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Protein

5-hydroxytryptamine receptor 6

Gene

Htr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650). Is an activator of TOR signaling (PubMed:23027611).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390666 Serotonin receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 6
Short name:
5-HT-6
Short name:
5-HT6
Alternative name(s):
Serotonin receptor 6
Gene namesi
Name:Htr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1196627 Htr6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 57Helical; Name=1By similarityAdd BLAST23
Topological domaini58 – 64CytoplasmicBy similarity7
Transmembranei65 – 85Helical; Name=2By similarityAdd BLAST21
Topological domaini86 – 100ExtracellularBy similarityAdd BLAST15
Transmembranei101 – 122Helical; Name=3By similarityAdd BLAST22
Topological domaini123 – 144CytoplasmicBy similarityAdd BLAST22
Transmembranei145 – 166Helical; Name=4By similarityAdd BLAST22
Topological domaini167 – 184ExtracellularBy similarityAdd BLAST18
Transmembranei185 – 208Helical; Name=5By similarityAdd BLAST24
Topological domaini209 – 267CytoplasmicBy similarityAdd BLAST59
Transmembranei268 – 292Helical; Name=6By similarityAdd BLAST25
Topological domaini293 – 297ExtracellularBy similarity5
Transmembranei298 – 322Helical; Name=7By similarityAdd BLAST25
Topological domaini323 – 440CytoplasmicBy similarityAdd BLAST118

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075268

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689751 – 4405-hydroxytryptamine receptor 6Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R1C8
PRIDEiQ9R1C8

PTM databases

PhosphoSitePlusiQ9R1C8

Expressioni

Gene expression databases

BgeeiENSMUSG00000028747 Expressed in 21 organ(s), highest expression level in cortical intermediate zone
CleanExiMM_HTR6
ExpressionAtlasiQ9R1C8 baseline and differential
GenevisibleiQ9R1C8 MM

Interactioni

Subunit structurei

Interacts with CDK5 (PubMed:25078650). Interacts with MTOR (PubMed:23027611). Interacts with RPTOR and NF1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi200479, 2 interactors
STRINGi10090.ENSMUSP00000068333

Chemistry databases

BindingDBiQ9R1C8

Structurei

3D structure databases

ProteinModelPortaliQ9R1C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000241520
HOVERGENiHBG106962
InParanoidiQ9R1C8
KOiK04162
OMAiGWHELGH
OrthoDBiEOG091G06VI
PhylomeDBiQ9R1C8
TreeFamiTF351753

Family and domain databases

CDDicd15054 7tmA_5-HT6, 1 hit
InterProiView protein in InterPro
IPR002232 5HT6_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R1C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIAL
60 70 80 90 100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL
110 120 130 140 150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA
160 170 180 190 200
WSLAALASFL PLLLGWHELG KARTSAPGQC RLLASLPYVL VASGVTFFLP
210 220 230 240 250
SGAICFTYCR ILLAARKQAV QVASLTTGTA TAGQALETLQ VPRTPRPGME
260 270 280 290 300
SADSRRLTTK HSRKALKASL TLGILLSMFF VTWLPFFVAS IAQAVCDCIS
310 320 330 340 350
PGLFDVLTWL GYCNSTMNPI IYPLFMRDFK RALGRFVPCV HCPPEHRASP
360 370 380 390 400
ASPSMWTSHS GARPGLSLQQ VLPLPLPPNS DSDSASGGTS GLQLTAQLLL
410 420 430 440
PGEATRDPPP PTRAPTVVNF FVTDSVEPEI RQHPLGSPMN
Length:440
Mass (Da):46,998
Last modified:May 1, 2000 - v1
Checksum:i4440CDEBE01FEF0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134158 mRNA Translation: AAD46490.1
CCDSiCCDS18838.1
RefSeqiNP_067333.1, NM_021358.2
XP_011248498.1, XM_011250196.2
UniGeneiMm.291096

Genome annotation databases

EnsembliENSMUST00000068036; ENSMUSP00000068333; ENSMUSG00000028747
ENSMUST00000105802; ENSMUSP00000101428; ENSMUSG00000028747
GeneIDi15565
KEGGimmu:15565
UCSCiuc008vlr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134158 mRNA Translation: AAD46490.1
CCDSiCCDS18838.1
RefSeqiNP_067333.1, NM_021358.2
XP_011248498.1, XM_011250196.2
UniGeneiMm.291096

3D structure databases

ProteinModelPortaliQ9R1C8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200479, 2 interactors
STRINGi10090.ENSMUSP00000068333

Chemistry databases

BindingDBiQ9R1C8
ChEMBLiCHEMBL1075268

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9R1C8

Proteomic databases

PaxDbiQ9R1C8
PRIDEiQ9R1C8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068036; ENSMUSP00000068333; ENSMUSG00000028747
ENSMUST00000105802; ENSMUSP00000101428; ENSMUSG00000028747
GeneIDi15565
KEGGimmu:15565
UCSCiuc008vlr.1 mouse

Organism-specific databases

CTDi3362
MGIiMGI:1196627 Htr6

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000241520
HOVERGENiHBG106962
InParanoidiQ9R1C8
KOiK04162
OMAiGWHELGH
OrthoDBiEOG091G06VI
PhylomeDBiQ9R1C8
TreeFamiTF351753

Enzyme and pathway databases

ReactomeiR-MMU-390666 Serotonin receptors
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:Q9R1C8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028747 Expressed in 21 organ(s), highest expression level in cortical intermediate zone
CleanExiMM_HTR6
ExpressionAtlasiQ9R1C8 baseline and differential
GenevisibleiQ9R1C8 MM

Family and domain databases

CDDicd15054 7tmA_5-HT6, 1 hit
InterProiView protein in InterPro
IPR002232 5HT6_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5HT6R_MOUSE
AccessioniPrimary (citable) accession number: Q9R1C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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