UniProtKB - Q9R1E6 (ENPP2_MOUSE)
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>sp|Q9R1E6|ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 OS=Mus musculus OX=10090 GN=Enpp2 PE=1 SV=3 MARQGCFGSYQVISLFTFAIGVNLCLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKG RCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCS EDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKK GSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDAT FHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERP SVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHG MEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHF KPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKV NSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFR PTLPEEVSRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGR PAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSP GFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLV KKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQP ADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRK TSRSYSEILTLKTYLHTYESEICommunity curation ()Add a publicationFeedback
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Enpp2
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:17208043, PubMed:28414242, PubMed:27780639).
Major substrate is lysophosphatidylcholine (PubMed:17208043, PubMed:27780639).
Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:18175805).
Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition (By similarity).
Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity).
Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity).
By similarity<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
1 Publication<p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
- Ref.7"Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression."
Boucher J., Quilliot D., Pradere J.P., Simon M.F., Gres S., Guigne C., Prevot D., Ferry G., Boutin J.A., Carpene C., Valet P., Saulnier-Blache J.S.
Diabetologia 48:569-577(2005) [PubMed] [Europe PMC] [Abstract]Cited for: INDUCTION, POSSIBLE FUNCTION IN OBESITY.
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY. - Ref.8"Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase."
Pradere J.P., Tarnus E., Gres S., Valet P., Saulnier-Blache J.S.
Biochim. Biophys. Acta 1771:93-102(2007) [PubMed] [Europe PMC] [Abstract]Cited for: PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION, FUNCTION, CATALYTIC ACTIVITY, GLYCOSYLATION, MUTAGENESIS OF 12-VAL--VAL-22; 12-VAL--GLY-27; 23-ASN--GLY-27; CYS-25; GLY-27; 27-GLY--ALA-30; 27-GLY--ARG-35; 30-ALA--ILE-33; 30-ALA--GLY-41; 32-ARG--ARG-35; 36-ALA--GLU-40; ASN-53 AND ASN-410. - Ref.11"Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis."
Desroy N., Housseman C., Bock X., Joncour A., Bienvenu N., Cherel L., Labeguere V., Rondet E., Peixoto C., Grassot J.M., Picolet O., Annoot D., Triballeau N., Monjardet A., Wakselman E., Roncoroni V., Le Tallec S., Blanque R. , Cottereaux C., Vandervoort N., Christophe T., Mollat P., Lamers M., Auberval M., Hrvacic B., Ralic J., Oste L., van der Aar E., Brys R., Heckmann B.
J. Med. Chem. 60:3580-3590(2017) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. - Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249. - Ref.15"Discovery of potent inhibitors of the lysophospholipase autotaxin."
Shah P., Cheasty A., Foxton C., Raynham T., Farooq M., Gutierrez I.F., Lejeune A., Pritchard M., Turnbull A., Pang L., Owen P., Boyd S., Stowell A., Jordan A., Hamilton N.M., Hitchin J.R., Stockley M., MacDonald E. , Quesada M.J., Trivier E., Skeete J., Ovaa H., Moolenaar W.H., Ryder H.
Bioorg. Med. Chem. Lett. 26:5403-5410(2016) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 36-862 IN COMPLEX WITH SYNTHETIC INHIBITOR; CALCIUM AND ZINC, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, GLYCOSYLATION AT ASN-410 AND ASN-524, DISULFIDE BONDS.
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi
- 1-O-alkyl-sn-glycero-3-phosphoethanolamineEC:3.1.4.39
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Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY. - Ref.8"Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase."
Pradere J.P., Tarnus E., Gres S., Valet P., Saulnier-Blache J.S.
Biochim. Biophys. Acta 1771:93-102(2007) [PubMed] [Europe PMC] [Abstract]Cited for: PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION, FUNCTION, CATALYTIC ACTIVITY, GLYCOSYLATION, MUTAGENESIS OF 12-VAL--VAL-22; 12-VAL--GLY-27; 23-ASN--GLY-27; CYS-25; GLY-27; 27-GLY--ALA-30; 27-GLY--ARG-35; 30-ALA--ILE-33; 30-ALA--GLY-41; 32-ARG--ARG-35; 36-ALA--GLU-40; ASN-53 AND ASN-410. - Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249. - Ref.14"Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe."
Kawaguchi M., Okabe T., Okudaira S., Nishimasu H., Ishitani R., Kojima H., Nureki O., Aoki J., Nagano T.
ACS Chem. Biol. 8:1713-1721(2013) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS; CALCIUM AND ZINC, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BOND. - Ref.15"Discovery of potent inhibitors of the lysophospholipase autotaxin."
Shah P., Cheasty A., Foxton C., Raynham T., Farooq M., Gutierrez I.F., Lejeune A., Pritchard M., Turnbull A., Pang L., Owen P., Boyd S., Stowell A., Jordan A., Hamilton N.M., Hitchin J.R., Stockley M., MacDonald E. , Quesada M.J., Trivier E., Skeete J., Ovaa H., Moolenaar W.H., Ryder H.
Bioorg. Med. Chem. Lett. 26:5403-5410(2016) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 36-862 IN COMPLEX WITH SYNTHETIC INHIBITOR; CALCIUM AND ZINC, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, GLYCOSYLATION AT ASN-410 AND ASN-524, DISULFIDE BONDS.
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Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY. - Ref.8"Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase."
Pradere J.P., Tarnus E., Gres S., Valet P., Saulnier-Blache J.S.
Biochim. Biophys. Acta 1771:93-102(2007) [PubMed] [Europe PMC] [Abstract]Cited for: PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION, FUNCTION, CATALYTIC ACTIVITY, GLYCOSYLATION, MUTAGENESIS OF 12-VAL--VAL-22; 12-VAL--GLY-27; 23-ASN--GLY-27; CYS-25; GLY-27; 27-GLY--ALA-30; 27-GLY--ARG-35; 30-ALA--ILE-33; 30-ALA--GLY-41; 32-ARG--ARG-35; 36-ALA--GLU-40; ASN-53 AND ASN-410. - Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249. - Ref.14"Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe."
Kawaguchi M., Okabe T., Okudaira S., Nishimasu H., Ishitani R., Kojima H., Nureki O., Aoki J., Nagano T.
ACS Chem. Biol. 8:1713-1721(2013) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS; CALCIUM AND ZINC, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BOND. - Ref.15"Discovery of potent inhibitors of the lysophospholipase autotaxin."
Shah P., Cheasty A., Foxton C., Raynham T., Farooq M., Gutierrez I.F., Lejeune A., Pritchard M., Turnbull A., Pang L., Owen P., Boyd S., Stowell A., Jordan A., Hamilton N.M., Hitchin J.R., Stockley M., MacDonald E. , Quesada M.J., Trivier E., Skeete J., Ovaa H., Moolenaar W.H., Ryder H.
Bioorg. Med. Chem. Lett. 26:5403-5410(2016) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 36-862 IN COMPLEX WITH SYNTHETIC INHIBITOR; CALCIUM AND ZINC, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, GLYCOSYLATION AT ASN-410 AND ASN-524, DISULFIDE BONDS.
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1-O-alkyl-sn-glycero-3-phosphoethanolamine- Search proteins in UniProtKB for this molecule.
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- 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
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- a 2-acyl-sn-glycero-3-phosphocholine
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a 2-acyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=a 2-acyl-sn-glycerol 3-phosphate- Search proteins in UniProtKB for this molecule.
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- a 2-acyl-sn-glycero-3-phospho-L-serine
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a 2-acyl-sn-glycero-3-phospho-L-serine- Search proteins in UniProtKB for this molecule.
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- 1-dodecanoyl-sn-glycero-3-phosphocholine
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- H2O
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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H2O- Search proteins in UniProtKB for this molecule.
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+sphing-4-enine-phosphocholine- Search proteins in UniProtKB for this molecule.
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=choline- Search proteins in UniProtKB for this molecule.
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+sphing-4-enine 1-phosphate- Search proteins in UniProtKB for this molecule.
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- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+H2O- Search proteins in UniProtKB for this molecule.
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=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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+H+- Search proteins in UniProtKB for this molecule.
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- 1-tetradecanoyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-tetradecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-tetradecanoyl-sn-glycerol 3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1-decanoyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-decanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-decanoyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1-hexadecanoyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1-octadecanoyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-octadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-octadecanoyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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+H+- Search proteins in UniProtKB for this molecule.
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- 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1-O-hexadecyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-O-hexadecyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-O-hexadecyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1-hexanoyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-hexanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-hexanoyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1,2-dioctanoyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1,2-dioctanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1,2-dioctanoyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1,2-didecanoyl-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1,2-didecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1,2-didecanoyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-O-(1Z-alkenyl)-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+choline- Search proteins in UniProtKB for this molecule.
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- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine- Search proteins in UniProtKB for this molecule.
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=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+ethanolamine- Search proteins in UniProtKB for this molecule.
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- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
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=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+H+- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
+L-serine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
zoom
<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori
Protein has several cofactor binding sites:- Zn2+
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249. - Ref.14"Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe."
Kawaguchi M., Okabe T., Okudaira S., Nishimasu H., Ishitani R., Kojima H., Nureki O., Aoki J., Nagano T.
ACS Chem. Biol. 8:1713-1721(2013) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS; CALCIUM AND ZINC, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BOND. - Ref.15"Discovery of potent inhibitors of the lysophospholipase autotaxin."
Shah P., Cheasty A., Foxton C., Raynham T., Farooq M., Gutierrez I.F., Lejeune A., Pritchard M., Turnbull A., Pang L., Owen P., Boyd S., Stowell A., Jordan A., Hamilton N.M., Hitchin J.R., Stockley M., MacDonald E. , Quesada M.J., Trivier E., Skeete J., Ovaa H., Moolenaar W.H., Ryder H.
Bioorg. Med. Chem. Lett. 26:5403-5410(2016) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 36-862 IN COMPLEX WITH SYNTHETIC INHIBITOR; CALCIUM AND ZINC, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, GLYCOSYLATION AT ASN-410 AND ASN-524, DISULFIDE BONDS.
Manual assertion based on experiment ini
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249. - Ref.14"Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe."
Kawaguchi M., Okabe T., Okudaira S., Nishimasu H., Ishitani R., Kojima H., Nureki O., Aoki J., Nagano T.
ACS Chem. Biol. 8:1713-1721(2013) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS; CALCIUM AND ZINC, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BOND. - Ref.15"Discovery of potent inhibitors of the lysophospholipase autotaxin."
Shah P., Cheasty A., Foxton C., Raynham T., Farooq M., Gutierrez I.F., Lejeune A., Pritchard M., Turnbull A., Pang L., Owen P., Boyd S., Stowell A., Jordan A., Hamilton N.M., Hitchin J.R., Stockley M., MacDonald E. , Quesada M.J., Trivier E., Skeete J., Ovaa H., Moolenaar W.H., Ryder H.
Bioorg. Med. Chem. Lett. 26:5403-5410(2016) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 36-862 IN COMPLEX WITH SYNTHETIC INHIBITOR; CALCIUM AND ZINC, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, GLYCOSYLATION AT ASN-410 AND ASN-524, DISULFIDE BONDS.
- Ca2+
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249. - Ref.14"Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe."
Kawaguchi M., Okabe T., Okudaira S., Nishimasu H., Ishitani R., Kojima H., Nureki O., Aoki J., Nagano T.
ACS Chem. Biol. 8:1713-1721(2013) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS; CALCIUM AND ZINC, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BOND. - Ref.15"Discovery of potent inhibitors of the lysophospholipase autotaxin."
Shah P., Cheasty A., Foxton C., Raynham T., Farooq M., Gutierrez I.F., Lejeune A., Pritchard M., Turnbull A., Pang L., Owen P., Boyd S., Stowell A., Jordan A., Hamilton N.M., Hitchin J.R., Stockley M., MacDonald E. , Quesada M.J., Trivier E., Skeete J., Ovaa H., Moolenaar W.H., Ryder H.
Bioorg. Med. Chem. Lett. 26:5403-5410(2016) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 36-862 IN COMPLEX WITH SYNTHETIC INHIBITOR; CALCIUM AND ZINC, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, GLYCOSYLATION AT ASN-410 AND ASN-524, DISULFIDE BONDS.
Manual assertion based on experiment ini
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249. - Ref.14"Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe."
Kawaguchi M., Okabe T., Okudaira S., Nishimasu H., Ishitani R., Kojima H., Nureki O., Aoki J., Nagano T.
ACS Chem. Biol. 8:1713-1721(2013) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS; CALCIUM AND ZINC, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BOND. - Ref.15"Discovery of potent inhibitors of the lysophospholipase autotaxin."
Shah P., Cheasty A., Foxton C., Raynham T., Farooq M., Gutierrez I.F., Lejeune A., Pritchard M., Turnbull A., Pang L., Owen P., Boyd S., Stowell A., Jordan A., Hamilton N.M., Hitchin J.R., Stockley M., MacDonald E. , Quesada M.J., Trivier E., Skeete J., Ovaa H., Moolenaar W.H., Ryder H.
Bioorg. Med. Chem. Lett. 26:5403-5410(2016) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 36-862 IN COMPLEX WITH SYNTHETIC INHIBITOR; CALCIUM AND ZINC, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, GLYCOSYLATION AT ASN-410 AND ASN-524, DISULFIDE BONDS.
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi
- KM=12.9 mM for pNppp (isoform 1)1 Publication
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
- KM=4.4 mM for pNppp (isoform 2)1 Publication
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
- KM=11.8 mM for pNppp (isoform 3)1 Publication
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
- Vmax=1.9 nmol/min/µg enzyme with pNppp as substrate (isoform 1)1 Publication
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
- Vmax=0.35 nmol/min/µg enzyme with pNppp as substrate (isoform 2)1 Publication
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
- Vmax=1.8 nmol/min/µg enzyme with pNppp as substrate (isoform 3)1 Publication
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
pH dependencei
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
Temperature dependencei
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi | 171 | Zinc 1; catalyticCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0007744">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei | 209 | Nucleophile1 Publication Manual assertion inferred by curator fromi
| 1 | |
Metal bindingi | 209 | Zinc 1; catalyticCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei | 230 | SubstrateCombined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion based on experiment ini
| 1 | |
Binding sitei | 306 | SubstrateCombined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion based on experiment ini
| 1 | |
Metal bindingi | 311 | Zinc 2; catalyticCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 315 | Zinc 2; via tele nitrogen; catalyticCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 358 | Zinc 1; catalyticCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 359 | Zinc 1; via tele nitrogen; catalyticCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 474 | Zinc 2; via tele nitrogen; catalyticCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 739 | CalciumCombined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 741 | CalciumCombined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 743 | CalciumCombined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 745 | Calcium; via carbonyl oxygenCombined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| 1 | |
Metal bindingi | 747 | CalciumCombined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| 1 | |
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei | 852 | Essential for catalytic activity1 Publication Manual assertion based on experiment ini
| 1 |
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- alkylglycerophosphoethanolamine phosphodiesterase activity Source: MGI
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p>
Inferred from direct assayi
- "Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2."
Cimpean A., Stefan C., Gijsbers R., Stalmans W., Bollen M.
Biochem J 381:71-77(2004) [PubMed] [Europe PMC] [Abstract]
- calcium ion binding Source: UniProtKBInferred from direct assayi
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249.
- lysophospholipase activity Source: UniProtKBInferred from direct assayi
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249.
- nucleic acid binding Source: InterPro
- nucleotide diphosphatase activity Source: MGI
<p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p>
Inferred from sequence or structural similarityi
- "Developmental expression analysis of murine autotaxin (ATX)."
Bachner D., Ahrens M., Betat N., Schroder D., Gross G.
Mech Dev 84:121-125(1999) [PubMed] [Europe PMC] [Abstract]
- phosphodiesterase I activity Source: MGIInferred from sequence or structural similarityi
- "Developmental expression analysis of murine autotaxin (ATX)."
Bachner D., Ahrens M., Betat N., Schroder D., Gross G.
Mech Dev 84:121-125(1999) [PubMed] [Europe PMC] [Abstract]
- polysaccharide binding Source: InterPro
- scavenger receptor activity Source: InterPro
- zinc ion binding Source: UniProtKBInferred from direct assayi
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249.
GO - Biological processi
- cell chemotaxis Source: MGI
- estrous cycle Source: GO_Central
<p>Inferred from Biological aspect of Ancestor</p>
<p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p>
Inferred from biological aspect of ancestori
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
- immune response Source: InterPro
- negative regulation of cell-matrix adhesion Source: MGI
- phosphatidylcholine catabolic process Source: UniProtKBInferred from direct assayi
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249.
- phospholipid catabolic process Source: MGI
- phospholipid metabolic process Source: MGIInferred from direct assayi
- "Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis."
Tsuboi K., Okamoto Y., Rahman I.A., Uyama T., Inoue T., Tokumura A., Ueda N.
Biochim. Biophys. Acta 1851:537-548(2015) [PubMed] [Europe PMC] [Abstract]
- positive regulation of cell population proliferation Source: MGI
- positive regulation of epithelial cell migration Source: MGI
- positive regulation of focal adhesion assembly Source: MGI
- positive regulation of lamellipodium morphogenesis Source: MGI
- positive regulation of oligodendrocyte differentiation Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of substrate adhesion-dependent cell spreading Source: MGI
- regulation of angiogenesis Source: InterPro
- regulation of cell migration Source: MGI
- sphingolipid catabolic process Source: UniProtKB
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
Molecular function | Hydrolase |
Biological process | Chemotaxis, Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
BRENDA Comprehensive Enzyme Information System More...BRENDAi | 3.1.4.39, 3474 |
SABIO-RK: Biochemical Reaction Kinetics Database More...SABIO-RKi | Q9R1E6 |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (EC:3.1.4.39
Manual assertion based on experiment ini
Short name: E-NPP 2 Alternative name(s): Autotaxin1 Publication <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
Extracellular lysophospholipase D Short name: LysoPLD |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:Enpp2 Synonyms:Npps2, Pdnp21 Publication Manual assertion based on opinion ini
|
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Mus musculus (Mouse) |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 10090 [NCBI] |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Mouse genome database (MGD) from Mouse Genome Informatics (MGI) More...MGIi | MGI:1321390, Enpp2 |
Eukaryotic Pathogen, Vector and Host Database Resources More...VEuPathDBi | HostDB:ENSMUSG00000022425 |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Extracellular region or secreted
- Secreted 3 Publications
Manual assertion based on experiment ini
- Ref.8"Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase."
Pradere J.P., Tarnus E., Gres S., Valet P., Saulnier-Blache J.S.
Biochim. Biophys. Acta 1771:93-102(2007) [PubMed] [Europe PMC] [Abstract]Cited for: PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION, FUNCTION, CATALYTIC ACTIVITY, GLYCOSYLATION, MUTAGENESIS OF 12-VAL--VAL-22; 12-VAL--GLY-27; 23-ASN--GLY-27; CYS-25; GLY-27; 27-GLY--ALA-30; 27-GLY--ARG-35; 30-ALA--ILE-33; 30-ALA--GLY-41; 32-ARG--ARG-35; 36-ALA--GLU-40; ASN-53 AND ASN-410. - Ref.9"Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin."
Jansen S., Andries M., Derua R., Waelkens E., Bollen M.
J. Biol. Chem. 284:14296-14302(2009) [PubMed] [Europe PMC] [Abstract]Cited for: SUBCELLULAR LOCATION, INTERDOMAIN DISULFIDE BOND, MUTAGENESIS OF 851-LEU--THR-853; LEU-851; LYS-852 AND THR-853. - Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249.
- Secreted 3 Publications
Extracellular region or secreted
- extracellular space Source: UniProtKBInferred from direct assayi
- Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249.
- extracellular space Source: UniProtKBInferred from direct assayi
Golgi apparatus
- Golgi apparatus Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: MGIInferred from sequence or structural similarityi
- "Developmental expression analysis of murine autotaxin (ATX)."
Bachner D., Ahrens M., Betat N., Schroder D., Gross G.
Mech Dev 84:121-125(1999) [PubMed] [Europe PMC] [Abstract]
- integral component of plasma membrane Source: MGIInferred from sequence or structural similarityi
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Secreted<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei
Manual assertion based on experiment ini
- Ref.7"Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression."
Boucher J., Quilliot D., Pradere J.P., Simon M.F., Gres S., Guigne C., Prevot D., Ferry G., Boutin J.A., Carpene C., Valet P., Saulnier-Blache J.S.
Diabetologia 48:569-577(2005) [PubMed] [Europe PMC] [Abstract]Cited for: INDUCTION, POSSIBLE FUNCTION IN OBESITY.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 12 – 27 | Missing : Complete inhibition of secretion. 1 Publication Manual assertion based on experiment ini
| 16 | |
Mutagenesisi | 12 – 22 | Missing : Complete inhibition of secretion. 1 Publication Manual assertion based on experiment ini
| 11 | |
Mutagenesisi | 23 – 27 | Missing : No effect on secretion. 1 Publication Manual assertion based on experiment ini
| 5 | |
Mutagenesisi | 23 | Missing : No effect on secretion. | 1 | |
Mutagenesisi | 25 | Missing : No effect on secretion. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 27 – 35 | Missing : No effect on secretion nor lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 9 | |
Mutagenesisi | 27 – 30 | Missing : No effect on secretion. 1 Publication Manual assertion based on experiment ini
| 4 | |
Mutagenesisi | 27 | Missing : No effect on secretion. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 30 – 41 | Missing : No effect on secretion nor lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 12 | |
Mutagenesisi | 30 – 33 | Missing : No effect on secretion nor lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 4 | |
Mutagenesisi | 32 – 35 | Missing : No effect on secretion nor lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 4 | |
Mutagenesisi | 36 – 40 | Missing : No effect on secretion nor lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 5 | |
Mutagenesisi | 53 | Missing : No effect on secretion; slightly decreases lysophospholipase activity. Almost complete loss of lysophospholipase activity; when associated with N-410 del. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 210 | F → A: Reduced lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 213 | L → A: Reduced lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 230 | N → A: Reduced lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 243 | L → A: Reduced lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 247 | E → A: Reduced lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 249 | F → A: Reduced lysophospholipase activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 410 | Missing : No effect on secretion; greatly inhibits lysoPLD activity. Inhibits secretion. Almost complete loss of lysoPLD activity; when associated with N-53 del. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 512 | M → A: Reduced lysophospholipase activity. | 1 | |
Mutagenesisi | 851 – 853 | LKT → AAA, RRR or SSS: No catalytic activity. 1 Publication Manual assertion based on experiment ini
| 3 | |
Mutagenesisi | 851 | L → A: No effect. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 852 | K → A or R: Strongly reduced catalytic activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 853 | T → A: No effect. 1 Publication Manual assertion based on experiment ini
| 1 |
Keywords - Diseasei
ObesityChemistry databases
ChEMBL database of bioactive drug-like small molecules More...ChEMBLi | CHEMBL3826871 |
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYi | 2901 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei | 1 – 27 | By similarity Manual assertion inferred from sequence similarity toi Add BLAST | 27 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000281650 | 28 – 35 | Removed by furinBy similarity Manual assertion inferred from sequence similarity toi | 8 | |
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000188568 | 36 – 862 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Add BLAST | 827 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi | 53 | N-linked (GlcNAc...) asparagineCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi | 58 ↔ 75 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 62 ↔ 93 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 73 ↔ 86 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 79 ↔ 85 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 102 ↔ 119 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 107 ↔ 137 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 117 ↔ 130 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 123 ↔ 129 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 148 ↔ 194 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 156 ↔ 350 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 366 ↔ 468 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| ||
Glycosylationi | 410 | N-linked (GlcNAc...) asparagineCombined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| 1 | |
Disulfide bondi | 413 ↔ 805 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Glycosylationi | 524 | N-linked (GlcNAc...) asparagineCombined sources Manual assertion inferred from combination of experimental and computational evidencei 3 PublicationsManual assertion based on experiment ini
| 1 | |
Disulfide bondi | 566 ↔ 666 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 568 ↔ 651 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Disulfide bondi | 774 ↔ 784 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei 4 PublicationsManual assertion based on experiment ini
| ||
Glycosylationi | 806 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi
Manual assertion based on experiment ini
- Ref.8"Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase."
Pradere J.P., Tarnus E., Gres S., Valet P., Saulnier-Blache J.S.
Biochim. Biophys. Acta 1771:93-102(2007) [PubMed] [Europe PMC] [Abstract]Cited for: PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION, FUNCTION, CATALYTIC ACTIVITY, GLYCOSYLATION, MUTAGENESIS OF 12-VAL--VAL-22; 12-VAL--GLY-27; 23-ASN--GLY-27; CYS-25; GLY-27; 27-GLY--ALA-30; 27-GLY--ARG-35; 30-ALA--ILE-33; 30-ALA--GLY-41; 32-ARG--ARG-35; 36-ALA--GLU-40; ASN-53 AND ASN-410. - Ref.12"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
Nishimasu H., Okudaira S., Hama K., Mihara E., Dohmae N., Inoue A., Ishitani R., Takagi J., Aoki J., Nureki O.
Nat. Struct. Mol. Biol. 18:205-212(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BONDS, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249. - Ref.14"Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe."
Kawaguchi M., Okabe T., Okudaira S., Nishimasu H., Ishitani R., Kojima H., Nureki O., Aoki J., Nagano T.
ACS Chem. Biol. 8:1713-1721(2013) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS; CALCIUM AND ZINC, GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524, CATALYTIC ACTIVITY, COFACTOR, DISULFIDE BOND.
Manual assertion based on experiment ini
- Ref.9"Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin."
Jansen S., Andries M., Derua R., Waelkens E., Bollen M.
J. Biol. Chem. 284:14296-14302(2009) [PubMed] [Europe PMC] [Abstract]Cited for: SUBCELLULAR LOCATION, INTERDOMAIN DISULFIDE BOND, MUTAGENESIS OF 851-LEU--THR-853; LEU-851; LYS-852 AND THR-853.
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MaxQB - The MaxQuant DataBase More...MaxQBi | Q9R1E6 |
PeptideAtlas More...PeptideAtlasi | Q9R1E6 |
PRoteomics IDEntifications database More...PRIDEi | Q9R1E6 |
ProteomicsDB: a multi-organism proteome resource More...ProteomicsDBi | 275871 [Q9R1E6-1] 275872 [Q9R1E6-2] 275873 [Q9R1E6-3] |
PTM databases
GlyConnect protein glycosylation platform More...GlyConnecti | 2275, 5 N-Linked glycans (2 sites) |
GlyGen: Computational and Informatics Resources for Glycoscience More...GlyGeni | Q9R1E6, 4 sites, 5 N-linked glycans (2 sites) |
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q9R1E6 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q9R1E6 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
Manual assertion based on experiment ini
- Ref.2"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A., Rodriguez M., Fould B., Moulharat N., Coge F., Chomarat P., Galizzi J.-P., Valet P., Saulnier-Blache J.-S., Boutin J.A., Ferry G.
J. Biol. Chem. 283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), CATALYTIC ACTIVITY, FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni
Manual assertion based on experiment ini
- Ref.7"Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression."
Boucher J., Quilliot D., Pradere J.P., Simon M.F., Gres S., Guigne C., Prevot D., Ferry G., Boutin J.A., Carpene C., Valet P., Saulnier-Blache J.S.
Diabetologia 48:569-577(2005) [PubMed] [Europe PMC] [Abstract]Cited for: INDUCTION, POSSIBLE FUNCTION IN OBESITY.
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSMUSG00000022425, Expressed in choroid plexus epithelium and 420 other tissues |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q9R1E6, baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q9R1E6, MM |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
Protein-protein interaction databases
STRING: functional protein association networks More...STRINGi | 10090.ENSMUSP00000132640 |
Chemistry databases
BindingDB database of measured binding affinities More...BindingDBi | Q9R1E6 |
Miscellaneous databases
RNAct, Protein-RNA interaction predictions for model organisms. More...RNActi | Q9R1E6, protein |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
Secondary structure
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/structure%5Fsection">'Structure'</a> section is used to indicate the positions of experimentally determined helical regions within the protein sequence.<p><a href='/help/helix' target='_top'>More...</a></p>Helixi | 53 – 55 | Combined sources <p>Information inferred from a combination of experimental and computational evidence, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000213">More...</a></p> Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/structure%5Fsection">'Structure'</a> section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. These elements correspond to the DSSP secondary structure code 'T'.<p><a href='/help/turn' target='_top'>More...</a></p>Turni | 59 – 63 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 5 | |
Helixi | 77 – 79 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Turni | 80 – 83 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 89 – 93 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 5 | |
Turni | 98 – 100 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 104 – 106 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/structure%5Fsection">'Structure'</a> section is used to indicate the positions of experimentally determined beta strands within the protein sequence.<p><a href='/help/strand' target='_top'>More...</a></p>Beta strandi | 115 – 118 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 123 – 126 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 133 – 138 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 6 | |
Helixi | 143 – 145 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 165 – 171 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 7 | |
Helixi | 175 – 183 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 9 | |
Helixi | 186 – 194 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 9 | |
Beta strandi | 195 – 197 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 209 – 218 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 10 | |
Helixi | 222 – 225 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Beta strandi | 229 – 234 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 6 | |
Turni | 235 – 238 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Beta strandi | 239 – 241 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 243 – 246 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 247 – 249 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 251 – 253 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 259 – 265 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 7 | |
Helixi | 281 – 292 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 12 | |
Turni | 296 – 298 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 301 – 310 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 10 | |
Helixi | 311 – 317 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 7 | |
Helixi | 322 – 324 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 325 – 344 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 20 | |
Turni | 348 – 350 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 352 – 358 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 7 | |
Beta strandi | 368 – 371 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 372 – 374 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 379 – 381 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 382 – 385 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Beta strandi | 387 – 396 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 10 | |
Helixi | 404 – 411 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 8 | |
Beta strandi | 419 – 424 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 6 | |
Helixi | 425 – 427 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 430 – 432 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 442 – 447 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 6 | |
Beta strandi | 452 – 456 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 5 | |
Helixi | 457 – 459 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 471 – 473 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 481 – 483 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 487 – 494 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 8 | |
Beta strandi | 496 – 499 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 505 – 507 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 508 – 515 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 8 | |
Turni | 527 – 530 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 531 – 533 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 534 – 536 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 559 – 561 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 579 – 581 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Turni | 583 – 586 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Turni | 593 – 595 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 609 – 613 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 5 | |
Beta strandi | 618 – 622 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 5 | |
Turni | 623 – 626 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Beta strandi | 627 – 635 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 9 | |
Helixi | 646 – 648 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 660 – 662 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 666 – 671 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 6 | |
Beta strandi | 676 – 681 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 6 | |
Helixi | 683 – 685 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 689 – 695 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 7 | |
Helixi | 698 – 700 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 701 – 704 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 706 – 717 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 12 | |
Helixi | 719 – 727 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 9 | |
Beta strandi | 729 – 737 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 9 | |
Beta strandi | 743 – 745 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 749 – 751 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 765 – 776 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 12 | |
Helixi | 781 – 783 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 788 – 796 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 9 | |
Turni | 805 – 808 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 4 | |
Helixi | 811 – 813 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 815 – 821 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 7 | |
Helixi | 826 – 833 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 8 | |
Beta strandi | 834 – 836 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 845 – 853 | Combined sources Automatic assertion inferred from combination of experimental and computational evidencei | 9 |
3D structure databases
AlphaFold Protein Structure Database More...AlphaFoldDBi | Q9R1E6 |
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | Q9R1E6 |
Database of comparative protein structure models More...ModBasei | Search... |
Protein Data Bank in Europe - Knowledge Base More...PDBe-KBi | Search... |
Miscellaneous databases
Relative evolutionary importance of amino acids within a protein sequence More...EvolutionaryTracei | Q9R1E6 |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini | 54 – 97 | SMB 1PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 44 | |
Domaini | 98 – 142 | SMB 2PROSITE-ProRule annotation Manual assertion according to rulesi Add BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 144 – 501 | PhosphodiesteraseAdd BLAST | 358 | |
Regioni | 210 – 213 | Substrate bindingCombined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion based on experiment ini
| 4 | |
Regioni | 243 – 254 | Substrate binding1 Publication Manual assertion inferred by curator fromi
| 12 | |
Regioni | 597 – 862 | NucleaseAdd BLAST | 266 | |
Regioni | 829 – 850 | Required for secretionAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi | 126 – 128 | Cell attachment siteSequence analysis | 3 |
<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG2645, Eukaryota |
Ensembl GeneTree More...GeneTreei | ENSGT00940000155778 |
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More...HOGENOMi | CLU_012256_0_0_1 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q9R1E6 |
Identification of Orthologs from Complete Genome Data More...OMAi | TNYHVVC |
Database of Orthologous Groups More...OrthoDBi | 999163at2759 |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q9R1E6 |
TreeFam database of animal gene trees More...TreeFami | TF330032 |
Family and domain databases
Gene3D Structural and Functional Annotation of Protein Families More...Gene3Di | 3.40.570.10, 1 hit 3.40.720.10, 1 hit |
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR001604, DNA/RNA_non-sp_Endonuclease IPR044929, DNA/RNA_non-sp_Endonuclease_sf IPR029881, ENPP2 IPR020821, Extracellular_endonuc_su_A IPR044925, His-Me_finger_sf IPR002591, Phosphodiest/P_Trfase IPR020436, SMB_chordata IPR036024, Somatomedin_B-like_dom_sf IPR001212, Somatomedin_B_dom |
The PANTHER Classification System More...PANTHERi | PTHR10151:SF21, PTHR10151:SF21, 1 hit |
Pfam protein domain database More...Pfami | View protein in Pfam PF01223, Endonuclease_NS, 1 hit PF01663, Phosphodiest, 1 hit PF01033, Somatomedin_B, 2 hits |
Protein Motif fingerprint database; a protein domain database More...PRINTSi | PR00022, SOMATOMEDINB |
Simple Modular Architecture Research Tool; a protein domain database More...SMARTi | View protein in SMART SM00892, Endonuclease_NS, 1 hit SM00477, NUC, 1 hit SM00201, SO, 2 hits |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF53649, SSF53649, 1 hit SSF54060, SSF54060, 1 hit SSF90188, SSF90188, 2 hits |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS00524, SMB_1, 2 hits PS50958, SMB_2, 2 hits |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.
This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MARQGCFGSY QVISLFTFAI GVNLCLGFTA SRIKRAEWDE GPPTVLSDSP
60 70 80 90 100
WTNTSGSCKG RCFELQEVGP PDCRCDNLCK SYSSCCHDFD ELCLKTARGW
110 120 130 140 150
ECTKDRCGEV RNEENACHCS EDCLSRGDCC TNYQVVCKGE SHWVDDDCEE
160 170 180 190 200
IRVPECPAGF VRPPLIIFSV DGFRASYMKK GSKVMPNIEK LRSCGTHAPY
210 220 230 240 250
MRPVYPTKTF PNLYTLATGL YPESHGIVGN SMYDPVFDAT FHLRGREKFN
260 270 280 290 300
HRWWGGQPLW ITATKQGVRA GTFFWSVSIP HERRILTILQ WLSLPDNERP
310 320 330 340 350
SVYAFYSEQP DFSGHKYGPF GPEMTNPLRE IDKTVGQLMD GLKQLKLHRC
360 370 380 390 400
VNVIFVGDHG MEDVTCDRTE FLSNYLTNVD DITLVPGTLG RIRPKIPNNL
410 420 430 440 450
KYDPKAIIAN LTCKKPDQHF KPYMKQHLPK RLHYANNRRI EDLHLLVERR
460 470 480 490 500
WHVARKPLDV YKKPSGKCFF QGDHGFDNKV NSMQTVFVGY GPTFKYRTKV
510 520 530 540 550
PPFENIELYN VMCDLLGLKP APNNGTHGSL NHLLRTNTFR PTLPEEVSRP
560 570 580 590 600
NYPGIMYLQS DFDLGCTCDD KVEPKNKLEE LNKRLHTKGS TEERHLLYGR
610 620 630 640 650
PAVLYRTSYD ILYHTDFESG YSEIFLMPLW TSYTISKQAE VSSIPEHLTN
660 670 680 690 700
CVRPDVRVSP GFSQNCLAYK NDKQMSYGFL FPPYLSSSPE AKYDAFLVTN
710 720 730 740 750
MVPMYPAFKR VWTYFQRVLV KKYASERNGV NVISGPIFDY NYNGLRDIED
760 770 780 790 800
EIKQYVEGSS IPVPTHYYSI ITSCLDFTQP ADKCDGPLSV SSFILPHRPD
810 820 830 840 850
NDESCNSSED ESKWVEELMK MHTARVRDIE HLTGLDFYRK TSRSYSEILT
860
LKTYLHTYES EI
The sequence of this isoform differs from the canonical sequence as follows:
323-323: E → EESSYGSPLTPAKRPKRKVAPKRRQERPVAPPKKRRRKLHRMDHYTAETRQDK
10 20 30 40 50
MARQGCFGSY QVISLFTFAI GVNLCLGFTA SRIKRAEWDE GPPTVLSDSP
60 70 80 90 100
WTNTSGSCKG RCFELQEVGP PDCRCDNLCK SYSSCCHDFD ELCLKTARGW
110 120 130 140 150
ECTKDRCGEV RNEENACHCS EDCLSRGDCC TNYQVVCKGE SHWVDDDCEE
160 170 180 190 200
IRVPECPAGF VRPPLIIFSV DGFRASYMKK GSKVMPNIEK LRSCGTHAPY
210 220 230 240 250
MRPVYPTKTF PNLYTLATGL YPESHGIVGN SMYDPVFDAT FHLRGREKFN
260 270 280 290 300
HRWWGGQPLW ITATKQGVRA GTFFWSVSIP HERRILTILQ WLSLPDNERP
310 320 330 340 350
SVYAFYSEQP DFSGHKYGPF GPEESSYGSP LTPAKRPKRK VAPKRRQERP
360 370 380 390 400
VAPPKKRRRK LHRMDHYTAE TRQDKMTNPL REIDKTVGQL MDGLKQLKLH
410 420 430 440 450
RCVNVIFVGD HGMEDVTCDR TEFLSNYLTN VDDITLVPGT LGRIRPKIPN
460 470 480 490 500
NLKYDPKAII ANLTCKKPDQ HFKPYMKQHL PKRLHYANNR RIEDLHLLVE
510 520 530 540 550
RRWHVARKPL DVYKKPSGKC FFQGDHGFDN KVNSMQTVFV GYGPTFKYRT
560 570 580 590 600
KVPPFENIEL YNVMCDLLGL KPAPNNGTHG SLNHLLRTNT FRPTLPEEVS
610 620 630 640 650
RPNYPGIMYL QSDFDLGCTC DDKVEPKNKL EELNKRLHTK GSTEERHLLY
660 670 680 690 700
GRPAVLYRTS YDILYHTDFE SGYSEIFLMP LWTSYTISKQ AEVSSIPEHL
710 720 730 740 750
TNCVRPDVRV SPGFSQNCLA YKNDKQMSYG FLFPPYLSSS PEAKYDAFLV
760 770 780 790 800
TNMVPMYPAF KRVWTYFQRV LVKKYASERN GVNVISGPIF DYNYNGLRDI
810 820 830 840 850
EDEIKQYVEG SSIPVPTHYY SIITSCLDFT QPADKCDGPL SVSSFILPHR
860 870 880 890 900
PDNDESCNSS EDESKWVEEL MKMHTARVRD IEHLTGLDFY RKTSRSYSEI
910
LTLKTYLHTY ESEI
The sequence of this isoform differs from the canonical sequence as follows:
592-592: E → EAETGKFRGSKHENKKSLNGNVEPRK
10 20 30 40 50
MARQGCFGSY QVISLFTFAI GVNLCLGFTA SRIKRAEWDE GPPTVLSDSP
60 70 80 90 100
WTNTSGSCKG RCFELQEVGP PDCRCDNLCK SYSSCCHDFD ELCLKTARGW
110 120 130 140 150
ECTKDRCGEV RNEENACHCS EDCLSRGDCC TNYQVVCKGE SHWVDDDCEE
160 170 180 190 200
IRVPECPAGF VRPPLIIFSV DGFRASYMKK GSKVMPNIEK LRSCGTHAPY
210 220 230 240 250
MRPVYPTKTF PNLYTLATGL YPESHGIVGN SMYDPVFDAT FHLRGREKFN
260 270 280 290 300
HRWWGGQPLW ITATKQGVRA GTFFWSVSIP HERRILTILQ WLSLPDNERP
310 320 330 340 350
SVYAFYSEQP DFSGHKYGPF GPEMTNPLRE IDKTVGQLMD GLKQLKLHRC
360 370 380 390 400
VNVIFVGDHG MEDVTCDRTE FLSNYLTNVD DITLVPGTLG RIRPKIPNNL
410 420 430 440 450
KYDPKAIIAN LTCKKPDQHF KPYMKQHLPK RLHYANNRRI EDLHLLVERR
460 470 480 490 500
WHVARKPLDV YKKPSGKCFF QGDHGFDNKV NSMQTVFVGY GPTFKYRTKV
510 520 530 540 550
PPFENIELYN VMCDLLGLKP APNNGTHGSL NHLLRTNTFR PTLPEEVSRP
560 570 580 590 600
NYPGIMYLQS DFDLGCTCDD KVEPKNKLEE LNKRLHTKGS TEAETGKFRG
610 620 630 640 650
SKHENKKSLN GNVEPRKERH LLYGRPAVLY RTSYDILYHT DFESGYSEIF
660 670 680 690 700
LMPLWTSYTI SKQAEVSSIP EHLTNCVRPD VRVSPGFSQN CLAYKNDKQM
710 720 730 740 750
SYGFLFPPYL SSSPEAKYDA FLVTNMVPMY PAFKRVWTYF QRVLVKKYAS
760 770 780 790 800
ERNGVNVISG PIFDYNYNGL RDIEDEIKQY VEGSSIPVPT HYYSIITSCL
810 820 830 840 850
DFTQPADKCD GPLSVSSFIL PHRPDNDESC NSSEDESKWV EELMKMHTAR
860 870 880
VRDIEHLTGL DFYRKTSRSY SEILTLKTYL HTYESEI
<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketEntry | Entry name | Protein names | Gene names | Length | Annotation | ||
---|---|---|---|---|---|---|---|
G3UXY9 | G3UXY9_MOUSE | Ectonucleotide pyrophosphatase/phos... Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | 910 | Annotation score: Annotation score:3 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
A0A2I3BR60 | A0A2I3BR60_MOUSE | Ectonucleotide pyrophosphatase/phos... Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | 62 | Annotation score: Annotation score:2 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
A0A2I3BS26 | A0A2I3BS26_MOUSE | Ectonucleotide pyrophosphatase/phos... Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | 118 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 103 | T → I in ACD12866 (Ref. 3) Curated | 1 | |
Sequence conflicti | 517 | G → S in AAD46480 (PubMed:10702660).Curated | 1 | |
Sequence conflicti | 550 | P → T in AAD46480 (PubMed:10702660).Curated | 1 | |
Sequence conflicti | 573 | E → K in AAD46480 (PubMed:10702660).Curated | 1 | |
Sequence conflicti | 743 | N → D in ACD12866 (Ref. 3) Curated | 1 | |
Sequence conflicti | 743 | N → D in AAH03264 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036396 | 323 | E → EESSYGSPLTPAKRPKRKVA PKRRQERPVAPPKKRRRKLH RMDHYTAETRQDK in isoform 2. 1 Publication Manual assertion based on opinion ini
| 1 | |
Alternative sequenceiVSP_036397 | 592 | E → EAETGKFRGSKHENKKSLNG NVEPRK in isoform 3. 1 Publication Manual assertion based on opinion ini
| 1 |
Sequence databases
Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | AF123542 mRNA Translation: AAD46480.1 EU131009 mRNA Translation: ABW38314.1 EU131010 mRNA Translation: ABW38315.1 EU677474 Genomic DNA Translation: ACD12865.1 EU677475 Genomic DNA Translation: ACD12866.1 AK161144 mRNA Translation: BAE36214.1 CH466545 Genomic DNA Translation: EDL29265.1 BC003264 mRNA Translation: AAH03264.1 BC058759 mRNA Translation: AAH58759.1 |
The Consensus CDS (CCDS) project More...CCDSi | CCDS27472.1 [Q9R1E6-1] CCDS49607.1 [Q9R1E6-2] CCDS70628.1 [Q9R1E6-3] |
NCBI Reference Sequences More...RefSeqi | NP_001129549.1, NM_001136077.3 [Q9R1E6-2] NP_001272923.1, NM_001285994.2 [Q9R1E6-3] NP_001272924.1, NM_001285995.2 NP_056559.2, NM_015744.4 [Q9R1E6-1] |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENSMUST00000041591; ENSMUSP00000036180; ENSMUSG00000022425 [Q9R1E6-1] ENSMUST00000167541; ENSMUSP00000132640; ENSMUSG00000022425 [Q9R1E6-3] ENSMUST00000171545; ENSMUSP00000128941; ENSMUSG00000022425 [Q9R1E6-2] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 18606 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | mmu:18606 |
UCSC genome browser More...UCSCi | uc007vro.3, mouse [Q9R1E6-1] uc007vrq.3, mouse [Q9R1E6-3] uc011zsx.2, mouse [Q9R1E6-2] |
Keywords - Coding sequence diversityi
Alternative splicing<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF123542 mRNA Translation: AAD46480.1 EU131009 mRNA Translation: ABW38314.1 EU131010 mRNA Translation: ABW38315.1 EU677474 Genomic DNA Translation: ACD12865.1 EU677475 Genomic DNA Translation: ACD12866.1 AK161144 mRNA Translation: BAE36214.1 CH466545 Genomic DNA Translation: EDL29265.1 BC003264 mRNA Translation: AAH03264.1 BC058759 mRNA Translation: AAH58759.1 |
CCDSi | CCDS27472.1 [Q9R1E6-1] CCDS49607.1 [Q9R1E6-2] CCDS70628.1 [Q9R1E6-3] |
RefSeqi | NP_001129549.1, NM_001136077.3 [Q9R1E6-2] NP_001272923.1, NM_001285994.2 [Q9R1E6-3] NP_001272924.1, NM_001285995.2 NP_056559.2, NM_015744.4 [Q9R1E6-1] |
3D structure databases
Select the link destinations: Protein Data Bank Europe More...PDBeiProtein Data Bank RCSB More...RCSB PDBiProtein Data Bank Japan More...PDBjiLinks Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3NKM | X-ray | 2.00 | A | 36-862 | [»] | |
3NKN | X-ray | 1.80 | A | 36-862 | [»] | |
3NKO | X-ray | 1.75 | A | 36-862 | [»] | |
3NKP | X-ray | 1.75 | A | 36-862 | [»] | |
3NKQ | X-ray | 1.70 | A | 36-862 | [»] | |
3NKR | X-ray | 1.70 | A | 36-862 | [»] | |
3WAV | X-ray | 1.80 | A | 36-862 | [»] | |
3WAW | X-ray | 1.95 | A | 36-862 | [»] | |
3WAX | X-ray | 1.90 | A | 36-862 | [»] | |
3WAY | X-ray | 1.75 | A | 36-862 | [»] | |
4GTW | X-ray | 2.70 | A/B | 51-58 | [»] | |
4GTX | X-ray | 3.20 | A/B | 51-58 | [»] | |
4GTY | X-ray | 3.19 | A/B |