Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tripartite motif-containing protein 3

Gene

Trim3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (PubMed:24086586).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 63RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri110 – 151B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 3
Alternative name(s):
RING finger protein 22
RING finger protein HAC1
Gene namesi
Name:Trim3
Synonyms:Hac1, Rnf22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1860040 Trim3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome, Golgi apparatus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000561982 – 744Tripartite motif-containing protein 3Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9R1R2
PaxDbiQ9R1R2
PRIDEiQ9R1R2

PTM databases

iPTMnetiQ9R1R2
PhosphoSitePlusiQ9R1R2

Expressioni

Gene expression databases

BgeeiENSMUSG00000036989 Expressed in 271 organ(s), highest expression level in cerebellum
CleanExiMM_TRIM3
ExpressionAtlasiQ9R1R2 baseline and differential
GenevisibleiQ9R1R2 MM

Interactioni

Subunit structurei

Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3 (By similarity). Interacts with ZFYVE28/LST2 (By similarity). Interacts with KIF21B (PubMed:24086586).By similarity1 Publication

Protein-protein interaction databases

BioGridi207763, 10 interactors
IntActiQ9R1R2, 11 interactors
MINTiQ9R1R2
STRINGi10090.ENSMUSP00000053384

Structurei

3D structure databases

ProteinModelPortaliQ9R1R2
SMRiQ9R1R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati317 – 418FilaminAdd BLAST102
Repeati473 – 516NHL 1Add BLAST44
Repeati520 – 563NHL 2Add BLAST44
Repeati564 – 605NHL 3Add BLAST42
Repeati609 – 652NHL 4Add BLAST44
Repeati656 – 699NHL 5Add BLAST44
Repeati700 – 743NHL 6Add BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 290Interaction with KIF21B1 PublicationAdd BLAST289

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 224Sequence analysisAdd BLAST72

Domaini

The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 63RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri110 – 151B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF9 Eukaryota
ENOG410ZAM4 LUCA
GeneTreeiENSGT00920000148978
HOGENOMiHOG000220817
HOVERGENiHBG054843
InParanoidiQ9R1R2
KOiK11997
OMAiPEHPHEN
OrthoDBiEOG091G06IK
PhylomeDBiQ9R1R2
TreeFamiTF331018

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di2.120.10.30, 2 hits
2.60.40.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003649 Bbox_C
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00630 Filamin, 1 hit
PF01436 NHL, 6 hits
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 1 hit
SM00557 IG_FLMN, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50194 FILAMIN_REPEAT, 1 hit
PS51125 NHL, 6 hits
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9R1R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKREDSPGP EVQPMDKQFL VCSICLDRYR CPKVLPCLHT FCERCLQNYI
60 70 80 90 100
PPQSLTLSCP VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPEGAHDPE
110 120 130 140 150
DPHPLSAVAG RPLSCPNHEG KTMEFYCEAC ETAMCGECRA GEHREHGTVL
160 170 180 190 200
LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI ALVGGISQQL QERKAEALAQ
210 220 230 240 250
ISAAFEDLEQ ALQQRKQALV SDLESICGAK QKVLQTQLDT LRQGQEHIGS
260 270 280 290 300
SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL
310 320 330 340 350
EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK
360 370 380 390 400
DGRLVRTGSA ELCAEITGPD GVRLAVPVVD HKNGTYELVY TARTEGDLLL
410 420 430 440 450
SVLLYGQPVR GSPFRVRALR PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV
460 470 480 490 500
RRPSSMYSTG GKRKDNPIED ELVFRVGSRG REKGEFTNLQ GVSAASSGRI
510 520 530 540 550
VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA VDTNGDIIVA
560 570 580 590 600
DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF
610 620 630 640 650
TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS
660 670 680 690 700
ADGEFLFKFG SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG
710 720 730 740
SFLSYINTSA EPLYGPQGLA LTSDGHVVVA DAGNHCFKAY RYLQ
Length:744
Mass (Da):80,774
Last modified:May 1, 2000 - v1
Checksum:iD9AEF4FA264BA168
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TDT0Q3TDT0_MOUSE
Tripartite motif-containing protein...
Trim3
717Annotation score:
D3YUY7D3YUY7_MOUSE
Tripartite motif protein 3, isoform...
Trim3 mCG_19734
744Annotation score:
D3Z7V9D3Z7V9_MOUSE
Tripartite motif-containing protein...
Trim3
287Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030912 mRNA Translation: BAA83343.1
AF220019 mRNA Translation: AAG53473.1
AK019165 mRNA Translation: BAB31580.1
AK144674 mRNA Translation: BAE26003.1
BC034263 mRNA Translation: AAH34263.1
CCDSiCCDS21655.1
RefSeqiNP_001272799.1, NM_001285870.1
NP_001272800.1, NM_001285871.1
NP_001272802.1, NM_001285873.1
NP_061368.1, NM_018880.3
UniGeneiMm.29290
Mm.326799

Genome annotation databases

EnsembliENSMUST00000057525; ENSMUSP00000053384; ENSMUSG00000036989
ENSMUST00000106789; ENSMUSP00000102401; ENSMUSG00000036989
ENSMUST00000147044; ENSMUSP00000114822; ENSMUSG00000036989
GeneIDi55992
KEGGimmu:55992
UCSCiuc009iym.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030912 mRNA Translation: BAA83343.1
AF220019 mRNA Translation: AAG53473.1
AK019165 mRNA Translation: BAB31580.1
AK144674 mRNA Translation: BAE26003.1
BC034263 mRNA Translation: AAH34263.1
CCDSiCCDS21655.1
RefSeqiNP_001272799.1, NM_001285870.1
NP_001272800.1, NM_001285871.1
NP_001272802.1, NM_001285873.1
NP_061368.1, NM_018880.3
UniGeneiMm.29290
Mm.326799

3D structure databases

ProteinModelPortaliQ9R1R2
SMRiQ9R1R2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207763, 10 interactors
IntActiQ9R1R2, 11 interactors
MINTiQ9R1R2
STRINGi10090.ENSMUSP00000053384

PTM databases

iPTMnetiQ9R1R2
PhosphoSitePlusiQ9R1R2

Proteomic databases

MaxQBiQ9R1R2
PaxDbiQ9R1R2
PRIDEiQ9R1R2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057525; ENSMUSP00000053384; ENSMUSG00000036989
ENSMUST00000106789; ENSMUSP00000102401; ENSMUSG00000036989
ENSMUST00000147044; ENSMUSP00000114822; ENSMUSG00000036989
GeneIDi55992
KEGGimmu:55992
UCSCiuc009iym.2 mouse

Organism-specific databases

CTDi10612
MGIiMGI:1860040 Trim3

Phylogenomic databases

eggNOGiENOG410ITF9 Eukaryota
ENOG410ZAM4 LUCA
GeneTreeiENSGT00920000148978
HOGENOMiHOG000220817
HOVERGENiHBG054843
InParanoidiQ9R1R2
KOiK11997
OMAiPEHPHEN
OrthoDBiEOG091G06IK
PhylomeDBiQ9R1R2
TreeFamiTF331018

Miscellaneous databases

ChiTaRSiTrim3 mouse
PROiPR:Q9R1R2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036989 Expressed in 271 organ(s), highest expression level in cerebellum
CleanExiMM_TRIM3
ExpressionAtlasiQ9R1R2 baseline and differential
GenevisibleiQ9R1R2 MM

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di2.120.10.30, 2 hits
2.60.40.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003649 Bbox_C
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00630 Filamin, 1 hit
PF01436 NHL, 6 hits
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 1 hit
SM00557 IG_FLMN, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50194 FILAMIN_REPEAT, 1 hit
PS51125 NHL, 6 hits
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRIM3_MOUSE
AccessioniPrimary (citable) accession number: Q9R1R2
Secondary accession number(s): Q3UMU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again