UniProtKB - Q9R1M7 (NMD3A_RAT)
Glutamate receptor ionotropic, NMDA 3A
Grin3a
Functioni
GO - Molecular functioni
- calcium channel activity Source: RGD
- glycine binding Source: UniProtKB
- identical protein binding Source: RGD
- ionotropic glutamate receptor activity Source: RGD
- ligand-gated ion channel activity Source: GO_Central
- neurotransmitter binding Source: RGD
- NMDA glutamate receptor activity Source: RGD
- protein phosphatase 2A binding Source: UniProtKB
- signaling receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: RGD
GO - Biological processi
- calcium ion transport Source: UniProtKB
- dendrite development Source: RGD
- ionotropic glutamate receptor signaling pathway Source: RGD
- prepulse inhibition Source: RGD
- regulation of synaptic vesicle exocytosis Source: RGD
- response to ethanol Source: RGD
- rhythmic process Source: RGD
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Calcium, Magnesium |
Enzyme and pathway databases
Reactomei | R-RNO-9609736, Assembly and cell surface presentation of NMDA receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptor ionotropic, NMDA 3AShort name: GluN3A Alternative name(s): Glutamate receptor chi-1 N-methyl-D-aspartate receptor N-methyl-D-aspartate receptor subtype 3A Short name: NMDAR3A Short name: NR3A NMDAR-L NMDAR-L1 |
Gene namesi | Name:Grin3a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621704, Grin3a |
Subcellular locationi
Plasma membrane
Other locations
Note: Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane.
Plasma Membrane
- NMDA selective glutamate receptor complex Source: UniProtKB
- plasma membrane Source: GO_Central
- postsynaptic membrane Source: RGD
Other locations
- glutamatergic synapse Source: RGD
- membrane Source: RGD
- neuron projection Source: RGD
- neuronal cell body Source: RGD
- postsynaptic density Source: UniProtKB-SubCell
- synapse Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 674 | ExtracellularSequence analysisAdd BLAST | 651 | |
Transmembranei | 675 – 695 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 696 – 748 | CytoplasmicSequence analysisAdd BLAST | 53 | |
Transmembranei | 749 – 769 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 770 – 930 | ExtracellularSequence analysisAdd BLAST | 161 | |
Transmembranei | 931 – 951 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 952 – 1135 | CytoplasmicSequence analysisAdd BLAST | 184 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000011569 | 24 – 1135 | Glutamate receptor ionotropic, NMDA 3AAdd BLAST | 1112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 275 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 285 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 296 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 426 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 549 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 565 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 886 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9R1M7 |
PRIDEi | Q9R1M7 |
PTM databases
GlyGeni | Q9R1M7, 11 sites |
iPTMneti | Q9R1M7 |
PhosphoSitePlusi | Q9R1M7 |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
Subunit structurei
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels.
Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA.
4 PublicationsGO - Molecular functioni
- identical protein binding Source: RGD
- protein phosphatase 2A binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 251320, 2 interactors |
CORUMi | Q9R1M7 |
IntActi | Q9R1M7, 2 interactors |
STRINGi | 10116.ENSRNOP00000007957 |
Chemistry databases
BindingDBi | Q9R1M7 |
Structurei
Secondary structure
3D structure databases
SMRi | Q9R1M7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9R1M7 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 951 – 987 | PPP2CB binding siteAdd BLAST | 37 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1080 – 1129 | Sequence analysisAdd BLAST | 50 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1053, Eukaryota |
InParanoidi | Q9R1M7 |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q9R1M7 |
TreeFami | TF314731 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV
60 70 80 90 100
GAVHLQPWTT APRAASRAQE GGRAGAQRDD PESGTWRPPA PSQGARWLGS
110 120 130 140 150
ALHGRGPPGS RKLGEGAGAE TLWPRDALLF AVENLNRVEG LLPYNLSLEV
160 170 180 190 200
VMAIEAGLGD LPLMPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP
210 220 230 240 250
QSQGEMMELD LVSSVLHIPV LSIVRHEFPR ESQNPLHLQL SLENSLSSDA
260 270 280 290 300
DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTENNSKFH LESVINITAN
310 320 330 340 350
LSSTKDLLSF LQVQMDNIRN STPTMVMFGC DMDSIRQIFE MSTQFGLSPP
360 370 380 390 400
ELHWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEYYVQ DAMELVARAV
410 420 430 440 450
ATATMIQPEL ALLPSTMNCM DVKTTNLTSG QYLSRFLANT TFRGLSGSIK
460 470 480 490 500
VKGSTIISSE NNFFIWNLQH DPMGKPMWTR LGSWQGGRIV MDSGIWPEQA
510 520 530 540 550
QRHKTHFQHP NKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND
560 570 580 590 600
SSMLDRLFSS LHSSNDTVPI KFKKCCYGYC IDLLEQLAED MNFDFDLYIV
610 620 630 640 650
GDGKYGAWKN GHWTGLVGDL LSGTANMAVT SFSINTARSQ VIDFTSPFFS
660 670 680 690 700
TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAI FLTLYEWKSP
710 720 730 740 750
FGMTPKGRNR NKVFSFSSAL NVCYALLFGR TAAIKPPKCW TGRFLMNLWA
760 770 780 790 800
IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES
810 820 830 840 850
SAEDYVRQSF PEMHEYMRRY NVPATPDGVQ YLKNDPEKLD AFIMDKALLD
860 870 880 890 900
YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTSNISEL ISQYKSHGFM
910 920 930 940 950
DVLHDKWYKV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI
960 970 980 990 1000
GEHIVHRLLL PRIKNKSKLQ YWLHTSQRFH RALNTSFVEE KQPRSKTKRV
1010 1020 1030 1040 1050
EKSRWRRWTC KTEGDSELSL FPRSNLGPQQ LMVWNTSNLS HDNQRKYIFN
1060 1070 1080 1090 1100
DEEGQNQLGT QAHQDIPLPQ RRRELPASLT TNGKADSLNV TRSSVIQELS
1110 1120 1130
ELEKQIQVIR QELQLAVSRK TELEEYQKTN RTCES
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A096MIS4 | A0A096MIS4_RAT | Glutamate receptor | Grin3a | 903 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011512 | 1003 – 1022 | Missing in isoform 2. 2 PublicationsAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L34938 mRNA Translation: AAA99501.1 U29873 mRNA Translation: AAB58957.1 AF073379 mRNA Translation: AAD41650.1 AF061945 mRNA Translation: AAD11811.1 |
PIRi | T31068 |
RefSeqi | NP_001185512.1, NM_001198583.2 [Q9R1M7-2] NP_612555.1, NM_138546.2 [Q9R1M7-1] |
Genome annotation databases
GeneIDi | 191573 |
KEGGi | rno:191573 |
UCSCi | RGD:621704, rat [Q9R1M7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L34938 mRNA Translation: AAA99501.1 U29873 mRNA Translation: AAB58957.1 AF073379 mRNA Translation: AAD41650.1 AF061945 mRNA Translation: AAD11811.1 |
PIRi | T31068 |
RefSeqi | NP_001185512.1, NM_001198583.2 [Q9R1M7-2] NP_612555.1, NM_138546.2 [Q9R1M7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RC7 | X-ray | 1.58 | A/B | 511-660 | [»] | |
A/B | 776-915 | [»] | ||||
2RC8 | X-ray | 1.45 | A/B | 511-660 | [»] | |
A/B | 776-915 | [»] | ||||
2RC9 | X-ray | 1.96 | A/B | 511-660 | [»] | |
A/B | 776-915 | [»] | ||||
4KCD | X-ray | 1.68 | A/B | 511-660 | [»] | |
A/B | 776-915 | [»] | ||||
SMRi | Q9R1M7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 251320, 2 interactors |
CORUMi | Q9R1M7 |
IntActi | Q9R1M7, 2 interactors |
STRINGi | 10116.ENSRNOP00000007957 |
Chemistry databases
BindingDBi | Q9R1M7 |
ChEMBLi | CHEMBL342 |
DrugCentrali | Q9R1M7 |
PTM databases
GlyGeni | Q9R1M7, 11 sites |
iPTMneti | Q9R1M7 |
PhosphoSitePlusi | Q9R1M7 |
Proteomic databases
PaxDbi | Q9R1M7 |
PRIDEi | Q9R1M7 |
Protocols and materials databases
ABCDi | Q9R1M7, 1 sequenced antibody |
Genome annotation databases
GeneIDi | 191573 |
KEGGi | rno:191573 |
UCSCi | RGD:621704, rat [Q9R1M7-1] |
Organism-specific databases
CTDi | 116443 |
RGDi | 621704, Grin3a |
Phylogenomic databases
eggNOGi | KOG1053, Eukaryota |
InParanoidi | Q9R1M7 |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q9R1M7 |
TreeFami | TF314731 |
Enzyme and pathway databases
Reactomei | R-RNO-9609736, Assembly and cell surface presentation of NMDA receptors |
Miscellaneous databases
EvolutionaryTracei | Q9R1M7 |
PROi | PR:Q9R1M7 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NMD3A_RAT | |
Accessioni | Q9R1M7Primary (citable) accession number: Q9R1M7 Secondary accession number(s): O09098 Q9Z2H0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families