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Protein

Transgelin-3

Gene

Tagln3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin-3
Alternative name(s):
Neuronal protein NP25
Gene namesi
Name:Tagln3
Synonyms:Np25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1926784 Tagln3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047891 – 199Transgelin-3Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9R1Q8
MaxQBiQ9R1Q8
PaxDbiQ9R1Q8
PeptideAtlasiQ9R1Q8
PRIDEiQ9R1Q8

PTM databases

iPTMnetiQ9R1Q8
PhosphoSitePlusiQ9R1Q8

Expressioni

Gene expression databases

BgeeiENSMUSG00000022658 Expressed in 241 organ(s), highest expression level in cerebellum
CleanExiMM_TAGLN3
GenevisibleiQ9R1Q8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207932, 1 interactor
IntActiQ9R1Q8, 3 interactors
MINTiQ9R1Q8
STRINGi10090.ENSMUSP00000093762

Structurei

3D structure databases

ProteinModelPortaliQ9R1Q8
SMRiQ9R1Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 136Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST113
Repeati174 – 199Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiQ9R1Q8
KOiK20526
OMAiETQMAFK
OrthoDBiEOG091G0LY2
PhylomeDBiQ9R1Q8
TreeFamiTF313921

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029973 TAGLN3
PANTHERiPTHR18959:SF57 PTHR18959:SF57, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R1Q8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA
60 70 80 90 100
HFQKWLMDGT VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA
110 120 130 140 150
EVYGVRTTDI FQTVDLWEGK DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW
160 170 180 190
FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS NKGASQAGMT GYGMPRQIM
Length:199
Mass (Da):22,471
Last modified:May 1, 2000 - v1
Checksum:i53802F6F94958202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031291 mRNA Translation: BAA83499.1
BC043027 mRNA Translation: AAH43027.1
BC055338 mRNA Translation: AAH55338.1
CCDSiCCDS28200.1
RefSeqiNP_062728.1, NM_019754.3
UniGeneiMm.24183

Genome annotation databases

EnsembliENSMUST00000096057; ENSMUSP00000093762; ENSMUSG00000022658
GeneIDi56370
KEGGimmu:56370
UCSCiuc007ziw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031291 mRNA Translation: BAA83499.1
BC043027 mRNA Translation: AAH43027.1
BC055338 mRNA Translation: AAH55338.1
CCDSiCCDS28200.1
RefSeqiNP_062728.1, NM_019754.3
UniGeneiMm.24183

3D structure databases

ProteinModelPortaliQ9R1Q8
SMRiQ9R1Q8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207932, 1 interactor
IntActiQ9R1Q8, 3 interactors
MINTiQ9R1Q8
STRINGi10090.ENSMUSP00000093762

PTM databases

iPTMnetiQ9R1Q8
PhosphoSitePlusiQ9R1Q8

Proteomic databases

EPDiQ9R1Q8
MaxQBiQ9R1Q8
PaxDbiQ9R1Q8
PeptideAtlasiQ9R1Q8
PRIDEiQ9R1Q8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096057; ENSMUSP00000093762; ENSMUSG00000022658
GeneIDi56370
KEGGimmu:56370
UCSCiuc007ziw.1 mouse

Organism-specific databases

CTDi29114
MGIiMGI:1926784 Tagln3

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiQ9R1Q8
KOiK20526
OMAiETQMAFK
OrthoDBiEOG091G0LY2
PhylomeDBiQ9R1Q8
TreeFamiTF313921

Miscellaneous databases

ChiTaRSiTagln3 mouse
PROiPR:Q9R1Q8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022658 Expressed in 241 organ(s), highest expression level in cerebellum
CleanExiMM_TAGLN3
GenevisibleiQ9R1Q8 MM

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029973 TAGLN3
PANTHERiPTHR18959:SF57 PTHR18959:SF57, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL3_MOUSE
AccessioniPrimary (citable) accession number: Q9R1Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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