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Protein

Transmembrane protein 176B

Gene

Tmem176b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells.By similarity1 Publication

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • negative regulation of dendritic cell differentiation Source: MGI

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 176B
Alternative name(s):
Protein LR8
Gene namesi
Name:Tmem176b
Synonyms:Clast1, Lr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916348 Tmem176b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice exhibit abnormal development of the cerebellum and severe ataxia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002798761 – 263Transmembrane protein 176BAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei253PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9R1Q6
MaxQBiQ9R1Q6
PaxDbiQ9R1Q6
PeptideAtlasiQ9R1Q6
PRIDEiQ9R1Q6

PTM databases

iPTMnetiQ9R1Q6
PhosphoSitePlusiQ9R1Q6
SwissPalmiQ9R1Q6

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in lung, liver, kidney and colon. Expressed in cerebellar granule cells.1 Publication

Developmental stagei

Expressed in the developing cerebellum at constant levels from E18 to P7.1 Publication

Gene expression databases

BgeeiENSMUSG00000029810 Expressed in 313 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_TMEM176B
ExpressionAtlasiQ9R1Q6 baseline and differential
GenevisibleiQ9R1Q6 MM

Interactioni

Protein-protein interaction databases

BioGridi211160, 1 interactor
STRINGi10090.ENSMUSP00000098972

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM176 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXII Eukaryota
ENOG410ZDNZ LUCA
GeneTreeiENSGT00530000064074
HOGENOMiHOG000290691
HOVERGENiHBG094020
InParanoidiQ9R1Q6
OMAiLSQPTHI
OrthoDBiEOG091G0OE0
PhylomeDBiQ9R1Q6
TreeFamiTF335389

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR009281 TMEM176A/TMEM176B
PANTHERiPTHR15756 PTHR15756, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9R1Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQSTVTVNG VKVASTHPQS AHISIHIHQK SALEQLLGAV GSLKKFLSWP
60 70 80 90 100
QARIHYGQLS LGVTQILLGL VSCALGVCLY FGPWTELCAF GCAFWSGSVA
110 120 130 140 150
ILAGVGTIVH EKRQGKLSGQ VSCLLLLACI ATAAAATVLG VNSLIRQTSV
160 170 180 190 200
PYYVEIFSTC NPLQSSMDPG YGTVRYSDDS DWKTERCREY LNMMMNLFLA
210 220 230 240 250
FCIMLTVVCI LEIVVSVASL GLSLRSMYGR SSQALNEEES ERKLLDGHPA
260
PASPAKEKIP AIL
Length:263
Mass (Da):28,367
Last modified:May 1, 2000 - v1
Checksum:i4D2C11EA67EB357C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SUS9A0A0N4SUS9_MOUSE
Transmembrane protein 176B
Tmem176b
69Annotation score:
A0A0N4SV46A0A0N4SV46_MOUSE
Transmembrane protein 176B
Tmem176b
196Annotation score:
A0A0N4SUM7A0A0N4SUM7_MOUSE
Transmembrane protein 176B
Tmem176b
172Annotation score:
A0A0N4SUY1A0A0N4SUY1_MOUSE
Transmembrane protein 176B
Tmem176b
194Annotation score:
A0A0N4SVT4A0A0N4SVT4_MOUSE
Transmembrane protein 176B
Tmem176b
195Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54I → V in AAD28721 (PubMed:9922225).Curated1
Sequence conflicti260P → S in AAD28721 (PubMed:9922225).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115426 mRNA Translation: AAD28721.1
AB031386 mRNA Translation: BAA83596.1
AK007408 mRNA Translation: BAB25020.1
AK156042 mRNA Translation: BAE33560.1
CT010176 mRNA Translation: CAJ18384.1
BC019539 mRNA Translation: AAH19539.1
BC022166 mRNA Translation: AAH22166.1
CCDSiCCDS20116.1
RefSeqiNP_001157679.1, NM_001164207.1
NP_001157680.1, NM_001164208.1
NP_001157681.1, NM_001164209.2
NP_001273580.1, NM_001286651.1
NP_001273581.1, NM_001286652.1
NP_075543.1, NM_023056.4
XP_006506519.1, XM_006506456.3
XP_006506520.1, XM_006506457.3
XP_006506521.1, XM_006506458.3
XP_006506522.1, XM_006506459.3
XP_006506523.1, XM_006506460.3
XP_006506524.1, XM_006506461.3
XP_017177199.1, XM_017321710.1
UniGeneiMm.28385

Genome annotation databases

EnsembliENSMUST00000101429; ENSMUSP00000098972; ENSMUSG00000029810
ENSMUST00000164733; ENSMUSP00000128705; ENSMUSG00000029810
ENSMUST00000166247; ENSMUSP00000131064; ENSMUSG00000029810
ENSMUST00000203355; ENSMUSP00000145395; ENSMUSG00000029810
ENSMUST00000204073; ENSMUSP00000144864; ENSMUSG00000029810
GeneIDi65963
KEGGimmu:65963
UCSCiuc009bvu.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115426 mRNA Translation: AAD28721.1
AB031386 mRNA Translation: BAA83596.1
AK007408 mRNA Translation: BAB25020.1
AK156042 mRNA Translation: BAE33560.1
CT010176 mRNA Translation: CAJ18384.1
BC019539 mRNA Translation: AAH19539.1
BC022166 mRNA Translation: AAH22166.1
CCDSiCCDS20116.1
RefSeqiNP_001157679.1, NM_001164207.1
NP_001157680.1, NM_001164208.1
NP_001157681.1, NM_001164209.2
NP_001273580.1, NM_001286651.1
NP_001273581.1, NM_001286652.1
NP_075543.1, NM_023056.4
XP_006506519.1, XM_006506456.3
XP_006506520.1, XM_006506457.3
XP_006506521.1, XM_006506458.3
XP_006506522.1, XM_006506459.3
XP_006506523.1, XM_006506460.3
XP_006506524.1, XM_006506461.3
XP_017177199.1, XM_017321710.1
UniGeneiMm.28385

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211160, 1 interactor
STRINGi10090.ENSMUSP00000098972

PTM databases

iPTMnetiQ9R1Q6
PhosphoSitePlusiQ9R1Q6
SwissPalmiQ9R1Q6

Proteomic databases

EPDiQ9R1Q6
MaxQBiQ9R1Q6
PaxDbiQ9R1Q6
PeptideAtlasiQ9R1Q6
PRIDEiQ9R1Q6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101429; ENSMUSP00000098972; ENSMUSG00000029810
ENSMUST00000164733; ENSMUSP00000128705; ENSMUSG00000029810
ENSMUST00000166247; ENSMUSP00000131064; ENSMUSG00000029810
ENSMUST00000203355; ENSMUSP00000145395; ENSMUSG00000029810
ENSMUST00000204073; ENSMUSP00000144864; ENSMUSG00000029810
GeneIDi65963
KEGGimmu:65963
UCSCiuc009bvu.3 mouse

Organism-specific databases

CTDi28959
MGIiMGI:1916348 Tmem176b

Phylogenomic databases

eggNOGiENOG410IXII Eukaryota
ENOG410ZDNZ LUCA
GeneTreeiENSGT00530000064074
HOGENOMiHOG000290691
HOVERGENiHBG094020
InParanoidiQ9R1Q6
OMAiLSQPTHI
OrthoDBiEOG091G0OE0
PhylomeDBiQ9R1Q6
TreeFamiTF335389

Miscellaneous databases

ChiTaRSiTmem176b mouse
PROiPR:Q9R1Q6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029810 Expressed in 313 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_TMEM176B
ExpressionAtlasiQ9R1Q6 baseline and differential
GenevisibleiQ9R1Q6 MM

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR009281 TMEM176A/TMEM176B
PANTHERiPTHR15756 PTHR15756, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT176B_MOUSE
AccessioniPrimary (citable) accession number: Q9R1Q6
Secondary accession number(s): Q9WU52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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