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Protein

Connective tissue growth factor

Gene

Ctgf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).By similarity

GO - Molecular functioni

  • fibronectin binding Source: RGD
  • growth factor activity Source: RGD
  • heparin binding Source: GO_Central
  • insulin-like growth factor binding Source: InterPro
  • integrin binding Source: GO_Central
  • protein C-terminus binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion, DNA synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Connective tissue growth-related protein
Gene namesi
Name:Ctgf
Synonyms:Ccn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621392 Ctgf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001440525 – 347Connective tissue growth factorAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi254 ↔ 291By similarity
Disulfide bondi271 ↔ 305By similarity
Disulfide bondi282 ↔ 321By similarity
Disulfide bondi285 ↔ 323By similarity
Disulfide bondi290 ↔ 327By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9R1E9
PRIDEiQ9R1E9

Expressioni

Gene expression databases

BgeeiENSRNOG00000015036 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ9R1E9 baseline and differential
GenevisibleiQ9R1E9 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020528

Structurei

3D structure databases

ProteinModelPortaliQ9R1E9
SMRiQ9R1E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 96IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST72
Domaini99 – 165VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini196 – 241TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini254 – 328CTCKPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni245 – 347Heparin-bindingBy similarityAdd BLAST103

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH0W Eukaryota
ENOG4111F77 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiQ9R1E9
KOiK06827
OMAiCTPHRTA
OrthoDBiEOG091G0SQP
PhylomeDBiQ9R1E9
TreeFamiTF326070

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9R1E9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLASVAGPVS LALVLLLCTR PATGQDCSAQ CQCAAEAAPR CPAGVSLVLD
60 70 80 90 100
GCGCCRVCAK QLGELCTERD PCDPHKGLFC DFGSPANRKI GVCTAKDGAP
110 120 130 140 150
CVFGGSVYRS GESFQSSCKY QCTCLDGAVG CVPLCSMDVR LPSPDCPFPR
160 170 180 190 200
RVKLPGKCCE EWVCDEPKDR TVVGPALAAY RLEDTFGPDP TMMRANCLVQ
210 220 230 240 250
TTEWSACSKT CGMGISTRVT NDNTFCRLEK QSRLCMVRPC EADLEENIKK
260 270 280 290 300
GKKCIRTPKI AKPVKFELSG CTSVKTYRAK FCGVCTDGRC CTPHRTTTLP
310 320 330 340
VEFKCPDGEI MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA
Length:347
Mass (Da):37,756
Last modified:May 1, 2000 - v1
Checksum:iCFBE1A19766B7B16
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6IN11Q6IN11_RAT
Connective tissue growth factor
Ctgf
287Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35A → R in BAA82125 (PubMed:10393331).Curated1
Sequence conflicti94T → P in BAA82125 (PubMed:10393331).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120275 mRNA Translation: AAD39132.1
AB023068 mRNA Translation: BAA82125.1
AY596447 Transcribed RNA Translation: AAT08023.1
RefSeqiNP_071602.1, NM_022266.2
UniGeneiRn.17145

Genome annotation databases

EnsembliENSRNOT00000020528; ENSRNOP00000020528; ENSRNOG00000015036
GeneIDi64032
KEGGirno:64032

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120275 mRNA Translation: AAD39132.1
AB023068 mRNA Translation: BAA82125.1
AY596447 Transcribed RNA Translation: AAT08023.1
RefSeqiNP_071602.1, NM_022266.2
UniGeneiRn.17145

3D structure databases

ProteinModelPortaliQ9R1E9
SMRiQ9R1E9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020528

Proteomic databases

PaxDbiQ9R1E9
PRIDEiQ9R1E9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020528; ENSRNOP00000020528; ENSRNOG00000015036
GeneIDi64032
KEGGirno:64032

Organism-specific databases

CTDi1490
RGDi621392 Ctgf

Phylogenomic databases

eggNOGiENOG410IH0W Eukaryota
ENOG4111F77 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiQ9R1E9
KOiK06827
OMAiCTPHRTA
OrthoDBiEOG091G0SQP
PhylomeDBiQ9R1E9
TreeFamiTF326070

Miscellaneous databases

PROiPR:Q9R1E9

Gene expression databases

BgeeiENSRNOG00000015036 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ9R1E9 baseline and differential
GenevisibleiQ9R1E9 RN

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTGF_RAT
AccessioniPrimary (citable) accession number: Q9R1E9
Secondary accession number(s): Q53YJ0, Q9WVS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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