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Protein

Multidrug resistance-associated protein 6

Gene

Abcc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi661 – 668ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1294 – 1301ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: MGI
  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-382556 ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 6
Alternative name(s):
ATP-binding cassette sub-family C member 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc6
Synonyms:Mrp6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1351634 Abcc6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 37ExtracellularBy similarityAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini59 – 78CytoplasmicBy similarityAdd BLAST20
Transmembranei79 – 99Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini100 – 104ExtracellularBy similarity5
Transmembranei105 – 125Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini126 – 137CytoplasmicBy similarityAdd BLAST12
Transmembranei138 – 155Helical; Name=4PROSITE-ProRule annotationAdd BLAST18
Topological domaini156 – 173ExtracellularBy similarityAdd BLAST18
Transmembranei174 – 194Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini195 – 300CytoplasmicBy similarityAdd BLAST106
Transmembranei301 – 321Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini322 – 347ExtracellularBy similarityAdd BLAST26
Transmembranei348 – 368Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini369 – 424CytoplasmicBy similarityAdd BLAST56
Transmembranei425 – 445Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini446 – 448ExtracellularBy similarity3
Transmembranei449 – 469Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini470 – 531CytoplasmicBy similarityAdd BLAST62
Transmembranei532 – 552Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini553 – 574ExtracellularBy similarityAdd BLAST22
Transmembranei575 – 595Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini596 – 934CytoplasmicBy similarityAdd BLAST339
Transmembranei935 – 955Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini956 – 992ExtracellularBy similarityAdd BLAST37
Transmembranei993 – 1013Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1014 – 1056CytoplasmicBy similarityAdd BLAST43
Transmembranei1057 – 1077Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1078ExtracellularBy similarity1
Transmembranei1079 – 1099Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1100 – 1170CytoplasmicBy similarityAdd BLAST71
Transmembranei1171 – 1191Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1192 – 1193ExtracellularBy similarity2
Transmembranei1194 – 1214Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1215 – 1498CytoplasmicBy similarityAdd BLAST284

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933671 – 1498Multidrug resistance-associated protein 6Add BLAST1498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1281PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9R1S7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9R1S7

PeptideAtlas

More...
PeptideAtlasi
Q9R1S7

PRoteomics IDEntifications database

More...
PRIDEi
Q9R1S7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9R1S7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9R1S7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9R1S7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030834 Expressed in 31 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9R1S7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9R1S7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000002850

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9R1S7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9R1S7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 592ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini627 – 851ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini942 – 1223ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1260 – 1494ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157145

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108314

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9R1S7

KEGG Orthology (KO)

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KOi
K05669

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWADDPT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00IN

TreeFam database of animal gene trees

More...
TreeFami
TF105199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030239 ABCC6
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF339 PTHR24223:SF339, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9R1S7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRGRSMATP GEQCAGLRVW NQTEQEPAAY HLLSLCFVRA ASSWVPPMYL
60 70 80 90 100
WVLGPIYLLY IHRHGRCYLR MSHLFKTKMV LGLALILLYT FNVAVPLWRI
110 120 130 140 150
HQGVPQAPEL LIHPTVWLTT MSFATFLIHM ERRKGVRSSG VLFGYWLLCC
160 170 180 190 200
ILPGINTVQQ ASAGNFRQEP LHHLATYLCL SLVVAELVLS CLVDQPPFFS
210 220 230 240 250
EDSQPLNPCP EAEASFPSKA MFWWASGLLW RGYKKLLGPK DLWSLGRENS
260 270 280 290 300
SEELVSQLER EWRRSCNGLP GHKGHSSVGA PETEAFLQPE RSQRGPLLRA
310 320 330 340 350
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDR NSSAWTGWLL
360 370 380 390 400
AVLMFAAACL QTLFEQQHMY RAKVLQMRLR TAITGLVYRK VLVLSSGSRK
410 420 430 440 450
SSAAGDVVNL VSVDIQRLAE SIIYLNGLWL LFLWIFVCFV YLWQLLGPSA
460 470 480 490 500
LTAVAVFLSL LPLNFFITKK RGFHQEEQMR QKASRARLTS SMLRTVRTIK
510 520 530 540 550
SHGWEHAFLE RLLHIRGQEL SALKTSTLLF SVSLVSFQVS TFLVALVVFA
560 570 580 590 600
VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCI VQARVSFDRL
610 620 630 640 650
AAFLCLEEVD PNGMIASNSR RSSKDRISVH NGTFAWSQES PPCLHGINLT
660 670 680 690 700
VPQGCLLAVV GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV
710 720 730 740 750
QNTSVVENVC FRQELDLPWL QKVLDACALG SDVASFPAGV HTPIGEQGMN
760 770 780 790 800
LSGGQKQRLS LARAVYKKAA IYLLDDPLAA LDAHVSQQVF KQVIGPSGLL
810 820 830 840 850
QGTTRILVTH TLHVLPQADR ILVLANGTIA EMGSYQDLLQ RNGALVGLLD
860 870 880 890 900
GARQPAGTHD AATSDDLGGF PGGGRPTCRP DRPRPTEAAP VKGRSTSEVQ
910 920 930 940 950
MEASLDDPEA TGLTAEEDSV RYGRVKTTIY LSYLRAVGTP LCTYTLFLFL
960 970 980 990 1000
CQQVASFSQG YWLSLWADDP VVDGRQMHAA LRGWVFGLLG CLQAIGLFAS
1010 1020 1030 1040 1050
MAAVFLGGAR ASGLLFRSLL WDVARSPIGF FERTPVGNLL NRFSKETDTV
1060 1070 1080 1090 1100
DVDIPDKLRS LLTYAFGLLE VGLAVTMATP LAIVAILPLM VLYAGFQSLY
1110 1120 1130 1140 1150
VATSCQLRRL ESARYSSVCS HMAETFQGSL VVRAFRAQAS FTAQHDALMD
1160 1170 1180 1190 1200
ENQRVSFPKL VADRWLATNL ELLGNGLVFV AATCAVLSKA HLSAGLVGFS
1210 1220 1230 1240 1250
VSAALQVTQT LQWVVRSWTD LENSMVAVER VQDYARIPKE APWRLPTCAA
1260 1270 1280 1290 1300
QPLWPCGGQI EFRDFGLRHR PELPLAVQGV SLKIHAGEKV GIVGRTGAGK
1310 1320 1330 1340 1350
SSLAWGLLRL QEAAEGNIWI DGVPITHVGL HTLRSRITII PQDPVLFPGS
1360 1370 1380 1390 1400
LRMNLDLLQE HTDEGIWAAL ETVQLKAFVT SLPGQLQYEC AGQGDDLSVG
1410 1420 1430 1440 1450
QKQLLCLARA LLRKTQILIL DEATASVDPG TEMQMQAALE RWFTQCTVLL
1460 1470 1480 1490
IAHRLRSVMD CARVLVMDEG QVAESGSPAQ LLAQKGLFYR LAHESGLA
Length:1,498
Mass (Da):164,857
Last modified:December 14, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F426D8CF629E835
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRV2A0A1B0GRV2_MOUSE
Multidrug resistance-associated pro...
Abcc6
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3R → S in BAA83820 (Ref. 1) Curated1
Sequence conflicti28A → V in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti28A → V in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti95V → M in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti95V → M in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti127L → Q in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti138S → A in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti138S → A in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti151I → V in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti151I → V in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti166F → L in BAA83820 (Ref. 1) Curated1
Sequence conflicti231R → G in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti528L → P in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti572V → L in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti621R → C in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti621R → C in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti706V → A in BAA83820 (Ref. 1) Curated1
Sequence conflicti706V → A in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti706V → A in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti767K → R in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti767K → R in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti839L → P in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti927T → I in BAA83820 (Ref. 1) Curated1
Sequence conflicti927T → I in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti927T → I in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti1058L → Q in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti1368A → T in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti1368A → T in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti1370L → P in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti1401Q → H in BAA83820 (Ref. 1) Curated1
Sequence conflicti1448V → L in BAA83820 (Ref. 1) Curated1
Sequence conflicti1451I → T in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti1477S → N in BAA83820 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB028737 mRNA Translation: BAA83820.1
EF109740 mRNA Translation: ABM89087.1
EF109741 mRNA Translation: ABM89088.1
AC115036 Genomic DNA No translation available.
BC049980 mRNA Translation: AAH49980.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS21272.1

NCBI Reference Sequences

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RefSeqi
NP_061265.2, NM_018795.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.63514

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000002850; ENSMUSP00000002850; ENSMUSG00000030834

Database of genes from NCBI RefSeq genomes

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GeneIDi
27421

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:27421

UCSC genome browser

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UCSCi
uc009gya.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028737 mRNA Translation: BAA83820.1
EF109740 mRNA Translation: ABM89087.1
EF109741 mRNA Translation: ABM89088.1
AC115036 Genomic DNA No translation available.
BC049980 mRNA Translation: AAH49980.1
CCDSiCCDS21272.1
RefSeqiNP_061265.2, NM_018795.2
UniGeneiMm.63514

3D structure databases

ProteinModelPortaliQ9R1S7
SMRiQ9R1S7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002850

PTM databases

iPTMnetiQ9R1S7
PhosphoSitePlusiQ9R1S7
SwissPalmiQ9R1S7

Proteomic databases

MaxQBiQ9R1S7
PaxDbiQ9R1S7
PeptideAtlasiQ9R1S7
PRIDEiQ9R1S7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002850; ENSMUSP00000002850; ENSMUSG00000030834
GeneIDi27421
KEGGimmu:27421
UCSCiuc009gya.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
368
MGIiMGI:1351634 Abcc6

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000157145
HOVERGENiHBG108314
InParanoidiQ9R1S7
KOiK05669
OMAiLWADDPT
OrthoDBiEOG091G00IN
TreeFamiTF105199

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9R1S7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030834 Expressed in 31 organ(s), highest expression level in liver
ExpressionAtlasiQ9R1S7 baseline and differential
GenevisibleiQ9R1S7 MM

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030239 ABCC6
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF339 PTHR24223:SF339, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9R1S7
Secondary accession number(s): A2TAJ0
, A2TAJ1, F8VPT2, Q80YB6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 14, 2011
Last modified: December 5, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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