9R1W5
SMRiQ9R1W5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3149 CGRP receptor complex
CPX-3150 Adrenomedullin receptor AM1 complex
CPX-3151 Adrenomedullin receptor AM2 complex
STRINGi10090.ENSMUSP00000073875

Chemistry databases

BindingDBiQ9R1W5
ChEMBLiCHEMBL2034811
GuidetoPHARMACOLOGYi47

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9R1W5
PhosphoSitePlusiQ9R1W5

Proteomic databases

MaxQBiQ9R1W5
PaxDbiQ9R1W5
PRIDEiQ9R1W5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588
ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588
GeneIDi54598
KEGGimmu:54598
UCSCiuc008kii.3 mouse

Organism-specific databases

CTDi10203
MGIiMGI:1926944 Calcrl

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00900000140884
HOGENOMiHOG000230695
HOVERGENiHBG102129
InParanoidiQ9R1W5
KOiK04577
OMAiTESMQHC
OrthoDBiEOG091G027C
PhylomeDBiQ9R1W5
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Miscellaneous databases

PROiPR:Q9R1W5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059588 Expressed in 247 organ(s), highest expression level in lung
CleanExiMM_CALCRL
ExpressionAtlasiQ9R1W5 baseline and differential
GenevisibleiQ9R1W5 MM

Family and domain databases

CDDicd15274 7tmB1_calcitonin_R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR003289 GPCR_2_CGRP1_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01351 CGRPRECEPTOR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCALRL_MOUSE
AccessioniPrimary (citable) accession number: Q9R1W5
Secondary accession number(s): Q9QXH8, Q9WUP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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